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- Antigen structure
- References [17]
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- Validations
- Western blot [1]
- Immunohistochemistry [1]
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- Product number
- 10189-2-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#10189-2-AP, RRID:AB_2123233
- Product name
- IGFBP3 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated IGFBP3 antibody (Cat. #10189-2-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse and has been validated for the following applications: IF, IHC, WB,ELISA.
- Reactivity
- Human, Mouse
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Choline-induced SLC5A7 impairs colorectal cancer growth by stabilizing p53 protein.
Cyclovirobuxine inhibits the progression of clear cell renal cell carcinoma by suppressing the IGFBP3-AKT/STAT3/MAPK-Snail signalling pathway.
Wound healing with topical BRAF inhibitor therapy in a diabetic model suggests tissue regenerative effects.
Elevated Sodium Pump α3 Subunit Expression Promotes Colorectal Liver Metastasis via the p53-PTEN/IGFBP3-AKT-mTOR Axis.
The glucose-sensing transcription factor MLX balances metabolism and stress to suppress apoptosis and maintain spermatogenesis.
Podocyte apoptosis in diabetic nephropathy by BASP1 activation of the p53 pathway via WT1.
Interleukin-33 alleviates diabetic cardiomyopathy through regulation of endoplasmic reticulum stress and autophagy via insulin-like growth factor-binding protein 3.
Xanthatin synergizes with cisplatin to suppress homologous recombination through JAK2/STAT4/BARD1 axis in human NSCLC cells.
Runt related transcription factor-1 plays a central role in vessel co-option of colorectal cancer liver metastases.
RGC-32 Regulates Generation of Reactive Astrocytes in Experimental Autoimmune Encephalomyelitis.
Quercetin Attenuates Atherosclerosis via Modulating Oxidized LDL-Induced Endothelial Cellular Senescence.
Exosomes derived from miR-375-overexpressing human adipose mesenchymal stem cells promote bone regeneration.
Normoxia is not favorable for maintaining stemness of human endothelial progenitor cells.
Silencing HOXD10 by promoter region hypermethylation activates ERK signaling in hepatocellular carcinoma.
Selenium deficiency-induced thioredoxin suppression and thioredoxin knock down disbalanced insulin responsiveness in chicken cardiomyocytes through PI3K/Akt pathway inhibition.
Disruption of the AMPK-TBC1D1 nexus increases lipogenic gene expression and causes obesity in mice via promoting IGF1 secretion.
Protective potential of epigallocatechin-3-gallate against benign prostatic hyperplasia in metabolic syndrome rats.
Yin Y, Jiang Z, Fu J, Li Y, Fang C, Yin X, Chen Y, Chen N, Li J, Ji Y, Su X, Qiu M, Huang W, Zhang B, Deng H, Dai L
Cancer letters 2022 Jan 28;525:55-66
Cancer letters 2022 Jan 28;525:55-66
Cyclovirobuxine inhibits the progression of clear cell renal cell carcinoma by suppressing the IGFBP3-AKT/STAT3/MAPK-Snail signalling pathway.
Liu Y, Lv H, Li X, Liu J, Chen S, Chen Y, Jin Y, An R, Yu S, Wang Z
International journal of biological sciences 2021;17(13):3522-3537
International journal of biological sciences 2021;17(13):3522-3537
Wound healing with topical BRAF inhibitor therapy in a diabetic model suggests tissue regenerative effects.
Escuin-Ordinas H, Liu Y, Sun L, Hugo W, Dimatteo R, Huang RR, Krystofinski P, Azhdam A, Lee J, Comin-Anduix B, Cochran AJ, Lo RS, Segura T, Scumpia PO, Ribas A
PloS one 2021;16(6):e0252597
PloS one 2021;16(6):e0252597
Elevated Sodium Pump α3 Subunit Expression Promotes Colorectal Liver Metastasis via the p53-PTEN/IGFBP3-AKT-mTOR Axis.
Wu D, Yu HQ, Xiong HJ, Zhang YJ, Lin XT, Zhang J, Wu W, Wang T, Liu XY, Xie CM
Frontiers in oncology 2021;11:743824
Frontiers in oncology 2021;11:743824
The glucose-sensing transcription factor MLX balances metabolism and stress to suppress apoptosis and maintain spermatogenesis.
Carroll PA, Freie BW, Cheng PF, Kasinathan S, Gu H, Hedrich T, Dowdle JA, Venkataramani V, Ramani V, Wu X, Raftery D, Shendure J, Ayer DE, Muller CH, Eisenman RN
PLoS biology 2021 Oct;19(10):e3001085
PLoS biology 2021 Oct;19(10):e3001085
Podocyte apoptosis in diabetic nephropathy by BASP1 activation of the p53 pathway via WT1.
Zhang Y, Xu C, Ye Q, Tong L, Jiang H, Zhu X, Huang L, Lin W, Fu H, Wang J, Persson PB, Lai EY, Mao J
Acta physiologica (Oxford, England) 2021 May;232(1):e13634
Acta physiologica (Oxford, England) 2021 May;232(1):e13634
Interleukin-33 alleviates diabetic cardiomyopathy through regulation of endoplasmic reticulum stress and autophagy via insulin-like growth factor-binding protein 3.
Wu MX, Wang SH, Xie Y, Chen ZT, Guo Q, Yuan WL, Guan C, Xu CZ, Huang YN, Wang JF, Zhang HF, Chen YX
Journal of cellular physiology 2021 Jun;236(6):4403-4419
Journal of cellular physiology 2021 Jun;236(6):4403-4419
Xanthatin synergizes with cisplatin to suppress homologous recombination through JAK2/STAT4/BARD1 axis in human NSCLC cells.
Zhang J, Yang S, Guan H, Zhou J, Gao Y
Journal of cellular and molecular medicine 2021 Feb;25(3):1688-1699
Journal of cellular and molecular medicine 2021 Feb;25(3):1688-1699
Runt related transcription factor-1 plays a central role in vessel co-option of colorectal cancer liver metastases.
Rada M, Kapelanski-Lamoureux A, Petrillo S, Tabariès S, Siegel P, Reynolds AR, Lazaris A, Metrakos P
Communications biology 2021 Aug 10;4(1):950
Communications biology 2021 Aug 10;4(1):950
RGC-32 Regulates Generation of Reactive Astrocytes in Experimental Autoimmune Encephalomyelitis.
Tatomir A, Beltrand A, Nguyen V, Boodhoo D, Mekala A, Cudrici C, Badea TC, Muresanu DF, Rus V, Rus H
Frontiers in immunology 2020;11:608294
Frontiers in immunology 2020;11:608294
Quercetin Attenuates Atherosclerosis via Modulating Oxidized LDL-Induced Endothelial Cellular Senescence.
Jiang YH, Jiang LY, Wang YC, Ma DF, Li X
Frontiers in pharmacology 2020;11:512
Frontiers in pharmacology 2020;11:512
Exosomes derived from miR-375-overexpressing human adipose mesenchymal stem cells promote bone regeneration.
Chen S, Tang Y, Liu Y, Zhang P, Lv L, Zhang X, Jia L, Zhou Y
Cell proliferation 2019 Sep;52(5):e12669
Cell proliferation 2019 Sep;52(5):e12669
Normoxia is not favorable for maintaining stemness of human endothelial progenitor cells.
Lin Y, Liu B, Deng T, Zhong J, Feng Z, Zeng Q, Huang G, Chen Z
Stem cell research 2019 Jul;38:101464
Stem cell research 2019 Jul;38:101464
Silencing HOXD10 by promoter region hypermethylation activates ERK signaling in hepatocellular carcinoma.
Guo Y, Peng Y, Gao D, Zhang M, Yang W, Linghu E, Herman JG, Fuks F, Dong G, Guo M
Clinical epigenetics 2017;9:116
Clinical epigenetics 2017;9:116
Selenium deficiency-induced thioredoxin suppression and thioredoxin knock down disbalanced insulin responsiveness in chicken cardiomyocytes through PI3K/Akt pathway inhibition.
Yang J, Hamid S, Cai J, Liu Q, Xu S, Zhang Z
Cellular signalling 2017 Oct;38:192-200
Cellular signalling 2017 Oct;38:192-200
Disruption of the AMPK-TBC1D1 nexus increases lipogenic gene expression and causes obesity in mice via promoting IGF1 secretion.
Chen L, Chen Q, Xie B, Quan C, Sheng Y, Zhu S, Rong P, Zhou S, Sakamoto K, MacKintosh C, Wang HY, Chen S
Proceedings of the National Academy of Sciences of the United States of America 2016 Jun 28;113(26):7219-24
Proceedings of the National Academy of Sciences of the United States of America 2016 Jun 28;113(26):7219-24
Protective potential of epigallocatechin-3-gallate against benign prostatic hyperplasia in metabolic syndrome rats.
Chen J, Song H
Environmental toxicology and pharmacology 2016 Jul;45:315-20
Environmental toxicology and pharmacology 2016 Jul;45:315-20
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- A2780 cells were subjected to SDS PAGE followed by western blot with 10189-2-AP(IGFBP3 antibody) at dilution of 1:100
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The IGFBP3 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human IGFBP3. This antibody recognizes human,mouse,rat antigen. The IGFBP3 antibody has been validated for the following applications: ELISA, WB, IHC analysis.
