Ab134116

antibody from Aladdin Scientific Corporation

Targeting: VEGFD FIGF, VEGF-D

Western blot (Data presented on provider website)

Immunocytochemistry (Data presented on provider website)

Immunohistochemistry (Data presented on provider website)

Antibody Data

Product number

Ab134116

Provider

Aladdin Scientific Corporation

Product name

Recombinant VEGFD Antibody

Antibody type

Recombinant

Description

Rabbit anti Human VEGFD Antibody, Recombinant (R03-8H6), could be used for WB, IHC, ICC, IF and so on.Application:WB: 1/500 - 1/1000IHC: 1/50-1/100ICC/IF: 1/50-1/200Protein FunctionPost-translational Growth factor active in angiogenesis, lymphangiogenesis and endothelial cell growth, stimulating their proliferation and migration and also has effects on the permeability of blood vessels. May function in the formation of the venous and lymphatic vascular systems during embryogenesis, and also in the maintenance of differentiated lymphatic endothelium in adults. Binds and activates VEGFR-2 (KDR/FLK1) and VEGFR-3 (FLT4) receptors.Activated by phosphorylation at Ser-218 by PDPK1. Autophosphorylated on Ser-377, as part of the activation process. May be phosphorylated at Thr-356 and Ser-360 by MAPK1/ERK2 and MAPK3/ERK1. N-terminal myristoylation results in an activated kinase in the absence of added growth factors.Post-translationalUndergoes a complex proteolytic maturation which generates a variety of processed secreted forms with increased activity toward VEGFR-3 and VEGFR-2. VEGF-D first form an antiparallel homodimer linked by disulfide bonds before secretion. The fully processed VEGF-D is composed mostly of two VEGF homology domains (VHDs) bound by non-covalent interactions.

Reactivity

Human, Mouse, Rat

Host

Rabbit

Conjugate

Unconjugated

Antigen sequence

AA 242-255


Antibody clone number

R03-8H6

Vial size

100μl,10μl,1ml,50μl

Concentration

1,5 mg/ml

Storage

Store at 4°C short term (1-2 weeks). Store at -20°C long term (24 months). Upon delivery aliquot. Avoid freeze/thaw cycle.