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Protein structure
MASP1
Mannan binding lectin serine peptidase 1CRARF, MASP, PRSS5
This gene encodes a serine protease that functions as a component of the lectin pathway of complement activation. The complement pathway plays an essential role in the innate and adaptive immune response. The encoded protein is synthesized as a zymogen and is activated when it complexes with the pathogen recognition molecules of lectin pathway, the mannose-binding lectin and the ficolins. This protein is not directly involved in complement activation but may play a role as an amplifier of complement activation by cleaving complement C2 or by activating another complement serine protease, MASP-2. The encoded protein is also able to cleave fibrinogen and factor XIII and may may be involved in coagulation. A splice variant of this gene which lacks the serine protease domain functions as an inhibitor of the complement pathway. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Apr 2010]
Top validated antibodies |
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| Proteintech Group |  21837-1-AP |
Polyclonal |
WB
EL
IHC
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| Novus Biologicals | AF1724 |
1 references | Polyclonal |
WB
IP
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| R&D Systems | AF1724 |
1 references | Polyclonal |
WB
IP
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| antibodies-online | ABIN733508 |
Polyclonal |
WB
ICC
IHC
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| OriGene | AM32981PU-N |
Monoclonal |
WB
EL
IP
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