66504-1-Ig

antibody from Proteintech Group

Targeting: NFE2L2 NRF2

Western blot (Data presented on provider website)

ELISA (Data presented on provider website)

Antibody Data

Product number

66504-1-Ig

Provider

Proteintech Group

Product name

NRF2, NFE2L2 antibody

Antibody type

Monoclonal

Description

KD/KO validated NRF2, NFE2L2 antibody (Cat. #66504-1-Ig) is a mouse monoclonal antibody that shows reactivity with Human and has been validated for the following applications: WB,ELISA.

Reactivity

Human

Host

Mouse

Conjugate

Unconjugated

Isotype

IgG

Antibody clone number

1E9E3

Vial size

20ul, 150ul

References

Submitted references

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Chen X, Zhang M, Xue Y, Liang D, An W, Jia G, Zhao H, Liu G, Huang Z
The Journal of nutritional biochemistry 2022 Jan;99:108859

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Farrerol Enhances Nrf2-Mediated Defense Mechanisms against Hydrogen Peroxide-Induced Oxidative Damage in Human Retinal Pigment Epithelial Cells by Activating Akt and MAPK.

Ma N, Yang X, Qi C, Yu Q, Zhu C, Ren H
Oxidative medicine and cellular longevity 2021;2021:8847844

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Limonin Inhibits IL-1β-Induced Inflammation and Catabolism in Chondrocytes and Ameliorates Osteoarthritis by Activating Nrf2.

Jin J, Lv X, Wang B, Ren C, Jiang J, Chen H, Chen X, Gu M, Pan Z, Tian N, Wu A, Sun L, Gao W, Wang X, Zhang X, Wu Y, Zhou Y
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MCC950, the NLRP3 Inhibitor, Protects against Cartilage Degradation in a Mouse Model of Osteoarthritis.

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Bioactive Peptide F2d Isolated from Rice Residue Exerts Antioxidant Effects via Nrf2 Signaling Pathway.

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Atorvastatin Regulates MALAT1/miR-200c/NRF2 Activity to Protect Against Podocyte Pyroptosis Induced by High Glucose.

Zuo Y, Chen L, He X, Ye Z, Li L, Liu Z, Zhou S
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Synergistic Protective Effect of Konjac Mannan Oligosaccharides and Bacillus subtilis on Intestinal Epithelial Barrier Dysfunction in Caco-2 Cell Model and Mice Model of Lipopolysaccharide Stimulation.

Chen L, Zhang S, Wu S, Ren Z, Liu G, Wu J
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Bakuchiol ameliorates cerebral ischemia-reperfusion injury by modulating NLRP3 inflammasome and Nrf2 signaling.

Xu Y, Gao X, Wang L, Yang M, Xie R
Respiratory physiology & neurobiology 2021 Oct;292:103707

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Li L, Liu S, Zhou Y, Zhao M, Wang Y, Wang C, Lou P, Huang R, Ma L, Lu Y, Fu P, Liu J
Journal of cellular and molecular medicine 2021 Oct;25(20):9863-9877

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The Role of Nrf2 Transcription Factor and Sp1-Nrf2 Protein Complex in Glutamine Transporter SN1 Regulation in Mouse Cortical Astrocytes Exposed to Ammonia.

Dąbrowska K, Skowrońska K, Popek M, Albrecht J, Zielińska M
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Aronia melanocarpa polysaccharide ameliorates inflammation and aging in mice by modulating the AMPK/SIRT1/NF-κB signaling pathway and gut microbiota.

Zhao Y, Liu X, Zheng Y, Liu W, Ding C
Scientific reports 2021 Oct 18;11(1):20558

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Cyanidin-3-O-glucoside and its metabolite protocatechuic acid ameliorate 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) induced cytotoxicity in HepG2 cells by regulating apoptotic and Nrf2/p62 pathways.

Zhao L, Zhou N, Zhang H, Pan F, Ai X, Wang Y, Hao S, Wang C
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2021 Nov;157:112582

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Physalin B inhibits PDGF-BB-induced VSMC proliferation, migration and phenotypic transformation by activating the Nrf2 pathway.

Qiu L, Hu L, Liu X, Li W, Zhang X, Xia H, Zhang C
Food & function 2021 Nov 1;12(21):10950-10966

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Pristimerin reduces dextran sulfate sodium-induced colitis in mice by inhibiting microRNA-155.

Tian M, Peng S, Wang S, Li X, Li H, Shen L
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The near-infrared dye IR-61 restores erectile function in a streptozotocin-induced diabetes model via mitochondrial protection.

Yue XF, Shen CX, Wang JW, Dai LY, Fang Q, Long L, Zhi Y, Li XR, Wang YW, Shen GF, Liu ZJ, Shi CM, Li WB
Asian journal of andrology 2021 May-Jun;23(3):249-258

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Protective effects and mechanisms of high-dose vitamin C on sepsis-associated cognitive impairment in rats.

Zhang N, Zhao W, Hu ZJ, Ge SM, Huo Y, Liu LX, Gao BL
Scientific reports 2021 Jul 15;11(1):14511

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DJ-1 modulates Nrf2-mediated MRP1 expression by activating Wnt3a/β-catenin signalling in A549 cells exposed to cigarette smoke extract and LPS.

Zhou J, Qi C, Fang X, Wang Z, Zhang S, Li D, Song J
Life sciences 2021 Jul 1;276:119089

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H₂S probe CPC inhibits autophagy and promotes apoptosis by inhibiting glutathionylation of Keap1 at Cys434.

Li N, Wang J, Zang X, Wang Z, Zhang T, Zhao B, Miao J, Lin Z
Apoptosis : an international journal on programmed cell death 2021 Feb;26(1-2):111-131

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Galangin ameliorates severe acute pancreatitis in mice by activating the nuclear factor E2-related factor 2/heme oxygenase 1 pathway.

Song YD, Liu YY, Li DJ, Yang SJ, Wang QF, Liu YN, Li MK, Mei CP, Cui HN, Chen SY, Zhu CJ
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2021 Dec;144:112293

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Dietary dihydromyricetin supplementation enhances antioxidant capacity and improves lipid metabolism in finishing pigs.

Guo Z, Chen X, Huang Z, Chen D, Yu B, Chen H, Yu J, Yan H, Zheng P, Luo Y
Food & function 2021 Aug 2;12(15):6925-6935

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Kaempferol induces ROS-dependent apoptosis in pancreatic cancer cells via TGM2-mediated Akt/mTOR signaling.

Wang F, Wang L, Qu C, Chen L, Geng Y, Cheng C, Yu S, Wang D, Yang L, Meng Z, Chen Z
BMC cancer 2021 Apr 12;21(1):396

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Koumine Alleviates Lipopolysaccharide-Induced Intestinal Barrier Dysfunction in IPEC-J2 Cells by Regulating Nrf2/NF-κB Pathway.

Wu J, Yang CL, Sha YK, Wu Y, Liu ZY, Yuan ZH, Sun ZL
The American journal of Chinese medicine 2020;48(1):127-142

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Effect of Quercetin on PC12 Alzheimer's Disease Cell Model Induced by Aβ _25-35 and Its Mechanism Based on Sirtuin1/Nrf2/HO-1 Pathway.

Yu X, Li Y, Mu X
BioMed research international 2020;2020:8210578

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Role of CYP4F2 as a novel biomarker regulating malignant phenotypes of liver cancer cells via the Nrf2 signaling axis.

Wan S, Pan Q, Yang G, Kuang J, Luo S
Oncology letters 2020 Oct;20(4):13

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Protective Effects of Ischemic Postconditioning on Livers in Rats with Limb Ischemia-Reperfusion via Glycogen Synthase Kinase 3 beta (GSK-3β)/Fyn/Nuclear Receptor-Erythroid-2-Related Factor (Nrf2) Pathway.

Niu Q, Sun W, Chen Q, Long Y, Cao W, Wen S, Li A, Dong F, Shi H
Medical science monitor : international medical journal of experimental and clinical research 2020 Jul 20;26:e923049

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Pyridoxine induces glutathione synthesis via PKM2-mediated Nrf2 transactivation and confers neuroprotection.

Wei Y, Lu M, Mei M, Wang H, Han Z, Chen M, Yao H, Song N, Ding X, Ding J, Xiao M, Hu G
Nature communications 2020 Feb 18;11(1):941

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Dietary Ferulic Acid Supplementation Improves Antioxidant Capacity and Lipid Metabolism in Weaned Piglets.

Wang Y, Chen X, Huang Z, Chen D, Yu B, Yu J, Chen H, He J, Luo Y, Zheng P
Nutrients 2020 Dec 12;12(12)

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Induction of Nrf2 pathway by Dendrobium nobile Lindl. alkaloids protects against carbon tetrachloride induced acute liver injury.

Li S, Zhou J, Xu S, Li J, Liu J, Lu Y, Shi J, Zhou S, Wu Q
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2019 Sep;117:109073

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Aucubin inhibited lipid accumulation and oxidative stress via Nrf2/HO-1 and AMPK signalling pathways.

Shen B, Zhao C, Wang Y, Peng Y, Cheng J, Li Z, Wu L, Jin M, Feng H
Journal of cellular and molecular medicine 2019 Jun;23(6):4063-4075

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Repair Effects of Astragalus Polysaccharides with Different Molecular Weights on Oxidatively Damaged HK-2 Cells.

Han J, Guo D, Sun XY, Wang JM, Ouyang JM, Gui BS
Scientific reports 2019 Jul 8;9(1):9871

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Activation of the Nuclear Erythroid 2-Related Factor 2 Antioxidant Responsive Element (Nrf2-ARE) Signaling Pathway Alleviates Acute Graft-Versus-Host Disease by Reducing Oxidative Stress and Inhibiting Infiltration of Inflammatory Cells in an Allogeneic Stem Cell Transplantation Mouse Model.

Yi T, Li X, Wang E, Zhang Y, Fu Y, Li J, Jiang T
Medical science monitor : international medical journal of experimental and clinical research 2018 Aug 27;24:5973-5979

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4-Hydroxy-7-oxo-5-heptenoic Acid Lactone Is a Potent Inducer of the Complement Pathway in Human Retinal Pigmented Epithelial Cells.

Linetsky M, Bondelid KS, Losovskiy S, Gabyak V, Rullo MJ, Stiadle TI, Munjapara V, Saxena P, Ma D, Cheng YS, Howes AM, Udeigwe E, Salomon RG
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