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- Antibody Data
- Antigen structure
- References [591]
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- Western blot [1]
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- Product number
- 16396-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#16396-1-AP, RRID:AB_2782956
- Product name
- NRF2, NFE2L2 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated NRF2, NFE2L2 antibody (Cat. #16396-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: FC, IF, IHC, IP, WB, ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Moringa oleifera Lam. seed extract protects kidney function in rats with diabetic nephropathy by increasing GSK-3β activity and activating the Nrf2/HO-1 pathway.
Protective effects of Huang-Lian-Jie-Du Decoction on diabetic nephropathy through regulating AGEs/RAGE/Akt/Nrf2 pathway and metabolic profiling in db/db mice.
GRP78 Antibodies Are Associated With Blood-Brain Barrier Breakdown in Anti-Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disorder.
CAMKK2 Defines Ferroptosis Sensitivity of Melanoma Cells by Regulating AMPK‒NRF2 Pathway.
Overexpressed Smurf1 is degraded in glioblastoma cells through autophagy in a p62-dependent manner.
The ethanol extract of flower buds of Tussilago farfara L. attenuates cigarette smoke-induced lung inflammation through regulating NLRP3 inflammasome, Nrf2, and NF-κB.
Suhuang antitussive capsule ameliorates post-infectious cough in mice through AhR-Nrf2 pathway.
Glyphosate-induced gut microbiota dysbiosis facilitates male reproductive toxicity in rats.
NMN recruits GSH to enhance GPX4-mediated ferroptosis defense in UV irradiation induced skin injury.
Dietary mulberry-leaf flavonoids improve the eggshell quality of aged breeder hens.
Anti-fatigue effect of hypericin in a chronic forced exercise mouse model.
SLC7A11 Reduces Laser-Induced Choroidal Neovascularization by Inhibiting RPE Ferroptosis and VEGF Production.
Lactobacillus acidophilus ATCC 4356 Alleviates Renal Ischemia-Reperfusion Injury Through Antioxidant Stress and Anti-inflammatory Responses and Improves Intestinal Microbial Distribution.
Hengshun Aromatic Vinegar Ameliorates Vascular Endothelial Injury via Regulating PKCζ-Mediated Oxidative Stress and Apoptosis.
Nicotinic Acid against Acetaminophen-Induced Hepatotoxicity via Sirt1/Nrf2 Antioxidative Pathway in Mice.
Betanin Prevents Experimental Abdominal Aortic Aneurysm Progression by Modulating the TLR4/NF-κB and Nrf2/HO-1 Pathways.
H2S improves doxorubicin-induced myocardial fibrosis by inhibiting oxidative stress and apoptosis via Keap1-Nrf2.
Metabolic Activation of Retrorsine may Disrupt Bile Acid Homeostasis in Mice through the Nrf2 Pathway.
Zisheng Shenqi Decoction Ameliorates Monosodium Urate-Mediated Gouty Arthritis in Rats via Promotion of Autophagy through the AMPK/mTOR Signaling Pathway.
Fenofibrate Ameliorates Hepatic Ischemia/Reperfusion Injury in Mice: Involvements of Apoptosis, Autophagy, and PPAR-α Activation.
MCU That Is Transcriptionally Regulated by Nrf2 Augments Malignant Biological Behaviors in Oral Squamous Cell Carcinoma Cells.
Antioral Squamous Cell Carcinoma Effects of Carvacrol via Inhibiting Inflammation, Proliferation, and Migration Related to Nrf2/Keap1 Pathway.
Tubeimoside I Ameliorates Myocardial Ischemia-Reperfusion Injury through SIRT3-Dependent Regulation of Oxidative Stress and Apoptosis.
Design, Synthesis, and Biological Evaluation of a Novel Aminothiol Compound as Potential Radioprotector.
Microglia-Derived Exosomes Improve Spinal Cord Functional Recovery after Injury via Inhibiting Oxidative Stress and Promoting the Survival and Function of Endothelia Cells.
PKM2 Is a Potential Diagnostic and Therapeutic Target for Retinitis Pigmentosa.
Gastric Electrical Pacing Reduces Apoptosis of Interstitial Cells of Cajal via Antioxidative Stress Effect Attributing to Phenotypic Polarization of M2 Macrophages in Diabetic Rats.
Copper Nanoparticles Induce Oxidative Stress via the Heme Oxygenase 1 Signaling Pathway in vitro Studies.
Baicalin Alleviates Oxidative Stress and Inflammation in Diabetic Nephropathy via Nrf2 and MAPK Signaling Pathway.
Sodium Propionate Enhances Nrf2-Mediated Protective Defense Against Oxidative Stress and Inflammation in Lipopolysaccharide-Induced Neonatal Mice.
Induction of Mitosis Delay and Apoptosis by CDDO-TFEA in Glioblastoma Multiforme.
Paeoniflorin Suppresses TBHP-Induced Oxidative Stress and Apoptosis in Human Umbilical Vein Endothelial Cells via the Nrf2/HO-1 Signaling Pathway and Improves Skin Flap Survival.
Caveolin-1 Alleviates Acetaminophen-Induced Fat Accumulation in Non-Alcoholic Fatty Liver Disease by Enhancing Hepatic Antioxidant Ability via Activating AMPK Pathway.
Geniposide Combined With Notoginsenoside R1 Attenuates Inflammation and Apoptosis in Atherosclerosis via the AMPK/mTOR/Nrf2 Signaling Pathway.
Astragaloside IV Attenuates the Myocardial Injury Caused by Adriamycin by Inhibiting Autophagy.
Downregulated MicroRNA-327 Attenuates Oxidative Stress-Mediated Myocardial Ischemia Reperfusion Injury Through Regulating the FGF10/Akt/Nrf2 Signaling Pathway.
The Protective Effects of Sulforaphane on High-Fat Diet-Induced Obesity in Mice Through Browning of White Fat.
Tanshinone I Inhibits Oxidative Stress-Induced Cardiomyocyte Injury by Modulating Nrf2 Signaling.
The Protective Effects of Shengmai Formula Against Myocardial Injury Induced by Ultrafine Particulate Matter Exposure and Myocardial Ischemia are Mediated by the PI3K/AKT/p38 MAPK/Nrf2 Pathway.
Inhibition of BAG3 enhances the anticancer effect of shikonin in hepatocellular carcinoma.
Antioxidant activity of mesenchymal stem cell-derived extracellular vesicles restores hippocampal neurons following seizure damage.
Nrf2 Down-Regulation by Camptothecin Favors Inhibiting Invasion, Metastasis and Angiogenesis in Hepatocellular Carcinoma.
Daphnetin inhibits spinal glial activation via Nrf2/HO-1/NF-κB signaling pathway and attenuates CFA-induced inflammatory pain.
Polydatin has anti-inflammatory and antioxidant effects in LPS-induced macrophages and improves DSS-induced mice colitis.
Temozolomide Drives Ferroptosis via a DMT1-Dependent Pathway in Glioblastoma Cells.
TAZ as a novel regulator of oxidative damage in decidualization via Nrf2/ARE/Foxo1 pathway.
Compensatory expression of NRF2-dependent antioxidant genes is required to overcome the lethal effects of Kv11.1 activation in breast cancer cells and PDOs.
Dimethyl itaconate inhibits LPS‑induced microglia inflammation and inflammasome‑mediated pyroptosis via inducing autophagy and regulating the Nrf‑2/HO‑1 signaling pathway.
N2L, a novel lipoic acid-niacin dimer, attenuates ferroptosis and decreases lipid peroxidation in HT22 cells.
CSNK2B contributes to colorectal cancer cell proliferation by activating the mTOR signaling.
Celecoxib reverses the glioblastoma chemo-resistance to temozolomide through mitochondrial metabolism.
Enhanced Extracellular Matrix Degradation in Growth Plate Contributes to Manganese Deficiency-Induced Tibial Dyschondroplasia in Broiler Chicks.
Genistein exhibits therapeutic potential for PCOS mice via the ER-Nrf2-Foxo1-ROS pathway.
Anti-inflammatory and Antioxidant Effects of Pyrroloquinoline Quinone in L-NAME-Induced Preeclampsia-Like Rat Model.
Round Scad-Derived Octapeptide WCPFSRSF Confers Neuroprotection by Regulating Akt/Nrf2/NFκB Signaling.
Aged Ripe Pu-erh Tea Reduced Oxidative Stress-Mediated Inflammation in Dextran Sulfate Sodium-Induced Colitis Mice by Regulating Intestinal Microbes.
Yixin-Fumai granules improve sick sinus syndrome in aging mice through Nrf-2/HO-1 pathway: A new target for sick sinus syndrome.
Effect of different exercise training intensities on age-related cardiac damage in male mice.
Protective Effects and Mechanisms of Procyanidins on Parkinson's Disease In Vivo and In Vitro.
Baicalein Enhances the Effect of Acarbose on the Improvement of Nonalcoholic Fatty Liver Disease Associated with Prediabetes via the Inhibition of De Novo Lipogenesis.
MicroRNA-30c-5p protects against myocardial ischemia/reperfusion injury via regulation of Bach1/Nrf2.
LncRNA OIP5-AS1 inhibits ferroptosis in prostate cancer with long-term cadmium exposure through miR-128-3p/SLC7A11 signaling.
Inhibition of TNFAIP1 ameliorates the oxidative stress and inflammatory injury in myocardial ischemia/reperfusion injury through modulation of Akt/GSK-3β/Nrf2 pathway.
Thymus quinquecostatus Celak. ameliorates cerebral ischemia-reperfusion injury via dual antioxidant actions: Activating Keap1/Nrf2/HO-1 signaling pathway and directly scavenging ROS.
Cardioprotective effect of MLN4924 on ameliorating autophagic flux impairment in myocardial ischemia-reperfusion injury by Sirt1.
Black raspberry (Rubus occidentalis) attenuates inflammatory markers and vascular endothelial dysfunction in Wistar rats fed a high-fat diet with fructose solution.
Oridonin prevents oxidative stress-induced endothelial injury via promoting Nrf-2 pathway in ischaemic stroke.
A new ferroptosis inhibitor, isolated from Ajuga nipponensis, protects neuronal cells via activating NRF2-antioxidant response elements (AREs) pathway.
The Potential Protective Effect and Possible Mechanism of Peptides from Oyster (Crassostrea hongkongensis) Hydrolysate on Triptolide-Induced Testis Injury in Male Mice.
Nicotinic Acetylcholine Receptor Subunit α7 Mediates Cigarette Smoke-Induced PD-L1 Expression in Human Bronchial Epithelial Cells.
RTA404, an Activator of Nrf2, Activates the Checkpoint Kinases and Induces Apoptosis through Intrinsic Apoptotic Pathway in Malignant Glioma.
(-)-Epicatechin ameliorates cigarette smoke-induced lung inflammation via inhibiting ROS/NLRP3 inflammasome pathway in rats with COPD.
Hexavalent chromium inhibits the formation of neutrophil extracellular traps and promotes the apoptosis of neutrophils via AMPK signaling pathway.
Melatonin Analogues Potently Inhibit MAO-B and Protect PC12 Cells against Oxidative Stress.
Copper (Cu) induced changes of lipid metabolism through oxidative stress-mediated autophagy and Nrf2/PPARγ pathways.
Sitagliptin activates the p62-Keap1-Nrf2 signalling pathway to alleviate oxidative stress and excessive autophagy in severe acute pancreatitis-related acute lung injury.
Exercise Intervention Mitigates Pathological Liver Changes in NAFLD Zebrafish by Activating SIRT1/AMPK/NRF2 Signaling.
Protective effects of Nrf2 against sepsis-induced hepatic injury.
Antagonizing effects of curcumin against mercury-induced autophagic death and trace elements disorder by regulating PI3K/AKT and Nrf2 pathway in the spleen.
Nicotinamide improves NAD+ levels to protect against acetaminophen-induced acute liver injury in mice.
Loss of PHLDA1 has a protective role in OGD/R-injured neurons via regulation of the GSK-3β/Nrf2 pathway.
Tripartite motif-containing protein 16 protects against myocardial ischemia/reperfusion injury by affecting the Keap1/Nrf2 axis.
PHLDA3 inhibition protects against myocardial ischemia/reperfusion injury by alleviating oxidative stress and inflammatory response via the Akt/Nrf2 axis.
Chemical Constituents from the Rhizome of Ligusticum chuanxiong Hort. and Their Nrf2 Inducing Activity.
Resveratrol sustains intestinal barrier integrity, improves antioxidant capacity, and alleviates inflammation in the jejunum of ducks exposed to acute heat stress.
Isoliquiritigenin alleviates LPS/ D-GalN-induced acute liver failure by activating the PGC-1α/ Nrf2 pathway to reduce oxidative stress and inflammatory response.
CDDO-Im ameliorates osteoarthritis and inhibits chondrocyte apoptosis in mice via enhancing Nrf2-dependent autophagy.
Honokiol alleviates LPS-induced acute lung injury by inhibiting NLRP3 inflammasome-mediated pyroptosis via Nrf2 activation in vitro and in vivo.
Taxifolin retards the D-galactose-induced aging process through inhibiting Nrf2-mediated oxidative stress and regulating the gut microbiota in mice.
Role of Nox4 in High Calcium-Induced Renal Oxidative Stress Damage and Crystal Deposition.
TBHQ attenuates ferroptosis against 5-fluorouracil-induced intestinal epithelial cell injury and intestinal mucositis via activation of Nrf2.
Cynaropicrin Induces Cell Cycle Arrest and Apoptosis by Inhibiting PKM2 to Cause DNA Damage and Mitochondrial Fission in A549 Cells.
Ripened Pu-Erh Tea Improved the Enterohepatic Circulation in a Circadian Rhythm Disorder Mice Model.
TRIM32 Inhibition Attenuates Apoptosis, Oxidative Stress, and Inflammatory Injury in Podocytes Induced by High Glucose by Modulating the Akt/GSK-3β/Nrf2 Pathway.
Protective effect of cynaroside on sepsis-induced multiple organ injury through Nrf2/HO-1-dependent macrophage polarization.
Astragalus polysaccharide prevents ferroptosis in a murine model of experimental colitis and human Caco-2 cells via inhibiting NRF2/HO-1 pathway.
Intermittent hypoxia aggravates non-alcoholic fatty liver disease via RIPK3-dependent necroptosis-modulated Nrf2/NFκB signaling pathway.
Cetuximab promotes RSL3-induced ferroptosis by suppressing the Nrf2/HO-1 signalling pathway in KRAS mutant colorectal cancer.
Erythritol Improves Nonalcoholic Fatty Liver Disease by Activating Nrf2 Antioxidant Capacity.
Effective-component compatibility of Bufei Yishen formula protects COPD rats against PM2.5-induced oxidative stress via miR-155/FOXO3a pathway.
Protection of the enhanced Nrf2 deacetylation and its downstream transcriptional activity by SIRT1 in myocardial ischemia/reperfusion injury.
Heme supplementation ameliorates lupus nephritis through rectifying the disorder of splenocytes and alleviating renal inflammation and oxidative damage.
Trojan Horse Delivery of 4,4'-Dimethoxychalcone for Parkinsonian Neuroprotection.
Quiescin sulfhydryl oxidase 1 promotes sorafenib-induced ferroptosis in hepatocellular carcinoma by driving EGFR endosomal trafficking and inhibiting NRF2 activation.
Expression of COX-2 and Nrf2/GPx3 in the anterior vaginal wall tissues of women with pelvic organ prolapse.
Protective effects of gastrodin pretreatment on mouse hepatic ischemia-reperfusion occurring through antioxidant and anti-apoptotic mechanisms.
The role of PKA/PP2B-mediated Drp1 phosphorylation and the subsequent EGFR inhibition in Cr(VI)-induced premature senescence.
Development of phenyltriazole thiol-based derivatives as highly potent inhibitors of DCN1-UBC12 interaction.
Aromatic-Turmerone Analogs Protect Dopaminergic Neurons in Midbrain Slice Cultures through Their Neuroprotective Activities.
Lipoxin A4 protects primary spinal cord neurons from Erastin-induced ferroptosis by activating the Akt/Nrf2/HO-1 signaling pathway.
TRPV1 alleviates osteoarthritis by inhibiting M1 macrophage polarization via Ca2+/CaMKII/Nrf2 signaling pathway.
Neuroprotective Effects and Mechanisms of Procyanidins In Vitro and In Vivo.
Upregulation of Chemoresistance by Mg2+ Deficiency through Elevation of ATP Binding Cassette Subfamily B Member 1 Expression in Human Lung Adenocarcinoma A549 Cells.
4-Ethylguaiacol modulates neuroinflammation and Th1/Th17 differentiation to ameliorate disease severity in experimental autoimmune encephalomyelitis.
Anti-inflammatory activity of the water extract of Chloranthus serratus roots in LPS-stimulated RAW264.7 cells mediated by the Nrf2/HO-1, MAPK and NF-κB signaling pathways.
Twin drug design, synthesis and evaluation of diosgenin derivatives as multitargeted agents for the treatment of vascular dementia.
In vivo hepatoprotective activity and the underlying mechanism of chebulinic acid from Terminalia chebula fruit.
The deubiquitinase USP11 regulates cell proliferation and ferroptotic cell death via stabilization of NRF2 USP11 deubiquitinates and stabilizes NRF2.
Vicenin-2 inhibits the Helicobacterium pylori infection associated gastric carcinogenic events through modulation of PI3K/AKT and Nrf2 signaling in GES-1 cells.
Cordyceps acid alleviates lung cancer in nude mice.
Chondrocyte ferroptosis contribute to the progression of osteoarthritis.
Gambogic acid ameliorates high glucose- and palmitic acid-induced inflammatory response in ARPE-19 cells via activating Nrf2 signaling pathway: ex vivo.
AIDA directly connects sympathetic innervation to adaptive thermogenesis by UCP1.
Metformin attenuates hyperlipidaemia-associated vascular calcification through anti-ferroptotic effects.
Oxidative stress in retrotrapezoid nucleus/parafacial respiratory group and impairment of central chemoreception in rat offspring exposed to maternal cigarette smoke.
Sodium arsenite induces spatial learning and memory impairment associated with oxidative stress and activates the Nrf2/PPARγ pathway against oxidative injury in mice hippocampus.
Polyphenols from Penthorum chinense Pursh. Attenuates high glucose-induced vascular inflammation through directly interacting with Keap1 protein.
Loss of QKI in macrophage aggravates inflammatory bowel disease through amplified ROS signaling and microbiota disproportion.
Nox2 Inhibition Regulates Stress Response and Mitigates Skeletal Muscle Fiber Atrophy during Simulated Microgravity.
Cardamonin protects nucleus pulposus cells against IL-1β-induced inflammation and catabolism via Nrf2/NF-κB axis.
MiR-133a-3p relieves the oxidative stress induced trophoblast cell apoptosis through the BACH1/Nrf2/HO-1 signaling pathway.
Immunomodulation effects of polyphenols from thinned peach treated by different drying methods on RAW264.7 cells through the NF-κB and Nrf2 pathways.
Perilipin 5 ameliorates high-glucose-induced podocyte injury via Akt/GSK-3β/Nrf2-mediated suppression of apoptosis, oxidative stress, and inflammation.
Lupeol ameliorates LPS/D-GalN induced acute hepatic damage by suppressing inflammation and oxidative stress through TGFβ1-Nrf2 signal pathway.
Troxerutin Improves Dextran Sulfate Sodium-Induced Ulcerative Colitis in Mice.
CLIC1 Inhibition Protects Against Cellular Senescence and Endothelial Dysfunction Via the Nrf2/HO-1 Pathway.
Improving protection effects of eucalyptol via carboxymethyl chitosan-coated lipid nanoparticles on hyperglycaemia-induced vascular endothelial injury in rats.
Wogonin alleviates liver injury in sepsis through Nrf2-mediated NF-κB signalling suppression.
Synthesis and radioprotective effects of novel hybrid compounds containing edaravone analogue and 3-n-butylphthalide ring-opening derivatives.
Exploration of the hepatoprotective effect and mechanism of magnesium isoglycyrrhizinate in mice with arsenic trioxide‑induced acute liver injury.
Ginkgo biloba delays light-induced photoreceptor degeneration through antioxidant and antiapoptotic properties.
Oxymatrine pretreatment protects H9c2 cardiomyocytes from hypoxia/reoxygenation injury by modulating the PI3K/Akt pathway.
Hydrogen sulfide alleviates apoptosis and autophagy induced by beryllium sulfate in 16HBE cells.
Design, synthesis, and neuroprotective effects of novel hybrid compounds containing edaravone analogue and 3-n-butylphthalide ring-opened derivatives.
Effects of β-Asarone on Ischemic Stroke in Middle Cerebral Artery Occlusion Rats by an Nrf2-Antioxidant Response Elements (ARE) Pathway-Dependent Mechanism.
Hsa_circ_0005915 promotes N,N-dimethylformamide-induced oxidative stress in HL-7702 cells through NRF2/ARE axis.
Loss of FCHSD1 leads to amelioration of chronic obstructive pulmonary disease.
Guizhi Fuling Capsule ameliorates endometrial hyperplasia through promoting p62-Keap1-NRF2-mediated ferroptosis.
Inhibition of Oxidative Stress and ALOX12 and NF-κB Pathways Contribute to the Protective Effect of Baicalein on Carbon Tetrachloride-Induced Acute Liver Injury.
Effect of Chronic Stress Present in Fibroblasts Derived from Patients with a Sporadic Form of AD on Mitochondrial Function and Mitochondrial Turnover.
Alpinetin exerts anti-inflammatory, anti-oxidative and anti-angiogenic effects through activating the Nrf2 pathway and inhibiting NLRP3 pathway in carbon tetrachloride-induced liver fibrosis.
The piperine derivative HJ105 inhibits Aβ1-42-induced neuroinflammation and oxidative damage via the Keap1-Nrf2-TXNIP axis.
Astragaloside IV inhibits adriamycin-induced cardiac ferroptosis by enhancing Nrf2 signaling.
Selenium triggers Nrf2-AMPK crosstalk to alleviate cadmium-induced autophagy in rabbit cerebrum.
Exosomes are involved in total body irradiation-induced intestinal injury in mice.
Sestrin2 protects against traumatic brain injury by reinforcing the activation of Nrf2 signaling.
Resveratrol attenuates manganese-induced oxidative stress and neuroinflammation through SIRT1 signaling in mice.
Choline attenuates heat stress-induced oxidative injury and apoptosis in bovine mammary epithelial cells by modulating PERK/Nrf-2 signaling pathway.
Baicalin-loaded macrophage-derived exosomes ameliorate ischemic brain injury via the antioxidative pathway.
Tolerable upper intake level of iron damages the liver of weaned piglets.
Isoeucommin A attenuates kidney injury in diabetic nephropathy through the Nrf2/HO-1 pathway.
Synthesis and evaluation of multi-target-directed ligands with BACE-1 inhibitory and Nrf2 agonist activities as potential agents against Alzheimer's disease.
Proteomics analysis in the kidney of mice following oral feeding Realgar.
A rapid juvenile murine model of nonalcoholic steatohepatitis (NASH): Chronic intermittent hypoxia exacerbates Western diet-induced NASH.
Salvinorin A protects against methicillin resistant staphylococcus aureus-induced acute lung injury via Nrf2 pathway.
Sophoricoside attenuates lipopolysaccharide-induced acute lung injury by activating the AMPK/Nrf2 signaling axis.
Hyperoside ameliorates the progression of osteoarthritis: An in vitro and in vivo study.
RNA-seq reveals novel cancer-selective and disease subtype-independent mechanistic targets of withaferin A in human breast cancer cells.
CKIP-1 acts downstream to Cx43 on the activation of Nrf2 signaling pathway to protect from renal fibrosis in diabetes.
Obacunone Attenuates Liver Fibrosis with Enhancing Anti-Oxidant Effects of GPx-4 and Inhibition of EMT.
Aloin protects mice from diet-induced non-alcoholic steatohepatitis via activation of Nrf2/HO-1 signaling.
Curcumin ameliorates mercuric chloride-induced liver injury via modulating cytochrome P450 signaling and Nrf2/HO-1 pathway.
MiR-133a-3p relieves the oxidative stress induced trophoblast cell apoptosis through the BACH1/Nrf2/HO-1 signaling pathway.
Upregulation of silent information regulator 1 alleviates mitochondrial dysfunction in the trigeminal nucleus caudalis in a rat model of chronic migraine.
The Time-Course of Antioxidant Irisin Activity: Role of the Nrf2/HO-1/HMGB1 Axis.
Klotho ameliorates diabetic nephropathy by activating Nrf2 signaling pathway in podocytes.
Dietary alpha-lipoic acid supplementation improves spermatogenesis and semen quality via antioxidant and anti-apoptotic effects in aged breeder roosters.
SQSTM1/ p62 oligomerization contributes to Aβ-induced inhibition of Nrf2 signaling.
HIV-Tat and Cocaine Impact Brain Energy Metabolism: Redox Modification and Mitochondrial Biogenesis Influence NRF Transcription-Mediated Neurodegeneration.
20-HETE synthesis inhibition attenuates traumatic brain injury-induced mitochondrial dysfunction and neuronal apoptosis via the SIRT1/PGC-1α pathway: A translational study.
Protective Effects of Fisetin on Hepatic Ischemia-reperfusion Injury Through Alleviation of Apoptosis and Oxidative Stress.
H2S probe CPC inhibits autophagy and promotes apoptosis by inhibiting glutathionylation of Keap1 at Cys434.
Exercise reduces hyperlipidemia-induced kidney damage in apolipoprotein E-deficient mice.
Organic carbon monoxide prodrug, BW-CO-111, in protection against chemically-induced gastric mucosal damage.
Marine algal polysaccharides alleviate aflatoxin B1-induced bursa of Fabricius injury by regulating redox and apoptotic signaling pathway in broilers.
Oxidative stress-induced mitophagy is suppressed by the miR-106b-93-25 cluster in a protective manner.
Downregulation of CD151 induces oxidative stress and apoptosis in trophoblast cells via inhibiting ERK/Nrf2 signaling pathway in preeclampsia.
Physalin B ameliorates nonalcoholic steatohepatitis by stimulating autophagy and NRF2 activation mediated improvement in oxidative stress.
Nrf2 inhibition induces oxidative stress, renal inflammation and hypertension in mice.
Carnosic acid protects against ferroptosis in PC12 cells exposed to erastin through activation of Nrf2 pathway.
Prenylated xanthones from mangosteen (Garcinia mangostana) activate the AhR and Nrf2 pathways and protect intestinal barrier integrity in HT-29 cells.
Vascular endothelial cell-secreted exosomes facilitate osteoarthritis pathogenesis by promoting chondrocyte apoptosis.
ATF3 regulates oxidative stress and extracellular matrix degradation via p38/Nrf2 signaling pathway in pelvic organ prolapse.
Kaempferol-induced GPER upregulation attenuates atherosclerosis via the PI3K/AKT/Nrf2 pathway.
CoCrMo-Nanoparticles induced peri-implant osteolysis by promoting osteoblast ferroptosis via regulating Nrf2-ARE signalling pathway.
Dimethyl fumarate ameliorates endotoxin-induced acute kidney injury against macrophage oxidative stress.
Ethyl ferulate protects against lipopolysaccharide-induced acute lung injury by activating AMPK/Nrf2 signaling pathway.
Knockdown of RREB1 inhibits cell proliferation via enhanced p16 expression in gastric cancer.
Diterpenoid alkaloids from Delphinium forrestii var. viride and their anti-inflammation activity.
Pentagalloylglucose reduces AGE-induced inflammation by activating Nrf2/HO-1 and inhibiting the JAK2/STAT3 pathway in mesangial cells.
Senescence marker protein 30 (SMP30) protects against high glucose-induced apoptosis, oxidative stress and inflammatory response in retinal ganglion cells by enhancing Nrf2 activation via regulation of Akt/GSK-3β pathway.
Sulfiredoxin-1 protects retinal ganglion cells from high glucose-induced oxidative stress and inflammatory injury by potentiating Nrf2 signaling via the Akt/GSK-3β pathway.
Dietary hawthorn-leaves flavonoids improves ovarian function and liver lipid metabolism in aged breeder hens.
Exposure to DEHP induces testis toxicity and injury through the ROS/mTOR/NLRP3 signaling pathway in immature rats.
Fucoxanthin regulates Nrf2 signaling to decrease oxidative stress and improves renal fibrosis depending on Sirt1 in HG-induced GMCs and STZ-induced diabetic rats.
Tangeretin maintains antioxidant activity by reducing CUL3 mediated NRF2 ubiquitination.
Curcumin hinders PBDE-47-induced neutrophil extracellular traps release via Nrf2-associated ROS inhibition.
Lycopene attenuates zearalenone-induced oxidative damage of piglet sertoli cells through the nuclear factor erythroid-2 related factor 2 signaling pathway.
Effects of Inorganic and Organic Manganese Supplementation on Growth Performance, Tibia Development, and Oxidative Stress in Broiler Chickens.
Glutaredoxin 1 protects neurons from oxygen-glucose deprivation/reoxygenation (OGD/R)-induced apoptosis and oxidative stress via the modulation of GSK-3β/Nrf2 signaling.
The role of transcription factor Ap1 in the activation of the Nrf2/ARE pathway through TET1 in diabetic nephropathy.
PLK2 protects retinal ganglion cells from oxidative stress by potentiating Nrf2 signaling via GSK-3β.
Stabilization of Nrf2 leading to HO-1 activation protects against zinc oxide nanoparticles-induced endothelial cell death.
The in vitro and in vivo study of oleanolic acid indole derivatives as novel anti-inflammatory agents: Synthesis, biological evaluation, and mechanistic analysis.
Melatonin Promotes In Vitro Maturation of Vitrified-Warmed Mouse Germinal Vesicle Oocytes, Potentially by Reducing Oxidative Stress through the Nrf2 Pathway.
Manganese Mitigates Heat Stress-Induced Apoptosis by Alleviating Endoplasmic Reticulum Stress and Activating the NRF2/SOD2 Pathway in Primary Chick Embryonic Myocardial Cells.
Aloe polysaccharides ameliorate acute colitis in mice via Nrf2/HO-1 signaling pathway and short-chain fatty acids metabolism.
The novel nanocomplexes containing deoxycholic acid-grafted chitosan and oleanolic acid displays the hepatoprotective effect against CCl4-induced liver injury in vivo.
Modified citrus pectin inhibits breast cancer development in mice by targeting tumor-associated macrophage survival and polarization in hypoxic microenvironment.
The role of Nrf2 pathway in alleviating fluorine-induced apoptosis by different selenium sources in the chicken duodenum and jejunum.
Apatinib triggers autophagic and apoptotic cell death via VEGFR2/STAT3/PD-L1 and ROS/Nrf2/p62 signaling in lung cancer.
Virtual screening identified natural Keap1-Nrf2 PPI inhibitor alleviates inflammatory osteoporosis through Nrf2-mir214-Traf3 axis.
PSMD12 promotes glioma progression by upregulating the expression of Nrf2.
Silicon Oxynitrophosphide Nanoscale Coating Enhances Antioxidant Marker-Induced Angiogenesis During in vivo Cranial Bone-Defect Healing.
Exosomal miR-27 negatively regulates ROS production and promotes granulosa cells apoptosis by targeting SPRY2 in OHSS.
Myricetin protects against H2 O2 -induced oxidative damage and apoptosis in bovine mammary epithelial cells.
Regulatory effects of flavonoids luteolin on BDE-209-induced intestinal epithelial barrier damage in Caco-2 cell monolayer model.
Adenosine 5'-monophosphate-activated protein kinase ameliorates bovine adipocyte oxidative stress by inducing antioxidant responses and autophagy.
The protective role of Zingerone in a murine asthma model via activation of the AMPK/Nrf2/HO-1 pathway.
Heme-Mediated Activation of the Nrf2/HO-1 Axis Attenuates Calcification of Valve Interstitial Cells.
AKR1B10 negatively regulates autophagy through reducing GAPDH upon glucose starvation in colon cancer.
Reparative Effects of Ethanol-Induced Intestinal Barrier Injury by Flavonoid Luteolin via MAPK/NF-κB/MLCK and Nrf2 Signaling Pathways.
S-allyl cysteine ameliorates heat stress-induced oxidative stress by activating Nrf2/HO-1 signaling pathway in BMECs.
Prolyl endopeptidase disruption reduces hepatic inflammation and oxidative stress in methionine-choline-deficient diet-induced steatohepatitis.
Koumine Alleviates Lipopolysaccharide-Induced Intestinal Barrier Dysfunction in IPEC-J2 Cells by Regulating Nrf2/NF-κ
Effects of Compound Centella on Oxidative Stress and Keap1-Nrf2-ARE Pathway Expression in Diabetic Kidney Disease Rats.
TBHQ Attenuates Neurotoxicity Induced by Methamphetamine in the VTA through the Nrf2/HO-1 and PI3K/AKT Signaling Pathways.
Effect of Quercetin on PC12 Alzheimer's Disease Cell Model Induced by Aβ 25-35 and Its Mechanism Based on Sirtuin1/Nrf2/HO-1 Pathway.
Neuroprotective Effect of Salvianolic Acid A against Diabetic Peripheral Neuropathy through Modulation of Nrf2.
Role of Nrf2 in Lipopolysaccharide-Induced Acute Kidney Injury: Protection by Human Umbilical Cord Blood Mononuclear Cells.
Protective Effect of Simplicillium sp. Ethyl Acetate Extract against High Glucose-Induced Oxidative Stress in HUVECs.
The Nrf2/PGC1α Pathway Regulates Antioxidant and Proteasomal Activity to Alter Cisplatin Sensitivity in Ovarian Cancer.
Fasting Induces Hepatocellular Carcinoma Cell Apoptosis by Inhibiting SET8 Expression.
Pentamethylquercetin Attenuates Cardiac Remodeling via Activation of the Sestrins/Keap1/Nrf2 Pathway in MSG-Induced Obese Mice.
Gentiopicroside Ameliorates Oxidative Stress and Lipid Accumulation through Nuclear Factor Erythroid 2-Related Factor 2 Activation.
Comparative effectiveness of 4 natural and chemical activators of Nrf2 on inflammation, oxidative stress, macrophage polarization, and bactericidal activity in an in vitro macrophage infection model.
Mechanisms and therapeutic implications of RTA 408, an activator of Nrf2, in subarachnoid hemorrhage-induced delayed cerebral vasospasm and secondary brain injury.
La2O3 Nanoparticles Induce Reproductive Toxicity Mediated by the Nrf-2/ARE Signaling Pathway in Kunming Mice.
Acacetin Alleviates Inflammation and Matrix Degradation in Nucleus Pulposus Cells and Ameliorates Intervertebral Disc Degeneration in vivo.
Emodin Protects Against Acute Pancreatitis-Associated Lung Injury by Inhibiting NLPR3 Inflammasome Activation via Nrf2/HO-1 Signaling.
Pristimerin Suppresses RANKL-Induced Osteoclastogenesis and Ameliorates Ovariectomy-Induced Bone Loss.
Oleoylethanolamide Protects Against Acute Liver Injury by Regulating Nrf-2/HO-1 and NLRP3 Pathways in Mice.
Rutaecarpine Ameliorates Ethanol-Induced Gastric Mucosal Injury in Mice by Modulating Genes Related to Inflammation, Oxidative Stress and Apoptosis.
Ursodeoxycholic Acid Protects Against Arsenic Induced Hepatotoxicity by the Nrf2 Signaling Pathway.
Gallic Acid Alleviates Gouty Arthritis by Inhibiting NLRP3 Inflammasome Activation and Pyroptosis Through Enhancing Nrf2 Signaling.
Formononetin Attenuates Airway Inflammation and Oxidative Stress in Murine Allergic Asthma.
α-Cyperone Attenuates H2O2-Induced Oxidative Stress and Apoptosis in SH-SY5Y Cells via Activation of Nrf2.
Purmorphamine Attenuates Neuro-Inflammation and Synaptic Impairments After Hypoxic-Ischemic Injury in Neonatal Mice via Shh Signaling.
MicroRNA-34a Inhibition Alleviates Lung Injury in Cecal Ligation and Puncture Induced Septic Mice.
Schisandrin B Inhibits Osteoclastogenesis and Protects Against Ovariectomy-Induced Bone Loss.
Kaempferol Protects Blood Vessels From Damage Induced by Oxidative Stress and Inflammation in Association With the Nrf2/HO-1 Signaling Pathway.
Cucurbitacin I induces apoptosis in ovarian cancer cells through oxidative stress and the p190B‑Rac1 signaling axis.
Sp4 controls constitutive expression of neuronal serine racemase and NF-E2-related factor-2 mediates its induction by valproic acid.
Metformin mitigates gastrointestinal radiotoxicity and radiosensitises P53 mutation colorectal tumours via optimising autophagy.
PPARγ activation mitigates mechanical allodynia in paclitaxel-induced neuropathic pain via induction of Nrf2/HO-1 signaling pathway.
Inhibition of miR-181a-5p reduces astrocyte and microglia activation and oxidative stress by activating SIRT1 in immature rats with epilepsy.
Cholestasis Differentially Affects Liver Connexins.
PTEN status determines chemosensitivity to proteasome inhibition in cholangiocarcinoma.
Astaxanthin attenuates oxidative stress and immune impairment in D-galactose-induced aging in rats by activating the Nrf2/Keap1 pathway and suppressing the NF-κB pathway.
(+)-Clausenamide protects against drug-induced liver injury by inhibiting hepatocyte ferroptosis.
NRF2 preserves genomic integrity by facilitating ATR activation and G2 cell cycle arrest.
Atypical Antipsychotic Drug Ziprasidone Protects against Rotenone-Induced Neurotoxicity: An In Vitro Study.
Four active monomers from Moutan Cortex exert inhibitory effects against oxidative stress by activating Nrf2/Keap1 signaling pathway.
Liraglutide Up-regulation Thioredoxin Attenuated Müller Cells Apoptosis in High Glucose by Regulating Oxidative Stress and Endoplasmic Reticulum Stress.
Oncogenic function of TRIM2 in pancreatic cancer by activating ROS-related NRF2/ITGB7/FAK axis.
NRF2 regulates the sensitivity of human NSCLC cells to cystine deprivation-induced ferroptosis via FOCAD-FAK signaling pathway.
MSC-derived exosomes protect against oxidative stress-induced skin injury via adaptive regulation of the NRF2 defense system.
MiR-23a-5p exacerbates intestinal ischemia-reperfusion injury by promoting oxidative stress via targeting PPAR alpha.
Melatonin improves hypoxic-ischemic brain damage through the Akt/Nrf2/Gpx4 signaling pathway.
Neuroprotective mechanism of L-cysteine after subarachnoid hemorrhage.
Protective effect of astaxanthin against La2O3 nanoparticles induced neurotoxicity by activating PI3K/AKT/Nrf-2 signaling in mice.
Tanshinone IIA attenuates acetaminophen-induced hepatotoxicity through HOTAIR-Nrf2-MRP2/4 signaling pathway.
The Preventive Effects of Xanthohumol on Vascular Calcification Induced by Vitamin D3 Plus Nicotine.
Exposure to Static Magnetic and Electric Fields Treats Type 2 Diabetes.
Functional validation of a human GLUD2 variant in a murine model of Parkinson's disease.
Astragalus polysaccharide alleviates cognitive impairment and β-amyloid accumulation in APP/PS1 mice via Nrf2 pathway.
Daidzein ameliorates LPS-induced hepatocyte injury by inhibiting inflammation and oxidative stress.
Upregulation of Glutaredoxin 2 alleviates oxygen-glucose deprivation/reoxygenation-induced apoptosis and ROS production in neurons by enhancing Nrf2 signaling via modulation of GSK-3β.
Brain Dicer1 Is Down-Regulated in a Mouse Model of Alzheimer's Disease Via Aβ42-Induced Repression of Nuclear Factor Erythroid 2-Related Factor 2.
Tannic acid attenuates hepatic oxidative stress, apoptosis and inflammation by activating the Keap1‑Nrf2/ARE signaling pathway in arsenic trioxide‑toxicated rats.
A novel danshensu derivative ameliorates experimental colitis by modulating NADPH oxidase 4-dependent NLRP3 inflammasome activation.
Crocin ameliorates arsenic trioxide‑induced cardiotoxicity via Keap1-Nrf2/HO-1 pathway: Reducing oxidative stress, inflammation, and apoptosis.
Down-regulation of miR-383-5p suppresses apoptosis in oxidative stress rat hepatocytes by targeting Bcl2.
Two resveratrol analogs, pinosylvin and 4,4'-dihydroxystilbene, improve oligoasthenospermia in a mouse model by attenuating oxidative stress via the Nrf2-ARE pathway.
Preconditioning the immature lung with enhanced Nrf2 activity protects against oxidant-induced hypoalveolarization in mice.
Anthocyanins decrease the internalization of TiO2 nanoparticles into 3D Caco-2 spheroids.
Sesn2 attenuates the damage of endothelial progenitor cells induced by angiotensin II through regulating the Keap1/Nrf2 signal pathway.
Mutual antagonism between indoleamine 2,3-dioxygenase 1 and nuclear factor E2-related factor 2 regulates the maturation status of DCs in liver fibrosis.
PDK4 promotes vascular calcification by interfering with autophagic activity and metabolic reprogramming.
Fostered Nrf2 expression antagonizes iron overload and glutathione depletion to promote resistance of neuron-like cells to ferroptosis.
Rice protein stimulates endogenous antioxidant response attributed to methionine availability in growing rats.
Exogenous spermine attenuates rat diabetic cardiomyopathy via suppressing ROS-p53 mediated downregulation of calcium-sensitive receptor.
Geniposide alleviates non-alcohol fatty liver disease via regulating Nrf2/AMPK/mTOR signalling pathways.
Inhibition of thioredoxin reductase 1 correlates with platinum-based chemotherapeutic induced tissue injury.
BMP8A promotes survival and drug resistance via Nrf2/TRIM24 signaling pathway in clear cell renal cell carcinoma.
High glucose inhibits vascular endothelial Keap1/Nrf2/ARE signal pathway via downregulation of monomethyltransferase SET8 expression.
p62/SQSTM1 accumulation due to degradation inhibition and transcriptional activation plays a critical role in silica nanoparticle-induced airway inflammation via NF-κB activation.
Adaptation of the master antioxidant response connects metabolism, lifespan and feather development pathways in birds.
Anti-Inflammatory Effects of Lasia spinosa Leaf Extract in Lipopolysaccharide-Induced RAW 264.7 Macrophages.
Evidence for Cytoprotective Effect of Carbon Monoxide Donor in the Development of Acute Esophagitis Leading to Acute Esophageal Epithelium Lesions.
Spinosin Inhibits Aβ1-42 Production and Aggregation via Activating Nrf2/HO-1 Pathway.
6-Gingerol ameliorates sepsis-induced liver injury through the Nrf2 pathway.
Mesenchymal stromal cells ameliorate acute lung injury induced by LPS mainly through stanniocalcin-2 mediating macrophage polarization.
NF-E2-related factor 2 activation boosts antioxidant defenses and ameliorates inflammatory and amyloid properties in human Presenilin-1 mutated Alzheimer's disease astrocytes.
MTFP1 overexpression promotes the growth of oral squamous cell carcinoma by inducing ROS production.
Jmjd3 regulates inflammasome activation and aggravates DSS-induced colitis in mice.
Nardosinanone N suppresses LPS-induced macrophage activation by modulating the Nrf2 pathway and mPGES-1.
Vinpocetine inhibits RANKL-induced osteoclastogenesis and attenuates ovariectomy-induced bone loss.
lncRNA SLC7A11-AS1 Promotes Chemoresistance by Blocking SCFβ-TRCP-Mediated Degradation of NRF2 in Pancreatic Cancer.
PTEN inhibitor VO-OHpic attenuates GC-associated endothelial progenitor cell dysfunction and osteonecrosis of the femoral head via activating Nrf2 signaling and inhibiting mitochondrial apoptosis pathway.
The protective effect of hesperetin in osteoarthritis: an in vitro and in vivo study.
Dietary Supplemented Curcumin Improves Meat Quality and Antioxidant Status of Intrauterine Growth Retardation Growing Pigs via Nrf2 Signal Pathway.
Resveratrol protects against CIH-induced myocardial injury by targeting Nrf2 and blocking NLRP3 inflammasome activation.
Polydatin ameliorates chemotherapy-induced cognitive impairment (chemobrain) by inhibiting oxidative stress, inflammatory response, and apoptosis in rats.
HJ22, a Novel derivative of piperine, Attenuates ibotenic acid-induced cognitive impairment, oxidativestress, apoptosis and inflammation via inhibiting the protein-protein interaction of Keap1-Nrf2.
Sulforaphane reduces intracellular survival of Staphylococcus aureus in macrophages through inhibition of JNK and p38 MAPK‑induced inflammation.
Exogenous Hydrogen Sulfide Regulates Mycoplasma pneumoniae Lipid-Associated Membrane Proteins to Induce Expression of Heme Oxygenase-1 and Proinflammatory Cytokines.
Protective effect of apigenin on d-galactosamine/LPS-induced hepatocellular injury by increment of Nrf-2 nucleus translocation.
Rice Protein Exerts Endogenous Antioxidant Capacity via Methionine Sulfoxide Reductase and the Nrf2 Antioxidant System Independent of Age.
Polychlorinated biphenyl quinone induces hepatocytes iron overload through up-regulating hepcidin expression.
Tannic acid ameliorates arsenic trioxide-induced nephrotoxicity, contribution of NF-κB and Nrf2 pathways.
BDH2 triggers ROS-induced cell death and autophagy by promoting Nrf2 ubiquitination in gastric cancer.
Inhibition of ROCK2 alleviates renal fibrosis and the metabolic disorders in the proximal tubular epithelial cells.
Isoquinoline Kelch-like ECH-Associated Protein 1-Nuclear Factor (Erythroid-Derived 2)-like 2 (KEAP1-NRF2) Inhibitors with High Metabolic Stability.
Non-Esterified Fatty Acid-Induced Reactive Oxygen Species Mediated Granulosa Cells Apoptosis Is Regulated by Nrf2/p53 Signaling Pathway.
Sestrin2 overexpression alleviates hydrogen peroxide-induced apoptosis and oxidative stress in retinal ganglion cells by enhancing Nrf2 activation via Keap1 downregulation.
Inhibition of ferroptosis attenuates busulfan-induced oligospermia in mice.
Stomatin-like protein-2 confers neuroprotection effect in oxygen-glucose deprivation/reoxygenation-injured neurons by regulating AMPK/Nrf2 signalling.
MicroRNA-214-3p enhances erastin-induced ferroptosis by targeting ATF4 in hepatoma cells.
Luteolin alleviates ochratoxin A induced oxidative stress by regulating Nrf2 and HIF-1α pathways in NRK-52E rat kidney cells.
Downregulation of RKIP promotes radioresistance of nasopharyngeal carcinoma by activating NRF2/NQO1 axis via downregulating miR-450b-5p.
Piceatannol Ameliorates Hepatic Oxidative Damage and Mitochondrial Dysfunction of Weaned Piglets Challenged with Diquat.
Targeting the MAPK/ERK and PI3K/AKT Signaling Pathways Affects NRF2, Trx and GSH Antioxidant Systems in Leukemia Cells.
Mechanism investigation on Bisphenol S-induced oxidative stress and inflammation in murine RAW264.7 cells: The role of NLRP3 inflammasome, TLR4, Nrf2 and MAPK.
Hydrogen gas protects against delayed encephalopathy after acute carbon monoxide poisoning in a rat model.
Inhibition of the Keap1-Nrf2 protein-protein interaction protects retinal cells and ameliorates retinal ischemia-reperfusion injury.
The expression of p-p62 and nuclear Nrf2 in esophageal squamous cell carcinoma and association with radioresistance.
Spermidine alleviates cardiac aging by improving mitochondrial biogenesis and function.
Baicalein Alleviates Liver Oxidative Stress and Apoptosis Induced by High-Level Glucose through the Activation of the PERK/Nrf2 Signaling Pathway.
HIPK2 overexpression relieves hypoxia/reoxygenation-induced apoptosis and oxidative damage of cardiomyocytes through enhancement of the Nrf2/ARE signaling pathway.
Critical role of caveolin-1 in aflatoxin B1-induced hepatotoxicity via the regulation of oxidation and autophagy.
Activation of cannabinoid receptor type 2-induced osteogenic differentiation involves autophagy induction and p62-mediated Nrf2 deactivation.
Chronic toxicity of methamphetamine: Oxidative remodeling of pulmonary arteries.
Activating PPARγ Increases NQO1 and γ-GCS Expression via Nrf2 in Thrombin-activated Microglia.
Protective effect of Liraglutide on diabetic retinal neurodegeneration via inhibiting oxidative stress and endoplasmic reticulum stress.
Evaluation and Exploration of Potentially Bioactive Peptides in Casein Hydrolysates against Liver Oxidative Damage in STZ/HFD-Induced Diabetic Rats.
NR1D1 modulates synovial inflammation and bone destruction in rheumatoid arthritis.
Syringin protects against colitis by ameliorating inflammation.
Codonopsis lanceolata polysaccharide CLPS alleviates high fat/high sucrose diet-induced insulin resistance via anti-oxidative stress.
Curcumin Protects Human Trophoblast HTR8/SVneo Cells from H2O2-Induced Oxidative Stress by Activating Nrf2 Signaling Pathway.
Protection of diabetes-induced kidney injury by phosphocreatine via the regulation of ERK/Nrf2/HO-1 signaling pathway.
Autophagy Inhibition Enables Nrf2 to Exaggerate the Progression of Diabetic Cardiomyopathy in Mice.
Hepatoprotective effects of Camellia nitidissima aqueous ethanol extract against CCl4-induced acute liver injury in SD rats related to Nrf2 and NF-κB signalling.
Oxidative stress-mediated hepatotoxicity in rats induced by ethanol extracts of different parts of Chloranthus serratus.
Resveratrol improves meat quality, muscular antioxidant capacity, lipid metabolism and fiber type composition of intrauterine growth retarded pigs.
Functional Food XingJiuTang Attenuates Alcohol-Induced Liver Injury by Regulating SIRT1/Nrf-2 Signaling Pathway.
Curcumin-cyclodextrin/cellulose nanocrystals improve the phenotype of Charcot-Marie-Tooth-1A transgenic rats through the reduction of oxidative stress.
Silibinin ameliorats H2O2-induced cell apoptosis and oxidative stress response by activating Nrf2 signaling in trophoblast cells.
Enterovirus 71 induces neural cell apoptosis and autophagy through promoting ACOX1 downregulation and ROS generation.
Oncogenic activation of PI3K-AKT-mTOR signaling suppresses ferroptosis via SREBP-mediated lipogenesis.
Hylocereus polyrhizus Peel Extract Retards Alcoholic Liver Disease Progression by Modulating Oxidative Stress and Inflammatory Responses in C57BL/6 Mice.
TRIM16 protects human periodontal ligament stem cells from oxidative stress-induced damage via activation of PICOT.
Effects of taraxasterol against ethanol and high-fat diet-induced liver injury by regulating TLR4/MyD88/NF-κB and Nrf2/HO-1 signaling pathways.
Akebia Saponin D suppresses inflammation in chondrocytes via the NRF2/HO-1/NF-κB axis and ameliorates osteoarthritis in mice.
Metformin attenuates cardiac remodeling in mice through the Nrf2/Keap1 signaling pathway.
Antioxidant activity of selenium-enriched Chrysomyia megacephala (Fabricius) larvae powder and its impact on intestinal microflora in D-galactose induced aging mice.
Effects of Launaea sarmentosa Extract on Lipopolysaccharide-Induced Inflammation via Suppression of NF-κB/MAPK Signaling and Nrf2 Activation.
Computational repositioning of dimethyl fumarate for treating alcoholic liver disease.
Silychristin A activates Nrf2-HO-1/SOD2 pathway to reduce apoptosis and improve GLP-1 production through upregulation of estrogen receptor α in GLUTag cells.
l-Arginine Inhibits Apoptosis of Ovine Intestinal Epithelial Cells through the l-Arginine-Nitric Oxide Pathway.
Dandelion Extract Alleviated Lipopolysaccharide-Induced Oxidative Stress through the Nrf2 Pathway in Bovine Mammary Epithelial Cells.
Protective effect of Dioscorea zingiberensis ethanol extract on the disruption of blood-testes barrier in high-fat diet/streptozotocin-induced diabetic mice by upregulating ZO-1 and Nrf2.
Long noncoding RNA TUG1 regulates prostate cancer cell proliferation, invasion and migration via the Nrf2 signaling axis.
Dimethyl itaconate, an itaconate derivative, exhibits immunomodulatory effects on neuroinflammation in experimental autoimmune encephalomyelitis.
4β-Hydroxywithanolide E from Goldenberry (Whole Fruits of Physalis peruviana L.) as a Promising Agent against Chronic Obstructive Pulmonary Disease.
Maternal curcumin supplementation ameliorates placental function and fetal growth in mice with intrauterine growth retardation†.
Cyclovirobuxine D protects against diabetic cardiomyopathy by activating Nrf2-mediated antioxidant responses.
Compensatory upregulation of aldo-keto reductase 1B10 to protect hepatocytes against oxidative stress during hepatocarcinogenesis.
SIRT5 Promotes Cisplatin Resistance in Ovarian Cancer by Suppressing DNA Damage in a ROS-Dependent Manner via Regulation of the Nrf2/HO-1 Pathway.
Involvement of the PI3K/Akt/Nrf2 Signaling Pathway in Resveratrol-Mediated Reversal of Drug Resistance in HL-60/ADR Cells.
KLF2 Protects against Osteoarthritis by Repressing Oxidative Response through Activation of Nrf2/ARE Signaling In Vitro and In Vivo.
Myricetin Alleviates Pathological Cardiac Hypertrophy via TRAF6/TAK1/MAPK and Nrf2 Signaling Pathway.
CCl4-Induced Liver Injury Was Ameliorated by Qi-Ge Decoction through the Antioxidant Pathway.
Carnosine Protects Mouse Podocytes from High Glucose Induced Apoptosis through PI3K/AKT and Nrf2 Pathways.
Effects of Ethyl Pyruvate on Bile Duct Ligation-Induced Liver Fibrosis by Regulating Nrf2 Pathway and Proinflammatory Cytokines in Rats.
Salvianolic Acid A Protects the Kidney against Oxidative Stress by Activating the Akt/GSK-3β/Nrf2 Signaling Pathway and Inhibiting the NF-κB Signaling Pathway in 5/6 Nephrectomized Rats.
Nrf2/Keap1/ARE Signaling Mediated an Antioxidative Protection of Human Placental Mesenchymal Stem Cells of Fetal Origin in Alveolar Epithelial Cells.
CGRP Reduces Apoptosis of DRG Cells Induced by High-Glucose Oxidative Stress Injury through PI3K/AKT Induction of Heme Oxygenase-1 and Nrf-2 Expression.
Protective Effects of Dioscin Against Doxorubicin-Induced Hepatotoxicity Via Regulation of Sirt1/FOXO1/NF-κb Signal.
Protective mechanism of Taxifolin for chlorpyrifos neurotoxicity in BV2 cells.
Ellagic acid supports neuron by regulating astroglia Nrf2.
Novel diterpenoid-type activators of the Keap1/Nrf2/ARE signaling pathway and their regulation of redox homeostasis.
Kinsenoside ameliorates intervertebral disc degeneration through the activation of AKT-ERK1/2-Nrf2 signaling pathway.
The Potential of Neoagaro-Oligosaccharides as a Treatment of Type II Diabetes in Mice.
Structural Characterization and Antioxidant Activity of Polysaccharides from Athyrium multidentatum (Doll.) Ching in d-Galactose-Induced Aging Mice via PI3K/AKT Pathway.
Lysosomal dysfunction is associated with persistent lung injury in dams caused by pregnancy exposure to carbon black nanoparticles.
Torularhodin Ameliorates Oxidative Activity in Vitro and d-Galactose-Induced Liver Injury via the Nrf2/HO-1 Signaling Pathway in Vivo.
Xanthohumol inhibits PRRSV proliferation and alleviates oxidative stress induced by PRRSV via the Nrf2-HMOX1 axis.
Artocarmitin B enhances intracellular antioxidant capacity via activation of Nrf2 signaling pathway in human lung epithelial cells.
Rice protein reduces DNA damage by activating the p53 pathway and stimulating endogenous antioxidant response in growing and adult rats.
Allicin ameliorates obesity comorbid depressive-like behaviors: involvement of the oxidative stress, mitochondrial function, autophagy, insulin resistance and NOX/Nrf2 imbalance in mice.
Resveratrol reduces brain injury after subarachnoid hemorrhage by inhibiting oxidative stress and endoplasmic reticulum stress.
Phytochemical composition, isolation and hepatoprotective activity of active fraction from Veronica ciliata against acetaminophen-induced acute liver injury via p62-Keap1-Nrf2 signaling pathway.
Botrysphin D attenuates arsenic-induced oxidative stress in human lung epithelial cells via activating Nrf2/ARE signaling pathways.
γ-Oryzanol alleviates acetaminophen-induced liver injury: roles of modulating AMPK/GSK3β/Nrf2 and NF-κB signaling pathways.
Oxidation Stress-Mediated MAPK Signaling Pathway Activation Induces Neuronal Loss in the CA1 and CA3 Regions of the Hippocampus of Mice Following Chronic Cold Exposure.
Neuroprotection of Andrographolide Against Microglia-Mediated Inflammatory Injury and Oxidative Damage in PC12 Neurons.
Absence of Dipeptidyl Peptidase 3 Increases Oxidative Stress and Causes Bone Loss.
The protective effect of lithocholic acid on the intestinal epithelial barrier is mediated by the vitamin D receptor via a SIRT1/Nrf2 and NF-κB dependent mechanism in Caco-2 cells.
MicroRNA-24 inhibits the oxidative stress induced by vascular injury by activating the Nrf2/Ho-1 signaling pathway.
The roles of Nrf2 and autophagy in modulating inflammation mediated by TLR4 - NFκB in A549 cell exposed to layer house particulate matter 2.5 (PM2.5).
Spinosin and 6'''‑Feruloylspinosin protect the heart against acute myocardial ischemia and reperfusion in rats.
Transsulfuration Activity Can Support Cell Growth upon Extracellular Cysteine Limitation.
Astaxanthin protects against osteoarthritis via Nrf2: a guardian of cartilage homeostasis.
Chitosan Oligosaccharide Attenuates Nonalcoholic Fatty Liver Disease Induced by High Fat Diet through Reducing Lipid Accumulation, Inflammation and Oxidative Stress in C57BL/6 Mice.
Promising therapeutic effect of thapsigargin nanoparticles on chronic kidney disease through the activation of Nrf2 and FoxO1.
Protective effect of dihydroartemisinin in inhibiting senescence of myeloid-derived suppressor cells from lupus mice via Nrf2/HO-1 pathway.
S-1-propenylmercaptocysteine protects murine hepatocytes against oxidative stress via persulfidation of Keap1 and activation of Nrf2.
The anti-nephritic activity of a polysaccharide from okra (Abelmoschus esculentus (L.) Moench) via modulation of AMPK-Sirt1-PGC-1α signaling axis mediated anti-oxidative in type 2 diabetes model mice.
Hydrogen sulfide ameliorates disorders in the parafacial respiratory group region of neonatal rats caused by prenatal cigarette smoke exposure via an antioxidative effect.
Effects of KEAP1 Silencing on the Regulation of NRF2 Activity in Neuroendocrine Lung Tumors.
Polysaccharide from Okra (Abelmoschus esculentus (L.) Moench) Improves Antioxidant Capacity via PI3K/AKT Pathways and Nrf2 Translocation in a Type 2 Diabetes Model.
Comparison of the Hepatoprotective Effects of the Three Main Stilbenes from Mulberry Twigs.
Astragaloside IV Regulates the PI3K/Akt/HO-1 Signaling Pathway and Inhibits H9c2 Cardiomyocyte Injury Induced by Hypoxia-Reoxygenation.
N-acetylcysteine alleviates fluoride-induced testicular apoptosis by modulating IRE1α/JNK signaling and nuclear Nrf2 activation.
Hepatoprotective effects and structure-activity relationship of five flavonoids against lipopolysaccharide/d-galactosamine induced acute liver failure in mice.
Betaine protects against heat exposure-induced oxidative stress and apoptosis in bovine mammary epithelial cells via regulation of ROS production.
Arsenic trioxide inhibits the differentiation of fibroblasts to myofibroblasts through nuclear factor erythroid 2-like 2 (NFE2L2) protein and the Smad2/3 pathway.
Combinatory FK506 and Minocycline Treatment Alleviates Prion-Induced Neurodegenerative Events via Caspase-Mediated MAPK-NRF2 Pathway.
Costunolide inhibits pulmonary fibrosis via regulating NF-kB and TGF-β1/Smad2/Nrf2-NOX4 signaling pathways.
Neuroprotective Effect of Dioscin on the Aging Brain.
Inhibition of SGK1 confers vulnerability to redox dysregulation in cervical cancer.
Hydrogen sulfide protects against DSS-induced colitis by inhibiting NLRP3 inflammasome.
Curcumin upregulates the Nrf2 system by repressing inflammatory signaling-mediated Keap1 expression in insulin-resistant conditions.
Selenepezil, a Selenium-Containing Compound, Exerts Neuroprotective Effect via Modulation of the Keap1-Nrf2-ARE Pathway and Attenuates Aβ-Induced Cognitive Impairment in Vivo.
Cortisol Excess-Mediated Mitochondrial Damage Induced Hippocampal Neuronal Apoptosis in Mice Following Cold Exposure.
Potent 5-Cyano-6-phenyl-pyrimidin-Based Derivatives Targeting DCN1-UBE2M Interaction.
Cordycepin prevents radiation ulcer by inhibiting cell senescence via NRF2 and AMPK in rodents.
p62/SQSTM1 and Nrf2 are essential for exercise-mediated enhancement of antioxidant protein expression in oxidative muscle.
Hesperetin suppresses RANKL-induced osteoclastogenesis and ameliorates lipopolysaccharide-induced bone loss.
Inhibitory Effects of Oxymatrine on Transdifferentiation of Neonatal Rat Cardiac Fibroblasts to Myofibroblasts Induced by Aldosterone via Keap1/Nrf2 Signaling Pathways In Vitro.
Melatonin protects circulatory death heart from ischemia/reperfusion injury via the JAK2/STAT3 signalling pathway.
Ginsenoside Compound K Regulates Amyloid β via the Nrf2/Keap1 Signaling Pathway in Mice with Scopolamine Hydrobromide-Induced Memory Impairments.
Induction of Endoplasmic Reticulum Stress by Cadmium and Its Regulation on Nrf2 Signaling Pathway in Kidneys of Rats.
Naringenin targets on astroglial Nrf2 to support dopaminergic neurons.
Potential mechanisms underlying the protective effects of salvianic acid A against atherosclerosis in vivo and vitro.
Antagonistic effect of epigallocatechin-3-gallate on neurotoxicity induced by formaldehyde.
Differential response to lead toxicity in rat primary microglia and astrocytes.
Sulforaphane Improves Lipid Metabolism by Enhancing Mitochondrial Function and Biogenesis In Vivo and In Vitro.
Allicin attenuated chronic social defeat stress induced depressive-like behaviors through suppression of NLRP3 inflammasome.
Electroacupuncture at ST-36 ameliorates DSS-induced acute colitis via regulating macrophage polarization induced by suppressing NLRP3/IL-1β and promoting Nrf2/HO-1.
Pterostilbene alleviates hydrogen peroxide-induced oxidative stress via nuclear factor erythroid 2 like 2 pathway in mouse preimplantation embryos.
Activation of Nrf2/Keap1 pathway by oral Dimethylfumarate administration alleviates oxidative stress and age-associated infertility might be delayed in the mouse ovary.
Dexmedetomidine attenuates lipopolysaccharide-induced liver oxidative stress and cell apoptosis in rats by increasing GSK-3β/MKP-1/Nrf2 pathway activity via the α2 adrenergic receptor.
Effect of hydrogen-rich water on the Nrf2/ARE signaling pathway in rats with myocardial ischemia-reperfusion injury.
Punicalagin Reversed the Hepatic Injury of Tetrachloromethane by Antioxidation and Enhancement of Autophagy.
Oxidative gastric mucosal damage induced by ischemia/reperfusion and the mechanisms of its prevention by carbon monoxide-releasing tricarbonyldichlororuthenium (II) dimer.
Astragaloside IV Protects Against Oxidative Stress in Calf Small Intestine Epithelial Cells via NFE2L2-Antioxidant Response Element Signaling.
Dietary Curcumin Supplementation Increases Antioxidant Capacity, Upregulates Nrf2 and Hmox1 Levels in the Liver of Piglet Model with Intrauterine Growth Retardation.
Curcumin Alleviates IUGR Jejunum Damage by Increasing Antioxidant Capacity through Nrf2/Keap1 Pathway in Growing Pigs.
Water-separated part of Chloranthus serratus alleviates lipopolysaccharide- induced RAW264.7 cell injury mainly by regulating the MAPK and Nrf2/HO-1 inflammatory pathways.
Melatonin ameliorates cerebral ischemia/reperfusion injury through SIRT3 activation.
Discovery of coumarin-derived imino sulfonates as a novel class of potential cardioprotective agents.
Dietary Dihydroartemisinin Supplementation Attenuates Hepatic Oxidative Damage of Weaned Piglets with Intrauterine Growth Retardation through the Nrf2/ARE Signaling Pathway.
Protective Effects of Fucoidan against Hydrogen Peroxide-Induced Oxidative Damage in Porcine Intestinal Epithelial Cells.
Icariin targets Nrf2 signaling to inhibit microglia-mediated neuroinflammation.
Disubstituted Dithiolethione ACDT Exerts Neuroprotective Effects Against 6-Hydroxydopamine-Induced Oxidative Stress in SH-SY5Y Cells.
MicroRNA-128-3p aggravates doxorubicin-induced liver injury by promoting oxidative stress via targeting Sirtuin-1.
l-Methionine activates Nrf2-ARE pathway to induce endogenous antioxidant activity for depressing ROS-derived oxidative stress in growing rats.
HO-1 reduces heat stress-induced apoptosis in bovine granulosa cells by suppressing oxidative stress.
Correction: Total saponins from Rosa laevigata Michx fruit attenuates hepatic steatosis induced by high-fat diet in rats.
KLF15 regulates endobiotic and xenobiotic metabolism.
Icariin attenuates neuroinflammation and exerts dopamine neuroprotection via an Nrf2-dependent manner.
Paeonol Ameliorates Diabetic Renal Fibrosis Through Promoting the Activation of the Nrf2/ARE Pathway via Up-Regulating Sirt1.
A Novel Derivative of the Natural Product Danshensu Suppresses Inflammatory Responses to Alleviate Caerulein-Induced Acute Pancreatitis.
Fangchinoline Ameliorates the Expressions of Angiogenic Molecule in Cerebral Ischemia Induced Neuronal Degeneration in Neonatal Rats.
Protective Effects of Hydrogen Sulfide Against Cigarette Smoke Exposure-Induced Placental Oxidative Damage by Alleviating Redox Imbalance via Nrf2 Pathway in Rats.
Ingredients from Litsea garrettii as Potential Preventive Agents against Oxidative Insult and Inflammatory Response.
Hepatoprotective Activity of the Ethanolic Extract of Polygonum multiflorum Thunb. against Oxidative Stress-Induced Liver Injury.
Nrf2 protects stellate cells from Smad-dependent cell activation.
Oral carbon monoxide therapy in murine sickle cell disease: Beneficial effects on vaso-occlusion, inflammation and anemia.
Resveratrol relieves particulate matter (mean diameter < 2.5 μm)-induced oxidative injury of lung cells through attenuation of autophagy deregulation.
Local low dose curcumin treatment improves functional recovery and remyelination in a rat model of sciatic nerve crush through inhibition of oxidative stress.
Ginsenoside Rg1 protects against acetaminophen-induced liver injury via activating Nrf2 signaling pathway in vivo and in vitro.
17-allylamino-17-demethoxygeldanamycin impeded chemotherapy through antioxidant activation via reducing reactive oxygen species-induced cell death.
Enhanced anti-obesity effects of bacterial cellulose combined with konjac glucomannan in high-fat diet-fed C57BL/6J mice.
Renoprotective Effects of Antroquinonol in Rats with Nω-Nitro-l-Arginine Methyl Ester-Induced Hypertension.
A novel Gallic acid derivative attenuates BLM-induced pulmonary fibrosis in mice.
Anti-neovascularization effects of DMBT in age-related macular degeneration by inhibition of VEGF secretion through ROS-dependent signaling pathway.
Boron Affects the Development of the Kidney Through Modulation of Apoptosis, Antioxidant Capacity, and Nrf2 Pathway in the African Ostrich Chicks.
(2R,3R)Dihydromyricetin inhibits osteoclastogenesis and bone loss through scavenging LPS-induced oxidative stress and NF-κB and MAPKs pathways activating.
Interleukin-18 binding protein attenuates lipopolysaccharide-induced acute lung injury in mice via suppression NF-κB and activation Nrf2 pathway.
Exposure to formaldehyde and diisononyl phthalate exacerbate neuroinflammation through NF-κB activation in a mouse asthma model.
Beneficial Effects of Exercise Pretreatment in a Sporadic Alzheimer's Rat Model.
Cardioprotection of CAPE-oNO2 against myocardial ischemia/reperfusion induced ROS generation via regulating the SIRT1/eNOS/NF-κB pathway in vivo and in vitro.
l-Arginine induces antioxidant response to prevent oxidative stress via stimulation of glutathione synthesis and activation of Nrf2 pathway.
Neuroprotective effect of phosphocreatine on oxidative stress and mitochondrial dysfunction induced apoptosis in vitro and in vivo: Involvement of dual PI3K/Akt and Nrf2/HO-1 pathways.
Deletion of both p62 and Nrf2 spontaneously results in the development of nonalcoholic steatohepatitis.
Oxyresveratrol prevents lipopolysaccharide/d-galactosamine-induced acute liver injury in mice.
Fragment-growing guided design of Keap1-Nrf2 protein-protein interaction inhibitors for targeting myocarditis.
Dimethyl fumarate attenuates reactive microglia and long-term memory deficits following systemic immune challenge.
Epidermal Growth Factor, through Alleviating Oxidative Stress, Protect IPEC-J2 Cells from Lipopolysaccharides-Induced Apoptosis.
Protective effects of dioscin against fructose-induced renal damage via adjusting Sirt3-mediated oxidative stress, fibrosis, lipid metabolism and inflammation.
Tert-butylhydroquinone post-treatment attenuates neonatal hypoxic-ischemic brain damage in rats.
The Nrf2 inhibitor brusatol is a potent antitumour agent in an orthotopic mouse model of colorectal cancer.
LncRNA MT1DP Aggravates Cadmium-Induced Oxidative Stress by Repressing the Function of Nrf2 and is Dependent on Interaction with miR-365.
Hypothermic machine perfusion attenuates ischemia/reperfusion injury against rat livers donated after cardiac death by activating the Keap1/Nrf2‑ARE signaling pathway.
Qing brick tea (QBT) aqueous extract protects monosodium glutamate-induced obese mice against metabolic syndrome and involves up-regulation Transcription Factor Nuclear Factor-Erythroid 2-Related Factor 2 (Nrf2) antioxidant pathway.
β-glucan Salecan Improves Exercise Performance and Displays Anti-Fatigue Effects through Regulating Energy Metabolism and Oxidative Stress in Mice.
Activation of Nrf2 might reduce oxidative stress in human granulosa cells.
Protective effect of dioscin against thioacetamide-induced acute liver injury via FXR/AMPK signaling pathway in vivo.
Curcumin Attenuates Colistin-Induced Neurotoxicity in N2a Cells via Anti-inflammatory Activity, Suppression of Oxidative Stress, and Apoptosis.
Activation of Nrf2 pathway and inhibition of NLRP3 inflammasome activation contribute to the protective effect of chlorogenic acid on acute liver injury.
The natural compound 2,3,5,4'-tetrahydroxystilbene-2-O-β-d glucoside protects against adriamycin-induced nephropathy through activating the Nrf2-Keap1 antioxidant pathway.
Curcumin Attenuates on Carbon Tetrachloride-Induced Acute Liver Injury in Mice via Modulation of the Nrf2/HO-1 and TGF-β1/Smad3 Pathway.
Salvianolic acid B inhibits myofibroblast transdifferentiation in experimental pulmonary fibrosis via the up-regulation of Nrf2.
NRF2 regulates core and stabilizing circadian clock loops, coupling redox and timekeeping in Mus musculus.
Intermittent hypoxia promotes melanoma lung metastasis via oxidative stress and inflammation responses in a mouse model of obstructive sleep apnea.
Modulation of autophagy in the protective effect of resveratrol on PM2.5-induced pulmonary oxidative injury in mice.
Protective effect of the ethanol extract from Ligusticum chuanxiong rhizome against streptozotocin-induced diabetic nephropathy in mice.
NRG1 regulates redox homeostasis via NRF2 in papillary thyroid cancer.
Regulation on SIRT1-PGC-1α/Nrf2 pathway together with selective inhibition of aldose reductase makes compound hr5F a potential agent for the treatment of diabetic complications.
T-2 toxin-induced toxicity in neuroblastoma-2a cells involves the generation of reactive oxygen, mitochondrial dysfunction and inhibition of Nrf2/HO-1 pathway.
Rapamycin Confers Neuroprotection against Colistin-Induced Oxidative Stress, Mitochondria Dysfunction, and Apoptosis through the Activation of Autophagy and mTOR/Akt/CREB Signaling Pathways.
Tamoxifen activates Nrf2-dependent SQSTM1 transcription to promote endometrial hyperplasia.
Potential Ameliorative Effects of Qing Ye Dan Against Cadmium Induced Prostatic Deficits via Regulating Nrf-2/HO-1 and TGF-β1/Smad Pathways.
Myricetin Possesses Potential Protective Effects on Diabetic Cardiomyopathy through Inhibiting IκBα/NFκB and Enhancing Nrf2/HO-1.
TBHQ Alleviated Endoplasmic Reticulum Stress-Apoptosis and Oxidative Stress by PERK-Nrf2 Crosstalk in Methamphetamine-Induced Chronic Pulmonary Toxicity.
Neuroprotective Effect and Mechanism of Thiazolidinedione on Dopaminergic Neurons In Vivo and In Vitro in Parkinson's Disease.
The therapeutic effect of zerumbone on chronic gastritis via antioxidant mechanisms.
Vitamin E antagonizes ozone-induced asthma exacerbation in Balb/c mice through the Nrf2 pathway.
The effect of hydrogen sulfide-releasing naproxen (ATB-346) versus naproxen on formation of stress-induced gastric lesions, the regulation of systemic inflammation, hypoxia and alterations in gastric microcirculation.
An Important Function of Petrosiol E in Inducing the Differentiation of Neuronal Progenitors and in Protecting Them against Oxidative Stress.
Carbon monoxide released from its pharmacological donor, tricarbonyldichlororuthenium (II) dimer, accelerates the healing of pre-existing gastric ulcers.
Therapeutic effects of L-Cysteine in newborn mice subjected to hypoxia-ischemia brain injury via the CBS/H2S system: Role of oxidative stress and endoplasmic reticulum stress.
Critical role of p21 on olaquindox-induced mitochondrial apoptosis and S-phase arrest involves activation of PI3K/AKT and inhibition of Nrf2/HO-1pathway.
An inducible form of Nrf2 confers enhanced protection against acute oxidative stresses in RPE cells.
SETD7 is a prognosis predicting factor of breast cancer and regulates redox homeostasis.
iASPP Is an Antioxidative Factor and Drives Cancer Growth and Drug Resistance by Competing with Nrf2 for Keap1 Binding.
3H-1,2-Dithiole-3-thione as a novel therapeutic agent for the treatment of ischemic stroke through Nrf2 defense pathway.
Involvement of the activation of Nrf2/HO-1, p38 MAPK signaling pathways and endoplasmic reticulum stress in furazolidone induced cytotoxicity and S phase arrest in human hepatocyte L02 cells: modulation of curcumin.
Nrf-2-driven long noncoding RNA ODRUL contributes to modulating silver nanoparticle-induced effects on erythroid cells.
Novel indolyl-chalcone derivatives inhibit A549 lung cancer cell growth through activating Nrf-2/HO-1 and inducing apoptosis in vitro and in vivo.
Oral exposure to diisodecyl phthalate aggravates allergic dermatitis by oxidative stress and enhancement of thymic stromal lymphopoietin.
Activation of Akt and JNK/Nrf2/NQO1 pathway contributes to the protective effect of coptisine against AAPH-induced oxidative stress.
Discovery of a novel Nrf2 inhibitor that induces apoptosis of human acute myeloid leukemia cells.
Fluoxetine protects against methamphetamine‑induced lung inflammation by suppressing oxidative stress through the SERT/p38 MAPK/Nrf2 pathway in rats.
Arsenite-induced stress granule formation is inhibited by elevated levels of reduced glutathione in West Nile virus-infected cells.
Mitochondrial Dysregulation Secondary to Endoplasmic Reticulum Stress in Autosomal Dominant Tubulointerstitial Kidney Disease - UMOD (ADTKD-UMOD).
Caffeic acid phenethyl ester up-regulates antioxidant levels in hepatic stellate cell line T6 via an Nrf2-mediated mitogen activated protein kinases pathway.
NADPH Oxidase 4 (Nox4) Suppresses Mitochondrial Biogenesis and Bioenergetics in Lung Fibroblasts via a Nuclear Factor Erythroid-derived 2-like 2 (Nrf2)-dependent Pathway.
Morin enhances hepatic Nrf2 expression in a liver fibrosis rat model.
Nrf2-mediated neuroprotection by MANF against 6-OHDA-induced cell damage via PI3K/AKT/GSK3β pathway.
(-)-7(S)-hydroxymatairesinol protects against tumor necrosis factor-α-mediated inflammation response in endothelial cells by blocking the MAPK/NF-κB and activating Nrf2/HO-1.
Protective effect of naringin against the LPS-induced apoptosis of PC12 cells: Implications for the treatment of neurodegenerative disorders.
Berberine protects against 6-OHDA-induced neurotoxicity in PC12 cells and zebrafish through hormetic mechanisms involving PI3K/AKT/Bcl-2 and Nrf2/HO-1 pathways.
Hydrogen sulfide decreases high glucose/palmitate-induced autophagy in endothelial cells by the Nrf2-ROS-AMPK signaling pathway.
Protective Effects of Hydrogen Sulfide in the Ageing Kidney.
Targeting HO-1 by Epigallocatechin-3-Gallate Reduces Contrast-Induced Renal Injury via Anti-Oxidative Stress and Anti-Inflammation Pathways.
Neuroprotective Effects of a Smoothened Receptor Agonist against Early Brain Injury after Experimental Subarachnoid Hemorrhage in Rats.
Polyphenols from hawthorn peels and fleshes differently mitigate dyslipidemia, inflammation and oxidative stress in association with modulation of liver injury in high fructose diet-fed mice.
3,3'-diindolylmethane mitigates total body irradiation-induced hematopoietic injury in mice.
15d-PGJ2 alleviates ConA-induced acute liver injury in mice by up-regulating HO-1 and reducing hepatic cell autophagy.
Gankyrin has an antioxidative role through the feedback regulation of Nrf2 in hepatocellular carcinoma.
Taurine protects against As2O3-induced autophagy in livers of rat offsprings through PPARγ pathway.
Dioscin alleviates dimethylnitrosamine-induced acute liver injury through regulating apoptosis, oxidative stress and inflammation.
Total Flavonoids from Rosa laevigata Michx Fruit Ameliorates Hepatic Ischemia/Reperfusion Injury through Inhibition of Oxidative Stress and Inflammation in Rats.
Protective Effect of the Total Flavonoids from Rosa laevigata Michx Fruit on Renal Ischemia-Reperfusion Injury through Suppression of Oxidative Stress and Inflammation.
Acute exposure of ozone induced pulmonary injury and the protective role of vitamin E through the Nrf2 pathway in Balb/c mice.
P21(Waf1/Cip1) plays a critical role in furazolidone-induced apoptosis in HepG2 cells through influencing the caspase-3 activation and ROS generation.
Resveratrol Ameliorated Vascular Calcification by Regulating Sirt-1 and Nrf2.
Chlorogenic acid protects against liver fibrosis in vivo and in vitro through inhibition of oxidative stress.
Hydrogen peroxide prevents vascular calcification induced ROS production by regulating Nrf-2 pathway.
Metformin exerts glucose-lowering action in high-fat fed mice via attenuating endotoxemia and enhancing insulin signaling.
Taurine protects against As2O3-induced autophagy in pancreas of rat offsprings through Nrf2/Trx pathway.
Transcriptional upregulation centra of HO-1 by EGB via the MAPKs/Nrf2 pathway in mouse C2C12 myoblasts.
Neohesperidin Dihydrochalcone versus CCl₄-Induced Hepatic Injury through Different Mechanisms: The Implication of Free Radical Scavenging and Nrf2 Activation.
Potent effects of dioscin against obesity in mice.
Tetrachlorobenzoquinone activates Nrf2 signaling by Keap1 cross-linking and ubiquitin translocation but not Keap1-Cullin3 complex dissociation.
Effect of Nrf2 on rat ovarian tissues against atrazine-induced anti-oxidative response.
Total saponins from Rosa laevigata Michx fruit attenuates hepatic steatosis induced by high-fat diet in rats.
Wen Y, Liu Y, Huang Q, Liu R, Liu J, Zhang F, Liu S, Jiang Y
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 Jan;95:153856
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 Jan;95:153856
Protective effects of Huang-Lian-Jie-Du Decoction on diabetic nephropathy through regulating AGEs/RAGE/Akt/Nrf2 pathway and metabolic profiling in db/db mice.
Tang D, He WJ, Zhang ZT, Shi JJ, Wang X, Gu WT, Chen ZQ, Xu YH, Chen YB, Wang SM
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 Jan;95:153777
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 Jan;95:153777
GRP78 Antibodies Are Associated With Blood-Brain Barrier Breakdown in Anti-Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disorder.
Shimizu F, Ogawa R, Mizukami Y, Watanabe K, Hara K, Kadono C, Takahashi T, Misu T, Takeshita Y, Sano Y, Fujisawa M, Maeda T, Nakashima I, Fujihara K, Kanda T
Neurology(R) neuroimmunology & neuroinflammation 2022 Jan;9(1)
Neurology(R) neuroimmunology & neuroinflammation 2022 Jan;9(1)
CAMKK2 Defines Ferroptosis Sensitivity of Melanoma Cells by Regulating AMPK‒NRF2 Pathway.
Wang S, Yi X, Wu Z, Guo S, Dai W, Wang H, Shi Q, Zeng K, Guo W, Li C
The Journal of investigative dermatology 2022 Jan;142(1):189-200.e8
The Journal of investigative dermatology 2022 Jan;142(1):189-200.e8
Overexpressed Smurf1 is degraded in glioblastoma cells through autophagy in a p62-dependent manner.
Han D, Li S, Xia Q, Meng X, Dong L
FEBS open bio 2022 Jan;12(1):118-129
FEBS open bio 2022 Jan;12(1):118-129
The ethanol extract of flower buds of Tussilago farfara L. attenuates cigarette smoke-induced lung inflammation through regulating NLRP3 inflammasome, Nrf2, and NF-κB.
Xu LT, Wang T, Fang KL, Zhao Y, Wang XN, Ren DM, Shen T
Journal of ethnopharmacology 2022 Jan 30;283:114694
Journal of ethnopharmacology 2022 Jan 30;283:114694
Suhuang antitussive capsule ameliorates post-infectious cough in mice through AhR-Nrf2 pathway.
Liang R, Tong X, Dong Z, Qin W, Fan L, Bai Z, Zhang Z, Xiang T, Wang Z, Tan N
Journal of ethnopharmacology 2022 Jan 30;283:114664
Journal of ethnopharmacology 2022 Jan 30;283:114664
Glyphosate-induced gut microbiota dysbiosis facilitates male reproductive toxicity in rats.
Liu JB, Chen K, Li ZF, Wang ZY, Wang L
The Science of the total environment 2022 Jan 20;805:150368
The Science of the total environment 2022 Jan 20;805:150368
NMN recruits GSH to enhance GPX4-mediated ferroptosis defense in UV irradiation induced skin injury.
Feng Z, Qin Y, Huo F, Jian Z, Li X, Geng J, Li Y, Wu J
Biochimica et biophysica acta. Molecular basis of disease 2022 Jan 1;1868(1):166287
Biochimica et biophysica acta. Molecular basis of disease 2022 Jan 1;1868(1):166287
Dietary mulberry-leaf flavonoids improve the eggshell quality of aged breeder hens.
Huang Z, Dai H, Jiang J, Ye N, Zhu S, Wei Q, Lv Z, Shi F
Theriogenology 2022 Feb;179:177-186
Theriogenology 2022 Feb;179:177-186
Anti-fatigue effect of hypericin in a chronic forced exercise mouse model.
Sun Y, Liang C, Zheng L, Liu L, Li Z, Yang G, Li Y
Journal of ethnopharmacology 2022 Feb 10;284:114767
Journal of ethnopharmacology 2022 Feb 10;284:114767
SLC7A11 Reduces Laser-Induced Choroidal Neovascularization by Inhibiting RPE Ferroptosis and VEGF Production.
Zhao X, Gao M, Liang J, Chen Y, Wang Y, Wang Y, Xiao Y, Zhao Z, Wan X, Jiang M, Luo X, Wang F, Sun X
Frontiers in cell and developmental biology 2021;9:639851
Frontiers in cell and developmental biology 2021;9:639851
Lactobacillus acidophilus ATCC 4356 Alleviates Renal Ischemia-Reperfusion Injury Through Antioxidant Stress and Anti-inflammatory Responses and Improves Intestinal Microbial Distribution.
Zhang P, Han X, Zhang X, Zhu X
Frontiers in nutrition 2021;8:667695
Frontiers in nutrition 2021;8:667695
Hengshun Aromatic Vinegar Ameliorates Vascular Endothelial Injury via Regulating PKCζ-Mediated Oxidative Stress and Apoptosis.
Li X, Gao M, Zhu S, Yin L, Zhang B, Qi Y, Zhao Y, Yu Y, Xu L
Frontiers in nutrition 2021;8:635232
Frontiers in nutrition 2021;8:635232
Nicotinic Acid against Acetaminophen-Induced Hepatotoxicity via Sirt1/Nrf2 Antioxidative Pathway in Mice.
Hu D, Zhang L, Jiang R, Liao C, Xu J, Jiang S, Yang Y, Lin L, Huang J, Shen Y, Tang L, Li L
Journal of nutritional science and vitaminology 2021;67(3):145-152
Journal of nutritional science and vitaminology 2021;67(3):145-152
Betanin Prevents Experimental Abdominal Aortic Aneurysm Progression by Modulating the TLR4/NF-κB and Nrf2/HO-1 Pathways.
Qiu R, Chen S, Hua F, Bian S, Chen J, Li G, Wu X
Biological & pharmaceutical bulletin 2021;44(9):1254-1262
Biological & pharmaceutical bulletin 2021;44(9):1254-1262
H2S improves doxorubicin-induced myocardial fibrosis by inhibiting oxidative stress and apoptosis via Keap1-Nrf2.
Li Y, Chandra TP, Song X, Nie L, Liu M, Yi J, Zheng X, Chu C, Yang J
Technology and health care : official journal of the European Society for Engineering and Medicine 2021;29(S1):195-209
Technology and health care : official journal of the European Society for Engineering and Medicine 2021;29(S1):195-209
Metabolic Activation of Retrorsine may Disrupt Bile Acid Homeostasis in Mice through the Nrf2 Pathway.
Pang X, Tang C, Cao P, Zhou L, Chen X
Current drug metabolism 2021;22(11):870-881
Current drug metabolism 2021;22(11):870-881
Zisheng Shenqi Decoction Ameliorates Monosodium Urate-Mediated Gouty Arthritis in Rats via Promotion of Autophagy through the AMPK/mTOR Signaling Pathway.
Han J, Shi G, Li W, Wang S, Bai J, Sun X, Xie Y, Sui F, Chen F, Jiang D
Evidence-based complementary and alternative medicine : eCAM 2021;2021:6918026
Evidence-based complementary and alternative medicine : eCAM 2021;2021:6918026
Fenofibrate Ameliorates Hepatic Ischemia/Reperfusion Injury in Mice: Involvements of Apoptosis, Autophagy, and PPAR-α Activation.
Zhang J, Cheng P, Dai W, Ji J, Wu L, Feng J, Wu J, Yu Q, Li J, Guo C
PPAR research 2021;2021:6658944
PPAR research 2021;2021:6658944
MCU That Is Transcriptionally Regulated by Nrf2 Augments Malignant Biological Behaviors in Oral Squamous Cell Carcinoma Cells.
Wu R, Zuo W, Xu X, Bi L, Zhang C, Chen H, Liu H
BioMed research international 2021;2021:6650791
BioMed research international 2021;2021:6650791
Antioral Squamous Cell Carcinoma Effects of Carvacrol via Inhibiting Inflammation, Proliferation, and Migration Related to Nrf2/Keap1 Pathway.
Liu H, Xu X, Wu R, Bi L, Zhang C, Chen H, Yang Y
BioMed research international 2021;2021:6616547
BioMed research international 2021;2021:6616547
Tubeimoside I Ameliorates Myocardial Ischemia-Reperfusion Injury through SIRT3-Dependent Regulation of Oxidative Stress and Apoptosis.
Lv D, Luo M, Cheng Z, Wang R, Yang X, Guo Y, Huang L, Li X, Huang B, Shen J, Luo S, Yan J
Oxidative medicine and cellular longevity 2021;2021:5577019
Oxidative medicine and cellular longevity 2021;2021:5577019
Design, Synthesis, and Biological Evaluation of a Novel Aminothiol Compound as Potential Radioprotector.
Li X, Wang X, Miao L, Guo Y, Yuan R, Ren J, Huang Y, Tian H
Oxidative medicine and cellular longevity 2021;2021:4714649
Oxidative medicine and cellular longevity 2021;2021:4714649
Microglia-Derived Exosomes Improve Spinal Cord Functional Recovery after Injury via Inhibiting Oxidative Stress and Promoting the Survival and Function of Endothelia Cells.
Peng W, Wan L, Luo Z, Xie Y, Liu Y, Huang T, Lu H, Hu J
Oxidative medicine and cellular longevity 2021;2021:1695087
Oxidative medicine and cellular longevity 2021;2021:1695087
PKM2 Is a Potential Diagnostic and Therapeutic Target for Retinitis Pigmentosa.
Zhu P, Yang Q, Li G, Chang Q
Disease markers 2021;2021:1602797
Disease markers 2021;2021:1602797
Gastric Electrical Pacing Reduces Apoptosis of Interstitial Cells of Cajal via Antioxidative Stress Effect Attributing to Phenotypic Polarization of M2 Macrophages in Diabetic Rats.
Wang H, Zhao K, Ba Y, Gao T, Shi N, Niu Q, Liu C, Chen Y
Oxidative medicine and cellular longevity 2021;2021:1298657
Oxidative medicine and cellular longevity 2021;2021:1298657
Copper Nanoparticles Induce Oxidative Stress via the Heme Oxygenase 1 Signaling Pathway in vitro Studies.
Zou L, Cheng G, Xu C, Liu H, Wang Y, Li N, Fan X, Zhu C, Xia W
International journal of nanomedicine 2021;16:1565-1573
International journal of nanomedicine 2021;16:1565-1573
Baicalin Alleviates Oxidative Stress and Inflammation in Diabetic Nephropathy via Nrf2 and MAPK Signaling Pathway.
Ma L, Wu F, Shao Q, Chen G, Xu L, Lu F
Drug design, development and therapy 2021;15:3207-3221
Drug design, development and therapy 2021;15:3207-3221
Sodium Propionate Enhances Nrf2-Mediated Protective Defense Against Oxidative Stress and Inflammation in Lipopolysaccharide-Induced Neonatal Mice.
Chen D, Gao ZQ, Wang YY, Wan BB, Liu G, Chen JL, Wu YX, Zhou Q, Jiang SY, Yu RQ, Pang QF
Journal of inflammation research 2021;14:803-816
Journal of inflammation research 2021;14:803-816
Induction of Mitosis Delay and Apoptosis by CDDO-TFEA in Glioblastoma Multiforme.
Tsai TH, Lieu AS, Huang TY, Kwan AL, Lin CL, Hsu YC
Frontiers in pharmacology 2021;12:756228
Frontiers in pharmacology 2021;12:756228
Paeoniflorin Suppresses TBHP-Induced Oxidative Stress and Apoptosis in Human Umbilical Vein Endothelial Cells via the Nrf2/HO-1 Signaling Pathway and Improves Skin Flap Survival.
Jiang J, Dong C, Zhai L, Lou J, Jin J, Cheng S, Chen Z, Guo X, Lin D, Ding J, Gao W
Frontiers in pharmacology 2021;12:735530
Frontiers in pharmacology 2021;12:735530
Caveolin-1 Alleviates Acetaminophen-Induced Fat Accumulation in Non-Alcoholic Fatty Liver Disease by Enhancing Hepatic Antioxidant Ability via Activating AMPK Pathway.
Wang J, Jiang W, Xin J, Xue W, Shi C, Wen J, Huang Y, Hu C
Frontiers in pharmacology 2021;12:717276
Frontiers in pharmacology 2021;12:717276
Geniposide Combined With Notoginsenoside R1 Attenuates Inflammation and Apoptosis in Atherosclerosis via the AMPK/mTOR/Nrf2 Signaling Pathway.
Liu X, Xu Y, Cheng S, Zhou X, Zhou F, He P, Hu F, Zhang L, Chen Y, Jia Y
Frontiers in pharmacology 2021;12:687394
Frontiers in pharmacology 2021;12:687394
Astragaloside IV Attenuates the Myocardial Injury Caused by Adriamycin by Inhibiting Autophagy.
Luo LF, Qin LY, Wang JX, Guan P, Wang N, Ji ES
Frontiers in pharmacology 2021;12:669782
Frontiers in pharmacology 2021;12:669782
Downregulated MicroRNA-327 Attenuates Oxidative Stress-Mediated Myocardial Ischemia Reperfusion Injury Through Regulating the FGF10/Akt/Nrf2 Signaling Pathway.
Zheng T, Yang J, Zhang J, Yang C, Fan Z, Li Q, Zhai Y, Liu H, Yang J
Frontiers in pharmacology 2021;12:669146
Frontiers in pharmacology 2021;12:669146
The Protective Effects of Sulforaphane on High-Fat Diet-Induced Obesity in Mice Through Browning of White Fat.
Liu Y, Fu X, Chen Z, Luo T, Zhu C, Ji Y, Bian Z
Frontiers in pharmacology 2021;12:665894
Frontiers in pharmacology 2021;12:665894
Tanshinone I Inhibits Oxidative Stress-Induced Cardiomyocyte Injury by Modulating Nrf2 Signaling.
Wu YT, Xie LP, Hua Y, Xu HL, Chen GH, Han X, Tan ZB, Fan HJ, Chen HM, Li J, Liu B, Zhou YC
Frontiers in pharmacology 2021;12:644116
Frontiers in pharmacology 2021;12:644116
The Protective Effects of Shengmai Formula Against Myocardial Injury Induced by Ultrafine Particulate Matter Exposure and Myocardial Ischemia are Mediated by the PI3K/AKT/p38 MAPK/Nrf2 Pathway.
Chen L, Guo Y, Qu S, Li K, Yang T, Yang Y, Zheng Z, Liu H, Wang X, Deng S, Zhang Y, Zhu X, Li Y
Frontiers in pharmacology 2021;12:619311
Frontiers in pharmacology 2021;12:619311
Inhibition of BAG3 enhances the anticancer effect of shikonin in hepatocellular carcinoma.
Lu J, Liu SY, Zhang J, Yang GM, Gao GB, Yu NN, Li YP, Li YX, Ma ZQ, Wang Y, Lu CH
American journal of cancer research 2021;11(7):3575-3593
American journal of cancer research 2021;11(7):3575-3593
Antioxidant activity of mesenchymal stem cell-derived extracellular vesicles restores hippocampal neurons following seizure damage.
Luo Q, Xian P, Wang T, Wu S, Sun T, Wang W, Wang B, Yang H, Yang Y, Wang H, Liu W, Long Q
Theranostics 2021;11(12):5986-6005
Theranostics 2021;11(12):5986-6005
Nrf2 Down-Regulation by Camptothecin Favors Inhibiting Invasion, Metastasis and Angiogenesis in Hepatocellular Carcinoma.
Liu Q, Zhao S, Meng F, Wang H, Sun L, Li G, Gao F, Chen F
Frontiers in oncology 2021;11:661157
Frontiers in oncology 2021;11:661157
Daphnetin inhibits spinal glial activation via Nrf2/HO-1/NF-κB signaling pathway and attenuates CFA-induced inflammatory pain.
Yang Y, Sheng Q, Nie Z, Liu L, Zhang W, Chen G, Ye F, Shi L, Lv Z, Xie J, Wang D
International immunopharmacology 2021 Sep;98:107882
International immunopharmacology 2021 Sep;98:107882
Polydatin has anti-inflammatory and antioxidant effects in LPS-induced macrophages and improves DSS-induced mice colitis.
Chen G, Yang Z, Wen D, Guo J, Xiong Q, Li P, Zhao L, Wang J, Wu C, Dong L
Immunity, inflammation and disease 2021 Sep;9(3):959-970
Immunity, inflammation and disease 2021 Sep;9(3):959-970
Temozolomide Drives Ferroptosis via a DMT1-Dependent Pathway in Glioblastoma Cells.
Song Q, Peng S, Sun Z, Heng X, Zhu X
Yonsei medical journal 2021 Sep;62(9):843-849
Yonsei medical journal 2021 Sep;62(9):843-849
TAZ as a novel regulator of oxidative damage in decidualization via Nrf2/ARE/Foxo1 pathway.
Yu HF, Zheng LW, Yang ZQ, Wang YS, Wang TT, Yue ZP, Guo B
Experimental & molecular medicine 2021 Sep;53(9):1307-1318
Experimental & molecular medicine 2021 Sep;53(9):1307-1318
Compensatory expression of NRF2-dependent antioxidant genes is required to overcome the lethal effects of Kv11.1 activation in breast cancer cells and PDOs.
Senyuk V, Eskandari N, Jiang Y, Garcia-Varela R, Sundstrom R, Leanza L, Peruzzo R, Burkard M, Minshall RD, Gentile S
Redox biology 2021 Sep;45:102030
Redox biology 2021 Sep;45:102030
Dimethyl itaconate inhibits LPS‑induced microglia inflammation and inflammasome‑mediated pyroptosis via inducing autophagy and regulating the Nrf‑2/HO‑1 signaling pathway.
Yang S, Zhang X, Zhang H, Lin X, Chen X, Zhang Y, Lin X, Huang L, Zhuge Q
Molecular medicine reports 2021 Sep;24(3)
Molecular medicine reports 2021 Sep;24(3)
N2L, a novel lipoic acid-niacin dimer, attenuates ferroptosis and decreases lipid peroxidation in HT22 cells.
Peng W, Zhu Z, Yang Y, Hou J, Lu J, Chen C, Liu F, Pi R
Brain research bulletin 2021 Sep;174:250-259
Brain research bulletin 2021 Sep;174:250-259
CSNK2B contributes to colorectal cancer cell proliferation by activating the mTOR signaling.
Yu S, Hu Q, Fan K, Yang C, Gao Y
Journal of cell communication and signaling 2021 Sep;15(3):383-392
Journal of cell communication and signaling 2021 Sep;15(3):383-392
Celecoxib reverses the glioblastoma chemo-resistance to temozolomide through mitochondrial metabolism.
Yin D, Jin G, He H, Zhou W, Fan Z, Gong C, Zhao J, Xiong H
Aging 2021 Sep 8;13(17):21268-21282
Aging 2021 Sep 8;13(17):21268-21282
Enhanced Extracellular Matrix Degradation in Growth Plate Contributes to Manganese Deficiency-Induced Tibial Dyschondroplasia in Broiler Chicks.
Dong PF, Jin C, Lian CY, Wang L, Wang ZY
Biological trace element research 2021 Sep 21;
Biological trace element research 2021 Sep 21;
Genistein exhibits therapeutic potential for PCOS mice via the ER-Nrf2-Foxo1-ROS pathway.
Luo M, Zheng LW, Wang YS, Huang JC, Yang ZQ, Yue ZP, Guo B
Food & function 2021 Sep 20;12(18):8800-8811
Food & function 2021 Sep 20;12(18):8800-8811
Anti-inflammatory and Antioxidant Effects of Pyrroloquinoline Quinone in L-NAME-Induced Preeclampsia-Like Rat Model.
Wang H, Li M, Chen P, Shi X
Reproductive sciences (Thousand Oaks, Calif.) 2021 Sep 20;
Reproductive sciences (Thousand Oaks, Calif.) 2021 Sep 20;
Round Scad-Derived Octapeptide WCPFSRSF Confers Neuroprotection by Regulating Akt/Nrf2/NFκB Signaling.
Zhang Q, Su G, Yang Q, Wei Z, Wang J, Zheng L, Zhao M
Journal of agricultural and food chemistry 2021 Sep 15;69(36):10606-10616
Journal of agricultural and food chemistry 2021 Sep 15;69(36):10606-10616
Aged Ripe Pu-erh Tea Reduced Oxidative Stress-Mediated Inflammation in Dextran Sulfate Sodium-Induced Colitis Mice by Regulating Intestinal Microbes.
Hu S, Li S, Liu Y, Sun K, Luo L, Zeng L
Journal of agricultural and food chemistry 2021 Sep 15;69(36):10592-10605
Journal of agricultural and food chemistry 2021 Sep 15;69(36):10592-10605
Yixin-Fumai granules improve sick sinus syndrome in aging mice through Nrf-2/HO-1 pathway: A new target for sick sinus syndrome.
Zhang H, Li L, Hao M, Chen K, Lu Y, Qi J, Chen W, Ren L, Cai X, Chen C, Liu Z, Zhao B, Li Z, Hou P
Journal of ethnopharmacology 2021 Sep 15;277:114254
Journal of ethnopharmacology 2021 Sep 15;277:114254
Effect of different exercise training intensities on age-related cardiac damage in male mice.
Pei Z, Yang C, Guo Y, Dong M, Wang F
Aging 2021 Sep 14;13(17):21700-21711
Aging 2021 Sep 14;13(17):21700-21711
Protective Effects and Mechanisms of Procyanidins on Parkinson's Disease In Vivo and In Vitro.
Chen J, Chen Y, Zheng Y, Zhao J, Yu H, Zhu J, Li D
Molecules (Basel, Switzerland) 2021 Sep 13;26(18)
Molecules (Basel, Switzerland) 2021 Sep 13;26(18)
Baicalein Enhances the Effect of Acarbose on the Improvement of Nonalcoholic Fatty Liver Disease Associated with Prediabetes via the Inhibition of De Novo Lipogenesis.
Xing Y, Ren X, Li X, Sui L, Shi X, Sun Y, Quan C, Xiu Z, Dong Y
Journal of agricultural and food chemistry 2021 Sep 1;69(34):9822-9836
Journal of agricultural and food chemistry 2021 Sep 1;69(34):9822-9836
MicroRNA-30c-5p protects against myocardial ischemia/reperfusion injury via regulation of Bach1/Nrf2.
Sun M, Guo M, Ma G, Zhang N, Pan F, Fan X, Wang R
Toxicology and applied pharmacology 2021 Sep 1;426:115637
Toxicology and applied pharmacology 2021 Sep 1;426:115637
LncRNA OIP5-AS1 inhibits ferroptosis in prostate cancer with long-term cadmium exposure through miR-128-3p/SLC7A11 signaling.
Zhang Y, Guo S, Wang S, Li X, Hou D, Li H, Wang L, Xu Y, Ma B, Wang H, Jiang X
Ecotoxicology and environmental safety 2021 Sep 1;220:112376
Ecotoxicology and environmental safety 2021 Sep 1;220:112376
Inhibition of TNFAIP1 ameliorates the oxidative stress and inflammatory injury in myocardial ischemia/reperfusion injury through modulation of Akt/GSK-3β/Nrf2 pathway.
Wen L, Yang QH, Ma XL, Li T, Xiao S, Sun CF
International immunopharmacology 2021 Oct;99:107993
International immunopharmacology 2021 Oct;99:107993
Thymus quinquecostatus Celak. ameliorates cerebral ischemia-reperfusion injury via dual antioxidant actions: Activating Keap1/Nrf2/HO-1 signaling pathway and directly scavenging ROS.
Fan S, Liu X, Wang Y, Ren X, Liu Y, Dong Y, Fan Q, Wei J, Ma J, Yu A, Song R, Sui H, Shen M, Fang F, Xia Q, She G
Phytomedicine : international journal of phytotherapy and phytopharmacology 2021 Oct;91:153673
Phytomedicine : international journal of phytotherapy and phytopharmacology 2021 Oct;91:153673
Cardioprotective effect of MLN4924 on ameliorating autophagic flux impairment in myocardial ischemia-reperfusion injury by Sirt1.
Zhang J, Cui J, Zhao F, Yang L, Xu X, Shi Y, Wei B
Redox biology 2021 Oct;46:102114
Redox biology 2021 Oct;46:102114
Black raspberry (Rubus occidentalis) attenuates inflammatory markers and vascular endothelial dysfunction in Wistar rats fed a high-fat diet with fructose solution.
Park SY, Jung H, Lin Z, Hwang KT, Kwak HK
Journal of food biochemistry 2021 Oct;45(10):e13917
Journal of food biochemistry 2021 Oct;45(10):e13917
Oridonin prevents oxidative stress-induced endothelial injury via promoting Nrf-2 pathway in ischaemic stroke.
Li L, Cheng SQ, Guo W, Cai ZY, Sun YQ, Huang XX, Yang J, Ji J, Chen YY, Dong YF, Cheng H, Sun XL
Journal of cellular and molecular medicine 2021 Oct;25(20):9753-9766
Journal of cellular and molecular medicine 2021 Oct;25(20):9753-9766
A new ferroptosis inhibitor, isolated from Ajuga nipponensis, protects neuronal cells via activating NRF2-antioxidant response elements (AREs) pathway.
Tan Q, Fang Y, Peng X, Zhou H, Xu J, Gu Q
Bioorganic chemistry 2021 Oct;115:105177
Bioorganic chemistry 2021 Oct;115:105177
The Potential Protective Effect and Possible Mechanism of Peptides from Oyster (Crassostrea hongkongensis) Hydrolysate on Triptolide-Induced Testis Injury in Male Mice.
Zhang X, Peng Z, Zheng H, Zhang C, Lin H, Qin X
Marine drugs 2021 Oct 9;19(10)
Marine drugs 2021 Oct 9;19(10)
Nicotinic Acetylcholine Receptor Subunit α7 Mediates Cigarette Smoke-Induced PD-L1 Expression in Human Bronchial Epithelial Cells.
Kwok HH, Gao B, Chan KH, Ip MS, Minna JD, Lam DC
Cancers 2021 Oct 25;13(21)
Cancers 2021 Oct 25;13(21)
RTA404, an Activator of Nrf2, Activates the Checkpoint Kinases and Induces Apoptosis through Intrinsic Apoptotic Pathway in Malignant Glioma.
Tsai TH, Lieu AS, Huang TY, Kwan AL, Lin CL, Hsu YC
Journal of clinical medicine 2021 Oct 20;10(21)
Journal of clinical medicine 2021 Oct 20;10(21)
(-)-Epicatechin ameliorates cigarette smoke-induced lung inflammation via inhibiting ROS/NLRP3 inflammasome pathway in rats with COPD.
Tian X, Xue Y, Xie G, Zhou Y, Xiao H, Ding F, Zhang M
Toxicology and applied pharmacology 2021 Oct 15;429:115674
Toxicology and applied pharmacology 2021 Oct 15;429:115674
Hexavalent chromium inhibits the formation of neutrophil extracellular traps and promotes the apoptosis of neutrophils via AMPK signaling pathway.
Ma Y, Li S, Ye S, Tang S, Hu D, Wei L, Xiao F
Ecotoxicology and environmental safety 2021 Oct 15;223:112614
Ecotoxicology and environmental safety 2021 Oct 15;223:112614
Melatonin Analogues Potently Inhibit MAO-B and Protect PC12 Cells against Oxidative Stress.
Elkamhawy A, Woo J, Gouda NA, Kim J, Nada H, Roh EJ, Park KD, Cho J, Lee K
Antioxidants (Basel, Switzerland) 2021 Oct 12;10(10)
Antioxidants (Basel, Switzerland) 2021 Oct 12;10(10)
Copper (Cu) induced changes of lipid metabolism through oxidative stress-mediated autophagy and Nrf2/PPARγ pathways.
Zhong CC, Zhao T, Hogstrand C, Chen F, Song CC, Luo Z
The Journal of nutritional biochemistry 2021 Oct 12;:108883
The Journal of nutritional biochemistry 2021 Oct 12;:108883
Sitagliptin activates the p62-Keap1-Nrf2 signalling pathway to alleviate oxidative stress and excessive autophagy in severe acute pancreatitis-related acute lung injury.
Kong L, Deng J, Zhou X, Cai B, Zhang B, Chen X, Chen Z, Wang W
Cell death & disease 2021 Oct 11;12(10):928
Cell death & disease 2021 Oct 11;12(10):928
Exercise Intervention Mitigates Pathological Liver Changes in NAFLD Zebrafish by Activating SIRT1/AMPK/NRF2 Signaling.
Zou Y, Chen Z, Sun C, Yang D, Zhou Z, Peng X, Zheng L, Tang C
International journal of molecular sciences 2021 Oct 10;22(20)
International journal of molecular sciences 2021 Oct 10;22(20)
Protective effects of Nrf2 against sepsis-induced hepatic injury.
Li L, Zhang Q, Zhang X, Xu X, Wang X, Huang X, Wang T, Jiang Z, Xiao L, Zhang L, Sun L
Life sciences 2021 Oct 1;282:119807
Life sciences 2021 Oct 1;282:119807
Antagonizing effects of curcumin against mercury-induced autophagic death and trace elements disorder by regulating PI3K/AKT and Nrf2 pathway in the spleen.
Zhao G, Qi L, Wang Y, Li X, Li Q, Tang X, Wang X, Wu C
Ecotoxicology and environmental safety 2021 Oct 1;222:112529
Ecotoxicology and environmental safety 2021 Oct 1;222:112529
Nicotinamide improves NAD+ levels to protect against acetaminophen-induced acute liver injury in mice.
Xu J, Zhang L, Jiang R, Hu K, Hu D, Liao C, Jiang S, Yang Y, Huang J, Tang L, Li L
Human & experimental toxicology 2021 Nov;40(11):1938-1946
Human & experimental toxicology 2021 Nov;40(11):1938-1946
Loss of PHLDA1 has a protective role in OGD/R-injured neurons via regulation of the GSK-3β/Nrf2 pathway.
Yang F, Chen R
Human & experimental toxicology 2021 Nov;40(11):1909-1920
Human & experimental toxicology 2021 Nov;40(11):1909-1920
Tripartite motif-containing protein 16 protects against myocardial ischemia/reperfusion injury by affecting the Keap1/Nrf2 axis.
Cui Q, Yan L
Cell and tissue research 2021 Nov;386(2):349-363
Cell and tissue research 2021 Nov;386(2):349-363
PHLDA3 inhibition protects against myocardial ischemia/reperfusion injury by alleviating oxidative stress and inflammatory response via the Akt/Nrf2 axis.
Meng X, Zhang L, Han B, Zhang Z
Environmental toxicology 2021 Nov;36(11):2266-2277
Environmental toxicology 2021 Nov;36(11):2266-2277
Chemical Constituents from the Rhizome of Ligusticum chuanxiong Hort. and Their Nrf2 Inducing Activity.
Zhang K, Fang KL, Wang T, Xu LT, Zhao Y, Wang XN, Xiang L, Shen T
Chemistry & biodiversity 2021 Nov;18(11):e2100302
Chemistry & biodiversity 2021 Nov;18(11):e2100302
Resveratrol sustains intestinal barrier integrity, improves antioxidant capacity, and alleviates inflammation in the jejunum of ducks exposed to acute heat stress.
Yang C, Luo P, Chen SJ, Deng ZC, Fu XL, Xu DN, Tian YB, Huang YM, Liu WJ
Poultry science 2021 Nov;100(11):101459
Poultry science 2021 Nov;100(11):101459
Isoliquiritigenin alleviates LPS/ D-GalN-induced acute liver failure by activating the PGC-1α/ Nrf2 pathway to reduce oxidative stress and inflammatory response.
Wang L, Wang X, Kong L, Wang S, Huang K, Wu J, Wang C, Sun H, Liu K, Meng Q
International immunopharmacology 2021 Nov;100:108159
International immunopharmacology 2021 Nov;100:108159
CDDO-Im ameliorates osteoarthritis and inhibits chondrocyte apoptosis in mice via enhancing Nrf2-dependent autophagy.
Dong J, Zhang KJ, Li GC, Chen XR, Lin JJ, Li JW, Lv ZY, Deng ZZ, Dai J, Cao W, Jiang Q
Acta pharmacologica Sinica 2021 Nov 9;
Acta pharmacologica Sinica 2021 Nov 9;
Honokiol alleviates LPS-induced acute lung injury by inhibiting NLRP3 inflammasome-mediated pyroptosis via Nrf2 activation in vitro and in vivo.
Liu Y, Zhou J, Luo Y, Li J, Shang L, Zhou F, Yang S
Chinese medicine 2021 Nov 29;16(1):127
Chinese medicine 2021 Nov 29;16(1):127
Taxifolin retards the D-galactose-induced aging process through inhibiting Nrf2-mediated oxidative stress and regulating the gut microbiota in mice.
Liu XL, Zhao YC, Zhu HY, Wu M, Zheng YN, Yang M, Cheng ZQ, Ding CB, Liu WC
Food & function 2021 Nov 29;12(23):12142-12158
Food & function 2021 Nov 29;12(23):12142-12158
Role of Nox4 in High Calcium-Induced Renal Oxidative Stress Damage and Crystal Deposition.
Xun Y, Zhou P, Yang Y, Li C, Zhang J, Hu H, Qin B, Zhang Z, Wang Q, Lu Y, Wang S
Antioxidants & redox signaling 2021 Nov 25;
Antioxidants & redox signaling 2021 Nov 25;
TBHQ attenuates ferroptosis against 5-fluorouracil-induced intestinal epithelial cell injury and intestinal mucositis via activation of Nrf2.
Deng S, Wu D, Li L, Li J, Xu Y
Cellular & molecular biology letters 2021 Nov 18;26(1):48
Cellular & molecular biology letters 2021 Nov 18;26(1):48
Cynaropicrin Induces Cell Cycle Arrest and Apoptosis by Inhibiting PKM2 to Cause DNA Damage and Mitochondrial Fission in A549 Cells.
Ding Z, Xi J, Zhong M, Chen F, Zhao H, Zhang B, Fang J
Journal of agricultural and food chemistry 2021 Nov 17;69(45):13557-13567
Journal of agricultural and food chemistry 2021 Nov 17;69(45):13557-13567
Ripened Pu-Erh Tea Improved the Enterohepatic Circulation in a Circadian Rhythm Disorder Mice Model.
Hu S, Chen Y, Zhao S, Sun K, Luo L, Zeng L
Journal of agricultural and food chemistry 2021 Nov 17;69(45):13533-13545
Journal of agricultural and food chemistry 2021 Nov 17;69(45):13533-13545
TRIM32 Inhibition Attenuates Apoptosis, Oxidative Stress, and Inflammatory Injury in Podocytes Induced by High Glucose by Modulating the Akt/GSK-3β/Nrf2 Pathway.
Chen Z, Tian L, Wang L, Ma X, Lei F, Chen X, Fu R
Inflammation 2021 Nov 16;
Inflammation 2021 Nov 16;
Protective effect of cynaroside on sepsis-induced multiple organ injury through Nrf2/HO-1-dependent macrophage polarization.
Feng J, Liu Z, Chen H, Zhang M, Ma X, Han Q, Lu D, Wang C
European journal of pharmacology 2021 Nov 15;911:174522
European journal of pharmacology 2021 Nov 15;911:174522
Astragalus polysaccharide prevents ferroptosis in a murine model of experimental colitis and human Caco-2 cells via inhibiting NRF2/HO-1 pathway.
Chen Y, Wang J, Li J, Zhu J, Wang R, Xi Q, Wu H, Shi T, Chen W
European journal of pharmacology 2021 Nov 15;911:174518
European journal of pharmacology 2021 Nov 15;911:174518
Intermittent hypoxia aggravates non-alcoholic fatty liver disease via RIPK3-dependent necroptosis-modulated Nrf2/NFκB signaling pathway.
Zhang H, Zhou L, Zhou Y, Wang L, Jiang W, Liu L, Yue S, Zheng P, Liu H
Life sciences 2021 Nov 15;285:119963
Life sciences 2021 Nov 15;285:119963
Cetuximab promotes RSL3-induced ferroptosis by suppressing the Nrf2/HO-1 signalling pathway in KRAS mutant colorectal cancer.
Yang J, Mo J, Dai J, Ye C, Cen W, Zheng X, Jiang L, Ye L
Cell death & disease 2021 Nov 13;12(11):1079
Cell death & disease 2021 Nov 13;12(11):1079
Erythritol Improves Nonalcoholic Fatty Liver Disease by Activating Nrf2 Antioxidant Capacity.
Jin M, Wei Y, Yu H, Ma X, Yan S, Zhao L, Ding L, Cheng J, Feng H
Journal of agricultural and food chemistry 2021 Nov 10;69(44):13080-13092
Journal of agricultural and food chemistry 2021 Nov 10;69(44):13080-13092
Effective-component compatibility of Bufei Yishen formula protects COPD rats against PM2.5-induced oxidative stress via miR-155/FOXO3a pathway.
Li J, Wang J, Li Y, Zhao P, Tian Y, Liu X, He H, Jia R
Ecotoxicology and environmental safety 2021 Nov 10;228:112918
Ecotoxicology and environmental safety 2021 Nov 10;228:112918
Protection of the enhanced Nrf2 deacetylation and its downstream transcriptional activity by SIRT1 in myocardial ischemia/reperfusion injury.
Xu JJ, Cui J, Lin Q, Chen XY, Zhang J, Gao EH, Wei B, Zhao W
International journal of cardiology 2021 Nov 1;342:82-93
International journal of cardiology 2021 Nov 1;342:82-93
Heme supplementation ameliorates lupus nephritis through rectifying the disorder of splenocytes and alleviating renal inflammation and oxidative damage.
Wu B, Wu Y, Fan C, Feng C, Wang H, Bai F, Zuo J, Tang W
International immunopharmacology 2021 May;94:107482
International immunopharmacology 2021 May;94:107482
Trojan Horse Delivery of 4,4'-Dimethoxychalcone for Parkinsonian Neuroprotection.
Zhang W, Chen H, Ding L, Gong J, Zhang M, Guo W, Xu P, Li S, Zhang Y
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2021 May;8(9):2004555
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2021 May;8(9):2004555
Quiescin sulfhydryl oxidase 1 promotes sorafenib-induced ferroptosis in hepatocellular carcinoma by driving EGFR endosomal trafficking and inhibiting NRF2 activation.
Sun J, Zhou C, Zhao Y, Zhang X, Chen W, Zhou Q, Hu B, Gao D, Raatz L, Wang Z, Nelson PJ, Jiang Y, Ren N, Bruns CJ, Zhou H
Redox biology 2021 May;41:101942
Redox biology 2021 May;41:101942
Expression of COX-2 and Nrf2/GPx3 in the anterior vaginal wall tissues of women with pelvic organ prolapse.
Lin T, Ji Y, Zhao Y, Xia Z
Archives of gynecology and obstetrics 2021 May;303(5):1245-1253
Archives of gynecology and obstetrics 2021 May;303(5):1245-1253
Protective effects of gastrodin pretreatment on mouse hepatic ischemia-reperfusion occurring through antioxidant and anti-apoptotic mechanisms.
Sun B, Jiang J, Zhu X, Yang D, Cui Z, Zhang Y, Zhang M, Qian Y, Liu R, Yang W
Experimental and therapeutic medicine 2021 May;21(5):471
Experimental and therapeutic medicine 2021 May;21(5):471
The role of PKA/PP2B-mediated Drp1 phosphorylation and the subsequent EGFR inhibition in Cr(VI)-induced premature senescence.
Li S, Ma Y, Liang Y, Liang N, Ye S, Xiao F
Ecotoxicology and environmental safety 2021 May 7;218:112300
Ecotoxicology and environmental safety 2021 May 7;218:112300
Development of phenyltriazole thiol-based derivatives as highly potent inhibitors of DCN1-UBC12 interaction.
Zhou W, Xu C, Dong G, Qiao H, Yang J, Liu H, Ding L, Sun K, Zhao W
European journal of medicinal chemistry 2021 May 5;217:113326
European journal of medicinal chemistry 2021 May 5;217:113326
Aromatic-Turmerone Analogs Protect Dopaminergic Neurons in Midbrain Slice Cultures through Their Neuroprotective Activities.
Hori Y, Tsutsumi R, Nasu K, Boateng A, Ashikari Y, Sugiura M, Nakajima M, Kurauchi Y, Hisatsune A, Katsuki H, Seki T
Cells 2021 May 3;10(5)
Cells 2021 May 3;10(5)
Lipoxin A4 protects primary spinal cord neurons from Erastin-induced ferroptosis by activating the Akt/Nrf2/HO-1 signaling pathway.
Wei N, Lu T, Yang L, Dong Y, Liu X
FEBS open bio 2021 May 28;
FEBS open bio 2021 May 28;
TRPV1 alleviates osteoarthritis by inhibiting M1 macrophage polarization via Ca2+/CaMKII/Nrf2 signaling pathway.
Lv Z, Xu X, Sun Z, Yang YX, Guo H, Li J, Sun K, Wu R, Xu J, Jiang Q, Ikegawa S, Shi D
Cell death & disease 2021 May 18;12(6):504
Cell death & disease 2021 May 18;12(6):504
Neuroprotective Effects and Mechanisms of Procyanidins In Vitro and In Vivo.
Chen J, Chen Y, Zheng Y, Zhao J, Yu H, Zhu J, Li D
Molecules (Basel, Switzerland) 2021 May 17;26(10)
Molecules (Basel, Switzerland) 2021 May 17;26(10)
Upregulation of Chemoresistance by Mg2+ Deficiency through Elevation of ATP Binding Cassette Subfamily B Member 1 Expression in Human Lung Adenocarcinoma A549 Cells.
Onuma S, Manabe A, Yoshino Y, Matsunaga T, Asai T, Ikari A
Cells 2021 May 12;10(5)
Cells 2021 May 12;10(5)
4-Ethylguaiacol modulates neuroinflammation and Th1/Th17 differentiation to ameliorate disease severity in experimental autoimmune encephalomyelitis.
Weng WT, Kuo PC, Brown DA, Scofield BA, Furnas D, Paraiso HC, Wang PY, Yu IC, Yen JH
Journal of neuroinflammation 2021 May 11;18(1):110
Journal of neuroinflammation 2021 May 11;18(1):110
Anti-inflammatory activity of the water extract of Chloranthus serratus roots in LPS-stimulated RAW264.7 cells mediated by the Nrf2/HO-1, MAPK and NF-κB signaling pathways.
Sun S, Zhang J, Li H, Du Y, Li S, Li A, Suo X, Wang Y, Sun Q
Journal of ethnopharmacology 2021 May 10;271:113880
Journal of ethnopharmacology 2021 May 10;271:113880
Twin drug design, synthesis and evaluation of diosgenin derivatives as multitargeted agents for the treatment of vascular dementia.
Yang GX, Sun JM, Zheng LL, Zhang L, Li J, Gan HX, Huang Y, Huang J, Diao XX, Tang Y, Wang R, Ma L
Bioorganic & medicinal chemistry 2021 May 1;37:116109
Bioorganic & medicinal chemistry 2021 May 1;37:116109
In vivo hepatoprotective activity and the underlying mechanism of chebulinic acid from Terminalia chebula fruit.
Feng XH, Xu HY, Wang JY, Duan S, Wang YC, Ma CM
Phytomedicine : international journal of phytotherapy and phytopharmacology 2021 Mar;83:153479
Phytomedicine : international journal of phytotherapy and phytopharmacology 2021 Mar;83:153479
The deubiquitinase USP11 regulates cell proliferation and ferroptotic cell death via stabilization of NRF2 USP11 deubiquitinates and stabilizes NRF2.
Meng C, Zhan J, Chen D, Shao G, Zhang H, Gu W, Luo J
Oncogene 2021 Mar;40(9):1706-1720
Oncogene 2021 Mar;40(9):1706-1720
Vicenin-2 inhibits the Helicobacterium pylori infection associated gastric carcinogenic events through modulation of PI3K/AKT and Nrf2 signaling in GES-1 cells.
Zhang Y, Sun J, Dong Y, Shen X, Zhang Z
Journal of biochemical and molecular toxicology 2021 Mar;35(3):e22680
Journal of biochemical and molecular toxicology 2021 Mar;35(3):e22680
Cordyceps acid alleviates lung cancer in nude mice.
Wang J, Chen H, Li W, Shan L
Journal of biochemical and molecular toxicology 2021 Mar;35(3):e22670
Journal of biochemical and molecular toxicology 2021 Mar;35(3):e22670
Chondrocyte ferroptosis contribute to the progression of osteoarthritis.
Yao X, Sun K, Yu S, Luo J, Guo J, Lin J, Wang G, Guo Z, Ye Y, Guo F
Journal of orthopaedic translation 2021 Mar;27:33-43
Journal of orthopaedic translation 2021 Mar;27:33-43
Gambogic acid ameliorates high glucose- and palmitic acid-induced inflammatory response in ARPE-19 cells via activating Nrf2 signaling pathway: ex vivo.
Chen J, Li L, Zhou Y, Zhang J, Chen L
Cell stress & chaperones 2021 Mar;26(2):367-375
Cell stress & chaperones 2021 Mar;26(2):367-375
AIDA directly connects sympathetic innervation to adaptive thermogenesis by UCP1.
Shi M, Huang XY, Ren XY, Wei XY, Ma Y, Lin ZZ, Liu DT, Song L, Zhao TJ, Li G, Yao L, Zhu M, Zhang C, Xie C, Wu Y, Wu HM, Fan LP, Ou J, Zhan YH, Lin SY, Lin SC
Nature cell biology 2021 Mar;23(3):268-277
Nature cell biology 2021 Mar;23(3):268-277
Metformin attenuates hyperlipidaemia-associated vascular calcification through anti-ferroptotic effects.
Ma WQ, Sun XJ, Zhu Y, Liu NF
Free radical biology & medicine 2021 Mar;165:229-242
Free radical biology & medicine 2021 Mar;165:229-242
Oxidative stress in retrotrapezoid nucleus/parafacial respiratory group and impairment of central chemoreception in rat offspring exposed to maternal cigarette smoke.
Lei F, Wang W, Fu Y, Wang J, Zheng Y
Reproductive toxicology (Elmsford, N.Y.) 2021 Mar;100:35-41
Reproductive toxicology (Elmsford, N.Y.) 2021 Mar;100:35-41
Sodium arsenite induces spatial learning and memory impairment associated with oxidative stress and activates the Nrf2/PPARγ pathway against oxidative injury in mice hippocampus.
Xiong L, Huang J, Gao Y, Gao Y, Wu C, He S, Zou L, Yang D, Han Y, Yuan Q, Zheng Z, Hu G
Toxicology research 2021 Mar;10(2):277-283
Toxicology research 2021 Mar;10(2):277-283
Polyphenols from Penthorum chinense Pursh. Attenuates high glucose-induced vascular inflammation through directly interacting with Keap1 protein.
Sun Y, He L, Wang W, Wang T, Hua W, Li T, Wang L, Gao T, Chen F, Tang L
Journal of ethnopharmacology 2021 Mar 25;268:113617
Journal of ethnopharmacology 2021 Mar 25;268:113617
Loss of QKI in macrophage aggravates inflammatory bowel disease through amplified ROS signaling and microbiota disproportion.
Wang W, Zhai D, Bai Y, Xue K, Deng L, Ma L, Du T, Ye Z, Qu D, Xiang A, Chen G, Zhao Y, Wang L, Lu Z
Cell death discovery 2021 Mar 23;7(1):58
Cell death discovery 2021 Mar 23;7(1):58
Nox2 Inhibition Regulates Stress Response and Mitigates Skeletal Muscle Fiber Atrophy during Simulated Microgravity.
Lawler JM, Hord JM, Ryan P, Holly D, Janini Gomes M, Rodriguez D, Guzzoni V, Garcia-Villatoro E, Green C, Lee Y, Little S, Garcia M, Hill L, Brooks MC, Lawler MS, Keys N, Mohajeri A, Kamal KY
International journal of molecular sciences 2021 Mar 23;22(6)
International journal of molecular sciences 2021 Mar 23;22(6)
Cardamonin protects nucleus pulposus cells against IL-1β-induced inflammation and catabolism via Nrf2/NF-κB axis.
Xie C, Ma H, Shi Y, Li J, Wu H, Wang B, Shao Z, Huang C, Chen J, Sun L, Zhou Y, Tian N, Wu Y, Gao W, Wu A, Wang X, Zhang X
Food & function 2021 Mar 21;12(6):2703-2714
Food & function 2021 Mar 21;12(6):2703-2714
MiR-133a-3p relieves the oxidative stress induced trophoblast cell apoptosis through the BACH1/Nrf2/HO-1 signaling pathway.
Guo H, Wang Y, Jia W, Liu L
Physiological research 2021 Mar 17;70(1):67-78
Physiological research 2021 Mar 17;70(1):67-78
Immunomodulation effects of polyphenols from thinned peach treated by different drying methods on RAW264.7 cells through the NF-κB and Nrf2 pathways.
Guo C, Bi J, Li X, Lyu J, Liu X, Wu X, Liu J
Food chemistry 2021 Mar 15;340:127931
Food chemistry 2021 Mar 15;340:127931
Perilipin 5 ameliorates high-glucose-induced podocyte injury via Akt/GSK-3β/Nrf2-mediated suppression of apoptosis, oxidative stress, and inflammation.
Feng J, Xie L, Yu X, Liu C, Dong H, Lu W, Kong R
Biochemical and biophysical research communications 2021 Mar 12;544:22-30
Biochemical and biophysical research communications 2021 Mar 12;544:22-30
Lupeol ameliorates LPS/D-GalN induced acute hepatic damage by suppressing inflammation and oxidative stress through TGFβ1-Nrf2 signal pathway.
Huang S, Mo C, Zeng T, Lai Y, Zhou C, Xie S, Chen L, Wang Y, Chen Y, Huang S, Gao L, Lv Z
Aging 2021 Mar 11;13(5):6592-6605
Aging 2021 Mar 11;13(5):6592-6605
Troxerutin Improves Dextran Sulfate Sodium-Induced Ulcerative Colitis in Mice.
Wang X, Gao Y, Wang L, Yang D, Bu W, Gou L, Huang J, Duan X, Pan Y, Cao S, Gao Z, Cheng C, Feng Z, Xie J, Yao R
Journal of agricultural and food chemistry 2021 Mar 10;69(9):2729-2744
Journal of agricultural and food chemistry 2021 Mar 10;69(9):2729-2744
CLIC1 Inhibition Protects Against Cellular Senescence and Endothelial Dysfunction Via the Nrf2/HO-1 Pathway.
Lu D, Le Y, Ding J, Dou X, Mao W, Zhu J
Cell biochemistry and biophysics 2021 Jun;79(2):239-252
Cell biochemistry and biophysics 2021 Jun;79(2):239-252
Improving protection effects of eucalyptol via carboxymethyl chitosan-coated lipid nanoparticles on hyperglycaemia-induced vascular endothelial injury in rats.
Peng J, Jiang Z, Wu G, Cai Z, Du Q, Tao L, Zhang Y, Chen Y, Shen X
Journal of drug targeting 2021 Jun;29(5):520-530
Journal of drug targeting 2021 Jun;29(5):520-530
Wogonin alleviates liver injury in sepsis through Nrf2-mediated NF-κB signalling suppression.
Dai JM, Guo WN, Tan YZ, Niu KW, Zhang JJ, Liu CL, Yang XM, Tao KS, Chen ZN, Dai JY
Journal of cellular and molecular medicine 2021 Jun;25(12):5782-5798
Journal of cellular and molecular medicine 2021 Jun;25(12):5782-5798
Synthesis and radioprotective effects of novel hybrid compounds containing edaravone analogue and 3-n-butylphthalide ring-opening derivatives.
Li X, Wang X, Miao L, Liu Y, Lin X, Guo Y, Yuan R, Tian H
Journal of cellular and molecular medicine 2021 Jun;25(12):5470-5485
Journal of cellular and molecular medicine 2021 Jun;25(12):5470-5485
Exploration of the hepatoprotective effect and mechanism of magnesium isoglycyrrhizinate in mice with arsenic trioxide‑induced acute liver injury.
Liu M, Zheng B, Liu P, Zhang J, Chu X, Dong C, Shi J, Liang Y, Chu L, Liu Y, Han X
Molecular medicine reports 2021 Jun;23(6)
Molecular medicine reports 2021 Jun;23(6)
Ginkgo biloba delays light-induced photoreceptor degeneration through antioxidant and antiapoptotic properties.
Chudhary M, Zhang C, Song S, Ren X, Kong L
Experimental and therapeutic medicine 2021 Jun;21(6):576
Experimental and therapeutic medicine 2021 Jun;21(6):576
Oxymatrine pretreatment protects H9c2 cardiomyocytes from hypoxia/reoxygenation injury by modulating the PI3K/Akt pathway.
Zhang Z, Qin X, Wang Z, Li Y, Chen F, Chen R, Li C, Zhang W, Zhang M
Experimental and therapeutic medicine 2021 Jun;21(6):556
Experimental and therapeutic medicine 2021 Jun;21(6):556
Hydrogen sulfide alleviates apoptosis and autophagy induced by beryllium sulfate in 16HBE cells.
Liu YP, Yuan XY, Li XY, Wang Y, Sun ZB, Deng WH, Lei YD, Huang L, Jiang TY, Zhang ZH
Journal of applied toxicology : JAT 2021 Jun 6;
Journal of applied toxicology : JAT 2021 Jun 6;
Design, synthesis, and neuroprotective effects of novel hybrid compounds containing edaravone analogue and 3-n-butylphthalide ring-opened derivatives.
Li X, Wang X, Miao L, Guo Y, Yuan R, Tian H
Biochemical and biophysical research communications 2021 Jun 4;556:99-105
Biochemical and biophysical research communications 2021 Jun 4;556:99-105
Effects of β-Asarone on Ischemic Stroke in Middle Cerebral Artery Occlusion Rats by an Nrf2-Antioxidant Response Elements (ARE) Pathway-Dependent Mechanism.
Pan H, Xu Y, Cai Q, Wu M, Ding M
Medical science monitor : international medical journal of experimental and clinical research 2021 Jun 4;27:e931884
Medical science monitor : international medical journal of experimental and clinical research 2021 Jun 4;27:e931884
Hsa_circ_0005915 promotes N,N-dimethylformamide-induced oxidative stress in HL-7702 cells through NRF2/ARE axis.
Liu Z, He Q, Liu Y, Zhang Y, Cui M, Peng H, Wang Y, Chen S, Li D, Chen L, Xiao Y, Chen W, Wang Q
Toxicology 2021 Jun 30;458:152838
Toxicology 2021 Jun 30;458:152838
Loss of FCHSD1 leads to amelioration of chronic obstructive pulmonary disease.
Kawasaki T, Sugihara F, Fukushima K, Matsuki T, Nabeshima H, Machida T, Mitsui Y, Fujimura S, Sagawa R, Gaheun L, Kuniyoshi K, Tanaka H, Narazaki M, Kumanogoh A, Akira S, Satoh T
Proceedings of the National Academy of Sciences of the United States of America 2021 Jun 29;118(26)
Proceedings of the National Academy of Sciences of the United States of America 2021 Jun 29;118(26)
Guizhi Fuling Capsule ameliorates endometrial hyperplasia through promoting p62-Keap1-NRF2-mediated ferroptosis.
Zhang M, Zhang T, Song C, Qu J, Gu Y, Liu S, Li H, Xiao W, Kong L, Sun Y, Lv W
Journal of ethnopharmacology 2021 Jun 28;274:114064
Journal of ethnopharmacology 2021 Jun 28;274:114064
Inhibition of Oxidative Stress and ALOX12 and NF-κB Pathways Contribute to the Protective Effect of Baicalein on Carbon Tetrachloride-Induced Acute Liver Injury.
Dai C, Li H, Wang Y, Tang S, Velkov T, Shen J
Antioxidants (Basel, Switzerland) 2021 Jun 18;10(6)
Antioxidants (Basel, Switzerland) 2021 Jun 18;10(6)
Effect of Chronic Stress Present in Fibroblasts Derived from Patients with a Sporadic Form of AD on Mitochondrial Function and Mitochondrial Turnover.
Drabik K, Malińska D, Piecyk K, Dębska-Vielhaber G, Vielhaber S, Duszyński J, Szczepanowska J
Antioxidants (Basel, Switzerland) 2021 Jun 10;10(6)
Antioxidants (Basel, Switzerland) 2021 Jun 10;10(6)
Alpinetin exerts anti-inflammatory, anti-oxidative and anti-angiogenic effects through activating the Nrf2 pathway and inhibiting NLRP3 pathway in carbon tetrachloride-induced liver fibrosis.
Zhu Z, Hu R, Li J, Xing X, Chen J, Zhou Q, Sun J
International immunopharmacology 2021 Jul;96:107660
International immunopharmacology 2021 Jul;96:107660
The piperine derivative HJ105 inhibits Aβ1-42-induced neuroinflammation and oxidative damage via the Keap1-Nrf2-TXNIP axis.
Yang X, Zhi J, Leng H, Chen Y, Gao H, Ma J, Ji J, Hu Q
Phytomedicine : international journal of phytotherapy and phytopharmacology 2021 Jul;87:153571
Phytomedicine : international journal of phytotherapy and phytopharmacology 2021 Jul;87:153571
Astragaloside IV inhibits adriamycin-induced cardiac ferroptosis by enhancing Nrf2 signaling.
Luo LF, Guan P, Qin LY, Wang JX, Wang N, Ji ES
Molecular and cellular biochemistry 2021 Jul;476(7):2603-2611
Molecular and cellular biochemistry 2021 Jul;476(7):2603-2611
Selenium triggers Nrf2-AMPK crosstalk to alleviate cadmium-induced autophagy in rabbit cerebrum.
Xue H, Cao H, Xing C, Feng J, Zhang L, Zhang C, Hu G, Yang F
Toxicology 2021 Jul;459:152855
Toxicology 2021 Jul;459:152855
Exosomes are involved in total body irradiation-induced intestinal injury in mice.
Li H, Jiang M, Zhao SY, Zhang SQ, Lu L, He X, Feng GX, Wu X, Fan SJ
Acta pharmacologica Sinica 2021 Jul;42(7):1111-1123
Acta pharmacologica Sinica 2021 Jul;42(7):1111-1123
Sestrin2 protects against traumatic brain injury by reinforcing the activation of Nrf2 signaling.
Liu X, Li M, Zhu J, Huang W, Song J
Human & experimental toxicology 2021 Jul;40(7):1095-1111
Human & experimental toxicology 2021 Jul;40(7):1095-1111
Resveratrol attenuates manganese-induced oxidative stress and neuroinflammation through SIRT1 signaling in mice.
Cong L, Lei MY, Liu ZQ, Liu ZF, Ma Z, Liu K, Li J, Deng Y, Liu W, Xu B
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2021 Jul;153:112283
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2021 Jul;153:112283
Choline attenuates heat stress-induced oxidative injury and apoptosis in bovine mammary epithelial cells by modulating PERK/Nrf-2 signaling pathway.
Yang M, Kuang M, Wang G, Ali I, Tang Y, Yang C, Li Y, Li L
Molecular immunology 2021 Jul;135:388-397
Molecular immunology 2021 Jul;135:388-397
Baicalin-loaded macrophage-derived exosomes ameliorate ischemic brain injury via the antioxidative pathway.
Huang Z, Guo L, Huang L, Shi Y, Liang J, Zhao L
Materials science & engineering. C, Materials for biological applications 2021 Jul;126:112123
Materials science & engineering. C, Materials for biological applications 2021 Jul;126:112123
Tolerable upper intake level of iron damages the liver of weaned piglets.
Ding H, Zhao Y, Yu X, Chen L, Han J, Feng J
Journal of animal physiology and animal nutrition 2021 Jul;105(4):668-677
Journal of animal physiology and animal nutrition 2021 Jul;105(4):668-677
Isoeucommin A attenuates kidney injury in diabetic nephropathy through the Nrf2/HO-1 pathway.
Huang Q, Ouyang DS, Liu Q
FEBS open bio 2021 Jul 6;
FEBS open bio 2021 Jul 6;
Synthesis and evaluation of multi-target-directed ligands with BACE-1 inhibitory and Nrf2 agonist activities as potential agents against Alzheimer's disease.
Qu L, Ji L, Wang C, Luo H, Li S, Peng W, Yin F, Lu D, Liu X, Kong L, Wang X
European journal of medicinal chemistry 2021 Jul 5;219:113441
European journal of medicinal chemistry 2021 Jul 5;219:113441
Proteomics analysis in the kidney of mice following oral feeding Realgar.
Zhang S, Li C, Feng T, Cao S, Zhou H, Li L, Hu Q, Mao X, Ji S
Journal of ethnopharmacology 2021 Jul 15;275:114118
Journal of ethnopharmacology 2021 Jul 15;275:114118
A rapid juvenile murine model of nonalcoholic steatohepatitis (NASH): Chronic intermittent hypoxia exacerbates Western diet-induced NASH.
Zhou J, Zhao Y, Guo YJ, Zhao YS, Liu H, Ren J, Li JR, Ji ES
Life sciences 2021 Jul 1;276:119403
Life sciences 2021 Jul 1;276:119403
Salvinorin A protects against methicillin resistant staphylococcus aureus-induced acute lung injury via Nrf2 pathway.
Zeng S, Chen D, Liu G, Wu YX, Gao ZQ, Su Y, Yuan JN, Liu L, Shan JC, Pang QF, Zhu T
International immunopharmacology 2021 Jan;90:107221
International immunopharmacology 2021 Jan;90:107221
Sophoricoside attenuates lipopolysaccharide-induced acute lung injury by activating the AMPK/Nrf2 signaling axis.
Wu YX, Zeng S, Wan BB, Wang YY, Sun HX, Liu G, Gao ZQ, Chen D, Chen YQ, Lu MD, Pang QF
International immunopharmacology 2021 Jan;90:107187
International immunopharmacology 2021 Jan;90:107187
Hyperoside ameliorates the progression of osteoarthritis: An in vitro and in vivo study.
Sun K, Luo J, Jing X, Xiang W, Guo J, Yao X, Liang S, Guo F, Xu T
Phytomedicine : international journal of phytotherapy and phytopharmacology 2021 Jan;80:153387
Phytomedicine : international journal of phytotherapy and phytopharmacology 2021 Jan;80:153387
RNA-seq reveals novel cancer-selective and disease subtype-independent mechanistic targets of withaferin A in human breast cancer cells.
Hahm ER, Kim SH, Singh KB, Singh SV
Molecular carcinogenesis 2021 Jan;60(1):3-14
Molecular carcinogenesis 2021 Jan;60(1):3-14
CKIP-1 acts downstream to Cx43 on the activation of Nrf2 signaling pathway to protect from renal fibrosis in diabetes.
Yang Y, Li J, Zhang L, Lin Z, Xiao H, Sun X, Zhang M, Liu P, Huang H
Pharmacological research 2021 Jan;163:105333
Pharmacological research 2021 Jan;163:105333
Obacunone Attenuates Liver Fibrosis with Enhancing Anti-Oxidant Effects of GPx-4 and Inhibition of EMT.
Bai Y, Wang W, Wang L, Ma L, Zhai D, Wang F, Shi R, Liu C, Xu Q, Chen G, Lu Z
Molecules (Basel, Switzerland) 2021 Jan 9;26(2)
Molecules (Basel, Switzerland) 2021 Jan 9;26(2)
Aloin protects mice from diet-induced non-alcoholic steatohepatitis via activation of Nrf2/HO-1 signaling.
Xu Q, Fan Y, Loor JJ, Liang Y, Lv H, Sun X, Jia H, Xu C
Food & function 2021 Jan 21;12(2):696-705
Food & function 2021 Jan 21;12(2):696-705
Curcumin ameliorates mercuric chloride-induced liver injury via modulating cytochrome P450 signaling and Nrf2/HO-1 pathway.
Li S, Wang X, Xiao Y, Wang Y, Wan Y, Li X, Li Q, Tang X, Cai D, Ran B, Wu C
Ecotoxicology and environmental safety 2021 Jan 15;208:111426
Ecotoxicology and environmental safety 2021 Jan 15;208:111426
MiR-133a-3p relieves the oxidative stress induced trophoblast cell apoptosis through the BACH1/Nrf2/HO-1 signaling pathway.
Guo H, Wang Y, Jia W, Liu L
Physiological research 2021 Jan 14;70(1)
Physiological research 2021 Jan 14;70(1)
Upregulation of silent information regulator 1 alleviates mitochondrial dysfunction in the trigeminal nucleus caudalis in a rat model of chronic migraine.
Liang J, Zhou X, Wang J, Fei ZY, Qin GC, Zhang DK, Zhou JY, Chen LX
Neuroreport 2021 Jan 13;32(2):144-156
Neuroreport 2021 Jan 13;32(2):144-156
The Time-Course of Antioxidant Irisin Activity: Role of the Nrf2/HO-1/HMGB1 Axis.
Mazur-Bialy AI, Pocheć E
Antioxidants (Basel, Switzerland) 2021 Jan 11;10(1)
Antioxidants (Basel, Switzerland) 2021 Jan 11;10(1)
Klotho ameliorates diabetic nephropathy by activating Nrf2 signaling pathway in podocytes.
Xing L, Guo H, Meng S, Zhu B, Fang J, Huang J, Chen J, Wang Y, Wang L, Yao X, Wang H
Biochemical and biophysical research communications 2021 Jan 1;534:450-456
Biochemical and biophysical research communications 2021 Jan 1;534:450-456
Dietary alpha-lipoic acid supplementation improves spermatogenesis and semen quality via antioxidant and anti-apoptotic effects in aged breeder roosters.
Ye N, Lv Z, Dai H, Huang Z, Shi F
Theriogenology 2021 Jan 1;159:20-27
Theriogenology 2021 Jan 1;159:20-27
SQSTM1/ p62 oligomerization contributes to Aβ-induced inhibition of Nrf2 signaling.
Guo C, Zhang Y, Nie Q, Cao D, Wang X, Wan X, Liu M, Cui J, Sun J, Bai Y, Li L
Neurobiology of aging 2021 Feb;98:10-20
Neurobiology of aging 2021 Feb;98:10-20
HIV-Tat and Cocaine Impact Brain Energy Metabolism: Redox Modification and Mitochondrial Biogenesis Influence NRF Transcription-Mediated Neurodegeneration.
Sivalingam K, Cirino TJ, McLaughlin JP, Samikkannu T
Molecular neurobiology 2021 Feb;58(2):490-504
Molecular neurobiology 2021 Feb;58(2):490-504
20-HETE synthesis inhibition attenuates traumatic brain injury-induced mitochondrial dysfunction and neuronal apoptosis via the SIRT1/PGC-1α pathway: A translational study.
Cui W, Wu X, Shi Y, Guo W, Luo J, Liu H, Zheng L, Du Y, Wang P, Wang Q, Feng D, Ge S, Qu Y
Cell proliferation 2021 Feb;54(2):e12964
Cell proliferation 2021 Feb;54(2):e12964
Protective Effects of Fisetin on Hepatic Ischemia-reperfusion Injury Through Alleviation of Apoptosis and Oxidative Stress.
Li Z, Wang Y, Zhang Y, Wang X, Gao B, Li Y, Li R, Wang J
Archives of medical research 2021 Feb;52(2):163-173
Archives of medical research 2021 Feb;52(2):163-173
H2S probe CPC inhibits autophagy and promotes apoptosis by inhibiting glutathionylation of Keap1 at Cys434.
Li N, Wang J, Zang X, Wang Z, Zhang T, Zhao B, Miao J, Lin Z
Apoptosis : an international journal on programmed cell death 2021 Feb;26(1-2):111-131
Apoptosis : an international journal on programmed cell death 2021 Feb;26(1-2):111-131
Exercise reduces hyperlipidemia-induced kidney damage in apolipoprotein E-deficient mice.
Qian C, Yang Q, Guo L, Zhu H, You X, Liu H, Sun Y
Experimental and therapeutic medicine 2021 Feb;21(2):153
Experimental and therapeutic medicine 2021 Feb;21(2):153
Organic carbon monoxide prodrug, BW-CO-111, in protection against chemically-induced gastric mucosal damage.
Bakalarz D, Surmiak M, Yang X, Wójcik D, Korbut E, Śliwowski Z, Ginter G, Buszewicz G, Brzozowski T, Cieszkowski J, Głowacka U, Magierowska K, Pan Z, Wang B, Magierowski M
Acta pharmaceutica Sinica. B 2021 Feb;11(2):456-475
Acta pharmaceutica Sinica. B 2021 Feb;11(2):456-475
Marine algal polysaccharides alleviate aflatoxin B1-induced bursa of Fabricius injury by regulating redox and apoptotic signaling pathway in broilers.
Guo Y, Balasubramanian B, Zhao ZH, Liu WC
Poultry science 2021 Feb;100(2):844-857
Poultry science 2021 Feb;100(2):844-857
Oxidative stress-induced mitophagy is suppressed by the miR-106b-93-25 cluster in a protective manner.
Zhang C, Nie P, Zhou C, Hu Y, Duan S, Gu M, Jiang D, Wang Y, Deng Z, Chen J, Chen S, Wang L
Cell death & disease 2021 Feb 24;12(2):209
Cell death & disease 2021 Feb 24;12(2):209
Downregulation of CD151 induces oxidative stress and apoptosis in trophoblast cells via inhibiting ERK/Nrf2 signaling pathway in preeclampsia.
Wang Z, Cai B, Cao C, Lv H, Dai Y, Zheng M, Zhao G, Peng Y, Gou W, Wang J, Liu D, Hu Y
Free radical biology & medicine 2021 Feb 20;164:249-257
Free radical biology & medicine 2021 Feb 20;164:249-257
Physalin B ameliorates nonalcoholic steatohepatitis by stimulating autophagy and NRF2 activation mediated improvement in oxidative stress.
Zhang MH, Li J, Zhu XY, Zhang YQ, Ye ST, Leng YR, Yang T, Zhang H, Kong LY
Free radical biology & medicine 2021 Feb 20;164:1-12
Free radical biology & medicine 2021 Feb 20;164:1-12
Nrf2 inhibition induces oxidative stress, renal inflammation and hypertension in mice.
Farooqui Z, Mohammad RS, Lokhandwala MF, Banday AA
Clinical and experimental hypertension (New York, N.Y. : 1993) 2021 Feb 17;43(2):175-180
Clinical and experimental hypertension (New York, N.Y. : 1993) 2021 Feb 17;43(2):175-180
Carnosic acid protects against ferroptosis in PC12 cells exposed to erastin through activation of Nrf2 pathway.
Cheng J, Xu T, Xun C, Guo H, Cao R, Gao S, Sheng W
Life sciences 2021 Feb 1;266:118905
Life sciences 2021 Feb 1;266:118905
Prenylated xanthones from mangosteen (Garcinia mangostana) activate the AhR and Nrf2 pathways and protect intestinal barrier integrity in HT-29 cells.
Tocmo R, Le B, Heun A, van Pijkeren JP, Parkin K, Johnson JJ
Free radical biology & medicine 2021 Feb 1;163:102-115
Free radical biology & medicine 2021 Feb 1;163:102-115
Vascular endothelial cell-secreted exosomes facilitate osteoarthritis pathogenesis by promoting chondrocyte apoptosis.
Yang RZ, Zheng HL, Xu WN, Zheng XF, Li B, Jiang LS, Jiang SD
Aging 2021 Feb 1;13(3):4647-4662
Aging 2021 Feb 1;13(3):4647-4662
ATF3 regulates oxidative stress and extracellular matrix degradation via p38/Nrf2 signaling pathway in pelvic organ prolapse.
Feng J, Li Y, Jin X, Gong R, Xia Z
Tissue & cell 2021 Dec;73:101660
Tissue & cell 2021 Dec;73:101660
Kaempferol-induced GPER upregulation attenuates atherosclerosis via the PI3K/AKT/Nrf2 pathway.
Feng Z, Wang C, Yue, Jin, Meng Q, Wu J, Sun H
Pharmaceutical biology 2021 Dec;59(1):1106-1116
Pharmaceutical biology 2021 Dec;59(1):1106-1116
CoCrMo-Nanoparticles induced peri-implant osteolysis by promoting osteoblast ferroptosis via regulating Nrf2-ARE signalling pathway.
Xu Y, Sang W, Zhong Y, Xue S, Yang M, Wang C, Lu H, Huan R, Mao X, Zhu L, He C, Ma J
Cell proliferation 2021 Dec;54(12):e13142
Cell proliferation 2021 Dec;54(12):e13142
Dimethyl fumarate ameliorates endotoxin-induced acute kidney injury against macrophage oxidative stress.
Zhou K, Xie M, Yi S, Tang Y, Luo H, Xiao Q, Xiao J, Li Y
Renal failure 2021 Dec;43(1):1229-1239
Renal failure 2021 Dec;43(1):1229-1239
Ethyl ferulate protects against lipopolysaccharide-induced acute lung injury by activating AMPK/Nrf2 signaling pathway.
Wu YX, Wang YY, Gao ZQ, Chen D, Liu G, Wan BB, Jiang FJ, Wei MX, Zuo J, Zhu J, Chen YQ, Qian F, Pang QF
Acta pharmacologica Sinica 2021 Dec;42(12):2069-2081
Acta pharmacologica Sinica 2021 Dec;42(12):2069-2081
Knockdown of RREB1 inhibits cell proliferation via enhanced p16 expression in gastric cancer.
Gao Q, Wu Y, Lu C, Kai W, Xie W, Wang Q, Wang L, Liu S, Pan Y
Cell cycle (Georgetown, Tex.) 2021 Dec;20(23):2465-2475
Cell cycle (Georgetown, Tex.) 2021 Dec;20(23):2465-2475
Diterpenoid alkaloids from Delphinium forrestii var. viride and their anti-inflammation activity.
Song Z, Gao C, Jiang Q, Xu J, Xiong L, Liu K, Sun D, Li H, Chen L
Phytochemistry 2021 Dec;192:112971
Phytochemistry 2021 Dec;192:112971
Pentagalloylglucose reduces AGE-induced inflammation by activating Nrf2/HO-1 and inhibiting the JAK2/STAT3 pathway in mesangial cells.
Tong J, Fang J, Zhu T, Xiang P, Shang J, Chen L, Zhao J, Wang Y, Tong L, Sun M
Journal of pharmacological sciences 2021 Dec;147(4):305-314
Journal of pharmacological sciences 2021 Dec;147(4):305-314
Senescence marker protein 30 (SMP30) protects against high glucose-induced apoptosis, oxidative stress and inflammatory response in retinal ganglion cells by enhancing Nrf2 activation via regulation of Akt/GSK-3β pathway.
Zhang L, Zhu T, He F, Li X
International immunopharmacology 2021 Dec;101(Pt B):108238
International immunopharmacology 2021 Dec;101(Pt B):108238
Sulfiredoxin-1 protects retinal ganglion cells from high glucose-induced oxidative stress and inflammatory injury by potentiating Nrf2 signaling via the Akt/GSK-3β pathway.
Zhu F, Shao J, Tian Y, Xu Z
International immunopharmacology 2021 Dec;101(Pt B):108221
International immunopharmacology 2021 Dec;101(Pt B):108221
Dietary hawthorn-leaves flavonoids improves ovarian function and liver lipid metabolism in aged breeder hens.
Dai H, Lv Z, Huang Z, Ye N, Li S, Jiang J, Cheng Y, Shi F
Poultry science 2021 Dec;100(12):101499
Poultry science 2021 Dec;100(12):101499
Exposure to DEHP induces testis toxicity and injury through the ROS/mTOR/NLRP3 signaling pathway in immature rats.
Hong Y, Zhou Y, Shen L, Wei Y, Long C, Fu Y, Wu H, Wang J, Wu Y, Wu S, Wei G
Ecotoxicology and environmental safety 2021 Dec 20;227:112889
Ecotoxicology and environmental safety 2021 Dec 20;227:112889
Fucoxanthin regulates Nrf2 signaling to decrease oxidative stress and improves renal fibrosis depending on Sirt1 in HG-induced GMCs and STZ-induced diabetic rats.
Yang G, Li Q, Peng J, Jin L, Zhu X, Zheng D, Zhang Y, Wang R, Song Y, Hu W, Xie X
European journal of pharmacology 2021 Dec 15;913:174629
European journal of pharmacology 2021 Dec 15;913:174629
Tangeretin maintains antioxidant activity by reducing CUL3 mediated NRF2 ubiquitination.
Wang Y, Jin R, Chen J, Cao J, Xiao J, Li X, Sun C
Food chemistry 2021 Dec 15;365:130470
Food chemistry 2021 Dec 15;365:130470
Curcumin hinders PBDE-47-induced neutrophil extracellular traps release via Nrf2-associated ROS inhibition.
Ye S, Li S, Ma Y, Hu D, Xiao F
Ecotoxicology and environmental safety 2021 Dec 1;225:112779
Ecotoxicology and environmental safety 2021 Dec 1;225:112779
Lycopene attenuates zearalenone-induced oxidative damage of piglet sertoli cells through the nuclear factor erythroid-2 related factor 2 signaling pathway.
Cao L, Zhao J, Ma L, Chen J, Xu J, Rahman SU, Feng S, Li Y, Wu J, Wang X
Ecotoxicology and environmental safety 2021 Dec 1;225:112737
Ecotoxicology and environmental safety 2021 Dec 1;225:112737
Effects of Inorganic and Organic Manganese Supplementation on Growth Performance, Tibia Development, and Oxidative Stress in Broiler Chickens.
Xia WH, Tang L, Wang ZY, Wang L
Biological trace element research 2021 Dec 1;
Biological trace element research 2021 Dec 1;
Glutaredoxin 1 protects neurons from oxygen-glucose deprivation/reoxygenation (OGD/R)-induced apoptosis and oxidative stress via the modulation of GSK-3β/Nrf2 signaling.
Qiu Z, Li X, Duan C, Li R, Han L
Journal of bioenergetics and biomembranes 2021 Aug;53(4):369-379
Journal of bioenergetics and biomembranes 2021 Aug;53(4):369-379
The role of transcription factor Ap1 in the activation of the Nrf2/ARE pathway through TET1 in diabetic nephropathy.
Tan Y, Cao H, Li Q, Sun J
Cell biology international 2021 Aug;45(8):1654-1665
Cell biology international 2021 Aug;45(8):1654-1665
PLK2 protects retinal ganglion cells from oxidative stress by potentiating Nrf2 signaling via GSK-3β.
Fan Y, Wang J, He N, Feng H
Journal of biochemical and molecular toxicology 2021 Aug;35(8):e22815
Journal of biochemical and molecular toxicology 2021 Aug;35(8):e22815
Stabilization of Nrf2 leading to HO-1 activation protects against zinc oxide nanoparticles-induced endothelial cell death.
Zhang L, Zou L, Jiang X, Cheng S, Zhang J, Qin X, Qin Z, Chen C, Zou Z
Nanotoxicology 2021 Aug;15(6):779-797
Nanotoxicology 2021 Aug;15(6):779-797
The in vitro and in vivo study of oleanolic acid indole derivatives as novel anti-inflammatory agents: Synthesis, biological evaluation, and mechanistic analysis.
Jin J, He H, Zhang X, Wu R, Gan L, Li D, Lu Y, Wu P, Wong WL, Zhang K
Bioorganic chemistry 2021 Aug;113:104981
Bioorganic chemistry 2021 Aug;113:104981
Melatonin Promotes In Vitro Maturation of Vitrified-Warmed Mouse Germinal Vesicle Oocytes, Potentially by Reducing Oxidative Stress through the Nrf2 Pathway.
Guo S, Yang J, Qin J, Qazi IH, Pan B, Zang S, Lv T, Deng S, Fang Y, Zhou G
Animals : an open access journal from MDPI 2021 Aug 6;11(8)
Animals : an open access journal from MDPI 2021 Aug 6;11(8)
Manganese Mitigates Heat Stress-Induced Apoptosis by Alleviating Endoplasmic Reticulum Stress and Activating the NRF2/SOD2 Pathway in Primary Chick Embryonic Myocardial Cells.
Qin S, Wang R, Tang D, Qin S, Guo Y, Shi Z
Biological trace element research 2021 Aug 4;
Biological trace element research 2021 Aug 4;
Aloe polysaccharides ameliorate acute colitis in mice via Nrf2/HO-1 signaling pathway and short-chain fatty acids metabolism.
Liu C, Hua H, Zhu H, Cheng Y, Guo Y, Yao W, Qian H
International journal of biological macromolecules 2021 Aug 31;185:804-812
International journal of biological macromolecules 2021 Aug 31;185:804-812
The novel nanocomplexes containing deoxycholic acid-grafted chitosan and oleanolic acid displays the hepatoprotective effect against CCl4-induced liver injury in vivo.
Xin C, Liu S, Qu H, Wang Z
International journal of biological macromolecules 2021 Aug 31;185:338-349
International journal of biological macromolecules 2021 Aug 31;185:338-349
Modified citrus pectin inhibits breast cancer development in mice by targeting tumor-associated macrophage survival and polarization in hypoxic microenvironment.
Wang L, Zhao L, Gong FL, Sun C, Du DD, Yang XX, Guo XL
Acta pharmacologica Sinica 2021 Aug 30;
Acta pharmacologica Sinica 2021 Aug 30;
The role of Nrf2 pathway in alleviating fluorine-induced apoptosis by different selenium sources in the chicken duodenum and jejunum.
Ju H, Chen S, Xue Y, Zhang X, Wang Y
Ecotoxicology and environmental safety 2021 Aug 27;224:112708
Ecotoxicology and environmental safety 2021 Aug 27;224:112708
Apatinib triggers autophagic and apoptotic cell death via VEGFR2/STAT3/PD-L1 and ROS/Nrf2/p62 signaling in lung cancer.
Xie C, Zhou X, Liang C, Li X, Ge M, Chen Y, Yin J, Zhu J, Zhong C
Journal of experimental & clinical cancer research : CR 2021 Aug 24;40(1):266
Journal of experimental & clinical cancer research : CR 2021 Aug 24;40(1):266
Virtual screening identified natural Keap1-Nrf2 PPI inhibitor alleviates inflammatory osteoporosis through Nrf2-mir214-Traf3 axis.
Hong J, Shi Z, Li C, Ji X, Li S, Chen Y, Jiang G, Shi M, Wang W, Zhang Y, Hu B, Yan S
Free radical biology & medicine 2021 Aug 1;171:365-378
Free radical biology & medicine 2021 Aug 1;171:365-378
PSMD12 promotes glioma progression by upregulating the expression of Nrf2.
Wang Z, Li Z, Xu H, Liao Y, Sun C, Chen Y, Sheng M, Lan Q, Wang Z
Annals of translational medicine 2021 Apr;9(8):700
Annals of translational medicine 2021 Apr;9(8):700
Silicon Oxynitrophosphide Nanoscale Coating Enhances Antioxidant Marker-Induced Angiogenesis During in vivo Cranial Bone-Defect Healing.
do Monte FA, Ahuja N, Awad KR, Pan Z, Young S, Kim HK, Aswath P, Brotto M, Varanasi VG
JBMR plus 2021 Apr;5(4):e10425
JBMR plus 2021 Apr;5(4):e10425
Exosomal miR-27 negatively regulates ROS production and promotes granulosa cells apoptosis by targeting SPRY2 in OHSS.
Liu K, Yang W, Hu M, Xie W, Huang J, Cui M, He X, Nie X
Journal of cellular and molecular medicine 2021 Apr;25(8):3976-3990
Journal of cellular and molecular medicine 2021 Apr;25(8):3976-3990
Myricetin protects against H2 O2 -induced oxidative damage and apoptosis in bovine mammary epithelial cells.
Kan X, Liu J, Chen Y, Guo W, Xu D, Cheng J, Cao Y, Yang Z, Fu S
Journal of cellular physiology 2021 Apr;236(4):2684-2695
Journal of cellular physiology 2021 Apr;236(4):2684-2695
Regulatory effects of flavonoids luteolin on BDE-209-induced intestinal epithelial barrier damage in Caco-2 cell monolayer model.
Yuan J, Che S, Ruan Z, Song L, Tang R, Zhang L
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2021 Apr;150:112098
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2021 Apr;150:112098
Adenosine 5'-monophosphate-activated protein kinase ameliorates bovine adipocyte oxidative stress by inducing antioxidant responses and autophagy.
Xu Q, Fan Y, Loor JJ, Liang Y, Sun X, Jia H, Zhao C, Xu C
Journal of dairy science 2021 Apr;104(4):4516-4528
Journal of dairy science 2021 Apr;104(4):4516-4528
The protective role of Zingerone in a murine asthma model via activation of the AMPK/Nrf2/HO-1 pathway.
Zhu Y, Wang C, Luo J, Hua S, Li D, Peng L, Liu H, Song L
Food & function 2021 Apr 7;12(7):3120-3131
Food & function 2021 Apr 7;12(7):3120-3131
Heme-Mediated Activation of the Nrf2/HO-1 Axis Attenuates Calcification of Valve Interstitial Cells.
Balogh E, Chowdhury A, Ababneh H, Csiki DM, Tóth A, Jeney V
Biomedicines 2021 Apr 15;9(4)
Biomedicines 2021 Apr 15;9(4)
AKR1B10 negatively regulates autophagy through reducing GAPDH upon glucose starvation in colon cancer.
Li W, Liu C, Huang Z, Shi L, Zhong C, Zhou W, Meng P, Li Z, Wang S, Luo F, Yan J, Wu T
Journal of cell science 2021 Apr 15;134(8)
Journal of cell science 2021 Apr 15;134(8)
Reparative Effects of Ethanol-Induced Intestinal Barrier Injury by Flavonoid Luteolin via MAPK/NF-κB/MLCK and Nrf2 Signaling Pathways.
Yuan J, Che S, Zhang L, Ruan Z
Journal of agricultural and food chemistry 2021 Apr 14;69(14):4101-4110
Journal of agricultural and food chemistry 2021 Apr 14;69(14):4101-4110
S-allyl cysteine ameliorates heat stress-induced oxidative stress by activating Nrf2/HO-1 signaling pathway in BMECs.
Wang Y, Wang HL, Xing GD, Qian Y, Zhong JF, Chen KL
Toxicology and applied pharmacology 2021 Apr 1;416:115469
Toxicology and applied pharmacology 2021 Apr 1;416:115469
Prolyl endopeptidase disruption reduces hepatic inflammation and oxidative stress in methionine-choline-deficient diet-induced steatohepatitis.
Zhang J, Jiang D, Lin S, Cheng Y, Pan J, Ding W, Chen Y, Fan J
Life sciences 2021 Apr 1;270:119131
Life sciences 2021 Apr 1;270:119131
Koumine Alleviates Lipopolysaccharide-Induced Intestinal Barrier Dysfunction in IPEC-J2 Cells by Regulating Nrf2/NF-
Wu J, Yang CL, Sha YK, Wu Y, Liu ZY, Yuan ZH, Sun ZL
The American journal of Chinese medicine 2020;48(1):127-142
The American journal of Chinese medicine 2020;48(1):127-142
Effects of Compound Centella on Oxidative Stress and Keap1-Nrf2-ARE Pathway Expression in Diabetic Kidney Disease Rats.
Zhu Q, Zeng J, Li J, Chen X, Miao J, Jin Q, Chen H
Evidence-based complementary and alternative medicine : eCAM 2020;2020:9817932
Evidence-based complementary and alternative medicine : eCAM 2020;2020:9817932
TBHQ Attenuates Neurotoxicity Induced by Methamphetamine in the VTA through the Nrf2/HO-1 and PI3K/AKT Signaling Pathways.
Meng X, Zhang C, Guo Y, Han Y, Wang C, Chu H, Kong L, Ma H
Oxidative medicine and cellular longevity 2020;2020:8787156
Oxidative medicine and cellular longevity 2020;2020:8787156
Effect of Quercetin on PC12 Alzheimer's Disease Cell Model Induced by Aβ 25-35 and Its Mechanism Based on Sirtuin1/Nrf2/HO-1 Pathway.
Yu X, Li Y, Mu X
BioMed research international 2020;2020:8210578
BioMed research international 2020;2020:8210578
Neuroprotective Effect of Salvianolic Acid A against Diabetic Peripheral Neuropathy through Modulation of Nrf2.
Xu C, Hou B, He P, Ma P, Yang X, Yang X, Zhang L, Qiang G, Li W, Du G
Oxidative medicine and cellular longevity 2020;2020:6431459
Oxidative medicine and cellular longevity 2020;2020:6431459
Role of Nrf2 in Lipopolysaccharide-Induced Acute Kidney Injury: Protection by Human Umbilical Cord Blood Mononuclear Cells.
Feng LX, Zhao F, Liu Q, Peng JC, Duan XJ, Yan P, Wu X, Wang HS, Deng YH, Duan SB
Oxidative medicine and cellular longevity 2020;2020:6123459
Oxidative medicine and cellular longevity 2020;2020:6123459
Protective Effect of Simplicillium sp. Ethyl Acetate Extract against High Glucose-Induced Oxidative Stress in HUVECs.
Tian TT, Li QR, Gan SQ, Chang CR, Shen XC
Evidence-based complementary and alternative medicine : eCAM 2020;2020:5172765
Evidence-based complementary and alternative medicine : eCAM 2020;2020:5172765
The Nrf2/PGC1α Pathway Regulates Antioxidant and Proteasomal Activity to Alter Cisplatin Sensitivity in Ovarian Cancer.
Deng X, Lin N, Fu J, Xu L, Luo H, Jin Y, Liu Y, Sun L, Su J
Oxidative medicine and cellular longevity 2020;2020:4830418
Oxidative medicine and cellular longevity 2020;2020:4830418
Fasting Induces Hepatocellular Carcinoma Cell Apoptosis by Inhibiting SET8 Expression.
Qi J, Chen X, Wu Q, Wang J, Zhang H, Mao A, Zhu M, Miao C
Oxidative medicine and cellular longevity 2020;2020:3985089
Oxidative medicine and cellular longevity 2020;2020:3985089
Pentamethylquercetin Attenuates Cardiac Remodeling via Activation of the Sestrins/Keap1/Nrf2 Pathway in MSG-Induced Obese Mice.
Du J, He W, Zhang C, Wu J, Li Z, Wang M, Feng S, Liang G
BioMed research international 2020;2020:3243906
BioMed research international 2020;2020:3243906
Gentiopicroside Ameliorates Oxidative Stress and Lipid Accumulation through Nuclear Factor Erythroid 2-Related Factor 2 Activation.
Jin M, Feng H, Wang Y, Yan S, Shen B, Li Z, Qin H, Wang Q, Li J, Liu G
Oxidative medicine and cellular longevity 2020;2020:2940746
Oxidative medicine and cellular longevity 2020;2020:2940746
Comparative effectiveness of 4 natural and chemical activators of Nrf2 on inflammation, oxidative stress, macrophage polarization, and bactericidal activity in an in vitro macrophage infection model.
Ali M, Bonay M, Vanhee V, Vinit S, Deramaudt TB
PloS one 2020;15(6):e0234484
PloS one 2020;15(6):e0234484
Mechanisms and therapeutic implications of RTA 408, an activator of Nrf2, in subarachnoid hemorrhage-induced delayed cerebral vasospasm and secondary brain injury.
Tsai TH, Lin SH, Wu CH, Tsai YC, Yang SF, Lin CL
PloS one 2020;15(10):e0240122
PloS one 2020;15(10):e0240122
La2O3 Nanoparticles Induce Reproductive Toxicity Mediated by the Nrf-2/ARE Signaling Pathway in Kunming Mice.
Yuan L, Li Q, Bai D, Shang X, Hu F, Chen Z, An T, Chen Y, Zhang X
International journal of nanomedicine 2020;15:3415-3431
International journal of nanomedicine 2020;15:3415-3431
Acacetin Alleviates Inflammation and Matrix Degradation in Nucleus Pulposus Cells and Ameliorates Intervertebral Disc Degeneration in vivo.
Wang H, Jiang Z, Pang Z, Zhou T, Gu Y
Drug design, development and therapy 2020;14:4801-4813
Drug design, development and therapy 2020;14:4801-4813
Emodin Protects Against Acute Pancreatitis-Associated Lung Injury by Inhibiting NLPR3 Inflammasome Activation via Nrf2/HO-1 Signaling.
Gao Z, Sui J, Fan R, Qu W, Dong X, Sun D
Drug design, development and therapy 2020;14:1971-1982
Drug design, development and therapy 2020;14:1971-1982
Pristimerin Suppresses RANKL-Induced Osteoclastogenesis and Ameliorates Ovariectomy-Induced Bone Loss.
Qi D, Liu H, Sun X, Luo D, Zhu M, Tao T, Gao C, Zhou C, Zhou W, Xiao J
Frontiers in pharmacology 2020;11:621110
Frontiers in pharmacology 2020;11:621110
Oleoylethanolamide Protects Against Acute Liver Injury by Regulating Nrf-2/HO-1 and NLRP3 Pathways in Mice.
Hu J, Zhu Z, Ying H, Yao J, Ma H, Li L, Zhao Y
Frontiers in pharmacology 2020;11:605065
Frontiers in pharmacology 2020;11:605065
Rutaecarpine Ameliorates Ethanol-Induced Gastric Mucosal Injury in Mice by Modulating Genes Related to Inflammation, Oxidative Stress and Apoptosis.
Ren S, Wei Y, Wang R, Wei S, Wen J, Yang T, Chen X, Wu S, Jing M, Li H, Wang M, Zhao Y
Frontiers in pharmacology 2020;11:600295
Frontiers in pharmacology 2020;11:600295
Ursodeoxycholic Acid Protects Against Arsenic Induced Hepatotoxicity by the Nrf2 Signaling Pathway.
Li C, Zhang S, Li L, Hu Q, Ji S
Frontiers in pharmacology 2020;11:594496
Frontiers in pharmacology 2020;11:594496
Gallic Acid Alleviates Gouty Arthritis by Inhibiting NLRP3 Inflammasome Activation and Pyroptosis Through Enhancing Nrf2 Signaling.
Lin Y, Luo T, Weng A, Huang X, Yao Y, Fu Z, Li Y, Liu A, Li X, Chen D, Pan H
Frontiers in immunology 2020;11:580593
Frontiers in immunology 2020;11:580593
Formononetin Attenuates Airway Inflammation and Oxidative Stress in Murine Allergic Asthma.
Yi, Cui J, Wang W, Tang W, Teng F, Zhu X, Qin J, Wuniqiemu T, Sun J, Wei Y, Dong J
Frontiers in pharmacology 2020;11:533841
Frontiers in pharmacology 2020;11:533841
α-Cyperone Attenuates H2O2-Induced Oxidative Stress and Apoptosis in SH-SY5Y Cells via Activation of Nrf2.
Huang B, Liu J, Fu S, Zhang Y, Li Y, He D, Ran X, Yan X, Du J, Meng T, Gao X, Liu D
Frontiers in pharmacology 2020;11:281
Frontiers in pharmacology 2020;11:281
Purmorphamine Attenuates Neuro-Inflammation and Synaptic Impairments After Hypoxic-Ischemic Injury in Neonatal Mice via Shh Signaling.
Liu D, Bai X, Ma W, Xin D, Chu X, Yuan H, Qiu J, Ke H, Yin S, Chen W, Wang Z
Frontiers in pharmacology 2020;11:204
Frontiers in pharmacology 2020;11:204
MicroRNA-34a Inhibition Alleviates Lung Injury in Cecal Ligation and Puncture Induced Septic Mice.
Chen S, Ding R, Hu Z, Yin X, Xiao F, Zhang W, Yan S, Lv C
Frontiers in immunology 2020;11:1829
Frontiers in immunology 2020;11:1829
Schisandrin B Inhibits Osteoclastogenesis and Protects Against Ovariectomy-Induced Bone Loss.
Wang J, Fang Z, Song C, Kang H, Guo Q, Dong Y, Zhang Y, Peng R, Guan H, Li F
Frontiers in pharmacology 2020;11:1175
Frontiers in pharmacology 2020;11:1175
Kaempferol Protects Blood Vessels From Damage Induced by Oxidative Stress and Inflammation in Association With the Nrf2/HO-1 Signaling Pathway.
Yao H, Sun J, Wei J, Zhang X, Chen B, Lin Y
Frontiers in pharmacology 2020;11:1118
Frontiers in pharmacology 2020;11:1118
Cucurbitacin I induces apoptosis in ovarian cancer cells through oxidative stress and the p190B‑Rac1 signaling axis.
Li R, Xiao J, Tang S, Lin X, Xu H, Han B, Yang M, Liu F
Molecular medicine reports 2020 Sep;22(3):2545-2550
Molecular medicine reports 2020 Sep;22(3):2545-2550
Sp4 controls constitutive expression of neuronal serine racemase and NF-E2-related factor-2 mediates its induction by valproic acid.
Zhang H, Lu J, Wu S
Biochimica et biophysica acta. Gene regulatory mechanisms 2020 Sep;1863(9):194597
Biochimica et biophysica acta. Gene regulatory mechanisms 2020 Sep;1863(9):194597
Metformin mitigates gastrointestinal radiotoxicity and radiosensitises P53 mutation colorectal tumours via optimising autophagy.
Chen L, Liao F, Jiang Z, Zhang C, Wang Z, Luo P, Jiang Q, Wu J, Wang Q, Luo M, Li X, Leng Y, Ma L, Shen G, Chen Z, Wang Y, Tan X, Gan Y, Liu D, Liu Y, Shi C
British journal of pharmacology 2020 Sep;177(17):3991-4006
British journal of pharmacology 2020 Sep;177(17):3991-4006
PPARγ activation mitigates mechanical allodynia in paclitaxel-induced neuropathic pain via induction of Nrf2/HO-1 signaling pathway.
Zhou YQ, Liu DQ, Chen SP, Chen N, Sun J, Wang XM, Li DY, Tian YK, Ye DW
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2020 Sep;129:110356
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2020 Sep;129:110356
Inhibition of miR-181a-5p reduces astrocyte and microglia activation and oxidative stress by activating SIRT1 in immature rats with epilepsy.
Kong H, Wang H, Zhuo Z, Li Z, Tian P, Wu J, Liu J, Chen Z, Zhang J, Luo Q
Laboratory investigation; a journal of technical methods and pathology 2020 Sep;100(9):1223-1237
Laboratory investigation; a journal of technical methods and pathology 2020 Sep;100(9):1223-1237
Cholestasis Differentially Affects Liver Connexins.
Cooreman A, Van Campenhout R, Crespo Yanguas S, Gijbels E, Leroy K, Pieters A, Tabernilla A, Van Brantegem P, Annaert P, Cogliati B, Vinken M
International journal of molecular sciences 2020 Sep 7;21(18)
International journal of molecular sciences 2020 Sep 7;21(18)
PTEN status determines chemosensitivity to proteasome inhibition in cholangiocarcinoma.
Jiang TY, Pan YF, Wan ZH, Lin YK, Zhu B, Yuan ZG, Ma YH, Shi YY, Zeng TM, Dong LW, Tan YX, Wang HY
Science translational medicine 2020 Sep 23;12(562)
Science translational medicine 2020 Sep 23;12(562)
Astaxanthin attenuates oxidative stress and immune impairment in D-galactose-induced aging in rats by activating the Nrf2/Keap1 pathway and suppressing the NF-κB pathway.
Chen Z, Xiao J, Liu H, Yao K, Hou X, Cao Y, Liu X
Food & function 2020 Sep 23;11(9):8099-8111
Food & function 2020 Sep 23;11(9):8099-8111
(+)-Clausenamide protects against drug-induced liver injury by inhibiting hepatocyte ferroptosis.
Wang M, Liu CY, Wang T, Yu HM, Ouyang SH, Wu YP, Gong HB, Ma XH, Jiao GL, Fu LL, Wu QS, Kurihara H, Li YF, Shen T, He RR
Cell death & disease 2020 Sep 19;11(9):781
Cell death & disease 2020 Sep 19;11(9):781
NRF2 preserves genomic integrity by facilitating ATR activation and G2 cell cycle arrest.
Sun X, Wang Y, Ji K, Liu Y, Kong Y, Nie S, Li N, Hao J, Xie Y, Xu C, Du L, Liu Q
Nucleic acids research 2020 Sep 18;48(16):9109-9123
Nucleic acids research 2020 Sep 18;48(16):9109-9123
Atypical Antipsychotic Drug Ziprasidone Protects against Rotenone-Induced Neurotoxicity: An In Vitro Study.
Terada K, Murata A, Toki E, Goto S, Yamakawa H, Setoguchi S, Watase D, Koga M, Takata J, Matsunaga K, Karube Y
Molecules (Basel, Switzerland) 2020 Sep 14;25(18)
Molecules (Basel, Switzerland) 2020 Sep 14;25(18)
Four active monomers from Moutan Cortex exert inhibitory effects against oxidative stress by activating Nrf2/Keap1 signaling pathway.
Zhang B, Yu D, Luo N, Yang C, Zhu Y
The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology 2020 Sep 1;24(5):373-384
The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology 2020 Sep 1;24(5):373-384
Liraglutide Up-regulation Thioredoxin Attenuated Müller Cells Apoptosis in High Glucose by Regulating Oxidative Stress and Endoplasmic Reticulum Stress.
Ren X, Sun L, Wei L, Liu J, Zhu J, Yu Q, Kong H, Kong L
Current eye research 2020 Oct;45(10):1283-1291
Current eye research 2020 Oct;45(10):1283-1291
Oncogenic function of TRIM2 in pancreatic cancer by activating ROS-related NRF2/ITGB7/FAK axis.
Sun Q, Ye Z, Qin Y, Fan G, Ji S, Zhuo Q, Xu W, Liu W, Hu Q, Liu M, Zhang Z, Xu X, Yu X
Oncogene 2020 Oct;39(42):6572-6588
Oncogene 2020 Oct;39(42):6572-6588
NRF2 regulates the sensitivity of human NSCLC cells to cystine deprivation-induced ferroptosis via FOCAD-FAK signaling pathway.
Liu P, Wu D, Duan J, Xiao H, Zhou Y, Zhao L, Feng Y
Redox biology 2020 Oct;37:101702
Redox biology 2020 Oct;37:101702
MSC-derived exosomes protect against oxidative stress-induced skin injury via adaptive regulation of the NRF2 defense system.
Wang T, Jian Z, Baskys A, Yang J, Li J, Guo H, Hei Y, Xian P, He Z, Li Z, Li N, Long Q
Biomaterials 2020 Oct;257:120264
Biomaterials 2020 Oct;257:120264
MiR-23a-5p exacerbates intestinal ischemia-reperfusion injury by promoting oxidative stress via targeting PPAR alpha.
Li LX, Yin LH, Gao M, Xu LN, Qi Y, Peng JY
Biochemical pharmacology 2020 Oct;180:114194
Biochemical pharmacology 2020 Oct;180:114194
Melatonin improves hypoxic-ischemic brain damage through the Akt/Nrf2/Gpx4 signaling pathway.
Gou Z, Su X, Hu X, Zhou Y, Huang L, Fan Y, Li J, Lu L
Brain research bulletin 2020 Oct;163:40-48
Brain research bulletin 2020 Oct;163:40-48
Neuroprotective mechanism of L-cysteine after subarachnoid hemorrhage.
Xiong Y, Xin DQ, Hu Q, Wang LX, Qiu J, Yuan HT, Chu XL, Liu DX, Li G, Wang Z
Neural regeneration research 2020 Oct;15(10):1920-1930
Neural regeneration research 2020 Oct;15(10):1920-1930
Protective effect of astaxanthin against La2O3 nanoparticles induced neurotoxicity by activating PI3K/AKT/Nrf-2 signaling in mice.
Yuan L, Qu Y, Li Q, An T, Chen Z, Chen Y, Deng X, Bai D
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2020 Oct;144:111582
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2020 Oct;144:111582
Tanshinone IIA attenuates acetaminophen-induced hepatotoxicity through HOTAIR-Nrf2-MRP2/4 signaling pathway.
Zhang X, Wang T, Yang Y, Li R, Chen Y, Li R, Jiang X, Wang L
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2020 Oct;130:110547
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2020 Oct;130:110547
The Preventive Effects of Xanthohumol on Vascular Calcification Induced by Vitamin D3 Plus Nicotine.
Liou SF, Nguyen TTN, Hsu JH, Sulistyowati E, Huang SE, Wu BN, Lin MC, Yeh JL
Antioxidants (Basel, Switzerland) 2020 Oct 6;9(10)
Antioxidants (Basel, Switzerland) 2020 Oct 6;9(10)
Exposure to Static Magnetic and Electric Fields Treats Type 2 Diabetes.
Carter CS, Huang SC, Searby CC, Cassaidy B, Miller MJ, Grzesik WJ, Piorczynski TB, Pak TK, Walsh SA, Acevedo M, Zhang Q, Mapuskar KA, Milne GL, Hinton AO Jr, Guo DF, Weiss R, Bradberry K, Taylor EB, Rauckhorst AJ, Dick DW, Akurathi V, Falls-Hubert KC, Wagner BA, Carter WA, Wang K, Norris AW, Rahmouni K, Buettner GR, Hansen JM, Spitz DR, Abel ED, Sheffield VC
Cell metabolism 2020 Oct 6;32(4):561-574.e7
Cell metabolism 2020 Oct 6;32(4):561-574.e7
Functional validation of a human GLUD2 variant in a murine model of Parkinson's disease.
Zhang W, Gong J, Ding L, Zhang Z, Pan X, Chen X, Guo W, Zhang X, Yang X, Peng G, Lin Y, Gao F, Li Y, Zhu X, Xuan A, Wang S, Sun X, Zhang Y, Xu P
Cell death & disease 2020 Oct 22;11(10):897
Cell death & disease 2020 Oct 22;11(10):897
Astragalus polysaccharide alleviates cognitive impairment and β-amyloid accumulation in APP/PS1 mice via Nrf2 pathway.
Qin X, Hua J, Lin SJ, Zheng HT, Wang JJ, Li W, Ke JJ, Cai HB
Biochemical and biophysical research communications 2020 Oct 20;531(3):431-437
Biochemical and biophysical research communications 2020 Oct 20;531(3):431-437
Daidzein ameliorates LPS-induced hepatocyte injury by inhibiting inflammation and oxidative stress.
Yu Z, Yang L, Deng S, Liang M
European journal of pharmacology 2020 Oct 15;885:173399
European journal of pharmacology 2020 Oct 15;885:173399
Upregulation of Glutaredoxin 2 alleviates oxygen-glucose deprivation/reoxygenation-induced apoptosis and ROS production in neurons by enhancing Nrf2 signaling via modulation of GSK-3β.
Wen J, Li X, Zheng S, Xiao Y
Brain research 2020 Oct 15;1745:146946
Brain research 2020 Oct 15;1745:146946
Brain Dicer1 Is Down-Regulated in a Mouse Model of Alzheimer's Disease Via Aβ42-Induced Repression of Nuclear Factor Erythroid 2-Related Factor 2.
Wang Y, Lian M, Zhou J, Wu S
Molecular neurobiology 2020 Nov;57(11):4417-4437
Molecular neurobiology 2020 Nov;57(11):4417-4437
Tannic acid attenuates hepatic oxidative stress, apoptosis and inflammation by activating the Keap1‑Nrf2/ARE signaling pathway in arsenic trioxide‑toxicated rats.
Li M, Liu P, Xue Y, Liang Y, Shi J, Han X, Zhang J, Chu X, Chu L
Oncology reports 2020 Nov;44(5):2306-2316
Oncology reports 2020 Nov;44(5):2306-2316
A novel danshensu derivative ameliorates experimental colitis by modulating NADPH oxidase 4-dependent NLRP3 inflammasome activation.
Pan LL, Ren Z, Liu Y, Zhao Y, Li H, Pan X, Fang X, Liang W, Wang Y, Yang J, Sun J
Journal of cellular and molecular medicine 2020 Nov;24(22):12955-12969
Journal of cellular and molecular medicine 2020 Nov;24(22):12955-12969
Crocin ameliorates arsenic trioxide‑induced cardiotoxicity via Keap1-Nrf2/HO-1 pathway: Reducing oxidative stress, inflammation, and apoptosis.
Liang Y, Zheng B, Li J, Shi J, Chu L, Han X, Chu X, Zhang X, Zhang J
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2020 Nov;131:110713
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2020 Nov;131:110713
Down-regulation of miR-383-5p suppresses apoptosis in oxidative stress rat hepatocytes by targeting Bcl2.
Xu B, Zang SC, Lang LM, Lian S, Lu J, Li SZ, Yang HM, Zhen L
Journal of animal physiology and animal nutrition 2020 Nov;104(6):1948-1959
Journal of animal physiology and animal nutrition 2020 Nov;104(6):1948-1959
Two resveratrol analogs, pinosylvin and 4,4'-dihydroxystilbene, improve oligoasthenospermia in a mouse model by attenuating oxidative stress via the Nrf2-ARE pathway.
Wang CN, Sang MM, Gong SN, Yang JF, Cheng CY, Sun F
Bioorganic chemistry 2020 Nov;104:104295
Bioorganic chemistry 2020 Nov;104:104295
Preconditioning the immature lung with enhanced Nrf2 activity protects against oxidant-induced hypoalveolarization in mice.
Tamatam CM, Reddy NM, Potteti HR, Ankireddy A, Noone PM, Yamamoto M, Kensler TW, Reddy SP
Scientific reports 2020 Nov 4;10(1):19034
Scientific reports 2020 Nov 4;10(1):19034
Anthocyanins decrease the internalization of TiO2 nanoparticles into 3D Caco-2 spheroids.
Wang J, Zhang J, Li S, Huang C, Xie Y, Cao Y
Food chemistry 2020 Nov 30;331:127360
Food chemistry 2020 Nov 30;331:127360
Sesn2 attenuates the damage of endothelial progenitor cells induced by angiotensin II through regulating the Keap1/Nrf2 signal pathway.
Ding S, Ma N, Liu H, Tang M, Mei J
Aging 2020 Nov 24;12(24):25505-25527
Aging 2020 Nov 24;12(24):25505-25527
Mutual antagonism between indoleamine 2,3-dioxygenase 1 and nuclear factor E2-related factor 2 regulates the maturation status of DCs in liver fibrosis.
Mo C, Xie S, Zhong W, Zeng T, Huang S, Lai Y, Deng G, Zhou C, Yan W, Chen Y, Huang S, Gao L, Lv Z
Free radical biology & medicine 2020 Nov 20;160:178-190
Free radical biology & medicine 2020 Nov 20;160:178-190
PDK4 promotes vascular calcification by interfering with autophagic activity and metabolic reprogramming.
Ma WQ, Sun XJ, Zhu Y, Liu NF
Cell death & disease 2020 Nov 17;11(11):991
Cell death & disease 2020 Nov 17;11(11):991
Fostered Nrf2 expression antagonizes iron overload and glutathione depletion to promote resistance of neuron-like cells to ferroptosis.
Liu Z, Lv X, Song E, Song Y
Toxicology and applied pharmacology 2020 Nov 15;407:115241
Toxicology and applied pharmacology 2020 Nov 15;407:115241
Rice protein stimulates endogenous antioxidant response attributed to methionine availability in growing rats.
Wang Z, Cai L, Li H, Liang M, Zhang Y, Wu Q, Yang L
Journal of food biochemistry 2020 May;44(5):e13180
Journal of food biochemistry 2020 May;44(5):e13180
Exogenous spermine attenuates rat diabetic cardiomyopathy via suppressing ROS-p53 mediated downregulation of calcium-sensitive receptor.
Wang Y, Chen J, Li S, Zhang X, Guo Z, Hu J, Shao X, Song N, Zhao Y, Li H, Yang G, Xu C, Wei C
Redox biology 2020 May;32:101514
Redox biology 2020 May;32:101514
Geniposide alleviates non-alcohol fatty liver disease via regulating Nrf2/AMPK/mTOR signalling pathways.
Shen B, Feng H, Cheng J, Li Z, Jin M, Zhao L, Wang Q, Qin H, Liu G
Journal of cellular and molecular medicine 2020 May;24(9):5097-5108
Journal of cellular and molecular medicine 2020 May;24(9):5097-5108
Inhibition of thioredoxin reductase 1 correlates with platinum-based chemotherapeutic induced tissue injury.
Cheng P, Liu H, Li Y, Pi P, Jiang Y, Zang S, Li X, Fu A, Ren X, Xu J, Holmgren A, Lu J
Biochemical pharmacology 2020 May;175:113873
Biochemical pharmacology 2020 May;175:113873
BMP8A promotes survival and drug resistance via Nrf2/TRIM24 signaling pathway in clear cell renal cell carcinoma.
Yu YP, Cai LC, Wang XY, Cheng SY, Zhang DM, Jian WG, Wang TD, Yang JK, Yang KB, Zhang C
Cancer science 2020 May;111(5):1555-1566
Cancer science 2020 May;111(5):1555-1566
High glucose inhibits vascular endothelial Keap1/Nrf2/ARE signal pathway via downregulation of monomethyltransferase SET8 expression.
Chen X, Qi J, Wu Q, Jiang H, Wang J, Chen W, Mao A, Zhu M
Acta biochimica et biophysica Sinica 2020 May 26;52(5):506-516
Acta biochimica et biophysica Sinica 2020 May 26;52(5):506-516
p62/SQSTM1 accumulation due to degradation inhibition and transcriptional activation plays a critical role in silica nanoparticle-induced airway inflammation via NF-κB activation.
Wu Y, Jin Y, Sun T, Zhu P, Li J, Zhang Q, Wang X, Jiang J, Chen G, Zhao X
Journal of nanobiotechnology 2020 May 19;18(1):77
Journal of nanobiotechnology 2020 May 19;18(1):77
Adaptation of the master antioxidant response connects metabolism, lifespan and feather development pathways in birds.
Castiglione GM, Xu Z, Zhou L, Duh EJ
Nature communications 2020 May 18;11(1):2476
Nature communications 2020 May 18;11(1):2476
Anti-Inflammatory Effects of Lasia spinosa Leaf Extract in Lipopolysaccharide-Induced RAW 264.7 Macrophages.
Nguyen TQC, Duy Binh T, Pham TLA, Nguyen YDH, Thi Xuan Trang D, Nguyen TT, Kanaori K, Kamei K
International journal of molecular sciences 2020 May 13;21(10)
International journal of molecular sciences 2020 May 13;21(10)
Evidence for Cytoprotective Effect of Carbon Monoxide Donor in the Development of Acute Esophagitis Leading to Acute Esophageal Epithelium Lesions.
Magierowska K, Bakalarz D, Wójcik D, Korbut E, Danielak A, Głowacka U, Pajdo R, Buszewicz G, Ginter G, Surmiak M, Kwiecień S, Chmura A, Magierowski M, Brzozowski T
Cells 2020 May 12;9(5)
Cells 2020 May 12;9(5)
Spinosin Inhibits Aβ1-42 Production and Aggregation via Activating Nrf2/HO-1 Pathway.
Zhang X, Wang J, Gong G, Ma R, Xu F, Yan T, Wu B, Jia Y
Biomolecules & therapeutics 2020 May 1;28(3):259-266
Biomolecules & therapeutics 2020 May 1;28(3):259-266
6-Gingerol ameliorates sepsis-induced liver injury through the Nrf2 pathway.
Hong MK, Hu LL, Zhang YX, Xu YL, Liu XY, He PK, Jia YH
International immunopharmacology 2020 Mar;80:106196
International immunopharmacology 2020 Mar;80:106196
Mesenchymal stromal cells ameliorate acute lung injury induced by LPS mainly through stanniocalcin-2 mediating macrophage polarization.
Lv H, Liu Q, Sun Y, Yi X, Wei X, Liu W, Zhang Q, Yi H, Chen G
Annals of translational medicine 2020 Mar;8(6):334
Annals of translational medicine 2020 Mar;8(6):334
NF-E2-related factor 2 activation boosts antioxidant defenses and ameliorates inflammatory and amyloid properties in human Presenilin-1 mutated Alzheimer's disease astrocytes.
Oksanen M, Hyötyläinen I, Trontti K, Rolova T, Wojciechowski S, Koskuvi M, Viitanen M, Levonen AL, Hovatta I, Roybon L, Lehtonen Š, Kanninen KM, Hämäläinen RH, Koistinaho J
Glia 2020 Mar;68(3):589-599
Glia 2020 Mar;68(3):589-599
MTFP1 overexpression promotes the growth of oral squamous cell carcinoma by inducing ROS production.
Xiao T, Sun J, Xing Z, Xie F, Yang L, Ding W
Cell biology international 2020 Mar;44(3):821-829
Cell biology international 2020 Mar;44(3):821-829
Jmjd3 regulates inflammasome activation and aggravates DSS-induced colitis in mice.
Huang M, Wang Q, Long F, Di Y, Wang J, Zhun Zhu Y, Liu X
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2020 Mar;34(3):4107-4119
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2020 Mar;34(3):4107-4119
Nardosinanone N suppresses LPS-induced macrophage activation by modulating the Nrf2 pathway and mPGES-1.
Lio CK, Luo JF, Shen XY, Dai Y, Machado J, Xie Y, Yao YD, Yu Y, Liu JX, Yao XS, Luo P, Zhou H
Biochemical pharmacology 2020 Mar;173:113639
Biochemical pharmacology 2020 Mar;173:113639
Vinpocetine inhibits RANKL-induced osteoclastogenesis and attenuates ovariectomy-induced bone loss.
Zhu M, Liu H, Sun K, Liu J, Mou Y, Qi D, Zhou C, Abudunaibi M, Tasiken B, Li J, Cheng H, Huang H
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2020 Mar;123:109769
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2020 Mar;123:109769
lncRNA SLC7A11-AS1 Promotes Chemoresistance by Blocking SCFβ-TRCP-Mediated Degradation of NRF2 in Pancreatic Cancer.
Yang Q, Li K, Huang X, Zhao C, Mei Y, Li X, Jiao L, Yang H
Molecular therapy. Nucleic acids 2020 Mar 6;19:974-985
Molecular therapy. Nucleic acids 2020 Mar 6;19:974-985
PTEN inhibitor VO-OHpic attenuates GC-associated endothelial progenitor cell dysfunction and osteonecrosis of the femoral head via activating Nrf2 signaling and inhibiting mitochondrial apoptosis pathway.
Yao X, Yu S, Jing X, Guo J, Sun K, Guo F, Ye Y
Stem cell research & therapy 2020 Mar 30;11(1):140
Stem cell research & therapy 2020 Mar 30;11(1):140
The protective effect of hesperetin in osteoarthritis: an in vitro and in vivo study.
Lin Z, Fu C, Yan Z, Wu Y, Zhan J, Lou Z, Liao X, Pan J
Food & function 2020 Mar 26;11(3):2654-2666
Food & function 2020 Mar 26;11(3):2654-2666
Dietary Supplemented Curcumin Improves Meat Quality and Antioxidant Status of Intrauterine Growth Retardation Growing Pigs via Nrf2 Signal Pathway.
Zhang L, Zhang J, Yan E, He J, Zhong X, Zhang L, Wang C, Wang T
Animals : an open access journal from MDPI 2020 Mar 24;10(3)
Animals : an open access journal from MDPI 2020 Mar 24;10(3)
Resveratrol protects against CIH-induced myocardial injury by targeting Nrf2 and blocking NLRP3 inflammasome activation.
Sun ZM, Guan P, Luo LF, Qin LY, Wang N, Zhao YS, Ji ES
Life sciences 2020 Mar 15;245:117362
Life sciences 2020 Mar 15;245:117362
Polydatin ameliorates chemotherapy-induced cognitive impairment (chemobrain) by inhibiting oxidative stress, inflammatory response, and apoptosis in rats.
Tong Y, Wang K, Sheng S, Cui J
Bioscience, biotechnology, and biochemistry 2020 Jun;84(6):1201-1210
Bioscience, biotechnology, and biochemistry 2020 Jun;84(6):1201-1210
HJ22, a Novel derivative of piperine, Attenuates ibotenic acid-induced cognitive impairment, oxidativestress, apoptosis and inflammation via inhibiting the protein-protein interaction of Keap1-Nrf2.
Yang X, Ji J, Liu C, Zhou M, Li H, Ye S, Hu Q
International immunopharmacology 2020 Jun;83:106383
International immunopharmacology 2020 Jun;83:106383
Sulforaphane reduces intracellular survival of Staphylococcus aureus in macrophages through inhibition of JNK and p38 MAPK‑induced inflammation.
Deramaudt TB, Ali M, Vinit S, Bonay M
International journal of molecular medicine 2020 Jun;45(6):1927-1941
International journal of molecular medicine 2020 Jun;45(6):1927-1941
Exogenous Hydrogen Sulfide Regulates Mycoplasma pneumoniae Lipid-Associated Membrane Proteins to Induce Expression of Heme Oxygenase-1 and Proinflammatory Cytokines.
Hu X, Zeng W, You X, Ding W, Liu P, Chen L, Zeng Y, Zhu C
Inflammation 2020 Jun;43(3):847-856
Inflammation 2020 Jun;43(3):847-856
Protective effect of apigenin on d-galactosamine/LPS-induced hepatocellular injury by increment of Nrf-2 nucleus translocation.
Zhou RJ, Zhao Y, Fan K, Xie ML
Naunyn-Schmiedeberg's archives of pharmacology 2020 Jun;393(6):929-936
Naunyn-Schmiedeberg's archives of pharmacology 2020 Jun;393(6):929-936
Rice Protein Exerts Endogenous Antioxidant Capacity via Methionine Sulfoxide Reductase and the Nrf2 Antioxidant System Independent of Age.
Li H, Liang M, Wang Z, Zhang Y, Wu Q, Yang L
Journal of medicinal food 2020 Jun;23(6):565-574
Journal of medicinal food 2020 Jun;23(6):565-574
Polychlorinated biphenyl quinone induces hepatocytes iron overload through up-regulating hepcidin expression.
Liu J, Tan Y, Yang B, Wu Y, Fan B, Zhu S, Song E, Song Y
Environment international 2020 Jun;139:105701
Environment international 2020 Jun;139:105701
Tannic acid ameliorates arsenic trioxide-induced nephrotoxicity, contribution of NF-κB and Nrf2 pathways.
Jin W, Xue Y, Xue Y, Han X, Song Q, Zhang J, Li Z, Cheng J, Guan S, Sun S, Chu L
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2020 Jun;126:110047
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2020 Jun;126:110047
BDH2 triggers ROS-induced cell death and autophagy by promoting Nrf2 ubiquitination in gastric cancer.
Liu JZ, Hu YL, Feng Y, Jiang Y, Guo YB, Liu YF, Chen X, Yang JL, Chen YY, Mao QS, Xue WJ
Journal of experimental & clinical cancer research : CR 2020 Jun 30;39(1):123
Journal of experimental & clinical cancer research : CR 2020 Jun 30;39(1):123
Inhibition of ROCK2 alleviates renal fibrosis and the metabolic disorders in the proximal tubular epithelial cells.
You R, Zhou W, Li Y, Zhang Y, Huang S, Jia Z, Zhang A
Clinical science (London, England : 1979) 2020 Jun 26;134(12):1357-1376
Clinical science (London, England : 1979) 2020 Jun 26;134(12):1357-1376
Isoquinoline Kelch-like ECH-Associated Protein 1-Nuclear Factor (Erythroid-Derived 2)-like 2 (KEAP1-NRF2) Inhibitors with High Metabolic Stability.
Lazzara PR, David BP, Ankireddy A, Richardson BG, Dye K, Ratia KM, Reddy SP, Moore TW
Journal of medicinal chemistry 2020 Jun 25;63(12):6547-6560
Journal of medicinal chemistry 2020 Jun 25;63(12):6547-6560
Non-Esterified Fatty Acid-Induced Reactive Oxygen Species Mediated Granulosa Cells Apoptosis Is Regulated by Nrf2/p53 Signaling Pathway.
Wang Y, Li C, Li J, Wang G, Li L
Antioxidants (Basel, Switzerland) 2020 Jun 14;9(6)
Antioxidants (Basel, Switzerland) 2020 Jun 14;9(6)
Sestrin2 overexpression alleviates hydrogen peroxide-induced apoptosis and oxidative stress in retinal ganglion cells by enhancing Nrf2 activation via Keap1 downregulation.
Fan Y, Xing Y, Xiong L, Wang J
Chemico-biological interactions 2020 Jun 1;324:109086
Chemico-biological interactions 2020 Jun 1;324:109086
Inhibition of ferroptosis attenuates busulfan-induced oligospermia in mice.
Zhao X, Liu Z, Gao J, Li H, Wang X, Li Y, Sun F
Toxicology 2020 Jul;440:152489
Toxicology 2020 Jul;440:152489
Stomatin-like protein-2 confers neuroprotection effect in oxygen-glucose deprivation/reoxygenation-injured neurons by regulating AMPK/Nrf2 signalling.
Wang M, Li C, Shi W
Journal of drug targeting 2020 Jul;28(6):600-608
Journal of drug targeting 2020 Jul;28(6):600-608
MicroRNA-214-3p enhances erastin-induced ferroptosis by targeting ATF4 in hepatoma cells.
Bai T, Liang R, Zhu R, Wang W, Zhou L, Sun Y
Journal of cellular physiology 2020 Jul;235(7-8):5637-5648
Journal of cellular physiology 2020 Jul;235(7-8):5637-5648
Luteolin alleviates ochratoxin A induced oxidative stress by regulating Nrf2 and HIF-1α pathways in NRK-52E rat kidney cells.
Liu M, Cheng C, Li X, Zhou S, Hua J, Huang J, Li Y, Yang K, Zhang P, Zhang Y, Tian J
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2020 Jul;141:111436
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2020 Jul;141:111436
Downregulation of RKIP promotes radioresistance of nasopharyngeal carcinoma by activating NRF2/NQO1 axis via downregulating miR-450b-5p.
Huang W, Shi G, Yong Z, Li J, Qiu J, Cao Y, Zhao Y, Yuan L
Cell death & disease 2020 Jul 6;11(7):504
Cell death & disease 2020 Jul 6;11(7):504
Piceatannol Ameliorates Hepatic Oxidative Damage and Mitochondrial Dysfunction of Weaned Piglets Challenged with Diquat.
Jia P, Ji S, Zhang H, Chen Y, Wang T
Animals : an open access journal from MDPI 2020 Jul 21;10(7)
Animals : an open access journal from MDPI 2020 Jul 21;10(7)
Targeting the MAPK/ERK and PI3K/AKT Signaling Pathways Affects NRF2, Trx and GSH Antioxidant Systems in Leukemia Cells.
Jasek-Gajda E, Jurkowska H, Jasińska M, Lis GJ
Antioxidants (Basel, Switzerland) 2020 Jul 17;9(7)
Antioxidants (Basel, Switzerland) 2020 Jul 17;9(7)
Mechanism investigation on Bisphenol S-induced oxidative stress and inflammation in murine RAW264.7 cells: The role of NLRP3 inflammasome, TLR4, Nrf2 and MAPK.
Xie C, Ge M, Jin J, Xu H, Mao L, Geng S, Wu J, Zhu J, Li X, Zhong C
Journal of hazardous materials 2020 Jul 15;394:122549
Journal of hazardous materials 2020 Jul 15;394:122549
Hydrogen gas protects against delayed encephalopathy after acute carbon monoxide poisoning in a rat model.
Shen M, Zheng Y, Zhu K, Cai Z, Liu W, Sun X, Liu J, Zhu D
Neurological research 2020 Jan;42(1):22-30
Neurological research 2020 Jan;42(1):22-30
Inhibition of the Keap1-Nrf2 protein-protein interaction protects retinal cells and ameliorates retinal ischemia-reperfusion injury.
Hui Q, Karlstetter M, Xu Z, Yang J, Zhou L, Eilken HM, Terjung C, Cho H, Gong J, Lai MJ, Nassar K, Duh EJ
Free radical biology & medicine 2020 Jan;146:181-188
Free radical biology & medicine 2020 Jan;146:181-188
The expression of p-p62 and nuclear Nrf2 in esophageal squamous cell carcinoma and association with radioresistance.
Wang Z, Zhang J, Li M, Kong L, Yu J
Thoracic cancer 2020 Jan;11(1):130-139
Thoracic cancer 2020 Jan;11(1):130-139
Spermidine alleviates cardiac aging by improving mitochondrial biogenesis and function.
Wang J, Li S, Wang J, Wu F, Chen Y, Zhang H, Guo Y, Lin Y, Li L, Yu X, Liu T, Zhao Y
Aging 2020 Jan 6;12(1):650-671
Aging 2020 Jan 6;12(1):650-671
Baicalein Alleviates Liver Oxidative Stress and Apoptosis Induced by High-Level Glucose through the Activation of the PERK/Nrf2 Signaling Pathway.
Dong Y, Xing Y, Sun J, Sun W, Xu Y, Quan C
Molecules (Basel, Switzerland) 2020 Jan 30;25(3)
Molecules (Basel, Switzerland) 2020 Jan 30;25(3)
HIPK2 overexpression relieves hypoxia/reoxygenation-induced apoptosis and oxidative damage of cardiomyocytes through enhancement of the Nrf2/ARE signaling pathway.
Dang X, Zhang R, Peng Z, Qin Y, Sun J, Niu Z, Pei H
Chemico-biological interactions 2020 Jan 25;316:108922
Chemico-biological interactions 2020 Jan 25;316:108922
Critical role of caveolin-1 in aflatoxin B1-induced hepatotoxicity via the regulation of oxidation and autophagy.
Xu Q, Shi W, Lv P, Meng W, Mao G, Gong C, Chen Y, Wei Y, He X, Zhao J, Han H, Sun M, Xiao K
Cell death & disease 2020 Jan 2;11(1):6
Cell death & disease 2020 Jan 2;11(1):6
Activation of cannabinoid receptor type 2-induced osteogenic differentiation involves autophagy induction and p62-mediated Nrf2 deactivation.
Xu A, Yang Y, Shao Y, Wu M, Sun Y
Cell communication and signaling : CCS 2020 Jan 15;18(1):9
Cell communication and signaling : CCS 2020 Jan 15;18(1):9
Chronic toxicity of methamphetamine: Oxidative remodeling of pulmonary arteries.
Liang LY, Wang MM, Liu M, Zhao W, Wang X, Shi L, Zhu MJ, Zhao YL, Liu L, Maurya P, Wang Y
Toxicology in vitro : an international journal published in association with BIBRA 2020 Feb;62:104668
Toxicology in vitro : an international journal published in association with BIBRA 2020 Feb;62:104668
Activating PPARγ Increases NQO1 and γ-GCS Expression via Nrf2 in Thrombin-activated Microglia.
Hang H, Wang LK, Ren SY, Song AJ, Wu GF
Current medical science 2020 Feb;40(1):55-62
Current medical science 2020 Feb;40(1):55-62
Protective effect of Liraglutide on diabetic retinal neurodegeneration via inhibiting oxidative stress and endoplasmic reticulum stress.
Liu J, Wei L, Wang Z, Song S, Lin Z, Zhu J, Ren X, Kong L
Neurochemistry international 2020 Feb;133:104624
Neurochemistry international 2020 Feb;133:104624
Evaluation and Exploration of Potentially Bioactive Peptides in Casein Hydrolysates against Liver Oxidative Damage in STZ/HFD-Induced Diabetic Rats.
Wang C, Zheng L, Su G, Zeng XA, Sun B, Zhao M
Journal of agricultural and food chemistry 2020 Feb 26;68(8):2393-2405
Journal of agricultural and food chemistry 2020 Feb 26;68(8):2393-2405
NR1D1 modulates synovial inflammation and bone destruction in rheumatoid arthritis.
Liu H, Zhu Y, Gao Y, Qi D, Zhao L, Zhao L, Liu C, Tao T, Zhou C, Sun X, Guo F, Xiao J
Cell death & disease 2020 Feb 18;11(2):129
Cell death & disease 2020 Feb 18;11(2):129
Syringin protects against colitis by ameliorating inflammation.
Zhang H, Gu H, Jia Q, Zhao Y, Li H, Shen S, Liu X, Wang G, Shi Q
Archives of biochemistry and biophysics 2020 Feb 15;680:108242
Archives of biochemistry and biophysics 2020 Feb 15;680:108242
Codonopsis lanceolata polysaccharide CLPS alleviates high fat/high sucrose diet-induced insulin resistance via anti-oxidative stress.
Zhang Y, Wang H, Zhang L, Yuan Y, Yu D
International journal of biological macromolecules 2020 Feb 15;145:944-949
International journal of biological macromolecules 2020 Feb 15;145:944-949
Curcumin Protects Human Trophoblast HTR8/SVneo Cells from H2O2-Induced Oxidative Stress by Activating Nrf2 Signaling Pathway.
Qi L, Jiang J, Zhang J, Zhang L, Wang T
Antioxidants (Basel, Switzerland) 2020 Feb 1;9(2)
Antioxidants (Basel, Switzerland) 2020 Feb 1;9(2)
Protection of diabetes-induced kidney injury by phosphocreatine via the regulation of ERK/Nrf2/HO-1 signaling pathway.
Shopit A, Niu M, Wang H, Tang Z, Li X, Tesfaldet T, Ai J, Ahmad N, Al-Azab M, Tang Z
Life sciences 2020 Feb 1;242:117248
Life sciences 2020 Feb 1;242:117248
Autophagy Inhibition Enables Nrf2 to Exaggerate the Progression of Diabetic Cardiomyopathy in Mice.
Zang H, Wu W, Qi L, Tan W, Nagarkatti P, Nagarkatti M, Wang X, Cui T
Diabetes 2020 Dec;69(12):2720-2734
Diabetes 2020 Dec;69(12):2720-2734
Hepatoprotective effects of Camellia nitidissima aqueous ethanol extract against CCl4-induced acute liver injury in SD rats related to Nrf2 and NF-κB signalling.
Zhang X, Feng J, Su S, Huang L
Pharmaceutical biology 2020 Dec;58(1):239-246
Pharmaceutical biology 2020 Dec;58(1):239-246
Oxidative stress-mediated hepatotoxicity in rats induced by ethanol extracts of different parts of Chloranthus serratus.
Sun S, Wang Y, Du Y, Sun Q, He L, Zhu E, Li J
Pharmaceutical biology 2020 Dec;58(1):1277-1289
Pharmaceutical biology 2020 Dec;58(1):1277-1289
Resveratrol improves meat quality, muscular antioxidant capacity, lipid metabolism and fiber type composition of intrauterine growth retarded pigs.
Cheng K, Yu C, Li Z, Li S, Yan E, Song Z, Zhang H, Zhang L, Wang T
Meat science 2020 Dec;170:108237
Meat science 2020 Dec;170:108237
Functional Food XingJiuTang Attenuates Alcohol-Induced Liver Injury by Regulating SIRT1/Nrf-2 Signaling Pathway.
Hao J, Ding Y, Shi W, Zhang C, Li R
Chemistry & biodiversity 2020 Dec;17(12):e2000619
Chemistry & biodiversity 2020 Dec;17(12):e2000619
Curcumin-cyclodextrin/cellulose nanocrystals improve the phenotype of Charcot-Marie-Tooth-1A transgenic rats through the reduction of oxidative stress.
Caillaud M, Msheik Z, Ndong-Ntoutoume GM, Vignaud L, Richard L, Favreau F, Faye PA, Sturtz F, Granet R, Vallat JM, Sol V, Desmoulière A, Billet F
Free radical biology & medicine 2020 Dec;161:246-262
Free radical biology & medicine 2020 Dec;161:246-262
Silibinin ameliorats H2O2-induced cell apoptosis and oxidative stress response by activating Nrf2 signaling in trophoblast cells.
Guo H, Wang Y, Liu D
Acta histochemica 2020 Dec;122(8):151620
Acta histochemica 2020 Dec;122(8):151620
Enterovirus 71 induces neural cell apoptosis and autophagy through promoting ACOX1 downregulation and ROS generation.
You L, Chen J, Liu W, Xiang Q, Luo Z, Wang W, Xu W, Wu K, Zhang Q, Liu Y, Wu J
Virulence 2020 Dec;11(1):537-553
Virulence 2020 Dec;11(1):537-553
Oncogenic activation of PI3K-AKT-mTOR signaling suppresses ferroptosis via SREBP-mediated lipogenesis.
Yi J, Zhu J, Wu J, Thompson CB, Jiang X
Proceedings of the National Academy of Sciences of the United States of America 2020 Dec 8;117(49):31189-31197
Proceedings of the National Academy of Sciences of the United States of America 2020 Dec 8;117(49):31189-31197
Hylocereus polyrhizus Peel Extract Retards Alcoholic Liver Disease Progression by Modulating Oxidative Stress and Inflammatory Responses in C57BL/6 Mice.
Yeh WJ, Tsai CC, Ko J, Yang HY
Nutrients 2020 Dec 18;12(12)
Nutrients 2020 Dec 18;12(12)
TRIM16 protects human periodontal ligament stem cells from oxidative stress-induced damage via activation of PICOT.
Zhao Y, Liu H, Xi X, Chen S, Liu D
Experimental cell research 2020 Dec 1;397(1):112336
Experimental cell research 2020 Dec 1;397(1):112336
Effects of taraxasterol against ethanol and high-fat diet-induced liver injury by regulating TLR4/MyD88/NF-κB and Nrf2/HO-1 signaling pathways.
Li Z, Lian Y, Wei R, Jin L, Cao H, Zhao T, Ma X, Zhong M, Gao Y, Zhang K
Life sciences 2020 Dec 1;262:118546
Life sciences 2020 Dec 1;262:118546
Akebia Saponin D suppresses inflammation in chondrocytes via the NRF2/HO-1/NF-κB axis and ameliorates osteoarthritis in mice.
Gu M, Jin J, Ren C, Chen X, Gao W, Wang X, Wu Y, Tian N, Pan Z, Wu A, Zhou Y, Zhang X
Food & function 2020 Dec 1;11(12):10852-10863
Food & function 2020 Dec 1;11(12):10852-10863
Metformin attenuates cardiac remodeling in mice through the Nrf2/Keap1 signaling pathway.
Du J, Zhu M, Li H, Liang G, Li Y, Feng S
Experimental and therapeutic medicine 2020 Aug;20(2):838-845
Experimental and therapeutic medicine 2020 Aug;20(2):838-845
Antioxidant activity of selenium-enriched Chrysomyia megacephala (Fabricius) larvae powder and its impact on intestinal microflora in D-galactose induced aging mice.
Xie D, Jiang L, Lin Y, Liu Z
BMC complementary medicine and therapies 2020 Aug 27;20(1):264
BMC complementary medicine and therapies 2020 Aug 27;20(1):264
Effects of Launaea sarmentosa Extract on Lipopolysaccharide-Induced Inflammation via Suppression of NF-κB/MAPK Signaling and Nrf2 Activation.
Nguyen TQC, Binh TD, Kusunoki R, Pham TLA, Nguyen YDH, Nguyen TT, Kanaori K, Kamei K
Nutrients 2020 Aug 26;12(9)
Nutrients 2020 Aug 26;12(9)
Computational repositioning of dimethyl fumarate for treating alcoholic liver disease.
Zhang Y, Zhao S, Fu Y, Yan L, Feng Y, Chen Y, Wu Y, Deng Y, Zhang G, Chen Z, Chen Y, Liu T
Cell death & disease 2020 Aug 18;11(8):641
Cell death & disease 2020 Aug 18;11(8):641
Silychristin A activates Nrf2-HO-1/SOD2 pathway to reduce apoptosis and improve GLP-1 production through upregulation of estrogen receptor α in GLUTag cells.
Wang J, Zhang X, Zhang L, Yan T, Wu B, Xu F, Jia Y
European journal of pharmacology 2020 Aug 15;881:173236
European journal of pharmacology 2020 Aug 15;881:173236
l-Arginine Inhibits Apoptosis of Ovine Intestinal Epithelial Cells through the l-Arginine-Nitric Oxide Pathway.
Zhang H, Zhao F, Peng A, Guo S, Wang M, Elsabagh M, Loor JJ, Wang H
The Journal of nutrition 2020 Aug 1;150(8):2051-2060
The Journal of nutrition 2020 Aug 1;150(8):2051-2060
Dandelion Extract Alleviated Lipopolysaccharide-Induced Oxidative Stress through the Nrf2 Pathway in Bovine Mammary Epithelial Cells.
Sun Y, Wu Y, Wang Z, Chen J, Yang Y, Dong G
Toxins 2020 Aug 1;12(8)
Toxins 2020 Aug 1;12(8)
Protective effect of Dioscorea zingiberensis ethanol extract on the disruption of blood-testes barrier in high-fat diet/streptozotocin-induced diabetic mice by upregulating ZO-1 and Nrf2.
Zhou J, Xi Y, Zhang J, Tang J, Zhou X, Chen J, Nie C, Zhu Z, Ma B
Andrologia 2020 Apr;52(3):e13508
Andrologia 2020 Apr;52(3):e13508
Long noncoding RNA TUG1 regulates prostate cancer cell proliferation, invasion and migration via the Nrf2 signaling axis.
Yang G, Yin H, Lin F, Gao S, Zhan K, Tong H, Tang X, Pan Q, Gou X
Pathology, research and practice 2020 Apr;216(4):152851
Pathology, research and practice 2020 Apr;216(4):152851
Dimethyl itaconate, an itaconate derivative, exhibits immunomodulatory effects on neuroinflammation in experimental autoimmune encephalomyelitis.
Kuo PC, Weng WT, Scofield BA, Paraiso HC, Brown DA, Wang PY, Yu IC, Yen JH
Journal of neuroinflammation 2020 Apr 29;17(1):138
Journal of neuroinflammation 2020 Apr 29;17(1):138
4β-Hydroxywithanolide E from Goldenberry (Whole Fruits of Physalis peruviana L.) as a Promising Agent against Chronic Obstructive Pulmonary Disease.
Yang WJ, Chen XM, Wang SQ, Hu HX, Cheng XP, Xu LT, Ren DM, Wang XN, Zhao BB, Lou HX, Shen T
Journal of natural products 2020 Apr 24;83(4):1217-1228
Journal of natural products 2020 Apr 24;83(4):1217-1228
Maternal curcumin supplementation ameliorates placental function and fetal growth in mice with intrauterine growth retardation†.
Qi L, Jiang J, Zhang J, Zhang L, Wang T
Biology of reproduction 2020 Apr 24;102(5):1090-1101
Biology of reproduction 2020 Apr 24;102(5):1090-1101
Cyclovirobuxine D protects against diabetic cardiomyopathy by activating Nrf2-mediated antioxidant responses.
Jiang Z, Fu L, Xu Y, Hu X, Yang H, Zhang Y, Luo H, Gan S, Tao L, Liang G, Shen X
Scientific reports 2020 Apr 14;10(1):6427
Scientific reports 2020 Apr 14;10(1):6427
Compensatory upregulation of aldo-keto reductase 1B10 to protect hepatocytes against oxidative stress during hepatocarcinogenesis.
Liu Y, Zhang J, Liu H, Guan G, Zhang T, Wang L, Qi X, Zheng H, Chen CC, Liu J, Cao D, Lu F, Chen X
American journal of cancer research 2019;9(12):2730-2748
American journal of cancer research 2019;9(12):2730-2748
SIRT5 Promotes Cisplatin Resistance in Ovarian Cancer by Suppressing DNA Damage in a ROS-Dependent Manner via Regulation of the Nrf2/HO-1 Pathway.
Sun X, Wang S, Gai J, Guan J, Li J, Li Y, Zhao J, Zhao C, Fu L, Li Q
Frontiers in oncology 2019;9:754
Frontiers in oncology 2019;9:754
Involvement of the PI3K/Akt/Nrf2 Signaling Pathway in Resveratrol-Mediated Reversal of Drug Resistance in HL-60/ADR Cells.
Li Y, Guo Y, Feng Z, Bergan R, Li B, Qin Y, Zhao L, Zhang Z, Shi M
Nutrition and cancer 2019;71(6):1007-1018
Nutrition and cancer 2019;71(6):1007-1018
KLF2 Protects against Osteoarthritis by Repressing Oxidative Response through Activation of Nrf2/ARE Signaling In Vitro and In Vivo.
Gao X, Jiang S, Du Z, Ke A, Liang Q, Li X
Oxidative medicine and cellular longevity 2019;2019:8564681
Oxidative medicine and cellular longevity 2019;2019:8564681
Myricetin Alleviates Pathological Cardiac Hypertrophy via TRAF6/TAK1/MAPK and Nrf2 Signaling Pathway.
Liao HH, Zhang N, Meng YY, Feng H, Yang JJ, Li WJ, Chen S, Wu HM, Deng W, Tang QZ
Oxidative medicine and cellular longevity 2019;2019:6304058
Oxidative medicine and cellular longevity 2019;2019:6304058
CCl4-Induced Liver Injury Was Ameliorated by Qi-Ge Decoction through the Antioxidant Pathway.
Peng C, Zhou ZM, Li J, Luo Y, Zhou YS, Ke XH, Huang KE
Evidence-based complementary and alternative medicine : eCAM 2019;2019:5941263
Evidence-based complementary and alternative medicine : eCAM 2019;2019:5941263
Carnosine Protects Mouse Podocytes from High Glucose Induced Apoptosis through PI3K/AKT and Nrf2 Pathways.
Zhao K, Li Y, Wang Z, Han N, Wang Y
BioMed research international 2019;2019:4348973
BioMed research international 2019;2019:4348973
Effects of Ethyl Pyruvate on Bile Duct Ligation-Induced Liver Fibrosis by Regulating Nrf2 Pathway and Proinflammatory Cytokines in Rats.
Zong Y, Zhang M, Li S, Qi W, Li J, Liu T, Yang H, Lu C, Hu X
Gastroenterology research and practice 2019;2019:2969802
Gastroenterology research and practice 2019;2019:2969802
Salvianolic Acid A Protects the Kidney against Oxidative Stress by Activating the Akt/GSK-3β/Nrf2 Signaling Pathway and Inhibiting the NF-κB Signaling Pathway in 5/6 Nephrectomized Rats.
Zhang HF, Wang JH, Wang YL, Gao C, Gu YT, Huang J, Wang JH, Zhang Z
Oxidative medicine and cellular longevity 2019;2019:2853534
Oxidative medicine and cellular longevity 2019;2019:2853534
Nrf2/Keap1/ARE Signaling Mediated an Antioxidative Protection of Human Placental Mesenchymal Stem Cells of Fetal Origin in Alveolar Epithelial Cells.
Yan X, Fu X, Jia Y, Ma X, Tao J, Yang T, Ma H, Liang X, Liu X, Yang J, Wei J
Oxidative medicine and cellular longevity 2019;2019:2654910
Oxidative medicine and cellular longevity 2019;2019:2654910
CGRP Reduces Apoptosis of DRG Cells Induced by High-Glucose Oxidative Stress Injury through PI3K/AKT Induction of Heme Oxygenase-1 and Nrf-2 Expression.
Liu Y, Zhang S, Xue J, Wei Z, Ao P, Shen B, Ding L
Oxidative medicine and cellular longevity 2019;2019:2053149
Oxidative medicine and cellular longevity 2019;2019:2053149
Protective Effects of Dioscin Against Doxorubicin-Induced Hepatotoxicity Via Regulation of Sirt1/FOXO1/NF-κb Signal.
Song S, Chu L, Liang H, Chen J, Liang J, Huang Z, Zhang B, Chen X
Frontiers in pharmacology 2019;10:1030
Frontiers in pharmacology 2019;10:1030
Protective mechanism of Taxifolin for chlorpyrifos neurotoxicity in BV2 cells.
Zhang C, Zhan J, Zhao M, Dai H, Deng Y, Zhou W, Zhao L
Neurotoxicology 2019 Sep;74:74-80
Neurotoxicology 2019 Sep;74:74-80
Ellagic acid supports neuron by regulating astroglia Nrf2.
Wang GQ, He XM, Zhu GF, Li DD, Shi JS, Zhang F
Biotechnology and applied biochemistry 2019 Sep;66(5):738-743
Biotechnology and applied biochemistry 2019 Sep;66(5):738-743
Novel diterpenoid-type activators of the Keap1/Nrf2/ARE signaling pathway and their regulation of redox homeostasis.
Li AL, Shen T, Wang T, Zhou MX, Wang B, Song JT, Zhang PL, Wang XL, Ren DM, Lou HX, Wang XN
Free radical biology & medicine 2019 Sep;141:21-33
Free radical biology & medicine 2019 Sep;141:21-33
Kinsenoside ameliorates intervertebral disc degeneration through the activation of AKT-ERK1/2-Nrf2 signaling pathway.
Wang Y, Zuo R, Wang Z, Luo L, Wu J, Zhang C, Liu M, Shi C, Zhou Y
Aging 2019 Sep 23;11(18):7961-7977
Aging 2019 Sep 23;11(18):7961-7977
The Potential of Neoagaro-Oligosaccharides as a Treatment of Type II Diabetes in Mice.
Lin F, Yang D, Huang Y, Zhao Y, Ye J, Xiao M
Marine drugs 2019 Sep 20;17(10)
Marine drugs 2019 Sep 20;17(10)
Structural Characterization and Antioxidant Activity of Polysaccharides from Athyrium multidentatum (Doll.) Ching in d-Galactose-Induced Aging Mice via PI3K/AKT Pathway.
Jing L, Jiang JR, Liu DM, Sheng JW, Zhang WF, Li ZJ, Wei LY
Molecules (Basel, Switzerland) 2019 Sep 16;24(18)
Molecules (Basel, Switzerland) 2019 Sep 16;24(18)
Lysosomal dysfunction is associated with persistent lung injury in dams caused by pregnancy exposure to carbon black nanoparticles.
Liu X, Tu B, Jiang X, Xu G, Bai L, Zhang L, Meng P, Qin X, Chen C, Zou Z
Life sciences 2019 Sep 15;233:116741
Life sciences 2019 Sep 15;233:116741
Torularhodin Ameliorates Oxidative Activity in Vitro and d-Galactose-Induced Liver Injury via the Nrf2/HO-1 Signaling Pathway in Vivo.
Liu C, Cui Y, Pi F, Guo Y, Cheng Y, Qian H
Journal of agricultural and food chemistry 2019 Sep 11;67(36):10059-10068
Journal of agricultural and food chemistry 2019 Sep 11;67(36):10059-10068
Xanthohumol inhibits PRRSV proliferation and alleviates oxidative stress induced by PRRSV via the Nrf2-HMOX1 axis.
Liu X, Song Z, Bai J, Nauwynck H, Zhao Y, Jiang P
Veterinary research 2019 Sep 11;50(1):61
Veterinary research 2019 Sep 11;50(1):61
Artocarmitin B enhances intracellular antioxidant capacity via activation of Nrf2 signaling pathway in human lung epithelial cells.
Wu XY, Chen XM, Zhou MX, Hu HX, Zhang JZ, Wang XN, Ren DM, Lou HX, Shen T
Chemico-biological interactions 2019 Sep 1;310:108741
Chemico-biological interactions 2019 Sep 1;310:108741
Rice protein reduces DNA damage by activating the p53 pathway and stimulating endogenous antioxidant response in growing and adult rats.
Liang M, Li H, Wang Z, Cai L, Yang L
Journal of the science of food and agriculture 2019 Oct;99(13):6097-6107
Journal of the science of food and agriculture 2019 Oct;99(13):6097-6107
Allicin ameliorates obesity comorbid depressive-like behaviors: involvement of the oxidative stress, mitochondrial function, autophagy, insulin resistance and NOX/Nrf2 imbalance in mice.
Gao W, Wang W, Zhang J, Deng P, Hu J, Yang J, Deng Z
Metabolic brain disease 2019 Oct;34(5):1267-1280
Metabolic brain disease 2019 Oct;34(5):1267-1280
Resveratrol reduces brain injury after subarachnoid hemorrhage by inhibiting oxidative stress and endoplasmic reticulum stress.
Xie YK, Zhou X, Yuan HT, Qiu J, Xin DQ, Chu XL, Wang DC, Wang Z
Neural regeneration research 2019 Oct;14(10):1734-1742
Neural regeneration research 2019 Oct;14(10):1734-1742
Phytochemical composition, isolation and hepatoprotective activity of active fraction from Veronica ciliata against acetaminophen-induced acute liver injury via p62-Keap1-Nrf2 signaling pathway.
Lu Q, Tan S, Gu W, Li F, Hua W, Zhang S, Chen F, Tang L
Journal of ethnopharmacology 2019 Oct 28;243:112089
Journal of ethnopharmacology 2019 Oct 28;243:112089
Botrysphin D attenuates arsenic-induced oxidative stress in human lung epithelial cells via activating Nrf2/ARE signaling pathways.
Wang T, Sun XY, Li AL, Zhou MX, Han Y, Zhang JZ, Ren DM, Lou HX, Wang XN, Shen T
Biochemical and biophysical research communications 2019 Oct 20;518(3):526-532
Biochemical and biophysical research communications 2019 Oct 20;518(3):526-532
γ-Oryzanol alleviates acetaminophen-induced liver injury: roles of modulating AMPK/GSK3β/Nrf2 and NF-κB signaling pathways.
Shu G, Qiu Y, Hao J, Fu Q, Deng X
Food & function 2019 Oct 16;10(10):6858-6872
Food & function 2019 Oct 16;10(10):6858-6872
Oxidation Stress-Mediated MAPK Signaling Pathway Activation Induces Neuronal Loss in the CA1 and CA3 Regions of the Hippocampus of Mice Following Chronic Cold Exposure.
Xu B, Lang LM, Lian S, Guo JR, Wang JF, Yang HM, Li SZ
Brain sciences 2019 Oct 12;9(10)
Brain sciences 2019 Oct 12;9(10)
Neuroprotection of Andrographolide Against Microglia-Mediated Inflammatory Injury and Oxidative Damage in PC12 Neurons.
Xu Y, Tang D, Wang J, Wei H, Gao J
Neurochemical research 2019 Nov;44(11):2619-2630
Neurochemical research 2019 Nov;44(11):2619-2630
Absence of Dipeptidyl Peptidase 3 Increases Oxidative Stress and Causes Bone Loss.
Menale C, Robinson LJ, Palagano E, Rigoni R, Erreni M, Almarza AJ, Strina D, Mantero S, Lizier M, Forlino A, Besio R, Monari M, Vezzoni P, Cassani B, Blair HC, Villa A, Sobacchi C
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2019 Nov;34(11):2133-2148
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2019 Nov;34(11):2133-2148
The protective effect of lithocholic acid on the intestinal epithelial barrier is mediated by the vitamin D receptor via a SIRT1/Nrf2 and NF-κB dependent mechanism in Caco-2 cells.
Yao B, He J, Yin X, Shi Y, Wan J, Tian Z
Toxicology letters 2019 Nov;316:109-118
Toxicology letters 2019 Nov;316:109-118
MicroRNA-24 inhibits the oxidative stress induced by vascular injury by activating the Nrf2/Ho-1 signaling pathway.
Zhang J, Cai W, Fan Z, Yang C, Wang W, Xiong M, Ma C, Yang J
Atherosclerosis 2019 Nov;290:9-18
Atherosclerosis 2019 Nov;290:9-18
The roles of Nrf2 and autophagy in modulating inflammation mediated by TLR4 - NFκB in A549 cell exposed to layer house particulate matter 2.5 (PM2.5).
Dai P, Shen D, Shen J, Tang Q, Xi M, Li Y, Li C
Chemosphere 2019 Nov;235:1134-1145
Chemosphere 2019 Nov;235:1134-1145
Spinosin and 6'''‑Feruloylspinosin protect the heart against acute myocardial ischemia and reperfusion in rats.
Gu M, He P, Lyu C, Liu X, Xu Y, Cheng S, Gu Y, Jia Y
Molecular medicine reports 2019 Nov;20(5):4253-4261
Molecular medicine reports 2019 Nov;20(5):4253-4261
Transsulfuration Activity Can Support Cell Growth upon Extracellular Cysteine Limitation.
Zhu J, Berisa M, Schwörer S, Qin W, Cross JR, Thompson CB
Cell metabolism 2019 Nov 5;30(5):865-876.e5
Cell metabolism 2019 Nov 5;30(5):865-876.e5
Astaxanthin protects against osteoarthritis via Nrf2: a guardian of cartilage homeostasis.
Sun K, Luo J, Jing X, Guo J, Yao X, Hao X, Ye Y, Liang S, Lin J, Wang G, Guo F
Aging 2019 Nov 26;11(22):10513-10531
Aging 2019 Nov 26;11(22):10513-10531
Chitosan Oligosaccharide Attenuates Nonalcoholic Fatty Liver Disease Induced by High Fat Diet through Reducing Lipid Accumulation, Inflammation and Oxidative Stress in C57BL/6 Mice.
Tao W, Sun W, Liu L, Wang G, Xiao Z, Pei X, Wang M
Marine drugs 2019 Nov 16;17(11)
Marine drugs 2019 Nov 16;17(11)
Promising therapeutic effect of thapsigargin nanoparticles on chronic kidney disease through the activation of Nrf2 and FoxO1.
Cheng FY, Lee YH, Hsu YH, Chiu IJ, Chiu YJ, Lin YF, Chiu HW
Aging 2019 Nov 12;11(21):9875-9892
Aging 2019 Nov 12;11(21):9875-9892
Protective effect of dihydroartemisinin in inhibiting senescence of myeloid-derived suppressor cells from lupus mice via Nrf2/HO-1 pathway.
Li D, Qi J, Wang J, Pan Y, Li J, Xia X, Dou H, Hou Y
Free radical biology & medicine 2019 Nov 1;143:260-274
Free radical biology & medicine 2019 Nov 1;143:260-274
S-1-propenylmercaptocysteine protects murine hepatocytes against oxidative stress via persulfidation of Keap1 and activation of Nrf2.
Tocmo R, Parkin K
Free radical biology & medicine 2019 Nov 1;143:164-175
Free radical biology & medicine 2019 Nov 1;143:164-175
The anti-nephritic activity of a polysaccharide from okra (Abelmoschus esculentus (L.) Moench) via modulation of AMPK-Sirt1-PGC-1α signaling axis mediated anti-oxidative in type 2 diabetes model mice.
Liao Z, Zhang J, Wang J, Yan T, Xu F, Wu B, Xiao F, Bi K, Niu J, Jia Y
International journal of biological macromolecules 2019 Nov 1;140:568-576
International journal of biological macromolecules 2019 Nov 1;140:568-576
Hydrogen sulfide ameliorates disorders in the parafacial respiratory group region of neonatal rats caused by prenatal cigarette smoke exposure via an antioxidative effect.
Yan X, Zhao F, Zhang S, Lei F, Wang W, Zheng Y
Environmental toxicology and pharmacology 2019 May;68:80-90
Environmental toxicology and pharmacology 2019 May;68:80-90
Effects of KEAP1 Silencing on the Regulation of NRF2 Activity in Neuroendocrine Lung Tumors.
Sparaneo A, Fabrizio FP, la Torre A, Graziano P, Di Maio M, Fontana A, Bisceglia M, Rossi A, Pizzolitto S, De Maglio G, Tancredi A, Grimaldi F, Balsamo T, Centra F, Manzorra MC, Trombetta D, Pantalone A, Bonfitto A, Maiello E, Fazio VM, Muscarella LA
International journal of molecular sciences 2019 May 23;20(10)
International journal of molecular sciences 2019 May 23;20(10)
Polysaccharide from Okra (Abelmoschus esculentus (L.) Moench) Improves Antioxidant Capacity via PI3K/AKT Pathways and Nrf2 Translocation in a Type 2 Diabetes Model.
Liao Z, Zhang J, Liu B, Yan T, Xu F, Xiao F, Wu B, Bi K, Jia Y
Molecules (Basel, Switzerland) 2019 May 17;24(10)
Molecules (Basel, Switzerland) 2019 May 17;24(10)
Comparison of the Hepatoprotective Effects of the Three Main Stilbenes from Mulberry Twigs.
Jia YN, Peng YL, Zhao YP, Cheng XF, Zhou Y, Chai CL, Zeng LS, Pan MH, Xu L
Journal of agricultural and food chemistry 2019 May 15;67(19):5521-5529
Journal of agricultural and food chemistry 2019 May 15;67(19):5521-5529
Astragaloside IV Regulates the PI3K/Akt/HO-1 Signaling Pathway and Inhibits H9c2 Cardiomyocyte Injury Induced by Hypoxia-Reoxygenation.
Yang P, Zhou Y, Xia Q, Yao L, Chang X
Biological & pharmaceutical bulletin 2019 May 1;42(5):721-727
Biological & pharmaceutical bulletin 2019 May 1;42(5):721-727
N-acetylcysteine alleviates fluoride-induced testicular apoptosis by modulating IRE1α/JNK signaling and nuclear Nrf2 activation.
Hu Y, Wang Y, Yan T, Feng D, Ba Y, Zhang H, Zhu J, Cheng X, Cui L, Huang H
Reproductive toxicology (Elmsford, N.Y.) 2019 Mar;84:98-107
Reproductive toxicology (Elmsford, N.Y.) 2019 Mar;84:98-107
Hepatoprotective effects and structure-activity relationship of five flavonoids against lipopolysaccharide/d-galactosamine induced acute liver failure in mice.
He Y, Xia Z, Yu D, Wang J, Jin L, Huang D, Ye X, Li X, Zhang B
International immunopharmacology 2019 Mar;68:171-178
International immunopharmacology 2019 Mar;68:171-178
Betaine protects against heat exposure-induced oxidative stress and apoptosis in bovine mammary epithelial cells via regulation of ROS production.
Li C, Wang Y, Li L, Han Z, Mao S, Wang G
Cell stress & chaperones 2019 Mar;24(2):453-460
Cell stress & chaperones 2019 Mar;24(2):453-460
Arsenic trioxide inhibits the differentiation of fibroblasts to myofibroblasts through nuclear factor erythroid 2-like 2 (NFE2L2) protein and the Smad2/3 pathway.
Zhong L, Hao H, Chen D, Hou Q, Zhu Z, He W, Sun S, Sun M, Li M, Fu X
Journal of cellular physiology 2019 Mar;234(3):2606-2617
Journal of cellular physiology 2019 Mar;234(3):2606-2617
Combinatory FK506 and Minocycline Treatment Alleviates Prion-Induced Neurodegenerative Events via Caspase-Mediated MAPK-NRF2 Pathway.
Shah SZA, Zhao D, Taglialatela G, Hussain T, Dong H, Sabir N, Mangi MH, Wu W, Lai M, Zhang X, Duan Y, Wang L, Zhou X, Yang L
International journal of molecular sciences 2019 Mar 6;20(5)
International journal of molecular sciences 2019 Mar 6;20(5)
Costunolide inhibits pulmonary fibrosis via regulating NF-kB and TGF-β1/Smad2/Nrf2-NOX4 signaling pathways.
Liu B, Rong Y, Sun D, Li W, Chen H, Cao B, Wang T
Biochemical and biophysical research communications 2019 Mar 5;510(2):329-333
Biochemical and biophysical research communications 2019 Mar 5;510(2):329-333
Neuroprotective Effect of Dioscin on the Aging Brain.
Qi Y, Li R, Xu L, Yin L, Xu Y, Han X, Peng J
Molecules (Basel, Switzerland) 2019 Mar 30;24(7)
Molecules (Basel, Switzerland) 2019 Mar 30;24(7)
Inhibition of SGK1 confers vulnerability to redox dysregulation in cervical cancer.
Wang M, Xue Y, Shen L, Qin P, Sang X, Tao Z, Yi J, Wang J, Liu P, Cheng H
Redox biology 2019 Jun;24:101225
Redox biology 2019 Jun;24:101225
Hydrogen sulfide protects against DSS-induced colitis by inhibiting NLRP3 inflammasome.
Qin M, Long F, Wu W, Yang D, Huang M, Xiao C, Chen X, Liu X, Zhu YZ
Free radical biology & medicine 2019 Jun;137:99-109
Free radical biology & medicine 2019 Jun;137:99-109
Curcumin upregulates the Nrf2 system by repressing inflammatory signaling-mediated Keap1 expression in insulin-resistant conditions.
Ren L, Zhan P, Wang Q, Wang C, Liu Y, Yu Z, Zhang S
Biochemical and biophysical research communications 2019 Jun 30;514(3):691-698
Biochemical and biophysical research communications 2019 Jun 30;514(3):691-698
Selenepezil, a Selenium-Containing Compound, Exerts Neuroprotective Effect via Modulation of the Keap1-Nrf2-ARE Pathway and Attenuates Aβ-Induced Cognitive Impairment in Vivo.
Yan J, Pang Y, Zhuang J, Lin H, Zhang Q, Han L, Ke P, Zhuang J, Huang X
ACS chemical neuroscience 2019 Jun 19;10(6):2903-2914
ACS chemical neuroscience 2019 Jun 19;10(6):2903-2914
Cortisol Excess-Mediated Mitochondrial Damage Induced Hippocampal Neuronal Apoptosis in Mice Following Cold Exposure.
Xu B, Lang LM, Li SZ, Guo JR, Wang JF, Wang D, Zhang LP, Yang HM, Lian S
Cells 2019 Jun 18;8(6)
Cells 2019 Jun 18;8(6)
Potent 5-Cyano-6-phenyl-pyrimidin-Based Derivatives Targeting DCN1-UBE2M Interaction.
Zhou W, Ma L, Ding L, Guo Q, He Z, Yang J, Qiao H, Li L, Yang J, Yu S, Zhao L, Wang S, Liu HM, Suo Z, Zhao W
Journal of medicinal chemistry 2019 Jun 13;62(11):5382-5403
Journal of medicinal chemistry 2019 Jun 13;62(11):5382-5403
Cordycepin prevents radiation ulcer by inhibiting cell senescence via NRF2 and AMPK in rodents.
Wang Z, Chen Z, Jiang Z, Luo P, Liu L, Huang Y, Wang H, Wang Y, Long L, Tan X, Liu D, Jin T, Wang Y, Wang Y, Liao F, Zhang C, Chen L, Gan Y, Liu Y, Yang F, Huang C, Miao H, Chen J, Cheng T, Fu X, Shi C
Nature communications 2019 Jun 10;10(1):2538
Nature communications 2019 Jun 10;10(1):2538
p62/SQSTM1 and Nrf2 are essential for exercise-mediated enhancement of antioxidant protein expression in oxidative muscle.
Yamada M, Iwata M, Warabi E, Oishi H, Lira VA, Okutsu M
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2019 Jul;33(7):8022-8032
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2019 Jul;33(7):8022-8032
Hesperetin suppresses RANKL-induced osteoclastogenesis and ameliorates lipopolysaccharide-induced bone loss.
Liu H, Dong Y, Gao Y, Zhao L, Cai C, Qi D, Zhu M, Zhao L, Liu C, Guo F, Xiao J, Huang H
Journal of cellular physiology 2019 Jul;234(7):11009-11022
Journal of cellular physiology 2019 Jul;234(7):11009-11022
Inhibitory Effects of Oxymatrine on Transdifferentiation of Neonatal Rat Cardiac Fibroblasts to Myofibroblasts Induced by Aldosterone via Keap1/Nrf2 Signaling Pathways In Vitro.
Yang Y, Chen S, Tao L, Gan S, Luo H, Xu Y, Shen X
Medical science monitor : international medical journal of experimental and clinical research 2019 Jul 20;25:5375-5388
Medical science monitor : international medical journal of experimental and clinical research 2019 Jul 20;25:5375-5388
Melatonin protects circulatory death heart from ischemia/reperfusion injury via the JAK2/STAT3 signalling pathway.
Lan H, Su Y, Liu Y, Deng C, Wang J, Chen T, Jules KED, Masau JF, Li H, Wei X
Life sciences 2019 Jul 1;228:35-46
Life sciences 2019 Jul 1;228:35-46
Ginsenoside Compound K Regulates Amyloid β via the Nrf2/Keap1 Signaling Pathway in Mice with Scopolamine Hydrobromide-Induced Memory Impairments.
Yang Q, Lin J, Zhang H, Liu Y, Kan M, Xiu Z, Chen X, Lan X, Li X, Shi X, Li N, Qu X
Journal of molecular neuroscience : MN 2019 Jan;67(1):62-71
Journal of molecular neuroscience : MN 2019 Jan;67(1):62-71
Induction of Endoplasmic Reticulum Stress by Cadmium and Its Regulation on Nrf2 Signaling Pathway in Kidneys of Rats.
Chen ZJ, Chen JX, Wu LK, Li BY, Tian YF, Xian M, Huang ZP, Yu RA
Biomedical and environmental sciences : BES 2019 Jan;32(1):1-10
Biomedical and environmental sciences : BES 2019 Jan;32(1):1-10
Naringenin targets on astroglial Nrf2 to support dopaminergic neurons.
Wang GQ, Zhang B, He XM, Li DD, Shi JS, Zhang F
Pharmacological research 2019 Jan;139:452-459
Pharmacological research 2019 Jan;139:452-459
Potential mechanisms underlying the protective effects of salvianic acid A against atherosclerosis in vivo and vitro.
Song Q, Zhang Y, Han X, Zhang Y, Zhang X, Gao Y, Zhang J, Chu L, Zhao S
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2019 Jan;109:945-956
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2019 Jan;109:945-956
Antagonistic effect of epigallocatechin-3-gallate on neurotoxicity induced by formaldehyde.
Huang J, Lu Y, Zhang B, Yang S, Zhang Q, Cui H, Lu X, Zhao Y, Yang X, Li R
Toxicology 2019 Jan 15;412:29-36
Toxicology 2019 Jan 15;412:29-36
Differential response to lead toxicity in rat primary microglia and astrocytes.
Peng J, Zhou F, Wang Y, Xu Y, Zhang H, Zou F, Meng X
Toxicology and applied pharmacology 2019 Jan 15;363:64-71
Toxicology and applied pharmacology 2019 Jan 15;363:64-71
Sulforaphane Improves Lipid Metabolism by Enhancing Mitochondrial Function and Biogenesis In Vivo and In Vitro.
Lei P, Tian S, Teng C, Huang L, Liu X, Wang J, Zhang Y, Li B, Shan Y
Molecular nutrition & food research 2019 Feb;63(4):e1800795
Molecular nutrition & food research 2019 Feb;63(4):e1800795
Allicin attenuated chronic social defeat stress induced depressive-like behaviors through suppression of NLRP3 inflammasome.
Gao W, Wang W, Liu G, Zhang J, Yang J, Deng Z
Metabolic brain disease 2019 Feb;34(1):319-329
Metabolic brain disease 2019 Feb;34(1):319-329
Electroacupuncture at ST-36 ameliorates DSS-induced acute colitis via regulating macrophage polarization induced by suppressing NLRP3/IL-1β and promoting Nrf2/HO-1.
Song S, An J, Li Y, Liu S
Molecular immunology 2019 Feb;106:143-152
Molecular immunology 2019 Feb;106:143-152
Pterostilbene alleviates hydrogen peroxide-induced oxidative stress via nuclear factor erythroid 2 like 2 pathway in mouse preimplantation embryos.
Ullah O, Li Z, Ali I, Xu L, Liu H, Shah SZA, Fang N
The Journal of reproduction and development 2019 Feb 8;65(1):73-81
The Journal of reproduction and development 2019 Feb 8;65(1):73-81
Activation of Nrf2/Keap1 pathway by oral Dimethylfumarate administration alleviates oxidative stress and age-associated infertility might be delayed in the mouse ovary.
Akino N, Wada-Hiraike O, Isono W, Terao H, Honjo H, Miyamoto Y, Tanikawa M, Sone K, Hirano M, Harada M, Hirata T, Hirota Y, Koga K, Oda K, Fujii T, Osuga Y
Reproductive biology and endocrinology : RB&E 2019 Feb 13;17(1):23
Reproductive biology and endocrinology : RB&E 2019 Feb 13;17(1):23
Dexmedetomidine attenuates lipopolysaccharide-induced liver oxidative stress and cell apoptosis in rats by increasing GSK-3β/MKP-1/Nrf2 pathway activity via the α2 adrenergic receptor.
Sha J, Zhang H, Zhao Y, Feng X, Hu X, Wang C, Song M, Fan H
Toxicology and applied pharmacology 2019 Feb 1;364:144-152
Toxicology and applied pharmacology 2019 Feb 1;364:144-152
Effect of hydrogen-rich water on the Nrf2/ARE signaling pathway in rats with myocardial ischemia-reperfusion injury.
Li L, Liu T, Liu L, Li S, Zhang Z, Zhang R, Zhou Y, Liu F
Journal of bioenergetics and biomembranes 2019 Dec;51(6):393-402
Journal of bioenergetics and biomembranes 2019 Dec;51(6):393-402
Punicalagin Reversed the Hepatic Injury of Tetrachloromethane by Antioxidation and Enhancement of Autophagy.
Luo J, Long Y, Ren G, Zhang Y, Chen J, Huang R, Yang L
Journal of medicinal food 2019 Dec;22(12):1271-1279
Journal of medicinal food 2019 Dec;22(12):1271-1279
Oxidative gastric mucosal damage induced by ischemia/reperfusion and the mechanisms of its prevention by carbon monoxide-releasing tricarbonyldichlororuthenium (II) dimer.
Magierowska K, Korbut E, Hubalewska-Mazgaj M, Surmiak M, Chmura A, Bakalarz D, Buszewicz G, Wójcik D, Śliwowski Z, Ginter G, Gromowski T, Kwiecień S, Brzozowski T, Magierowski M
Free radical biology & medicine 2019 Dec;145:198-208
Free radical biology & medicine 2019 Dec;145:198-208
Astragaloside IV Protects Against Oxidative Stress in Calf Small Intestine Epithelial Cells via NFE2L2-Antioxidant Response Element Signaling.
Wang Y, Jiang F, Cheng H, Tan X, Liu Y, Wei C, Song E
International journal of molecular sciences 2019 Dec 5;20(24)
International journal of molecular sciences 2019 Dec 5;20(24)
Dietary Curcumin Supplementation Increases Antioxidant Capacity, Upregulates Nrf2 and Hmox1 Levels in the Liver of Piglet Model with Intrauterine Growth Retardation.
Niu Y, He J, Ahmad H, Shen M, Zhao Y, Gan Z, Zhang L, Zhong X, Wang C, Wang T
Nutrients 2019 Dec 5;11(12)
Nutrients 2019 Dec 5;11(12)
Curcumin Alleviates IUGR Jejunum Damage by Increasing Antioxidant Capacity through Nrf2/Keap1 Pathway in Growing Pigs.
Yan E, Zhang J, Han H, Wu J, Gan Z, Wei C, Zhang L, Wang C, Wang T
Animals : an open access journal from MDPI 2019 Dec 24;10(1)
Animals : an open access journal from MDPI 2019 Dec 24;10(1)
Water-separated part of Chloranthus serratus alleviates lipopolysaccharide- induced RAW264.7 cell injury mainly by regulating the MAPK and Nrf2/HO-1 inflammatory pathways.
Sun S, Du Y, Yin C, Suo X, Wang R, Xia R, Zhang X
BMC complementary and alternative medicine 2019 Dec 2;19(1):343
BMC complementary and alternative medicine 2019 Dec 2;19(1):343
Melatonin ameliorates cerebral ischemia/reperfusion injury through SIRT3 activation.
Liu L, Chen H, Jin J, Tang Z, Yin P, Zhong D, Li G
Life sciences 2019 Dec 15;239:117036
Life sciences 2019 Dec 15;239:117036
Discovery of coumarin-derived imino sulfonates as a novel class of potential cardioprotective agents.
Wei B, Zhou J, Xu JJ, Cui J, Ping FF, Ling JJ, Chen YJ
European journal of medicinal chemistry 2019 Dec 15;184:111779
European journal of medicinal chemistry 2019 Dec 15;184:111779
Dietary Dihydroartemisinin Supplementation Attenuates Hepatic Oxidative Damage of Weaned Piglets with Intrauterine Growth Retardation through the Nrf2/ARE Signaling Pathway.
Zhao Y, Niu Y, He J, Zhang L, Wang C, Wang T
Animals : an open access journal from MDPI 2019 Dec 13;9(12)
Animals : an open access journal from MDPI 2019 Dec 13;9(12)
Protective Effects of Fucoidan against Hydrogen Peroxide-Induced Oxidative Damage in Porcine Intestinal Epithelial Cells.
Li Y, Zhao W, Wang L, Chen Y, Zhang H, Wang T, Yang X, Xing F, Yan J, Fang X
Animals : an open access journal from MDPI 2019 Dec 10;9(12)
Animals : an open access journal from MDPI 2019 Dec 10;9(12)
Icariin targets Nrf2 signaling to inhibit microglia-mediated neuroinflammation.
Zheng Y, Zhu G, He J, Wang G, Li D, Zhang F
International immunopharmacology 2019 Aug;73:304-311
International immunopharmacology 2019 Aug;73:304-311
Disubstituted Dithiolethione ACDT Exerts Neuroprotective Effects Against 6-Hydroxydopamine-Induced Oxidative Stress in SH-SY5Y Cells.
Betharia S, Rondόn-Ortiz AN, Brown DA
Neurochemical research 2019 Aug;44(8):1878-1892
Neurochemical research 2019 Aug;44(8):1878-1892
MicroRNA-128-3p aggravates doxorubicin-induced liver injury by promoting oxidative stress via targeting Sirtuin-1.
Zhao X, Jin Y, Li L, Xu L, Tang Z, Qi Y, Yin L, Peng J
Pharmacological research 2019 Aug;146:104276
Pharmacological research 2019 Aug;146:104276
l-Methionine activates Nrf2-ARE pathway to induce endogenous antioxidant activity for depressing ROS-derived oxidative stress in growing rats.
Wang Z, Liang M, Li H, Cai L, He H, Wu Q, Yang L
Journal of the science of food and agriculture 2019 Aug 15;99(10):4849-4862
Journal of the science of food and agriculture 2019 Aug 15;99(10):4849-4862
HO-1 reduces heat stress-induced apoptosis in bovine granulosa cells by suppressing oxidative stress.
Wang Y, Yang C, Elsheikh NAH, Li C, Yang F, Wang G, Li L
Aging 2019 Aug 12;11(15):5535-5547
Aging 2019 Aug 12;11(15):5535-5547
Correction: Total saponins from Rosa laevigata Michx fruit attenuates hepatic steatosis induced by high-fat diet in rats.
Dong D, Qi Y, Xu L, Yin L, Xu Y, Han X, Zhao Y, Peng J
Food & function 2019 Aug 1;10(8):5240-5241
Food & function 2019 Aug 1;10(8):5240-5241
KLF15 regulates endobiotic and xenobiotic metabolism.
Han S, Ray JW, Pathak P, Sweet DR, Zhang R, Gao H, Jain N, Koritzinsky EH, Matoba K, Xu W, Chan ER, Simon DI, Jain MK
Nature metabolism 2019 Apr;1(4):422-430
Nature metabolism 2019 Apr;1(4):422-430
Icariin attenuates neuroinflammation and exerts dopamine neuroprotection via an Nrf2-dependent manner.
Zhang B, Wang G, He J, Yang Q, Li D, Li J, Zhang F
Journal of neuroinflammation 2019 Apr 22;16(1):92
Journal of neuroinflammation 2019 Apr 22;16(1):92
Paeonol Ameliorates Diabetic Renal Fibrosis Through Promoting the Activation of the Nrf2/ARE Pathway via Up-Regulating Sirt1.
Zhang L, Chen Z, Gong W, Zou Y, Xu F, Chen L, Huang H
Frontiers in pharmacology 2018;9:512
Frontiers in pharmacology 2018;9:512
A Novel Derivative of the Natural Product Danshensu Suppresses Inflammatory Responses to Alleviate Caerulein-Induced Acute Pancreatitis.
Ren Z, Li H, Zhang M, Zhao Y, Fang X, Li X, Chen W, Zhang H, Wang Y, Pan LL, Sun J
Frontiers in immunology 2018;9:2513
Frontiers in immunology 2018;9:2513
Fangchinoline Ameliorates the Expressions of Angiogenic Molecule in Cerebral Ischemia Induced Neuronal Degeneration in Neonatal Rats.
Daicheng H, Shiwen X, Huaping Z, Yong L, Qianqian Z, Changxia H
Translational neuroscience 2018;9:117-122
Translational neuroscience 2018;9:117-122
Protective Effects of Hydrogen Sulfide Against Cigarette Smoke Exposure-Induced Placental Oxidative Damage by Alleviating Redox Imbalance via Nrf2 Pathway in Rats.
Zhao F, Lei F, Yan X, Zhang S, Wang W, Zheng Y
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2018;48(5):1815-1828
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2018;48(5):1815-1828
Ingredients from Litsea garrettii as Potential Preventive Agents against Oxidative Insult and Inflammatory Response.
Li YR, Li GH, Sun L, Li L, Liu Y, Kong DG, Wang SQ, Ren DM, Wang XN, Lou HX, Shen T
Oxidative medicine and cellular longevity 2018;2018:7616852
Oxidative medicine and cellular longevity 2018;2018:7616852
Hepatoprotective Activity of the Ethanolic Extract of Polygonum multiflorum Thunb. against Oxidative Stress-Induced Liver Injury.
Lin EY, Chagnaadorj A, Huang SJ, Wang CC, Chiang YH, Cheng CW
Evidence-based complementary and alternative medicine : eCAM 2018;2018:4130307
Evidence-based complementary and alternative medicine : eCAM 2018;2018:4130307
Nrf2 protects stellate cells from Smad-dependent cell activation.
Prestigiacomo V, Suter-Dick L
PloS one 2018;13(7):e0201044
PloS one 2018;13(7):e0201044
Oral carbon monoxide therapy in murine sickle cell disease: Beneficial effects on vaso-occlusion, inflammation and anemia.
Belcher JD, Gomperts E, Nguyen J, Chen C, Abdulla F, Kiser ZM, Gallo D, Levy H, Otterbein LE, Vercellotti GM
PloS one 2018;13(10):e0205194
PloS one 2018;13(10):e0205194
Resveratrol relieves particulate matter (mean diameter < 2.5 μm)-induced oxidative injury of lung cells through attenuation of autophagy deregulation.
Li Y, Qian W, Wang D, Meng Y, Wang X, Chen Y, Li X, Xie C, Zhong C, Fu S
Journal of applied toxicology : JAT 2018 Sep;38(9):1251-1261
Journal of applied toxicology : JAT 2018 Sep;38(9):1251-1261
Local low dose curcumin treatment improves functional recovery and remyelination in a rat model of sciatic nerve crush through inhibition of oxidative stress.
Caillaud M, Chantemargue B, Richard L, Vignaud L, Favreau F, Faye PA, Vignoles P, Sturtz F, Trouillas P, Vallat JM, Desmoulière A, Billet F
Neuropharmacology 2018 Sep 1;139:98-116
Neuropharmacology 2018 Sep 1;139:98-116
Ginsenoside Rg1 protects against acetaminophen-induced liver injury via activating Nrf2 signaling pathway in vivo and in vitro.
Ning C, Gao X, Wang C, Kong Y, Liu Z, Sun H, Sun P, Huo X, Ma X, Meng Q, Liu K
Regulatory toxicology and pharmacology : RTP 2018 Oct;98:58-68
Regulatory toxicology and pharmacology : RTP 2018 Oct;98:58-68
17-allylamino-17-demethoxygeldanamycin impeded chemotherapy through antioxidant activation via reducing reactive oxygen species-induced cell death.
Li Y, Chen Y, Qiu C, Ma X, Lei K, Cai G, Liang X, Liu J
Journal of cellular biochemistry 2018 Oct 30;
Journal of cellular biochemistry 2018 Oct 30;
Enhanced anti-obesity effects of bacterial cellulose combined with konjac glucomannan in high-fat diet-fed C57BL/6J mice.
Zhai X, Lin D, Zhao Y, Li W, Yang X
Food & function 2018 Oct 17;9(10):5260-5272
Food & function 2018 Oct 17;9(10):5260-5272
Renoprotective Effects of Antroquinonol in Rats with Nω-Nitro-l-Arginine Methyl Ester-Induced Hypertension.
Chen JR, Ko J, Yeh WJ, Huang WC, Yang HY
Nutrients 2018 Oct 17;10(10)
Nutrients 2018 Oct 17;10(10)
A novel Gallic acid derivative attenuates BLM-induced pulmonary fibrosis in mice.
Rong Y, Cao B, Liu B, Li W, Chen Y, Chen H, Liu Y, Liu T
International immunopharmacology 2018 Nov;64:183-191
International immunopharmacology 2018 Nov;64:183-191
Anti-neovascularization effects of DMBT in age-related macular degeneration by inhibition of VEGF secretion through ROS-dependent signaling pathway.
Chen S, Zhou Y, Zhou L, Guan Y, Zhang Y, Han X
Molecular and cellular biochemistry 2018 Nov;448(1-2):225-235
Molecular and cellular biochemistry 2018 Nov;448(1-2):225-235
Boron Affects the Development of the Kidney Through Modulation of Apoptosis, Antioxidant Capacity, and Nrf2 Pathway in the African Ostrich Chicks.
Khaliq H, Jing W, Ke X, Ke-Li Y, Peng-Peng S, Cui L, Wei-Wei Q, Zhixin L, Hua-Zhen L, Hui S, Ju-Ming Z, Ke-Mei P
Biological trace element research 2018 Nov;186(1):226-237
Biological trace element research 2018 Nov;186(1):226-237
(2R,3R)Dihydromyricetin inhibits osteoclastogenesis and bone loss through scavenging LPS-induced oxidative stress and NF-κB and MAPKs pathways activating.
Zhang X, Li X, Fang J, Hou X, Fang H, Guo F, Li F, Chen A, Huang S
Journal of cellular biochemistry 2018 Nov;119(11):8981-8995
Journal of cellular biochemistry 2018 Nov;119(11):8981-8995
Interleukin-18 binding protein attenuates lipopolysaccharide-induced acute lung injury in mice via suppression NF-κB and activation Nrf2 pathway.
Zhang LM, Zhang J, Zhang Y, Wang L, Fei C, Yi ZW, Dong L
Biochemical and biophysical research communications 2018 Nov 2;505(3):837-842
Biochemical and biophysical research communications 2018 Nov 2;505(3):837-842
Exposure to formaldehyde and diisononyl phthalate exacerbate neuroinflammation through NF-κB activation in a mouse asthma model.
Duan J, Kang J, Qin W, Deng T, Liu H, Li B, Yu W, Gong S, Yang X, Chen M
Ecotoxicology and environmental safety 2018 Nov 15;163:356-364
Ecotoxicology and environmental safety 2018 Nov 15;163:356-364
Beneficial Effects of Exercise Pretreatment in a Sporadic Alzheimer's Rat Model.
Wu C, Yang L, Tucker D, Dong Y, Zhu L, Duan R, Liu TC, Zhang Q
Medicine and science in sports and exercise 2018 May;50(5):945-956
Medicine and science in sports and exercise 2018 May;50(5):945-956
Cardioprotection of CAPE-oNO2 against myocardial ischemia/reperfusion induced ROS generation via regulating the SIRT1/eNOS/NF-κB pathway in vivo and in vitro.
Li D, Wang X, Huang Q, Li S, Zhou Y, Li Z
Redox biology 2018 May;15:62-73
Redox biology 2018 May;15:62-73
l-Arginine induces antioxidant response to prevent oxidative stress via stimulation of glutathione synthesis and activation of Nrf2 pathway.
Liang M, Wang Z, Li H, Cai L, Pan J, He H, Wu Q, Tang Y, Ma J, Yang L
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2018 May;115:315-328
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2018 May;115:315-328
Neuroprotective effect of phosphocreatine on oxidative stress and mitochondrial dysfunction induced apoptosis in vitro and in vivo: Involvement of dual PI3K/Akt and Nrf2/HO-1 pathways.
Li H, Tang Z, Chu P, Song Y, Yang Y, Sun B, Niu M, Qaed E, Shopit A, Han G, Ma X, Peng J, Hu M, Tang Z
Free radical biology & medicine 2018 May 20;120:228-238
Free radical biology & medicine 2018 May 20;120:228-238
Deletion of both p62 and Nrf2 spontaneously results in the development of nonalcoholic steatohepatitis.
Akiyama K, Warabi E, Okada K, Yanagawa T, Ishii T, Kose K, Tokushige K, Ishige K, Mizokami Y, Yamagata K, Onizawa K, Ariizumi SI, Yamamoto M, Shoda J
Experimental animals 2018 May 10;67(2):201-218
Experimental animals 2018 May 10;67(2):201-218
Oxyresveratrol prevents lipopolysaccharide/d-galactosamine-induced acute liver injury in mice.
Jia YN, Lu HP, Peng YL, Zhang BS, Gong XB, Su J, Zhou Y, Pan MH, Xu L
International immunopharmacology 2018 Mar;56:105-112
International immunopharmacology 2018 Mar;56:105-112
Fragment-growing guided design of Keap1-Nrf2 protein-protein interaction inhibitors for targeting myocarditis.
Meng N, Tang H, Zhang H, Jiang C, Su L, Min X, Zhang W, Zhang H, Miao Z, Zhang W, Zhuang C
Free radical biology & medicine 2018 Mar;117:228-237
Free radical biology & medicine 2018 Mar;117:228-237
Dimethyl fumarate attenuates reactive microglia and long-term memory deficits following systemic immune challenge.
Paraiso HC, Kuo PC, Curfman ET, Moon HJ, Sweazey RD, Yen JH, Chang FL, Yu IC
Journal of neuroinflammation 2018 Mar 29;15(1):100
Journal of neuroinflammation 2018 Mar 29;15(1):100
Epidermal Growth Factor, through Alleviating Oxidative Stress, Protect IPEC-J2 Cells from Lipopolysaccharides-Induced Apoptosis.
Tang X, Liu B, Wang X, Yu Q, Fang R
International journal of molecular sciences 2018 Mar 14;19(3)
International journal of molecular sciences 2018 Mar 14;19(3)
Protective effects of dioscin against fructose-induced renal damage via adjusting Sirt3-mediated oxidative stress, fibrosis, lipid metabolism and inflammation.
Qiao Y, Xu L, Tao X, Yin L, Qi Y, Xu Y, Han X, Tang Z, Ma X, Liu K, Peng J
Toxicology letters 2018 Mar 1;284:37-45
Toxicology letters 2018 Mar 1;284:37-45
Tert-butylhydroquinone post-treatment attenuates neonatal hypoxic-ischemic brain damage in rats.
Zhang J, Tucker LD, DongYan, Lu Y, Yang L, Wu C, Li Y, Zhang Q
Neurochemistry international 2018 Jun;116:1-12
Neurochemistry international 2018 Jun;116:1-12
The Nrf2 inhibitor brusatol is a potent antitumour agent in an orthotopic mouse model of colorectal cancer.
Evans JP, Winiarski BK, Sutton PA, Jones RP, Ressel L, Duckworth CA, Pritchard DM, Lin ZX, Fretwell VL, Tweedle EM, Costello E, Goldring CE, Copple IM, Park BK, Palmer DH, Kitteringham NR
Oncotarget 2018 Jun 5;9(43):27104-27116
Oncotarget 2018 Jun 5;9(43):27104-27116
LncRNA MT1DP Aggravates Cadmium-Induced Oxidative Stress by Repressing the Function of Nrf2 and is Dependent on Interaction with miR-365.
Gao M, Li C, Xu M, Liu Y, Cong M, Liu S
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2018 Jul;5(7):1800087
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2018 Jul;5(7):1800087
Hypothermic machine perfusion attenuates ischemia/reperfusion injury against rat livers donated after cardiac death by activating the Keap1/Nrf2‑ARE signaling pathway.
Xue S, He W, Zeng X, Tang Z, Feng S, Zhong Z, Xiong Y, Wang Y, Ye Q
Molecular medicine reports 2018 Jul;18(1):815-826
Molecular medicine reports 2018 Jul;18(1):815-826
Qing brick tea (QBT) aqueous extract protects monosodium glutamate-induced obese mice against metabolic syndrome and involves up-regulation Transcription Factor Nuclear Factor-Erythroid 2-Related Factor 2 (Nrf2) antioxidant pathway.
Gao W, Xiao C, Hu J, Chen B, Wang C, Cui B, Deng P, Yang J, Deng Z
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2018 Jul;103:637-644
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2018 Jul;103:637-644
β-glucan Salecan Improves Exercise Performance and Displays Anti-Fatigue Effects through Regulating Energy Metabolism and Oxidative Stress in Mice.
Xu X, Ding Y, Yang Y, Gao Y, Sun Q, Liu J, Yang X, Wang J, Zhang J
Nutrients 2018 Jul 3;10(7)
Nutrients 2018 Jul 3;10(7)
Activation of Nrf2 might reduce oxidative stress in human granulosa cells.
Akino N, Wada-Hiraike O, Terao H, Honjoh H, Isono W, Fu H, Hirano M, Miyamoto Y, Tanikawa M, Harada M, Hirata T, Hirota Y, Koga K, Oda K, Kawana K, Fujii T, Osuga Y
Molecular and cellular endocrinology 2018 Jul 15;470:96-104
Molecular and cellular endocrinology 2018 Jul 15;470:96-104
Protective effect of dioscin against thioacetamide-induced acute liver injury via FXR/AMPK signaling pathway in vivo.
Zheng L, Yin L, Xu L, Qi Y, Li H, Xu Y, Han X, Liu K, Peng J
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2018 Jan;97:481-488
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2018 Jan;97:481-488
Curcumin Attenuates Colistin-Induced Neurotoxicity in N2a Cells via Anti-inflammatory Activity, Suppression of Oxidative Stress, and Apoptosis.
Dai C, Ciccotosto GD, Cappai R, Tang S, Li D, Xie S, Xiao X, Velkov T
Molecular neurobiology 2018 Jan;55(1):421-434
Molecular neurobiology 2018 Jan;55(1):421-434
Activation of Nrf2 pathway and inhibition of NLRP3 inflammasome activation contribute to the protective effect of chlorogenic acid on acute liver injury.
Shi A, Shi H, Wang Y, Liu X, Cheng Y, Li H, Zhao H, Wang S, Dong L
International immunopharmacology 2018 Jan;54:125-130
International immunopharmacology 2018 Jan;54:125-130
The natural compound 2,3,5,4'-tetrahydroxystilbene-2-O-β-d glucoside protects against adriamycin-induced nephropathy through activating the Nrf2-Keap1 antioxidant pathway.
Lin EY, Bayarsengee U, Wang CC, Chiang YH, Cheng CW
Environmental toxicology 2018 Jan;33(1):72-82
Environmental toxicology 2018 Jan;33(1):72-82
Curcumin Attenuates on Carbon Tetrachloride-Induced Acute Liver Injury in Mice via Modulation of the Nrf2/HO-1 and TGF-β1/Smad3 Pathway.
Peng X, Dai C, Liu Q, Li J, Qiu J
Molecules (Basel, Switzerland) 2018 Jan 19;23(1)
Molecules (Basel, Switzerland) 2018 Jan 19;23(1)
Salvianolic acid B inhibits myofibroblast transdifferentiation in experimental pulmonary fibrosis via the up-regulation of Nrf2.
Liu M, Xu H, Zhang L, Zhang C, Yang L, Ma E, Liu L, Li Y
Biochemical and biophysical research communications 2018 Jan 1;495(1):325-331
Biochemical and biophysical research communications 2018 Jan 1;495(1):325-331
NRF2 regulates core and stabilizing circadian clock loops, coupling redox and timekeeping in Mus musculus.
Wible RS, Ramanathan C, Sutter CH, Olesen KM, Kensler TW, Liu AC, Sutter TR
eLife 2018 Feb 26;7
eLife 2018 Feb 26;7
Intermittent hypoxia promotes melanoma lung metastasis via oxidative stress and inflammation responses in a mouse model of obstructive sleep apnea.
Li L, Ren F, Qi C, Xu L, Fang Y, Liang M, Feng J, Chen B, Ning W, Cao J
Respiratory research 2018 Feb 12;19(1):28
Respiratory research 2018 Feb 12;19(1):28
Modulation of autophagy in the protective effect of resveratrol on PM2.5-induced pulmonary oxidative injury in mice.
Li Y, Fu S, Li E, Sun X, Xu H, Meng Y, Wang X, Chen Y, Xie C, Geng S, Wu J, Zhong C, Xu P
Phytotherapy research : PTR 2018 Dec;32(12):2480-2486
Phytotherapy research : PTR 2018 Dec;32(12):2480-2486
Protective effect of the ethanol extract from Ligusticum chuanxiong rhizome against streptozotocin-induced diabetic nephropathy in mice.
Yang WJ, Li YR, Gao H, Wu XY, Wang XL, Wang XN, Xiang L, Ren DM, Lou HX, Shen T
Journal of ethnopharmacology 2018 Dec 5;227:166-175
Journal of ethnopharmacology 2018 Dec 5;227:166-175
NRG1 regulates redox homeostasis via NRF2 in papillary thyroid cancer.
Zhang TT, Qu N, Sun GH, Zhang L, Wang YJ, Mu XM, Wei WJ, Wang YL, Wang Y, Ji QH, Zhu YX, Shi RL
International journal of oncology 2018 Aug;53(2):685-693
International journal of oncology 2018 Aug;53(2):685-693
Regulation on SIRT1-PGC-1α/Nrf2 pathway together with selective inhibition of aldose reductase makes compound hr5F a potential agent for the treatment of diabetic complications.
Wang Z, Yuan S, Li Y, Zhang Z, Xiao W, Tang D, Ye K, Liu Z, Wang C, Zheng Y, Nie H, Chen H
Biochemical pharmacology 2018 Apr;150:54-63
Biochemical pharmacology 2018 Apr;150:54-63
T-2 toxin-induced toxicity in neuroblastoma-2a cells involves the generation of reactive oxygen, mitochondrial dysfunction and inhibition of Nrf2/HO-1 pathway.
Zhang X, Wang Y, Velkov T, Tang S, Dai C
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2018 Apr;114:88-97
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2018 Apr;114:88-97
Rapamycin Confers Neuroprotection against Colistin-Induced Oxidative Stress, Mitochondria Dysfunction, and Apoptosis through the Activation of Autophagy and mTOR/Akt/CREB Signaling Pathways.
Dai C, Ciccotosto GD, Cappai R, Wang Y, Tang S, Hoyer D, Schneider EK, Velkov T, Xiao X
ACS chemical neuroscience 2018 Apr 18;9(4):824-837
ACS chemical neuroscience 2018 Apr 18;9(4):824-837
Tamoxifen activates Nrf2-dependent SQSTM1 transcription to promote endometrial hyperplasia.
Feng L, Li J, Yang L, Zhu L, Huang X, Zhang S, Luo L, Jiang Z, Jiang T, Xu W, Wang X, Jin H
Theranostics 2017;7(7):1890-1900
Theranostics 2017;7(7):1890-1900
Potential Ameliorative Effects of Qing Ye Dan Against Cadmium Induced Prostatic Deficits via Regulating Nrf-2/HO-1 and TGF-β1/Smad Pathways.
Du L, Lei Y, Chen J, Song H, Wu X
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2017;43(4):1359-1368
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2017;43(4):1359-1368
Myricetin Possesses Potential Protective Effects on Diabetic Cardiomyopathy through Inhibiting IκBα/NFκB and Enhancing Nrf2/HO-1.
Liao HH, Zhu JX, Feng H, Ni J, Zhang N, Chen S, Liu HJ, Yang Z, Deng W, Tang QZ
Oxidative medicine and cellular longevity 2017;2017:8370593
Oxidative medicine and cellular longevity 2017;2017:8370593
TBHQ Alleviated Endoplasmic Reticulum Stress-Apoptosis and Oxidative Stress by PERK-Nrf2 Crosstalk in Methamphetamine-Induced Chronic Pulmonary Toxicity.
Wang Y, Gu YH, Liu M, Bai Y, Liang LY, Wang HL
Oxidative medicine and cellular longevity 2017;2017:4310475
Oxidative medicine and cellular longevity 2017;2017:4310475
Neuroprotective Effect and Mechanism of Thiazolidinedione on Dopaminergic Neurons In Vivo and In Vitro in Parkinson's Disease.
Wang Y, Zhao W, Li G, Chen J, Guan X, Chen X, Guan Z
PPAR research 2017;2017:4089214
PPAR research 2017;2017:4089214
The therapeutic effect of zerumbone on chronic gastritis via antioxidant mechanisms.
Li L, Kong L, Song H
Experimental and therapeutic medicine 2017 Sep;14(3):2505-2510
Experimental and therapeutic medicine 2017 Sep;14(3):2505-2510
Vitamin E antagonizes ozone-induced asthma exacerbation in Balb/c mice through the Nrf2 pathway.
Duan L, Li J, Ma P, Yang X, Xu S
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2017 Sep;107(Pt A):47-56
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2017 Sep;107(Pt A):47-56
The effect of hydrogen sulfide-releasing naproxen (ATB-346) versus naproxen on formation of stress-induced gastric lesions, the regulation of systemic inflammation, hypoxia and alterations in gastric microcirculation.
Magierowski M, Magierowska K, Surmiak M, Hubalewska-Mazgaj M, Kwiecien S, Wallace JL, Brzozowski T
Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 2017 Oct;68(5):749-756
Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 2017 Oct;68(5):749-756
An Important Function of Petrosiol E in Inducing the Differentiation of Neuronal Progenitors and in Protecting Them against Oxidative Stress.
Liu J, Wang L, Du Y, Liu S
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2017 Oct;4(10):1700089
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2017 Oct;4(10):1700089
Carbon monoxide released from its pharmacological donor, tricarbonyldichlororuthenium (II) dimer, accelerates the healing of pre-existing gastric ulcers.
Magierowski M, Magierowska K, Hubalewska-Mazgaj M, Sliwowski Z, Ginter G, Pajdo R, Chmura A, Kwiecien S, Brzozowski T
British journal of pharmacology 2017 Oct;174(20):3654-3668
British journal of pharmacology 2017 Oct;174(20):3654-3668
Therapeutic effects of L-Cysteine in newborn mice subjected to hypoxia-ischemia brain injury via the CBS/H2S system: Role of oxidative stress and endoplasmic reticulum stress.
Liu S, Xin D, Wang L, Zhang T, Bai X, Li T, Xie Y, Xue H, Bo S, Liu D, Wang Z
Redox biology 2017 Oct;13:528-540
Redox biology 2017 Oct;13:528-540
Critical role of p21 on olaquindox-induced mitochondrial apoptosis and S-phase arrest involves activation of PI3K/AKT and inhibition of Nrf2/HO-1pathway.
Li D, Dai C, Yang X, Wang F, Yu X, Xiao X, Tang S
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2017 Oct;108(Pt A):148-160
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2017 Oct;108(Pt A):148-160
An inducible form of Nrf2 confers enhanced protection against acute oxidative stresses in RPE cells.
Vu KT, Hulleman JD
Experimental eye research 2017 Nov;164:31-36
Experimental eye research 2017 Nov;164:31-36
SETD7 is a prognosis predicting factor of breast cancer and regulates redox homeostasis.
Huang R, Li X, Yu Y, Ma L, Liu S, Zong X, Zheng Q
Oncotarget 2017 Nov 7;8(55):94080-94090
Oncotarget 2017 Nov 7;8(55):94080-94090
iASPP Is an Antioxidative Factor and Drives Cancer Growth and Drug Resistance by Competing with Nrf2 for Keap1 Binding.
Ge W, Zhao K, Wang X, Li H, Yu M, He M, Xue X, Zhu Y, Zhang C, Cheng Y, Jiang S, Hu Y
Cancer cell 2017 Nov 13;32(5):561-573.e6
Cancer cell 2017 Nov 13;32(5):561-573.e6
3H-1,2-Dithiole-3-thione as a novel therapeutic agent for the treatment of ischemic stroke through Nrf2 defense pathway.
Kuo PC, Yu IC, Scofield BA, Brown DA, Curfman ET, Paraiso HC, Chang FL, Yen JH
Brain, behavior, and immunity 2017 May;62:180-192
Brain, behavior, and immunity 2017 May;62:180-192
Involvement of the activation of Nrf2/HO-1, p38 MAPK signaling pathways and endoplasmic reticulum stress in furazolidone induced cytotoxicity and S phase arrest in human hepatocyte L02 cells: modulation of curcumin.
Dai C, Lei L, Li B, Lin Y, Xiao X, Tang S
Toxicology mechanisms and methods 2017 Mar;27(3):165-172
Toxicology mechanisms and methods 2017 Mar;27(3):165-172
Nrf-2-driven long noncoding RNA ODRUL contributes to modulating silver nanoparticle-induced effects on erythroid cells.
Gao M, Zhao B, Chen M, Liu Y, Xu M, Wang Z, Liu S, Zhang C
Biomaterials 2017 Jun;130:14-27
Biomaterials 2017 Jun;130:14-27
Novel indolyl-chalcone derivatives inhibit A549 lung cancer cell growth through activating Nrf-2/HO-1 and inducing apoptosis in vitro and in vivo.
Zhao X, Dong W, Gao Y, Shin DS, Ye Q, Su L, Jiang F, Zhao B, Miao J
Scientific reports 2017 Jun 20;7(1):3919
Scientific reports 2017 Jun 20;7(1):3919
Oral exposure to diisodecyl phthalate aggravates allergic dermatitis by oxidative stress and enhancement of thymic stromal lymphopoietin.
Shen S, Li J, You H, Wu Z, Wu Y, Zhao Y, Zhu Y, Guo Q, Li X, Li R, Ma P, Yang X, Chen M
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2017 Jan;99:60-69
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2017 Jan;99:60-69
Activation of Akt and JNK/Nrf2/NQO1 pathway contributes to the protective effect of coptisine against AAPH-induced oxidative stress.
Hu YR, Ma H, Zou ZY, He K, Xiao YB, Wang Y, Feng M, Ye XL, Li XG
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2017 Jan;85:313-322
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2017 Jan;85:313-322
Discovery of a novel Nrf2 inhibitor that induces apoptosis of human acute myeloid leukemia cells.
Zhang J, Su L, Ye Q, Zhang S, Kung H, Jiang F, Jiang G, Miao J, Zhao B
Oncotarget 2017 Jan 31;8(5):7625-7636
Oncotarget 2017 Jan 31;8(5):7625-7636
Fluoxetine protects against methamphetamine‑induced lung inflammation by suppressing oxidative stress through the SERT/p38 MAPK/Nrf2 pathway in rats.
Wang Y, Gu YH, Liu M, Bai Y, Wang HL
Molecular medicine reports 2017 Feb;15(2):673-680
Molecular medicine reports 2017 Feb;15(2):673-680
Arsenite-induced stress granule formation is inhibited by elevated levels of reduced glutathione in West Nile virus-infected cells.
Basu M, Courtney SC, Brinton MA
PLoS pathogens 2017 Feb;13(2):e1006240
PLoS pathogens 2017 Feb;13(2):e1006240
Mitochondrial Dysregulation Secondary to Endoplasmic Reticulum Stress in Autosomal Dominant Tubulointerstitial Kidney Disease - UMOD (ADTKD-UMOD).
Kemter E, Fröhlich T, Arnold GJ, Wolf E, Wanke R
Scientific reports 2017 Feb 21;7:42970
Scientific reports 2017 Feb 21;7:42970
Caffeic acid phenethyl ester up-regulates antioxidant levels in hepatic stellate cell line T6 via an Nrf2-mediated mitogen activated protein kinases pathway.
Yang N, Shi JJ, Wu FP, Li M, Zhang X, Li YP, Zhai S, Jia XL, Dang SS
World journal of gastroenterology 2017 Feb 21;23(7):1203-1214
World journal of gastroenterology 2017 Feb 21;23(7):1203-1214
NADPH Oxidase 4 (Nox4) Suppresses Mitochondrial Biogenesis and Bioenergetics in Lung Fibroblasts via a Nuclear Factor Erythroid-derived 2-like 2 (Nrf2)-dependent Pathway.
Bernard K, Logsdon NJ, Miguel V, Benavides GA, Zhang J, Carter AB, Darley-Usmar VM, Thannickal VJ
The Journal of biological chemistry 2017 Feb 17;292(7):3029-3038
The Journal of biological chemistry 2017 Feb 17;292(7):3029-3038
Morin enhances hepatic Nrf2 expression in a liver fibrosis rat model.
Sang L, Wang XM, Xu DY, Sang LX, Han Y, Jiang LY
World journal of gastroenterology 2017 Dec 21;23(47):8334-8344
World journal of gastroenterology 2017 Dec 21;23(47):8334-8344
Nrf2-mediated neuroprotection by MANF against 6-OHDA-induced cell damage via PI3K/AKT/GSK3β pathway.
Zhang J, Tong W, Sun H, Jiang M, Shen Y, Liu Y, Gu H, Guo J, Fang J, Jin L
Experimental gerontology 2017 Dec 15;100:77-86
Experimental gerontology 2017 Dec 15;100:77-86
(-)-7(S)-hydroxymatairesinol protects against tumor necrosis factor-α-mediated inflammation response in endothelial cells by blocking the MAPK/NF-κB and activating Nrf2/HO-1.
Yang D, Xiao CX, Su ZH, Huang MW, Qin M, Wu WJ, Jia WW, Zhu YZ, Hu JF, Liu XH
Phytomedicine : international journal of phytotherapy and phytopharmacology 2017 Aug 15;32:15-23
Phytomedicine : international journal of phytotherapy and phytopharmacology 2017 Aug 15;32:15-23
Protective effect of naringin against the LPS-induced apoptosis of PC12 cells: Implications for the treatment of neurodegenerative disorders.
Wang H, Xu YS, Wang ML, Cheng C, Bian R, Yuan H, Wang Y, Guo T, Zhu LL, Zhou H
International journal of molecular medicine 2017 Apr;39(4):819-830
International journal of molecular medicine 2017 Apr;39(4):819-830
Berberine protects against 6-OHDA-induced neurotoxicity in PC12 cells and zebrafish through hormetic mechanisms involving PI3K/AKT/Bcl-2 and Nrf2/HO-1 pathways.
Zhang C, Li C, Chen S, Li Z, Jia X, Wang K, Bao J, Liang Y, Wang X, Chen M, Li P, Su H, Wan JB, Lee SMY, Liu K, He C
Redox biology 2017 Apr;11:1-11
Redox biology 2017 Apr;11:1-11
Hydrogen sulfide decreases high glucose/palmitate-induced autophagy in endothelial cells by the Nrf2-ROS-AMPK signaling pathway.
Liu J, Wu J, Sun A, Sun Y, Yu X, Liu N, Dong S, Yang F, Zhang L, Zhong X, Xu C, Lu F, Zhang W
Cell & bioscience 2016;6:33
Cell & bioscience 2016;6:33
Protective Effects of Hydrogen Sulfide in the Ageing Kidney.
Hou CL, Wang MJ, Sun C, Huang Y, Jin S, Mu XP, Chen Y, Zhu YC
Oxidative medicine and cellular longevity 2016;2016:7570489
Oxidative medicine and cellular longevity 2016;2016:7570489
Targeting HO-1 by Epigallocatechin-3-Gallate Reduces Contrast-Induced Renal Injury via Anti-Oxidative Stress and Anti-Inflammation Pathways.
Gao Z, Han Y, Hu Y, Wu X, Wang Y, Zhang X, Fu J, Zou X, Zhang J, Chen X, Jose PA, Lu X, Zeng C
PloS one 2016;11(2):e0149032
PloS one 2016;11(2):e0149032
Neuroprotective Effects of a Smoothened Receptor Agonist against Early Brain Injury after Experimental Subarachnoid Hemorrhage in Rats.
Hu Q, Li T, Wang L, Xie Y, Liu S, Bai X, Zhang T, Bo S, Xin D, Xue H, Li G, Wang Z
Frontiers in cellular neuroscience 2016;10:306
Frontiers in cellular neuroscience 2016;10:306
Polyphenols from hawthorn peels and fleshes differently mitigate dyslipidemia, inflammation and oxidative stress in association with modulation of liver injury in high fructose diet-fed mice.
Han X, Li W, Huang D, Yang X
Chemico-biological interactions 2016 Sep 25;257:132-40
Chemico-biological interactions 2016 Sep 25;257:132-40
3,3'-diindolylmethane mitigates total body irradiation-induced hematopoietic injury in mice.
Lu L, Dong J, Li D, Zhang J, Fan S
Free radical biology & medicine 2016 Oct;99:463-471
Free radical biology & medicine 2016 Oct;99:463-471
15d-PGJ2 alleviates ConA-induced acute liver injury in mice by up-regulating HO-1 and reducing hepatic cell autophagy.
Chen K, Li J, Li S, Feng J, Wu L, Liu T, Zhang R, Xu S, Cheng K, Zhou Y, Zhou S, Wang F, Dai W, Xia Y, Lu J, Zhou Y, Guo C
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2016 May;80:183-192
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2016 May;80:183-192
Gankyrin has an antioxidative role through the feedback regulation of Nrf2 in hepatocellular carcinoma.
Yang C, Tan YX, Yang GZ, Zhang J, Pan YF, Liu C, Fu J, Chen Y, Ding ZW, Dong LW, Wang HY
The Journal of experimental medicine 2016 May 2;213(5):859-75
The Journal of experimental medicine 2016 May 2;213(5):859-75
Taurine protects against As2O3-induced autophagy in livers of rat offsprings through PPARγ pathway.
Bai J, Yao X, Jiang L, Zhang Q, Guan H, Liu S, Wu W, Qiu T, Gao N, Yang L, Yang G, Sun X
Scientific reports 2016 Jun 13;6:27733
Scientific reports 2016 Jun 13;6:27733
Dioscin alleviates dimethylnitrosamine-induced acute liver injury through regulating apoptosis, oxidative stress and inflammation.
Zhang W, Yin L, Tao X, Xu L, Zheng L, Han X, Xu Y, Wang C, Peng J
Environmental toxicology and pharmacology 2016 Jul;45:193-201
Environmental toxicology and pharmacology 2016 Jul;45:193-201
Total Flavonoids from Rosa laevigata Michx Fruit Ameliorates Hepatic Ischemia/Reperfusion Injury through Inhibition of Oxidative Stress and Inflammation in Rats.
Tao X, Sun X, Xu L, Yin L, Han X, Qi Y, Xu Y, Zhao Y, Wang C, Peng J
Nutrients 2016 Jul 8;8(7)
Nutrients 2016 Jul 8;8(7)
Protective Effect of the Total Flavonoids from Rosa laevigata Michx Fruit on Renal Ischemia-Reperfusion Injury through Suppression of Oxidative Stress and Inflammation.
Zhao L, Xu L, Tao X, Han X, Yin L, Qi Y, Peng J
Molecules (Basel, Switzerland) 2016 Jul 21;21(7)
Molecules (Basel, Switzerland) 2016 Jul 21;21(7)
Acute exposure of ozone induced pulmonary injury and the protective role of vitamin E through the Nrf2 pathway in Balb/c mice.
Zhu Y, Li J, Wu Z, Lu Y, You H, Li R, Li B, Yang X, Duan L
Toxicology research 2016 Jan 1;5(1):268-277
Toxicology research 2016 Jan 1;5(1):268-277
P21(Waf1/Cip1) plays a critical role in furazolidone-induced apoptosis in HepG2 cells through influencing the caspase-3 activation and ROS generation.
Deng S, Tang S, Dai C, Zhou Y, Yang X, Li D, Xiao X
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2016 Feb;88:1-12
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2016 Feb;88:1-12
Resveratrol Ameliorated Vascular Calcification by Regulating Sirt-1 and Nrf2.
Zhang P, Li Y, Du Y, Li G, Wang L, Zhou F
Transplantation proceedings 2016 Dec;48(10):3378-3386
Transplantation proceedings 2016 Dec;48(10):3378-3386
Chlorogenic acid protects against liver fibrosis in vivo and in vitro through inhibition of oxidative stress.
Shi H, Shi A, Dong L, Lu X, Wang Y, Zhao J, Dai F, Guo X
Clinical nutrition (Edinburgh, Scotland) 2016 Dec;35(6):1366-1373
Clinical nutrition (Edinburgh, Scotland) 2016 Dec;35(6):1366-1373
Hydrogen peroxide prevents vascular calcification induced ROS production by regulating Nrf-2 pathway.
Zhang W, Li Y, Ding H, Du Y, Wang L
Renal failure 2016 Aug;38(7):1099-106
Renal failure 2016 Aug;38(7):1099-106
Metformin exerts glucose-lowering action in high-fat fed mice via attenuating endotoxemia and enhancing insulin signaling.
Zhou ZY, Ren LW, Zhan P, Yang HY, Chai DD, Yu ZW
Acta pharmacologica Sinica 2016 Aug;37(8):1063-75
Acta pharmacologica Sinica 2016 Aug;37(8):1063-75
Taurine protects against As2O3-induced autophagy in pancreas of rat offsprings through Nrf2/Trx pathway.
Bai J, Yao X, Jiang L, Qiu T, Liu S, Qi B, Zheng Y, Kong Y, Yang G, Chen M, Liu X, Sun X
Biochimie 2016 Apr;123:1-6
Biochimie 2016 Apr;123:1-6
Transcriptional upregulation centra of HO-1 by EGB via the MAPKs/Nrf2 pathway in mouse C2C12 myoblasts.
Wang J, Zhang L, Zhang Y, Luo M, Wu Q, Yu L, Chu H
Toxicology in vitro : an international journal published in association with BIBRA 2015 Mar;29(2):380-8
Toxicology in vitro : an international journal published in association with BIBRA 2015 Mar;29(2):380-8
Neohesperidin Dihydrochalcone versus CCl₄-Induced Hepatic Injury through Different Mechanisms: The Implication of Free Radical Scavenging and Nrf2 Activation.
Su C, Xia X, Shi Q, Song X, Fu J, Xiao C, Chen H, Lu B, Sun Z, Wu S, Yang S, Li X, Ye X, Song E, Song Y
Journal of agricultural and food chemistry 2015 Jun 10;63(22):5468-75
Journal of agricultural and food chemistry 2015 Jun 10;63(22):5468-75
Potent effects of dioscin against obesity in mice.
Liu M, Xu L, Yin L, Qi Y, Xu Y, Han X, Zhao Y, Sun H, Yao J, Lin Y, Liu K, Peng J
Scientific reports 2015 Jan 22;5:7973
Scientific reports 2015 Jan 22;5:7973
Tetrachlorobenzoquinone activates Nrf2 signaling by Keap1 cross-linking and ubiquitin translocation but not Keap1-Cullin3 complex dissociation.
Su C, Zhang P, Song X, Shi Q, Fu J, Xia X, Bai H, Hu L, Xu D, Song E, Song Y
Chemical research in toxicology 2015 Apr 20;28(4):765-74
Chemical research in toxicology 2015 Apr 20;28(4):765-74
Effect of Nrf2 on rat ovarian tissues against atrazine-induced anti-oxidative response.
Zhao F, Li K, Zhao L, Liu J, Suo Q, Zhao J, Wang H, Zhao S
International journal of clinical and experimental pathology 2014;7(6):2780-9
International journal of clinical and experimental pathology 2014;7(6):2780-9
Total saponins from Rosa laevigata Michx fruit attenuates hepatic steatosis induced by high-fat diet in rats.
Dong D, Qi Y, Xu L, Yin L, Xu Y, Han X, Zhao Y, Peng J
Food & function 2014 Dec;5(12):3065-3075
Food & function 2014 Dec;5(12):3065-3075
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- DMSO treated HeLa cells were subjected to SDS PAGE followed by western blot with 16396-1-AP( NRF2, NFE2L2 Antibody) at dilution of 1:600
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- IP Result of anti-NRF2, NFE2L2 (IP:16396-1-AP, 3ug; Detection:16396-1-AP 1:300) with mouse kidney tissue lysate 7000ug.
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The NRF2, NFE2L2 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human NRF2, NFE2L2. This antibody recognizes human, mouse antigen. The NRF2, NFE2L2 antibody has been validated for the following applications: ELISA, IP, WB, IHC analysis.
