Tissue expression
Cell line expression
Protein structure
GPR149
G protein-coupled receptor 149IEDA, PGR10, R35
This gene encodes a seven-transmembrane G protein coupled receptor (GPCR) class A family member. Although categorized as a class A GPCR, the encoded protein lacks the first two charged amino acids of the highly conserved Asp-Arg-Tyr (DRY) motif found in the third transmembrane helix of class A receptors which is important for efficient G protein-coupled signal transduction. Mice with a knockout of the orthologous gene are viable and have normal maturation of the ovarian follicle, but show enhanced fertility and ovulation. All GPCRs have a common structural architecture consisting of seven transmembrane alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptor, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. [provided by RefSeq, Jul 2017]
Top validated antibodies |
|||||
Boster Biological Technology | A14274 | Polyclonal |
WB
EL
ICC
IHC |
||
Cusabio Biotech Co., Ltd | CSB-PA009468 | Polyclonal |
WB
EL
ICC
IHC |
||
Biorbyt | orb183877 | Polyclonal |
WB
EL
ICC
IHC |
||
St John's Laboratory | STJ93342 | Polyclonal |
WB
EL
ICC
IHC |
||
antibodies-online | ABIN2437903 | Polyclonal |
WB
EL
ICC
|
All Antibodies
Filters
Enhanced validation
Supportive data in Antibodypedia
Data presented on provider website
Data in Antibodypedia (inconclusive)
Recommended by provider
Supportive data in Antibodypedia
Data presented on provider website
Data in Antibodypedia (inconclusive)
Recommended by provider