SMARCA2

The protein encoded by this gene is a member of the SWI/SNF family of proteins and is highly similar to the brahma protein of Drosophila. Members of this family have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI, which is required for transcriptional activation of genes normally repressed by chromatin. Alternatively spliced transcript variants encoding different isoforms have been found for this gene, which contains a trinucleotide repeat (CAG) length polymorphism. [provided by RefSeq, Jan 2014]

Description

SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2

Tissue specificity

Low tissue specificity

Subcell location

Nucleoplasm, Vesicles, Intermediate filaments

Predicted location

Intracellular

Protein family

Disease related genes
Human disease related genes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Plasma proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

9:p24.3 (1980290 - 2193624)

Ensembl ID

ENSG00000080503  (ver. 103.38)

Orthologs

Mouse Smarca2: ENSMUSG00000024921

UniProt

P51531

neXtProt

NX_P51531

Human splice variants
Mouse splice variants