Tissue expression
Cell line expression
SMARCA2
gene productBAF190, BRM, hBRM, hSNF2a, SNF2, SNF2L2, SNF2LA, Sth1p, SWI2
The protein encoded by this gene is a member of the SWI/SNF family of proteins and is highly similar to the brahma protein of Drosophila. Members of this family have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI, which is required for transcriptional activation of genes normally repressed by chromatin. Alternatively spliced transcript variants encoding different isoforms have been found for this gene, which contains a trinucleotide repeat (CAG) length polymorphism. [provided by RefSeq, Jan 2014]
- Description
- SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
- Tissue specificity
- Low tissue specificity
- Subcell location
- Nucleoplasm, Vesicles, Intermediate filaments
- Predicted location
- Intracellular
- Protein family
- Disease related genes
Human disease related genes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Plasma proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)
- Chromosome
- 9:p24.3 (1980290 - 2193624)
- Ensembl ID
- ENSG00000080503 (ver. 103.38)
- Orthologs
- Mouse Smarca2: ENSMUSG00000024921
- UniProt
- P51531
- neXtProt
- NX_P51531
Human splice variants
Mouse splice variants
* nTPM: Normalized TPM levels represent consensus gene expression calculated using two data sets. Read more
RNA data sourced from Human Protein Atlas.
Featured antibodies
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2 references | Polyclonal |
ICC
IHC |