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- Product number
- PA5-40772 - Provider product page
- Provider
- Invitrogen Antibodies
- Product name
- FOXQ1 Polyclonal Antibody
- Antibody type
- Polyclonal
- Antigen
- Synthetic peptide
- Description
- Peptide sequence: MKLEVFVPRA AHGDKQGSDL EGAGGSDAPS PLSAAGDDSL GSDGDCAANS
- Concentration
- 0.5 mg/mL
Submitted references Foxq1 promotes metastasis of nasopharyngeal carcinoma by inducing vasculogenic mimicry via the EGFR signaling pathway.
Luo Y, Wang J, Wang F, Liu X, Lu J, Yu X, Ma X, Peng X, Li X
Cell death & disease 2021 Apr 19;12(5):411
Cell death & disease 2021 Apr 19;12(5):411
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Supportive validation
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- Invitrogen Antibodies (provider)
- Main image
- Experimental details
- Western blot analysis of human HepG2 cell lysate using an anti-FOXQ1 polyclonal antibody (Product # PA5-40772).
Supportive validation
- Submitted by
- Invitrogen Antibodies (provider)
- Main image
- Experimental details
- Immunohistochemistry analysis of human lung tissue using an anti-FOXQ1 polyclonal antibody (Product # PA5-40772).
Supportive validation
- Submitted by
- Invitrogen Antibodies (provider)
- Main image
- Experimental details
- Fig. 1 Foxq1 is highly expressed in NPC tissues, and with a significant correlation with VM formation. A Region showing typical Foxq1 expression in NPC and control; Scale bars represent 50 mum. B Typical morphology of VM (red arrow) and endothelial vessels (black arrow) in NPC visualized using CD31/PAS double staining; Scale bars represent 50 mum. C Statistical results of Foxq1 expression in NPC and control tissues; p < 0.001. D Relationship between Foxq1 grades and VM in NPC tissues; p < 0.001. E Kaplan-Meier survival curves between NPC-positive and negative VM groups; p = 0.046. F - H The relationship between VM and clinical stage ( p = 0.013), T stage ( p = 0.127) and N stage ( p = 0.004) in NPC. Data are presented as mean +- s.d of three independent experiments.
- Submitted by
- Invitrogen Antibodies (provider)
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- Experimental details
- Fig. 5 Foxq1 promotes VM formation, and NPC growth and metastasis through regulating EGFR in vivo. A Image of xenograft tumors from nude mice that were injected with Foxq1 overexpressing or control 5-8F cells (after 2 weeks). B The growth curves of xenograft tumors from each group; p < 0.001. C The weight of xenograft tumors from each group; p < 0.001. D IHC of Foxq1, EGFR and PAS/CD31 double staining of xenograft tumors from each group. Red arrows = VM; Black arrows = endothelial vessels; Scale bars represent 50 mum. E - G Statistical results of Foxq1( p < 0.001),and EGFR ( p < 0.001) expression and VM channels ( p < 0.001) in xenograft tumors from each group. H Metastatic nodules by tail vein injection of each group and normal lung (left). Image of H&E staining of lung sections from each group (right); Scale bars represent 500 mum. I Statistical results of the metastatic nodules in each group; p < 0.001. The expression of related genes in xenograft tumors from each group were monitored by qRT-PCR ( J ) and western blot ( K ). Data are presented as mean +- SD of three independent experiments.
