676702

antibody from BioLegend
Targeting: BACH1 BACH-1, BTBD24
Provider product page for 676702

Antibody data

Product number
676702 - Provider product page
Provider
BioLegend
Proper citation
BioLegend Cat#676702, RRID:AB_2565667
Product name
Purified anti-BACH1
Antibody type
Monoclonal
Antigen
Partial mouse BACH1 recombinant protein (174-415 a.a.) expressed in E. coli.
Description
BACH1 is a member of the cap'n'collar type of basic region leucine zipper factor family (CNC-bZip) and forms heterodimers with the bZip subfamily of small Maf proteins such as MafF, MafG, and MafK. The BACH1-Maf heterodimers bind to the Maf recognition element (MARE) in the promoter regions and repress transcription of several genes that are involved in the regulation of oxidative stress. In the absence of oxidative stress, BACH1 was shown to repress transcription of the heme oxygenase-1 (HO-1) gene, which produces the key enzyme of the heme degradation pathway. HO-1 converts heme to ferrous iron, bilirubin, and carbon monoxide, which are potent radical scavengers and possess cytoprotective roles. BACH1 was found to regulate the genes involving in osteolytic metastasis and invasiveness of breast cancer. BACH1 has been suggested to function with BACH2 in promoting B cell development by repressing the myeloid genes in the common lymphoid progenitor cells.
Reactivity
Human, Mouse
Host
Mouse
Conjugate
Unconjugated
Antibody clone number
11D11C25
Vial size
100 µg
Concentration
0.5 mg/ml
Storage
2°C-8°C
Handling
Ambient RT
BACH1 protein structure - 676702 shown in red.