BS7363

antibody from Bioworld Technology, Inc
Targeting: RIPK3 RIP3
Provider product page for BS7363
Western blot
Immunohistochemistry

Antibody data

Product number
BS7363 - Provider product page
Provider
Bioworld Technology, Inc
Product name
RIP3 polyclonal antibody
Antibody type
Polyclonal
Antigen
Recombinant full length Human RIP3.
Description
The death domain is a cytoplasmic domain of approximately 80 amino acids that is necessary for the transduction of apoptotic signals and is present in the apoptosis-mediating receptors TNF-R1 and FAS. Other death domain-containing, but otherwise structurally unrelated proteins have been identified on the basis of their ability to associate with the cytoplasmic domains of TNF-R1 or FAS. One of these proteins, the receptor-interacting protein 3 (RIP3), contains an N-terminal kinase domain and shares extensive homology with RIP and RIP2. However, RIP3 contains a unique C-terminal death domain, which promotes apoptosis. RIP3 can be expressed as two splice variants, RIP3ÉÇ and RIP3ÎÛ, which contain a truncated N-terminal kinase domain and a distinct and shorter C-terminus. Subsequently, expression of these splice variants downregulates RIP3-mediated apoptosis.
Reactivity
Mouse
Host
Rabbit
Isotype
IgG
Vial size
100ul
Concentration
1 mg/ml
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
RIPK3 protein structure - BS7363 shown in red.