AMM00006G

antibody from Leading Biology

Targeting: SERPINB9 CAP3, PI9

Western blot (Recommended by provider)

Antibody Data

Product number

AMM00006G

Provider

Leading Biology

Product name

Proteinase Inhibitor 9 (PI-9) Antibody (Clone PI9-17)

Antibody type

Monoclonal

Description

Proteinase inhibitor 9 (PI-9, also designated cytoplasmic antiproteinase 3, or CAP3) is a 42 kDa member of the ovalbumin family of serpins that is expressed in placenta, lung and cytotoxic lymphocytes. PI-9 is a potent inhibitor of granzyme B and of granzyme B-mediated apoptosis, and is also an inhibitor of capase-1 and, to a smaller extent, caspase-4 and caspase-8. PI-9 expression is also upregulated in response to inflammatory stimuli. This upregulation protects cells from apoptosis induced by endogenously expressed or released granzyme B, particulary during target cell killling.

Reactivity

Human

Host

Mouse

Antibody clone number

PI9-17

Storage

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.