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- References [9]
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- Western blot [1]
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- Product number
- 19508-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#19508-1-AP, RRID:AB_10643387
- Product name
- PACS2-Specific antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated PACS2-Specific antibody (Cat. #19508-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Rab32 uses its effector reticulon 3L to trigger autophagic degradation of mitochondria-associated membrane (MAM) proteins.
Shikonin suppresses colon cancer cell growth and exerts synergistic effects by regulating ADAM17 and the IL‑6/STAT3 signaling pathway.
Targeting mitochondria-associated membranes as a potential therapy against endothelial injury induced by hypoxia.
The Multifunctional Sorting Protein PACS-2 Controls Mitophagosome Formation in Human Vascular Smooth Muscle Cells through Mitochondria-ER Contact Sites.
PACS2 is required for ox-LDL-induced endothelial cell apoptosis by regulating mitochondria-associated ER membrane formation and mitochondrial Ca2+ elevation.
MITOL prevents ER stress-induced apoptosis by IRE1α ubiquitylation at ER-mitochondria contact sites.
Rab32 connects ER stress to mitochondrial defects in multiple sclerosis.
The sorting protein PACS-2 promotes ErbB signalling by regulating recycling of the metalloproteinase ADAM17.
Autophagosomes form at ER-mitochondria contact sites.
Herrera-Cruz MS, Yap MC, Tahbaz N, Phillips K, Thomas L, Thomas G, Simmen T
Biology direct 2021 Nov 7;16(1):22
Biology direct 2021 Nov 7;16(1):22
Shikonin suppresses colon cancer cell growth and exerts synergistic effects by regulating ADAM17 and the IL‑6/STAT3 signaling pathway.
Shi W, Men L, Pi X, Jiang T, Peng D, Huo S, Luo P, Wang M, Guo J, Jiang Y, Peng L, Lin L, Li S, Lv J
International journal of oncology 2021 Dec;59(6)
International journal of oncology 2021 Dec;59(6)
Targeting mitochondria-associated membranes as a potential therapy against endothelial injury induced by hypoxia.
Yang YD, Li MM, Xu G, Zhang EL, Chen J, Sun B, Chen DW, Gao YQ
Journal of cellular biochemistry 2019 Nov;120(11):18967-18978
Journal of cellular biochemistry 2019 Nov;120(11):18967-18978
The Multifunctional Sorting Protein PACS-2 Controls Mitophagosome Formation in Human Vascular Smooth Muscle Cells through Mitochondria-ER Contact Sites.
Moulis M, Grousset E, Faccini J, Richetin K, Thomas G, Vindis C
Cells 2019 Jun 25;8(6)
Cells 2019 Jun 25;8(6)
PACS2 is required for ox-LDL-induced endothelial cell apoptosis by regulating mitochondria-associated ER membrane formation and mitochondrial Ca2+ elevation.
Yu S, Zhang L, Liu C, Yang J, Zhang J, Huang L
Experimental cell research 2019 Jun 15;379(2):191-202
Experimental cell research 2019 Jun 15;379(2):191-202
MITOL prevents ER stress-induced apoptosis by IRE1α ubiquitylation at ER-mitochondria contact sites.
Takeda K, Nagashima S, Shiiba I, Uda A, Tokuyama T, Ito N, Fukuda T, Matsushita N, Ishido S, Iwawaki T, Uehara T, Inatome R, Yanagi S
The EMBO journal 2019 Aug 1;38(15):e100999
The EMBO journal 2019 Aug 1;38(15):e100999
Rab32 connects ER stress to mitochondrial defects in multiple sclerosis.
Haile Y, Deng X, Ortiz-Sandoval C, Tahbaz N, Janowicz A, Lu JQ, Kerr BJ, Gutowski NJ, Holley JE, Eggleton P, Giuliani F, Simmen T
Journal of neuroinflammation 2017 Jan 23;14(1):19
Journal of neuroinflammation 2017 Jan 23;14(1):19
The sorting protein PACS-2 promotes ErbB signalling by regulating recycling of the metalloproteinase ADAM17.
Dombernowsky SL, Samsøe-Petersen J, Petersen CH, Instrell R, Hedegaard AM, Thomas L, Atkins KM, Auclair S, Albrechtsen R, Mygind KJ, Fröhlich C, Howell M, Parker P, Thomas G, Kveiborg M
Nature communications 2015 Jun 25;6:7518
Nature communications 2015 Jun 25;6:7518
Autophagosomes form at ER-mitochondria contact sites.
Hamasaki M, Furuta N, Matsuda A, Nezu A, Yamamoto A, Fujita N, Oomori H, Noda T, Haraguchi T, Hiraoka Y, Amano A, Yoshimori T
Nature 2013 Mar 21;495(7441):389-93
Nature 2013 Mar 21;495(7441):389-93
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The PACS2-Specific antibody from Proteintech is a rabbit polyclonal antibody to a peptide of human PACS2-Specific. This antibody recognizes human,mouse,rat antigen. The PACS2-Specific antibody has been validated for the following applications: ELISA, WB analysis.
