Antibody data
- Antibody Data
- Antigen structure
- References [3]
- Comments [0]
- Validations [0]
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- Product number
- AF1092 - Provider product page
- Provider
- R&D Systems
- Product name
- Mouse SIGIRR Antibody
- Antibody type
- Polyclonal
- Description
- Antigen Affinity-purified. Detects mouse SIGIRR in direct ELISAs and Western blots. In direct ELISAs, less than 5% cross-reactivity with recombinant human (rh) SIGIRR is observed.
- Reactivity
- Mouse
- Host
- Goat
- Conjugate
- Unconjugated
- Antigen sequence
Q9JLZ8
- Isotype
- IgG
- Vial size
- 100 ug
- Concentration
- LYOPH
- Storage
- Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Submitted references Vasoactive intestinal peptide downregulates proinflammatory TLRs while upregulating anti-inflammatory TLRs in the infected cornea.
The receptor SIGIRR suppresses Th17 cell proliferation via inhibition of the interleukin-1 receptor pathway and mTOR kinase activation.
The Toll-IL-1R member Tir8/SIGIRR negatively regulates adaptive immunity against kidney grafts.
Jiang X, McClellan SA, Barrett RP, Zhang Y, Hazlett LD
Journal of immunology (Baltimore, Md. : 1950) 2012 Jul 1;189(1):269-78
Journal of immunology (Baltimore, Md. : 1950) 2012 Jul 1;189(1):269-78
The receptor SIGIRR suppresses Th17 cell proliferation via inhibition of the interleukin-1 receptor pathway and mTOR kinase activation.
Gulen MF, Kang Z, Bulek K, Youzhong W, Kim TW, Chen Y, Altuntas CZ, Sass Bak-Jensen K, McGeachy MJ, Do JS, Xiao H, Delgoffe GM, Min B, Powell JD, Tuohy VK, Cua DJ, Li X
Immunity 2010 Jan 29;32(1):54-66
Immunity 2010 Jan 29;32(1):54-66
The Toll-IL-1R member Tir8/SIGIRR negatively regulates adaptive immunity against kidney grafts.
Noris M, Cassis P, Azzollini N, Cavinato R, Cugini D, Casiraghi F, Aiello S, Solini S, Cassis L, Mister M, Todeschini M, Abbate M, Benigni A, Trionfini P, Tomasoni S, Mele C, Garlanda C, Polentarutti N, Mantovani A, Remuzzi G
Journal of immunology (Baltimore, Md. : 1950) 2009 Oct 1;183(7):4249-60
Journal of immunology (Baltimore, Md. : 1950) 2009 Oct 1;183(7):4249-60
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