BS9158

antibody from Bioworld Technology, Inc

Targeting: RREB1 HNT

Western blot (Data presented on provider website)

Immunohistochemistry (Data presented on provider website)

Antibody Data

Product number

BS9158

Provider

Bioworld Technology, Inc

Product name

RREB1 (E597) polyclonal antibody

Antibody type

Polyclonal

Antigen

Synthetic peptide, corresponding to amino acids 560-610 of Human RREB1.

Description

RREB1 (Ras responsive element binding protein 1), also known as FINB, LZ321 or Zep-1, is a 1,687 amino acid protein that localizes to nuclear speckles and contains fifteen C2H2-type zinc fingers. Expressed in pancreas, heart, liver, placenta, lung, kidney and skeletal muscle, RREB1 functions as a transcription factor that binds to the Ras-responsive element (RRE) of target gene promotors, thereby inducing their transcription. In addition, RREB1 is thought to be involved in Raf/Ras-mediated cell differentiation, possibly by enhancing the expression of Calcitonin, a hormone that is produced by the thyroid gland and plays an essential role in maintaining blood calcium levels. Due to its involvement in cell differentiation events, RREB1 may be involved in Raf/Rasrelated tumor formation. Four isoforms of RREB1 exist due to alternative splicing.

Reactivity

Human, Mouse

Host

Rabbit

Isotype

IgG

Vial size

100ul

Concentration

1 mg/ml

Storage

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.