13614-1-AP

antibody from Proteintech Group

Targeting: MLXIP bHLHe36, KIAA0867, MIR, MONDOA

Provider product page for 13614-1-AP

Western blot

ELISA

Immunocytochemistry

Immunoprecipitation

Immunohistochemistry

Antibody data

Antibody Data
Antigen structure
References [17]
Comments [0]
Validations
Western blot [1]
Immunohistochemistry [2]

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Product number: 13614-1-AP - Provider product page
Provider: Proteintech Group
Proper citation: Proteintech Cat#13614-1-AP, RRID:AB_2282153
Product name: MLXIP antibody
Antibody type: Polyclonal
Description: KD/KO validated MLXIP antibody (Cat. #13614-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, IP, WB, ELISA.
Reactivity: Human, Mouse, Rat
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

MLXIP protein structure - 13614-1-AP shown in red.

Submitted references D-mannose alleviates intervertebral disc degeneration through glutamine metabolism.

Dong ZL, Jiao X, Wang ZG, Yuan K, Yang YQ, Wang Y, Li YT, Wang TC, Kan TY, Wang J, Tao HR
Military Medical Research 2024 May 6;11(1):28

Depletion of pyruvate kinase (PK) activity causes glycolytic intermediate imbalances and reveals a PK-TXNIP regulatory axis.

Nieborak A, Lukauskas S, Capellades J, Heyn P, Santos GS, Motzler K, Zeigerer A, Bester R, Protzer U, Schelter F, Wagner M, Carell T, Hruscha A, Schmid B, Yanes O, Schneider R
Molecular metabolism 2023 Aug;74:101748

The glucose-sensing transcription factor MLX balances metabolism and stress to suppress apoptosis and maintain spermatogenesis.

Carroll PA, Freie BW, Cheng PF, Kasinathan S, Gu H, Hedrich T, Dowdle JA, Venkataramani V, Ramani V, Wu X, Raftery D, Shendure J, Ayer DE, Muller CH, Eisenman RN
PLoS biology 2021 Oct;19(10):e3001085

MondoA Is Required for Normal Myogenesis and Regulation of the Skeletal Muscle Glycogen Content in Mice.

Ran H, Lu Y, Zhang Q, Hu Q, Zhao J, Wang K, Tong X, Su Q
Diabetes & metabolism journal 2021 May;45(3):439-451

MondoA-Thioredoxin-Interacting Protein Axis Maintains Regulatory T-Cell Identity and Function in Colorectal Cancer Microenvironment.

Lu Y, Li Y, Liu Q, Tian N, Du P, Zhu F, Han Y, Liu X, Liu X, Peng X, Wang X, Wu Y, Tong L, Li Y, Zhu Y, Wu L, Zhang P, Xu Y, Chen H, Li B, Tong X
Gastroenterology 2021 Aug;161(2):575-591.e16

Protein synthesis inhibitors stimulate MondoA transcriptional activity by driving an accumulation of glucose 6-phosphate.

Wilde BR, Kaadige MR, Guillen KP, Butterfield A, Welm BE, Ayer DE
Cancer & metabolism 2020 Dec 4;8(1):27

Chow HM, Shi M, Cheng A, Gao Y, Chen G, Song X, So RWL, Zhang J, Herrup K
Nature neuroscience 2019 Nov;22(11):1806-1819

MondoA drives muscle lipid accumulation and insulin resistance.

Ahn B, Wan S, Jaiswal N, Vega RB, Ayer DE, Titchenell PM, Han X, Won KJ, Kelly DP
JCI insight 2019 Jul 9;5(15)

Cellular acidosis triggers human MondoA transcriptional activity by driving mitochondrial ATP production.

Wilde BR, Ye Z, Lim TY, Ayer DE
eLife 2019 Feb 5;8

Dl-3-n-Butylphthalide Inhibits NLRP3 Inflammasome and Mitigates Alzheimer's-Like Pathology via Nrf2-TXNIP-TrX Axis.

Wang CY, Xu Y, Wang X, Guo C, Wang T, Wang ZY
Antioxidants & redox signaling 2019 Apr 10;30(11):1411-1431

Ras Suppresses TXNIP Expression by Restricting Ribosome Translocation.

Ye Z, Ayer DE
Molecular and cellular biology 2018 Oct 15;38(20)

MondoA Is an Essential Glucose-Responsive Transcription Factor in Human Pancreatic β-Cells.

Richards P, Rachdi L, Oshima M, Marchetti P, Bugliani M, Armanet M, Postic C, Guilmeau S, Scharfmann R
Diabetes 2018 Mar;67(3):461-472

BRCA1 deficiency sensitizes breast cancer cells to bromodomain and extra-terminal domain (BET) inhibition.

Zhang B, Lyu J, Liu Y, Wu C, Yang EJ, Pardeshi L, Tan K, Wong KH, Chen Q, Xu X, Deng CX, Shim JS
Oncogene 2018 Dec;37(49):6341-6356

Latent KSHV Infected Endothelial Cells Are Glutamine Addicted and Require Glutaminolysis for Survival.

Sanchez EL, Carroll PA, Thalhofer AB, Lagunoff M
PLoS pathogens 2015 Jul;11(7):e1005052

MondoA-Mlx transcriptional activity is limited by mTOR-MondoA interaction.

Kaadige MR, Yang J, Wilde BR, Ayer DE
Molecular and cellular biology 2015 Jan;35(1):101-10

Deregulated Myc requires MondoA/Mlx for metabolic reprogramming and tumorigenesis.

Carroll PA, Diolaiti D, McFerrin L, Gu H, Djukovic D, Du J, Cheng PF, Anderson S, Ulrich M, Hurley JB, Raftery D, Ayer DE, Eisenman RN
Cancer cell 2015 Feb 9;27(2):271-85

Metabolic reprogramming in triple-negative breast cancer through Myc suppression of TXNIP.

Shen L, O'Shea JM, Kaadige MR, Cunha S, Wilde BR, Cohen AL, Welm AL, Ayer DE
Proceedings of the National Academy of Sciences of the United States of America 2015 Apr 28;112(17):5425-30

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: K-562 cells were subjected to SDS PAGE followed by western blot with 13614-1-AP(MLXIP antibody) at dilution of 1:500
Sample type: cell line

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: The MLXIP antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human MLXIP. This antibody recognizes human, mouse, rat antigen. The MLXIP antibody has been validated for the following applications: ELISA, WB, IHC analysis.
Appendix: 13614-1-AP.pdf

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: Immunohistochemical of paraffin-embedded human skeletal muscle using 13614-1-AP(MLXIP antibody) at dilution of 1:100 (under 10x lens)
Sample type: tissue