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Western blotAntibody data
- Antibody Data
- Antigen structure
- References [31]
- Comments [0]
- Validations [0]
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- Product number
- NBP2-24790 - Provider product page
- Provider
- Novus Biologicals
- Product name
- Mouse Monoclonal Noxa Antibody
- Antibody type
- Monoclonal
- Description
- Protein G purified. An ~80 kDa background band may also be seen in Jurkat cell lysate.
- Reactivity
- Human, Mouse, Rat
- Host
- Mouse
- Conjugate
- Biotin
- Isotype
- IgG
- Vial size
- 0.1 ml
- Storage
- Store at 4C. Do not freeze.
Submitted references Hypoxia-induced cytotoxic drug resistance in osteosarcoma is independent of HIF-1Alpha.
Cdk1/cyclin B plays a key role in mitotic arrest-induced apoptosis by phosphorylation of Mcl-1, promoting its degradation and freeing Bak from sequestration.
Tipping the Noxa/Mcl-1 balance overcomes ABT-737 resistance in chronic lymphocytic leukemia.
Energy restriction-mimetic agents induce apoptosis in prostate cancer cells in part through epigenetic activation of KLF6 tumor suppressor gene expression.
Perturbation of the Bcl-2 network and an induced Noxa/Bcl-xL interaction trigger mitochondrial dysfunction after DNA damage.
Interactions of the p53 protein family in cellular stress response in gastrointestinal tumors.
Identification of expression signatures predictive of sensitivity to the Bcl-2 family member inhibitor ABT-263 in small cell lung carcinoma and leukemia/lymphoma cell lines.
The Bcl-2 homology domain 3 mimetic ABT-737 targets the apoptotic machinery in acute lymphoblastic leukemia resulting in synergistic in vitro and in vivo interactions with established drugs.
Chemotherapeutic drugs sensitize human renal cell carcinoma cells to ABT-737 by a mechanism involving the Noxa-dependent inactivation of Mcl-1 or A1.
Noxa mediates hepatic stellate cell apoptosis by proteasome inhibition.
BH3-only protein Bik is involved in both apoptosis induction and sensitivity to oxidative stress in multiple myeloma.
C-terminal domain of p16(INK4a) is adequate in inducing cell cycle arrest, growth inhibition and CDK4/6 interaction similar to the full length protein in HT-1080 fibrosarcoma cells.
NF-kappaB inhibition through proteasome inhibition or IKKbeta blockade increases the susceptibility of melanoma cells to cytostatic treatment through distinct pathways.
Regulation of heat-induced apoptosis by Mcl-1 degradation and its inhibition by Hsp70.
Inhibition of apoptosis facilitates necrosis induced by cisplatin in gastric cancer cells.
Overexpression of OATP1B3 confers apoptotic resistance in colon cancer.
In vivo dynamics of stable chronic lymphocytic leukemia inversely correlate with somatic hypermutation levels and suggest no major leukemic turnover in bone marrow.
c-Abl kinase inhibitors overcome CD40-mediated drug resistance in CLL: implications for therapeutic targeting of chemoresistant niches.
Up-regulation of Mcl-1 is critical for survival of human melanoma cells upon endoplasmic reticulum stress.
Influence of Bcl-2 family members on the cellular response of small-cell lung cancer cell lines to ABT-737.
Novel link between E2F1 and Smac/DIABLO: proapoptotic Smac/DIABLO is transcriptionally upregulated by E2F1.
Id3 induces a caspase-3- and -9-dependent apoptosis and mediates UVB sensitization of HPV16 E6/7 immortalized human keratinocytes.
Inhibition of glutathione synthesis overcomes Bcl-2-mediated topoisomerase inhibitor resistance and induces nonapoptotic cell death via mitochondrial-independent pathway.
Tumor suppressor HIC1 directly regulates SIRT1 to modulate p53-dependent DNA-damage responses.
MDM2 antagonists induce p53-dependent apoptosis in AML: implications for leukemia therapy.
BOK and NOXA are essential mediators of p53-dependent apoptosis.
In vivo mitochondrial p53 translocation triggers a rapid first wave of cell death in response to DNA damage that can precede p53 target gene activation.
p53 has a direct apoptogenic role at the mitochondria.
p53 has a direct apoptogenic role at the mitochondria.
Bcl-xL deamidation is a critical switch in the regulation of the response to DNA damage.
Bcl-xL deamidation is a critical switch in the regulation of the response to DNA damage.
Adamski J, Price A, Dive C, Makin G
PloS one 2013;8(6):e65304
PloS one 2013;8(6):e65304
Cdk1/cyclin B plays a key role in mitotic arrest-induced apoptosis by phosphorylation of Mcl-1, promoting its degradation and freeing Bak from sequestration.
Chu R, Terrano DT, Chambers TC
Biochemical pharmacology 2012 Jan 15;83(2):199-206
Biochemical pharmacology 2012 Jan 15;83(2):199-206
Tipping the Noxa/Mcl-1 balance overcomes ABT-737 resistance in chronic lymphocytic leukemia.
Tromp JM, Geest CR, Breij EC, Elias JA, van Laar J, Luijks DM, Kater AP, Beaumont T, van Oers MH, Eldering E
Clinical cancer research : an official journal of the American Association for Cancer Research 2012 Jan 15;18(2):487-98
Clinical cancer research : an official journal of the American Association for Cancer Research 2012 Jan 15;18(2):487-98
Energy restriction-mimetic agents induce apoptosis in prostate cancer cells in part through epigenetic activation of KLF6 tumor suppressor gene expression.
Chen CH, Huang PH, Chu PC, Chen MC, Chou CC, Wang D, Kulp SK, Teng CM, Wang Q, Chen CS
The Journal of biological chemistry 2011 Mar 25;286(12):9968-76
The Journal of biological chemistry 2011 Mar 25;286(12):9968-76
Perturbation of the Bcl-2 network and an induced Noxa/Bcl-xL interaction trigger mitochondrial dysfunction after DNA damage.
Lopez H, Zhang L, George NM, Liu X, Pang X, Evans JJ, Targy NM, Luo X
The Journal of biological chemistry 2010 May 14;285(20):15016-26
The Journal of biological chemistry 2010 May 14;285(20):15016-26
Interactions of the p53 protein family in cellular stress response in gastrointestinal tumors.
Vilgelm AE, Washington MK, Wei J, Chen H, Prassolov VS, Zaika AI
Molecular cancer therapeutics 2010 Mar;9(3):693-705
Molecular cancer therapeutics 2010 Mar;9(3):693-705
Identification of expression signatures predictive of sensitivity to the Bcl-2 family member inhibitor ABT-263 in small cell lung carcinoma and leukemia/lymphoma cell lines.
Tahir SK, Wass J, Joseph MK, Devanarayan V, Hessler P, Zhang H, Elmore SW, Kroeger PE, Tse C, Rosenberg SH, Anderson MG
Molecular cancer therapeutics 2010 Mar;9(3):545-57
Molecular cancer therapeutics 2010 Mar;9(3):545-57
The Bcl-2 homology domain 3 mimetic ABT-737 targets the apoptotic machinery in acute lymphoblastic leukemia resulting in synergistic in vitro and in vivo interactions with established drugs.
High LM, Szymanska B, Wilczynska-Kalak U, Barber N, O'Brien R, Khaw SL, Vikstrom IB, Roberts AW, Lock RB
Molecular pharmacology 2010 Mar;77(3):483-94
Molecular pharmacology 2010 Mar;77(3):483-94
Chemotherapeutic drugs sensitize human renal cell carcinoma cells to ABT-737 by a mechanism involving the Noxa-dependent inactivation of Mcl-1 or A1.
Zall H, Weber A, Besch R, Zantl N, Häcker G
Molecular cancer 2010 Jun 24;9:164
Molecular cancer 2010 Jun 24;9:164
Noxa mediates hepatic stellate cell apoptosis by proteasome inhibition.
Sosa Seda IM, Mott JL, Akazawa Y, Barreyro FJ, Bronk SF, Kaufmann SH, Gores GJ
Hepatology research : the official journal of the Japan Society of Hepatology 2010 Jul 1;40(7):701-10
Hepatology research : the official journal of the Japan Society of Hepatology 2010 Jul 1;40(7):701-10
BH3-only protein Bik is involved in both apoptosis induction and sensitivity to oxidative stress in multiple myeloma.
Bodet L, Ménoret E, Descamps G, Pellat-Deceunynck C, Bataille R, Le Gouill S, Moreau P, Amiot M, Gomez-Bougie P
British journal of cancer 2010 Dec 7;103(12):1808-14
British journal of cancer 2010 Dec 7;103(12):1808-14
C-terminal domain of p16(INK4a) is adequate in inducing cell cycle arrest, growth inhibition and CDK4/6 interaction similar to the full length protein in HT-1080 fibrosarcoma cells.
Fahham N, Sardari S, Ostad SN, Vaziri B, Ghahremani MH
Journal of cellular biochemistry 2010 Dec 15;111(6):1598-606
Journal of cellular biochemistry 2010 Dec 15;111(6):1598-606
NF-kappaB inhibition through proteasome inhibition or IKKbeta blockade increases the susceptibility of melanoma cells to cytostatic treatment through distinct pathways.
Amschler K, Schön MP, Pletz N, Wallbrecht K, Erpenbeck L, Schön M
The Journal of investigative dermatology 2010 Apr;130(4):1073-86
The Journal of investigative dermatology 2010 Apr;130(4):1073-86
Regulation of heat-induced apoptosis by Mcl-1 degradation and its inhibition by Hsp70.
Stankiewicz AR, Livingstone AM, Mohseni N, Mosser DD
Cell death and differentiation 2009 Apr;16(4):638-47
Cell death and differentiation 2009 Apr;16(4):638-47
Inhibition of apoptosis facilitates necrosis induced by cisplatin in gastric cancer cells.
Zhang LJ, Hao YZ, Hu CS, Ye Y, Xie QP, Thorne RF, Hersey P, Zhang XD
Anti-cancer drugs 2008 Feb;19(2):159-66
Anti-cancer drugs 2008 Feb;19(2):159-66
Overexpression of OATP1B3 confers apoptotic resistance in colon cancer.
Lee W, Belkhiri A, Lockhart AC, Merchant N, Glaeser H, Harris EI, Washington MK, Brunt EM, Zaika A, Kim RB, El-Rifai W
Cancer research 2008 Dec 15;68(24):10315-23
Cancer research 2008 Dec 15;68(24):10315-23
In vivo dynamics of stable chronic lymphocytic leukemia inversely correlate with somatic hypermutation levels and suggest no major leukemic turnover in bone marrow.
van Gent R, Kater AP, Otto SA, Jaspers A, Borghans JA, Vrisekoop N, Ackermans MA, Ruiter AF, Wittebol S, Eldering E, van Oers MH, Tesselaar K, Kersten MJ, Miedema F
Cancer research 2008 Dec 15;68(24):10137-44
Cancer research 2008 Dec 15;68(24):10137-44
c-Abl kinase inhibitors overcome CD40-mediated drug resistance in CLL: implications for therapeutic targeting of chemoresistant niches.
Hallaert DY, Jaspers A, van Noesel CJ, van Oers MH, Kater AP, Eldering E
Blood 2008 Dec 15;112(13):5141-9
Blood 2008 Dec 15;112(13):5141-9
Up-regulation of Mcl-1 is critical for survival of human melanoma cells upon endoplasmic reticulum stress.
Jiang CC, Lucas K, Avery-Kiejda KA, Wade M, deBock CE, Thorne RF, Allen J, Hersey P, Zhang XD
Cancer research 2008 Aug 15;68(16):6708-17
Cancer research 2008 Aug 15;68(16):6708-17
Influence of Bcl-2 family members on the cellular response of small-cell lung cancer cell lines to ABT-737.
Tahir SK, Yang X, Anderson MG, Morgan-Lappe SE, Sarthy AV, Chen J, Warner RB, Ng SC, Fesik SW, Elmore SW, Rosenberg SH, Tse C
Cancer research 2007 Feb 1;67(3):1176-83
Cancer research 2007 Feb 1;67(3):1176-83
Novel link between E2F1 and Smac/DIABLO: proapoptotic Smac/DIABLO is transcriptionally upregulated by E2F1.
Xie W, Jiang P, Miao L, Zhao Y, Zhimin Z, Qing L, Zhu WG, Wu M
Nucleic acids research 2006;34(7):2046-55
Nucleic acids research 2006;34(7):2046-55
Id3 induces a caspase-3- and -9-dependent apoptosis and mediates UVB sensitization of HPV16 E6/7 immortalized human keratinocytes.
Simbulan-Rosenthal CM, Daher A, Trabosh V, Chen WC, Gerstel D, Soeda E, Rosenthal DS
Oncogene 2006 Jun 22;25(26):3649-60
Oncogene 2006 Jun 22;25(26):3649-60
Inhibition of glutathione synthesis overcomes Bcl-2-mediated topoisomerase inhibitor resistance and induces nonapoptotic cell death via mitochondrial-independent pathway.
Yoshida A, Takemura H, Inoue H, Miyashita T, Ueda T
Cancer research 2006 Jun 1;66(11):5772-80
Cancer research 2006 Jun 1;66(11):5772-80
Tumor suppressor HIC1 directly regulates SIRT1 to modulate p53-dependent DNA-damage responses.
Chen WY, Wang DH, Yen RC, Luo J, Gu W, Baylin SB
Cell 2005 Nov 4;123(3):437-48
Cell 2005 Nov 4;123(3):437-48
MDM2 antagonists induce p53-dependent apoptosis in AML: implications for leukemia therapy.
Kojima K, Konopleva M, Samudio IJ, Shikami M, Cabreira-Hansen M, McQueen T, Ruvolo V, Tsao T, Zeng Z, Vassilev LT, Andreeff M
Blood 2005 Nov 1;106(9):3150-9
Blood 2005 Nov 1;106(9):3150-9
BOK and NOXA are essential mediators of p53-dependent apoptosis.
Yakovlev AG, Di Giovanni S, Wang G, Liu W, Stoica B, Faden AI
The Journal of biological chemistry 2004 Jul 2;279(27):28367-74
The Journal of biological chemistry 2004 Jul 2;279(27):28367-74
In vivo mitochondrial p53 translocation triggers a rapid first wave of cell death in response to DNA damage that can precede p53 target gene activation.
Erster S, Mihara M, Kim RH, Petrenko O, Moll UM
Molecular and cellular biology 2004 Aug;24(15):6728-41
Molecular and cellular biology 2004 Aug;24(15):6728-41
p53 has a direct apoptogenic role at the mitochondria.
Mihara M, Erster S, Zaika A, Petrenko O, Chittenden T, Pancoska P, Moll UM
Molecular cell 2003 Mar;11(3):577-90
Molecular cell 2003 Mar;11(3):577-90
p53 has a direct apoptogenic role at the mitochondria.
Mihara M, Erster S, Zaika A, Petrenko O, Chittenden T, Pancoska P, Moll UM
Molecular cell 2003 Mar;11(3):577-90
Molecular cell 2003 Mar;11(3):577-90
Bcl-xL deamidation is a critical switch in the regulation of the response to DNA damage.
Deverman BE, Cook BL, Manson SR, Niederhoff RA, Langer EM, Rosová I, Kulans LA, Fu X, Weinberg JS, Heinecke JW, Roth KA, Weintraub SJ
Cell 2002 Oct 4;111(1):51-62
Cell 2002 Oct 4;111(1):51-62
Bcl-xL deamidation is a critical switch in the regulation of the response to DNA damage.
Deverman BE, Cook BL, Manson SR, Niederhoff RA, Langer EM, Rosová I, Kulans LA, Fu X, Weinberg JS, Heinecke JW, Roth KA, Weintraub SJ
Cell 2002 Oct 4;111(1):51-62
Cell 2002 Oct 4;111(1):51-62
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