Antibody data

Product number
10-1031-25 - Provider product page
Provider
ABEOMICS Inc.
Product name
Anti-Human NOXA Antibody
Antibody type
Monoclonal
Description
Noxa is a BH3-only pro-apoptotic protein that mediates apoptosis by specifically inhibiting the anti-apoptotic Bcl-2 family member Mcl-1. It consists of 54 amino acids with one BH3 domain. The gene for NOXA is a target of p53. In response to cellular stress Noxa is induced by p53 and mediates p53-induced apoptosis. But more recently, it has been shown that NOXA can also be induced independently of p53 by other transcription factors such as p73 and E2F1. Noxa is also found to be induced by hypoxia-inducible factor (HIF-1) and mediates HIF-1 induced hypoxic cell death. Noxa is commonly upregulated in melanomas, and is associated with melanoma development and progression. Increase in Noxa expression is driven by oncogenic activation of MEK/ERK signaling through the transcription factor CREB (cAMP responsive element binding protein).
Reactivity
Human
Host
Mouse
Conjugate
Unconjugated
Antigen sequence
Full length recombinant protein of
NOXA was used as the immunogen for
this antibody.
Isotype
IgG
Antibody clone number
ABM16G6
Vial size
100 µg
Concentration
0.5 mg/ml
Storage
Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeat freez thawing
PMAIP1 protein structure - 10-1031-25 shown in red.