ITGAE

Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This gene encodes an I-domain-containing alpha integrin that undergoes post-translational cleavage in the extracellular domain, yielding disulfide-linked heavy and light chains. In combination with the beta 7 integrin, this protein forms the E-cadherin binding integrin known as the human mucosal lymphocyte-1 antigen. This protein is preferentially expressed in human intestinal intraepithelial lymphocytes (IEL), and in addition to a role in adhesion, it may serve as an accessory molecule for IEL activation. [provided by RefSeq, Jul 2008]

Description

Integrin subunit alpha E

Tissue specificity

Tissue enhanced (bone marrow, intestine, lung, lymphoid tissue)

Predicted location

Intracellular, Membrane

Protein family

CD markers
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Predicted membrane proteins
Protein evidence (Kim et al 2014)

Chromosome

17 (3714628 - 3801188)

Ensembl ID

ENSG00000083457  (ver. 103.38)

Orthologs

Mouse Itgae: ENSMUSG00000005947

UniProt

P38570

neXtProt

NX_P38570

Human splice variants
Mouse splice variants

Protein structure