UNC13B

This gene is expressed in the kidney cortical epithelial cells and is upregulated by hyperglycemia. The encoded protein shares a high level of similarity to the rat homolog, and contains 3 C2 domains and a diacylglycerol-binding C1 domain. Hyperglycemia increases the levels of diacylglycerol, which has been shown to induce apoptosis in cells transfected with this gene and thus contribute to the renal cell complications of hyperglycemia. Studies in other species also indicate a role for this protein in the priming step of synaptic vesicle exocytosis. [provided by RefSeq, Jul 2008]

Description

Unc-13 homolog B

Tissue specificity

Low tissue specificity

Subcell location

Nucleoplasm, Golgi apparatus, Vesicles, Intermediate filaments

Predicted location

Intracellular

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

9 (35161992 - 35405338)

Ensembl ID

ENSG00000198722  (ver. 103.38)

Orthologs

Mouse Unc13b: ENSMUSG00000028456

UniProt

O14795

neXtProt

NX_O14795

Human splice variants
Mouse splice variants

Protein structure