NMU

This gene encodes a member of the neuromedin family of neuropeptides. The encoded protein is a precursor that is proteolytically processed to generate a biologically active neuropeptide that plays a role in pain, stress, immune-mediated inflammatory diseases and feeding regulation. Increased expression of this gene was observed in renal, pancreatic and lung cancers. Alternative splicing results in multiple transcript variants encoding different isoforms. Some of these isoforms may undergo similar processing to generate the mature peptide. [provided by RefSeq, Jul 2015]

Description

Neuromedin U

Tissue specificity

Tissue enhanced (esophagus, skin , vagina)

Predicted location

Secreted in other tissues

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted secreted proteins

Chromosome

4 (55595229 - 55636698)

Ensembl ID

ENSG00000109255  (ver. 103.38)

Orthologs

Mouse Nmu: ENSMUSG00000029236

UniProt

P48645

neXtProt

NX_P48645

Human splice variants
Mouse splice variants

Protein structure