BS6823

antibody from Bioworld Technology, Inc
Targeting: IL18 IGIF, IL-18, IL-1g, IL1F4
Provider product page for BS6823
Western blot
Immunohistochemistry

Antibody data

Product number
BS6823 - Provider product page
Provider
Bioworld Technology, Inc
Product name
IL18 polyclonal antibody
Antibody type
Polyclonal
Antigen
Recombinant full length Human IL18.
Description
Four structurally related IL-1 receptor ligands have been described. These include three agonists designated IL-1Ï«, IL-1ÉÇ and IL-1ÎÛ/IL-18 and a specific receptor antagonist, IL-1RÏ«. IL-1Ï« and IL-1ÉÇ play critical roles in the regulation of the immune response and inflammation, serving as activators of T and B lymphocytes and NK (natural killer) cells. IL-18 (also referred to as IL-1ÎÛ) has been shown to augment the secretion of IFN-ÎÛ from T lymphocytes and increase NK cell activity in spleen cells. IL-18 exhibits 19% and 12% identity with IL-1Ï« and IL-1ÉÇ respectively over the 12 ÉÇ-strands of the ÉÇ-trefoil fold domain, which is a signature feature of the IL-1 family. The unusual leader sequence of IL-18 may be analogous to the IL-1ÉÇ pro-domain which must be cleaved by the serine protease ICE for optimal secretion and biological activity. Originally described as IGIF (IFN-ÎÛ-inducing factor), IL-18 is induced by mouse liver subsequent to challenge with lipopolysaccharide (LPS).
Reactivity
Human
Host
Rabbit
Isotype
IgG
Vial size
100ul
Concentration
1 mg/ml
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
IL18 protein structure - BS6823 shown in red.