MADD

Tumor necrosis factor alpha (TNF-alpha) is a signaling molecule that interacts with one of two receptors on cells targeted for apoptosis. The apoptotic signal is transduced inside these cells by cytoplasmic adaptor proteins. The protein encoded by this gene is a death domain-containing adaptor protein that interacts with the death domain of TNF-alpha receptor 1 to activate mitogen-activated protein kinase (MAPK) and propagate the apoptotic signal. It is membrane-bound and expressed at a higher level in neoplastic cells than in normal cells. Several transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]

Description

MAP kinase activating death domain

Tissue specificity

Tissue enhanced (retina)

Subcell location

Plasma membrane, Cytosol

Predicted location

Intracellular, Membrane

Protein family

Human disease related genes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Predicted membrane proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

11 (47269161 - 47330031)

Ensembl ID

ENSG00000110514  (ver. 103.38)

Orthologs

Mouse Madd: ENSMUSG00000040687

UniProt

Q8WXG6

neXtProt

NX_Q8WXG6

Human splice variants
Mouse splice variants

Protein structure