COL15A1

This gene encodes the alpha chain of type XV collagen, a member of the FACIT collagen family (fibril-associated collagens with interrupted helices). Type XV collagen has a wide tissue distribution but the strongest expression is localized to basement membrane zones so it may function to adhere basement membranes to underlying connective tissue stroma. The proteolytically produced C-terminal fragment of type XV collagen is restin, a potentially antiangiogenic protein that is closely related to endostatin. Mouse studies have shown that collagen XV deficiency is associated with muscle and microvessel deterioration. [provided by RefSeq, May 2013]

Description

Collagen type XV alpha 1 chain

Tissue specificity

Tissue enhanced (placenta)

Subcell location

Endoplasmic reticulum

Predicted location

Secreted to extracellular matrix

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Plasma proteins
Predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

9 (98943179 - 99070792)

Ensembl ID

ENSG00000204291  (ver. 103.38)

Orthologs

Mouse Col15a1: ENSMUSG00000028339

UniProt

P39059

neXtProt

NX_P39059

Human splice variants
Mouse splice variants

Protein structure