Tissue expression
Cell line expression
Protein structure
KLHL3
Kelch like family member 3KIAA1129
This gene is ubiquitously expressed and encodes a full-length protein which has an N-terminal BTB domain followed by a BACK domain and six kelch-like repeats in the C-terminus. These kelch-like repeats promote substrate ubiquitination of bound proteins via interaction of the BTB domain with the CUL3 (cullin 3) component of a cullin-RING E3 ubiquitin ligase (CRL) complex. Muatations in this gene cause pseudohypoaldosteronism type IID (PHA2D); a rare Mendelian syndrome featuring hypertension, hyperkalaemia and metabolic acidosis. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Mar 2012]
Top validated antibodies |
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Proteintech Group | 16951-1-AP | 9 references | Polyclonal |
WB
EL
IP
IHC |
|
Invitrogen Antibodies | 16951-1-AP | Polyclonal |
WB
IP
IHC
OA |
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antibodies-online | ABIN1850052 | Polyclonal |
WB
EL
ICC
IHC |
||
NovoPro Bioscience Inc. | 112102 | Polyclonal |
WB
EL
IP
IHC |
||
Cusabio Biotech Co., Ltd | CSB-PA008716 | Polyclonal |
WB
EL
ICC
IHC |
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Supportive data in Antibodypedia
Data presented on provider website
Data in Antibodypedia (inconclusive)
Recommended by provider