327901

antibody from BioLegend

Targeting: ITGAV CD51, MSK8, VNRA, VTNR

ELISA (Recommended by provider)

Immunoprecipitation (Recommended by provider)

Flow cytometry (Data presented on provider website)

Antibody Data

Product number

327901

Provider

BioLegend

Product name

Purified anti-human CD51

Antibody type

Monoclonal

Antigen

Melonama cells

Description

CD51 is a type I integral membrane glycoprotein, known as vitronectin receptor α chain, or integrin αV. It forms heterodimer with integrin β1 (CD29), β3 (CD61), β5, β6, or β8. CD51 contains two disulfide-linked subunits of 125 kD and 24 kD, and is expressed on endothelial cells, fibroblasts, macrophages, platelets, osteoclasts, neuroblastoma, melanoma, and hepatoma cells. Many extracellular matrix proteins with RGD-motifs are CD51 ligands. In association with its β chains, CD51 binds vitronectin, von Willebrand factor, fibronectin, thrombospondin, osteopontin, fibrinogen, and laminin. CD51, as an adhesion molecule, plays important roles in leukocytes homing and rolling, mediates bone absorption and angiogenesis.

Reactivity

Human

Host

Mouse

Conjugate

Unconjugated

Isotype

IgG

Vial size

25 µg

Concentration

0.5 mg/ml

Storage

The antibody solution should be stored undiluted at 4°C.

References

Submitted references

Colon carcinoma cell glycolipids, integrins, and other glycoproteins mediate adhesion to HUVECs under flow.

Burdick MM, McCaffery JM, Kim YS, Bochner BS, Konstantopoulos K
American journal of physiology. Cell physiology 2003 Apr;284(4):C977-87

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Integrin recognition of different cell-binding fragments of laminin (P1, E3, E8) and evidence that alpha 6 beta 1 but not alpha 6 beta 4 functions as a major receptor for fragment E8.

Sonnenberg A, Linders CJ, Modderman PW, Damsky CH, Aumailley M, Timpl R
The Journal of cell biology 1990 Jun;110(6):2145-55