BS7875

antibody from Bioworld Technology, Inc
Targeting: COMP EDM1, EPD1, MED, PSACH, THBS5
Provider product page for BS7875
Western blot
Immunohistochemistry

Antibody data

Product number
BS7875 - Provider product page
Provider
Bioworld Technology, Inc
Product name
COMP polyclonal antibody
Antibody type
Polyclonal
Antigen
Recombinant full length Human COMP.
Description
Thrombospondin 5 (also designated THBS5, cartilage oligomeric matrix protein or COMP) is the fifth member of the Thrombospondin family of extracellular matrix proteins. The Thrombospondin family share overall homology, with significant homology in their carboxy-terminal globular domains. They all contain type 2 (epidermal growth factor-like) and type 3 (calmodulin-like) repeats in their central domains. The human COMP/THBS5 gene maps to chromosome 19p13.1. Thrombospondin 5 is expressed in all types of cartilage, tendon and vascular smooth muscle. Its localization in cartilage is developmentally regulated to the chondrocyte territorial and interterritorial matrix. Thrombospondin 5 also binds to Collagen Type I, II and IX in a zinc-dependent manner. Mutations in the COMP/THBS5 gene are associated with the human genetic disorders pseudoachondroplasia (PSACH) and some types of multiple epiphyseal dysplasia (MED). PSACH and MED are autosomal dominant chondrodysplasias, which cause mild to severe short-limb dwarfism and early-onset osteoarthritis.
Reactivity
Human, Mouse
Host
Rabbit
Isotype
IgG
Vial size
100ul
Concentration
1 mg/ml
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
COMP protein structure - BS7875 shown in red.