abx001518

antibody from Abbexa

Targeting: NR0B2 SHP

Western blot (Recommended by provider)

Immunocytochemistry (Recommended by provider)

Immunohistochemistry (Recommended by provider)

Antibody Data

Product number

abx001518

Provider

Abbexa

Product name

Nuclear Receptor Subfamily 0 Group B Member 2 (NR0B2) Antibody

Antibody type

Polyclonal

Description

NR0B2 Antibody is a Rabbit Polyclonal antibody against NR0B2. The protein encoded by this gene is an unusual orphan receptor that contains a putative ligand-binding domain but lacks a conventional DNA-binding domain. The gene product is a member of the nuclear hormone receptor family, a group of transcription factors regulated by small hydrophobic hormones, a subset of which do not have known ligands and are referred to as orphan nuclear receptors. The protein has been shown to interact with retinoid and thyroid hormone receptors, inhibiting their ligand-dependent transcriptional activation. In addition, interaction with estrogen receptors has been demonstrated, leading to inhibition of function. Studies suggest that the protein represses nuclear hormone receptor-mediated transactivation via two separate steps: competition with coactivators and the direct effects of its transcriptional repressor function.

Reactivity

Human, Mouse, Rat

Host

Rabbit

Conjugate

Unconjugated

Isotype

IgG

Vial size

100 µl

Concentration

2.04 mg/ml

Storage

Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.