KCNIP2

This gene encodes a member of the family of voltage-gated potassium (Kv) channel-interacting proteins (KCNIPs), which belongs to the recoverin branch of the EF-hand superfamily. Members of the KCNIP family are small calcium binding proteins. They all have EF-hand-like domains, and differ from each other in the N-terminus. They are integral subunit components of native Kv4 channel complexes. They may regulate A-type currents, and hence neuronal excitability, in response to changes in intracellular calcium. Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified from this gene. [provided by RefSeq, Jul 2008]

Description

Potassium voltage-gated channel interacting protein 2

Tissue specificity

Tissue enhanced (adipose tissue, brain, heart muscle)

Subcell location

Vesicles

Predicted location

Intracellular

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Transporters

Chromosome

10 (101825974 - 101843920)

Ensembl ID

ENSG00000120049  (ver. 103.38)

Orthologs

Mouse Kcnip2: ENSMUSG00000025221

UniProt

Q9NS61

neXtProt

NX_Q9NS61

Human splice variants
Mouse splice variants

Protein structure