MXI1

Expression of the c-myc gene, which produces an oncogenic transcription factor, is tightly regulated in normal cells but is frequently deregulated in human cancers. The protein encoded by this gene is a transcriptional repressor thought to negatively regulate MYC function, and is therefore a potential tumor suppressor. This protein inhibits the transcriptional activity of MYC by competing for MAX, another basic helix-loop-helix protein that binds to MYC and is required for its function. Defects in this gene are frequently found in patients with prostate tumors. Three alternatively spliced transcripts encoding different isoforms have been described. Additional alternatively spliced transcripts may exist but the products of these transcripts have not been verified experimentally. [provided by RefSeq, Jul 2008]

Description

MAX interactor 1, dimerization protein

Tissue specificity

Low tissue specificity

Subcell location

Nucleoplasm, Nucleoli, Nucleoli rim, Cytosol

Predicted location

Intracellular

Protein family

Cancer-related genes
Disease related genes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Transcription factors

Chromosome

10 (110207605 - 110287365)

Ensembl ID

ENSG00000119950  (ver. 103.38)

Orthologs

Mouse Mxi1: ENSMUSG00000025025

UniProt

P50539

neXtProt

NX_P50539

Human splice variants
Mouse splice variants

Protein structure