345304

antibody from BioLegend

Targeting: IL6R CD126

Antibody data

Submit

Validation data

Product number: 345304 - Provider product page
Provider: BioLegend
Proper citation: BioLegend Cat#345304, RRID:AB_2127910
Product name: Alexa Fluor® 647 anti-human CD126 (IL-6Ra) [BL-126]
Antibody type: Monoclonal
Antigen: CD126
Description: CD126 is an 80 kD IL-6 receptor α chain also known as IL-6R. It is a member of the immunoglobulin superfamily that is expressed on plasma cells, T cells, activated B cells, monocytes, hepatocytes, epithelial cells, and fibroblasts. Functional IL-6 receptors are formed by the non-covalent association of CD126 and the IL-6 receptor β chain (CD130 or gp130). CD126 binds IL-6 with low affinity, but does not signal. The β chain (gp130, CD130) does not bind IL-6 by itself, but associates with the α-chain/IL-6 complex to initiate signal transduction. IL-6 binding to the receptor complex results in the stimulation of B and T cells, and hematopoietic precursor proliferation and differentiation. Soluble form of CD126 has been found in human serum.
Reactivity: Human
Host: Mouse
Conjugate: Red dye
Isotype: IgG
Vial size: 100 tests
Storage: The antibody solution should be stored undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.

IL6R protein structure - 345304 shown in red.