CAPN9

Calpains are ubiquitous, well-conserved family of calcium-dependent, cysteine proteases. The calpain proteins are heterodimers consisting of an invariant small subunit and variable large subunits. The large subunit possesses a cysteine protease domain, and both subunits possess calcium-binding domains. Calpains have been implicated in neurodegenerative processes, as their activation can be triggered by calcium influx and oxidative stress. The protein encoded by this gene is expressed predominantly in stomach and small intestine and may have specialized functions in the digestive tract. This gene is thought to be associated with gastric cancer. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Description

Calpain 9

Tissue specificity

Tissue enhanced (intestine, stomach)

Subcell location

Golgi apparatus, Vesicles

Predicted location

Intracellular

Protein family

Enzymes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

1 (230747384 - 230802003)

Ensembl ID

ENSG00000135773  (ver. 103.38)

Orthologs

Mouse Capn9: ENSMUSG00000031981

UniProt

O14815

neXtProt

NX_O14815

Human splice variants
Mouse splice variants

Protein structure