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Western blot
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- Antibody Data
- Antigen structure
- References [11]
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- Western blot [3]
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- Product number
- GTX107538 - Provider product page
- Provider
- GeneTex
- Proper citation
- GeneTex Cat#GTX107538, RRID:AB_2037439
- Product name
- MLKL antibody
- Antibody type
- Polyclonal
- Reactivity
- Human, Mouse
- Host
- Rabbit
Submitted references Upregulation of human glycolipid transfer protein (GLTP) induces necroptosis in colon carcinoma cells.
Staphylococcus aureus Induces a Mucosal Type 2 Immune Response via Epithelial Cell-derived Cytokines.
Sorafenib inhibits therapeutic induction of necroptosis in acute leukemia cells.
Thioredoxin-1 actively maintains the pseudokinase MLKL in a reduced state to suppress disulfide bond-dependent MLKL polymer formation and necroptosis.
Therapeutic targeting of necroptosis by Smac mimetic bypasses apoptosis resistance in acute myeloid leukemia cells.
Sorafenib tosylate inhibits directly necrosome complex formation and protects in mouse models of inflammation and tissue injury.
Signalome-wide RNAi screen identifies GBA1 as a positive mediator of autophagic cell death.
A Bak-dependent mitochondrial amplification step contributes to Smac mimetic/glucocorticoid-induced necroptosis.
Smac mimetics and type II interferon synergistically induce necroptosis in various cancer cell lines.
Molecular features of the cytotoxicity of an NHE inhibitor: Evidence of mitochondrial alterations, ROS overproduction and DNA damage.
Necroptosis is preceded by nuclear translocation of the signaling proteins that induce it.
Mishra SK, Stephenson DJ, Chalfant CE, Brown RE
Biochimica et biophysica acta. Molecular and cell biology of lipids 2019 Feb;1864(2):158-167
Biochimica et biophysica acta. Molecular and cell biology of lipids 2019 Feb;1864(2):158-167
Staphylococcus aureus Induces a Mucosal Type 2 Immune Response via Epithelial Cell-derived Cytokines.
Lan F, Zhang N, Holtappels G, De Ruyck N, Krysko O, Van Crombruggen K, Braun H, Johnston SL, Papadopoulos NG, Zhang L, Bachert C
American journal of respiratory and critical care medicine 2018 Aug 15;198(4):452-463
American journal of respiratory and critical care medicine 2018 Aug 15;198(4):452-463
Sorafenib inhibits therapeutic induction of necroptosis in acute leukemia cells.
Feldmann F, Schenk B, Martens S, Vandenabeele P, Fulda S
Oncotarget 2017 Sep 15;8(40):68208-68220
Oncotarget 2017 Sep 15;8(40):68208-68220
Thioredoxin-1 actively maintains the pseudokinase MLKL in a reduced state to suppress disulfide bond-dependent MLKL polymer formation and necroptosis.
Reynoso E, Liu H, Li L, Yuan AL, Chen S, Wang Z
The Journal of biological chemistry 2017 Oct 20;292(42):17514-17524
The Journal of biological chemistry 2017 Oct 20;292(42):17514-17524
Therapeutic targeting of necroptosis by Smac mimetic bypasses apoptosis resistance in acute myeloid leukemia cells.
Safferthal C, Rohde K, Fulda S
Oncogene 2017 Mar;36(11):1487-1502
Oncogene 2017 Mar;36(11):1487-1502
Sorafenib tosylate inhibits directly necrosome complex formation and protects in mouse models of inflammation and tissue injury.
Martens S, Jeong M, Tonnus W, Feldmann F, Hofmans S, Goossens V, Takahashi N, Bräsen JH, Lee EW, Van der Veken P, Joossens J, Augustyns K, Fulda S, Linkermann A, Song J, Vandenabeele P
Cell death & disease 2017 Jun 29;8(6):e2904
Cell death & disease 2017 Jun 29;8(6):e2904
Signalome-wide RNAi screen identifies GBA1 as a positive mediator of autophagic cell death.
Dasari SK, Bialik S, Levin-Zaidman S, Levin-Salomon V, Merrill AH Jr, Futerman AH, Kimchi A
Cell death and differentiation 2017 Jul;24(7):1288-1302
Cell death and differentiation 2017 Jul;24(7):1288-1302
A Bak-dependent mitochondrial amplification step contributes to Smac mimetic/glucocorticoid-induced necroptosis.
Rohde K, Kleinesudeik L, Roesler S, Löwe O, Heidler J, Schröder K, Wittig I, Dröse S, Fulda S
Cell death and differentiation 2017 Jan;24(1):83-97
Cell death and differentiation 2017 Jan;24(1):83-97
Smac mimetics and type II interferon synergistically induce necroptosis in various cancer cell lines.
Cekay MJ, Roesler S, Frank T, Knuth AK, Eckhardt I, Fulda S
Cancer letters 2017 Dec 1;410:228-237
Cancer letters 2017 Dec 1;410:228-237
Molecular features of the cytotoxicity of an NHE inhibitor: Evidence of mitochondrial alterations, ROS overproduction and DNA damage.
Aredia F, Czaplinski S, Fulda S, Scovassi AI
BMC cancer 2016 Nov 5;16(1):851
BMC cancer 2016 Nov 5;16(1):851
Necroptosis is preceded by nuclear translocation of the signaling proteins that induce it.
Yoon S, Bogdanov K, Kovalenko A, Wallach D
Cell death and differentiation 2016 Feb;23(2):253-60
Cell death and differentiation 2016 Feb;23(2):253-60
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Supportive validation
- Submitted by
- GeneTex (provider)
- Main image
- Experimental details
- Sample (30 ug of whole cell lysate)? A: THP-1 B:? NCI-H929 10% SDS PAGE? GTX107538 diluted at 1:1000 ?
- Submitted by
- GeneTex (provider)
- Main image
- Experimental details
- Various whole cell extracts (30 ?g) were separated by 12% SDS-PAGE, and the membrane was blotted with MLKL antibody (GTX107538) diluted at 1:500. The HRP-conjugated anti-rabbit IgG antibody (GTX213110-01) was used to detect the primary antibody.
- Submitted by
- GeneTex (provider)
- Main image
- Experimental details
- Whole cell extract (30 ?g) was separated by 12% SDS-PAGE, and the membrane was blotted with MLKL antibody (GTX107538) diluted at 1:500. The HRP-conjugated anti-rabbit IgG antibody (GTX213110-01) was used to detect the primary antibody.
