Tissue expression
Cell line expression
Protein structure
MLKL
Mixed lineage kinase domain like pseudokinaseFLJ34389
This gene belongs to the protein kinase superfamily. The encoded protein contains a protein kinase-like domain; however, is thought to be inactive because it lacks several residues required for activity. This protein plays a critical role in tumor necrosis factor (TNF)-induced necroptosis, a programmed cell death process, via interaction with receptor-interacting protein 3 (RIP3), which is a key signaling molecule in necroptosis pathway. Inhibitor studies and knockdown of this gene inhibited TNF-induced necrosis. High levels of this protein and RIP3 are associated with inflammatory bowel disease in children. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Sep 2015]
Top validated antibodies |
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Proteintech Group | ![]() |
24 references | Polyclonal |
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Novus Biologicals | ![]() |
2 references | Monoclonal |
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Invitrogen Antibodies | ![]() |
2 references | Polyclonal |
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Biorbyt | ![]() |
Polyclonal |
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GeneTex | ![]() |
11 references | Polyclonal |
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