Tissue expression
Cell line expression
Protein structure
PSMF1
Proteasome inhibitor subunit 1PI31
The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a protein that inhibits the activation of the proteasome by the 11S and 19S regulators. Alternative transcript variants have been identified for this gene. [provided by RefSeq, Jul 2008]
Top validated antibodies |
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Cusabio Biotech Co., Ltd | CSB-PA852882DSR1HU | Polyclonal |
WB
EL
ICC
IHC |
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GeneTex | GTX104760 | 1 references | Polyclonal |
WB
ICC |
|
Atlas Antibodies | HPA041122 | Polyclonal |
WB
ICC
IHC
|
||
LSBio | LS-C334133 | Polyclonal |
WB
IHC |
||
Novus Biologicals | NB100-1178 | 2 references | Polyclonal |
WB
EL |
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