Tissue expression
Cell line expression
Protein structure
PIK3R5
Phosphoinositide-3-kinase regulatory subunit 5p101, P101-PI3K
Phosphatidylinositol 3-kinases (PI3Ks) phosphorylate the inositol ring of phosphatidylinositol at the 3-prime position, and play important roles in cell growth, proliferation, differentiation, motility, survival and intracellular trafficking. The PI3Ks are divided into three classes: I, II and III, and only the class I PI3Ks are involved in oncogenesis. This gene encodes the 101 kD regulatory subunit of the class I PI3K gamma complex, which is a dimeric enzyme, consisting of a 110 kD catalytic subunit gamma and a regulatory subunit of either 55, 87 or 101 kD. This protein recruits the catalytic subunit from the cytosol to the plasma membrane through high-affinity interaction with G-beta-gamma proteins. Multiple alternatively spliced transcript variants encoding two distinct isoforms have been found. [provided by RefSeq, Oct 2011]
Top validated antibodies |
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antibodies-online | ![]() |
4 references | Polyclonal |
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Proteintech Group | ![]() |
8 references | Polyclonal |
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LSBio | ![]() |
Monoclonal |
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Novus Biologicals | ![]() |
1 references | Monoclonal |
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NovoPro Bioscience Inc. | ![]() |
Polyclonal |
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