ASIP

In mice, the agouti gene encodes a paracrine signaling molecule that causes hair follicle melanocytes to synthesize pheomelanin, a yellow pigment, instead of the black or brown pigment, eumelanin. Pleiotropic effects of constitutive expression of the mouse gene include adult-onset obesity, increased tumor susceptibility, and premature infertility. This gene is highly similar to the mouse gene and encodes a secreted protein that may (1) affect the quality of hair pigmentation, (2) act as a pharmacological antagonist of alpha-melanocyte-stimulating hormone, (3) play a role in neuroendocrine aspects of melanocortin action, and (4) have a functional role in regulating lipid metabolism in adipocytes. [provided by RefSeq, Jul 2008]

Description

Agouti signaling protein

Tissue specificity

Group enriched (epididymis, heart muscle, ovary)

Subcell location

Vesicles

Predicted location

Secreted to blood

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted secreted proteins

Chromosome

20 (34194569 - 34269344)

Ensembl ID

ENSG00000101440  (ver. 103.38)

Orthologs

Mouse a: ENSMUSG00000027596

UniProt

P42127

neXtProt

NX_P42127

Human splice variants
Mouse splice variants

Protein structure