GP2

This gene encodes an integral membrane protein that is secreted from intracellular zymogen granules and associates with the plasma membrane via glycosylphosphatidylinositol (GPI) linkage. The encoded protein binds pathogens such as enterobacteria, thereby playing an important role in the innate immune response. The C-terminus of this protein is related to the C-terminus of the protein encoded by the neighboring gene, uromodulin (UMOD). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]

Description

Glycoprotein 2

Tissue specificity

Tissue enriched (pancreas)

Predicted location

Intracellular, Membrane, Secreted to digestive system

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Predicted membrane proteins
Predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

16 (20309574 - 20327808)

Ensembl ID

ENSG00000169347  (ver. 103.38)

Orthologs

Mouse Gp2: ENSMUSG00000030954

UniProt

P55259

neXtProt

NX_P55259

Human splice variants
Mouse splice variants

Protein structure