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Protein structure
PRDM16
PR/SET domain 16KIAA1675, KMT8F, MEL1, MGC166915, PFM13
The reciprocal translocation t(1;3)(p36;q21) occurs in a subset of myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML). This gene is located near the 1p36.3 breakpoint and has been shown to be specifically expressed in the t(1:3)(p36,q21)-positive MDS/AML. The protein encoded by this gene is a zinc finger transcription factor and contains an N-terminal PR domain. The translocation results in the overexpression of a truncated version of this protein that lacks the PR domain, which may play an important role in the pathogenesis of MDS and AML. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
Top validated antibodies |
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| Invitrogen Antibodies |  PA5-20872 |
12 references | Polyclonal |
WB
ICC
IHC
OA
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| OriGene | AP23499PU-N |
1 references | Polyclonal |
WB
EL
ICC
IHC
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| Novus Biologicals | NBP1-77096 |
2 references | Polyclonal |
WB
EL
ICC
IHC
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| antibodies-online | ABIN500533 |
4 references | Polyclonal |
WB
EL
IHC
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| R&D Systems | AF6295 |
10 references | Polyclonal |
WB
IHC
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