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ImmunohistochemistryAntibody data
- Antibody Data
- Antigen structure
- References [5]
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- Validations
- Immunohistochemistry [1]
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- Product number
- MAB4375 - Provider product page
- Provider
- R&D Systems
- Product name
- Human/Mouse/Rat Substance P Antibody
- Antibody type
- Monoclonal
- Description
- Protein A or G purified from hybridoma culture supernatant. Detects human, mouse, and rat Substance P.
- Reactivity
- Human, Mouse, Rat
- Host
- Mouse
- Conjugate
- Unconjugated
- Isotype
- IgG
- Antibody clone number
- 266815
- Vial size
- 100 ug
- Concentration
- LYOPH
- Storage
- Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Submitted references TRPA1 and substance P mediate stress induced duodenal lesions in water immersion restraint stress rat model.
The dual regulation of substance P-mediated inflammation via human synovial mast cells in rheumatoid arthritis.
Curcumin alleviates lumbar radiculopathy by reducing neuroinflammation, oxidative stress and nociceptive factors.
Target-derived neurotrophins coordinate transcription and transport of bclw to prevent axonal degeneration.
Expression and distribution of mTOR, p70S6K, 4E-BP1, and their phosphorylated counterparts in rat dorsal root ganglion and spinal cord dorsal horn.
Xu Y, Huang C, Deng H, Jia J, Wu Y, Yang J, Tu W
The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology 2018 Nov;29(6):692-700
The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology 2018 Nov;29(6):692-700
The dual regulation of substance P-mediated inflammation via human synovial mast cells in rheumatoid arthritis.
Okamura Y, Mishima S, Kashiwakura JI, Sasaki-Sakamoto T, Toyoshima S, Kuroda K, Saito S, Tokuhashi Y, Okayama Y
Allergology international : official journal of the Japanese Society of Allergology 2017 Sep;66S:S9-S20
Allergology international : official journal of the Japanese Society of Allergology 2017 Sep;66S:S9-S20
Curcumin alleviates lumbar radiculopathy by reducing neuroinflammation, oxidative stress and nociceptive factors.
Xiao L, Ding M, Fernandez A, Zhao P, Jin L, Li X
European cells & materials 2017 May 9;33:279-293
European cells & materials 2017 May 9;33:279-293
Target-derived neurotrophins coordinate transcription and transport of bclw to prevent axonal degeneration.
Cosker KE, Pazyra-Murphy MF, Fenstermacher SJ, Segal RA
The Journal of neuroscience : the official journal of the Society for Neuroscience 2013 Mar 20;33(12):5195-207
The Journal of neuroscience : the official journal of the Society for Neuroscience 2013 Mar 20;33(12):5195-207
Expression and distribution of mTOR, p70S6K, 4E-BP1, and their phosphorylated counterparts in rat dorsal root ganglion and spinal cord dorsal horn.
Xu JT, Zhao X, Yaster M, Tao YX
Brain research 2010 Jun 8;1336:46-57
Brain research 2010 Jun 8;1336:46-57
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Supportive validation
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- R&D Systems (provider)
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- Experimental details
- Substance P in Human Spinal Cord. Substance P was detected in immersion fixed paraffin-embedded sections of human spinal cord using 8 µg/mL Human/Mouse/Rat Substance P Monoclonal Antibody (Catalog # MAB4375) overnight at 4 °C. Tissue was stained with the Anti-Mouse HRP-DAB Cell & Tissue Staining Kit (brown; Catalog # CTS002) and counterstained with hematoxylin (blue). Specific labeling was localized to the spinal cord dorsal horn. View our protocol for Chromogenic IHC Staining of Paraffin-embedded Tissue Sections.
