SKIV2L

DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, which is a human homologue of yeast SKI2 and may be involved in antiviral activity by blocking translation of poly(A) deficient mRNAs. This gene is located in the class III region of the major histocompatibility complex. [provided by RefSeq, Jul 2008]

Description

Ski2 like RNA helicase

Tissue specificity

Low tissue specificity

Subcell location

Nucleoplasm, Nuclear bodies, Mitotic spindle, Cytosol

Predicted location

Intracellular

Protein family

Disease related genes
Human disease related genes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Plasma proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

6 (31959117 - 31969751)

Ensembl ID

ENSG00000204351  (ver. 103.38)

Orthologs

Mouse Skiv2l: ENSMUSG00000040356

UniProt

Q15477

neXtProt

NX_Q15477

Human splice variants
Mouse splice variants

Protein structure