ABIN251659
antibody from antibodies-online
Targeting: NOD2
BLAU, CARD15, CD, CLR16.3, IBD1, NLRC2, PSORAS1
Antibody data
- Antibody Data
- Antigen structure
- References [13]
- Comments [0]
- Validations
- Western blot [5]
- Immunohistochemistry [1]
- Flow cytometry [2]
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Validation data
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- Product number
- ABIN251659 - Provider product page
- Provider
- antibodies-online
- Product name
- anti-Nucleotide-Binding Oligomerization Domain Containing 2 (NOD2) (AA 28-301) antibody
- Antibody type
- Monoclonal
- Description
- Protein G purified
- Reactivity
- Human, Mouse
- Host
- Mouse
- Epitope
- AA 28-301
- Isotype
- IgG
- Antibody clone number
- 2D9
- Vial size
- 0.025 mL
- Storage
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
- Handling
- Avoid freeze-thaw cycles
Submitted references Vitamin D Promotes Pneumococcal Killing and Modulates Inflammatory Responses in Primary Human Neutrophils.
Activation of nucleotide oligomerization domain 2 (NOD2) by human cytomegalovirus initiates innate immune responses and restricts virus replication.
RNAi screening identifies mediators of NOD2 signaling: implications for spatial specificity of MDP recognition.
Functional expression of NOD2 in freshly isolated human peripheral blood γδ T cells.
Genome-wide expression profiling identifies an impairment of negative feedback signals in the Crohn's disease-associated NOD2 variant L1007fsinsC.
Caspase recruitment domain-containing protein 8 (CARD8) negatively regulates NOD2-mediated signaling.
NOD2 stimulation induces autophagy in dendritic cells influencing bacterial handling and antigen presentation.
DUOX2-derived reactive oxygen species are effectors of NOD2-mediated antibacterial responses.
NOD2 plays an important role in the inflammatory responses of microglia and astrocytes to bacterial CNS pathogens.
Altered host:pathogen interactions conferred by the Blau syndrome mutation of NOD2.
A role for Erbin in the regulation of Nod2-dependent NF-kappaB signaling.
Expression of NOD2 in Paneth cells: a possible link to Crohn's ileitis.
Crohn's disease and the NOD2 gene: a role for paneth cells.
Subramanian K, Bergman P, Henriques-Normark B
Journal of innate immunity 2017;9(4):375-386
Journal of innate immunity 2017;9(4):375-386
Activation of nucleotide oligomerization domain 2 (NOD2) by human cytomegalovirus initiates innate immune responses and restricts virus replication.
Kapoor A, Forman M, Arav-Boger R
PloS one 2014;9(3):e92704
PloS one 2014;9(3):e92704
RNAi screening identifies mediators of NOD2 signaling: implications for spatial specificity of MDP recognition.
Lipinski S, Grabe N, Jacobs G, Billmann-Born S, Till A, Häsler R, Aden K, Paulsen M, Arlt A, Kraemer L, Hagemann N, Erdmann KS, Schreiber S, Rosenstiel P
Proceedings of the National Academy of Sciences of the United States of America 2012 Dec 26;109(52):21426-31
Proceedings of the National Academy of Sciences of the United States of America 2012 Dec 26;109(52):21426-31
Functional expression of NOD2 in freshly isolated human peripheral blood γδ T cells.
Marischen L, Wesch D, Oberg HH, Rosenstiel P, Trad A, Shomali M, Grötzinger J, Janssen O, Tchikov V, Schütze S, Kabelitz D
Scandinavian journal of immunology 2011 Aug;74(2):126-34
Scandinavian journal of immunology 2011 Aug;74(2):126-34
Genome-wide expression profiling identifies an impairment of negative feedback signals in the Crohn's disease-associated NOD2 variant L1007fsinsC.
Billmann-Born S, Till A, Arlt A, Lipinski S, Sina C, Latiano A, Annese V, Häsler R, Kerick M, Manke T, Seegert D, Hanidu A, Schäfer H, van Heel D, Li J, Schreiber S, Rosenstiel P
Journal of immunology (Baltimore, Md. : 1950) 2011 Apr 1;186(7):4027-38
Journal of immunology (Baltimore, Md. : 1950) 2011 Apr 1;186(7):4027-38
Caspase recruitment domain-containing protein 8 (CARD8) negatively regulates NOD2-mediated signaling.
von Kampen O, Lipinski S, Till A, Martin SJ, Nietfeld W, Lehrach H, Schreiber S, Rosenstiel P
The Journal of biological chemistry 2010 Jun 25;285(26):19921-6
The Journal of biological chemistry 2010 Jun 25;285(26):19921-6
NOD2 stimulation induces autophagy in dendritic cells influencing bacterial handling and antigen presentation.
Cooney R, Baker J, Brain O, Danis B, Pichulik T, Allan P, Ferguson DJ, Campbell BJ, Jewell D, Simmons A
Nature medicine 2010 Jan;16(1):90-7
Nature medicine 2010 Jan;16(1):90-7
DUOX2-derived reactive oxygen species are effectors of NOD2-mediated antibacterial responses.
Lipinski S, Till A, Sina C, Arlt A, Grasberger H, Schreiber S, Rosenstiel P
Journal of cell science 2009 Oct 1;122(Pt 19):3522-30
Journal of cell science 2009 Oct 1;122(Pt 19):3522-30
NOD2 plays an important role in the inflammatory responses of microglia and astrocytes to bacterial CNS pathogens.
Chauhan VS, Sterka DG Jr, Furr SR, Young AB, Marriott I
Glia 2009 Mar;57(4):414-23
Glia 2009 Mar;57(4):414-23
Altered host:pathogen interactions conferred by the Blau syndrome mutation of NOD2.
Kim TH, Payne U, Zhang X, Iwanaga Y, Davey MP, Rosenbaum JT, Inman RD
Rheumatology international 2007 Jan;27(3):257-62
Rheumatology international 2007 Jan;27(3):257-62
A role for Erbin in the regulation of Nod2-dependent NF-kappaB signaling.
McDonald C, Chen FF, Ollendorff V, Ogura Y, Marchetto S, Lécine P, Borg JP, Nuñez G
The Journal of biological chemistry 2005 Dec 2;280(48):40301-9
The Journal of biological chemistry 2005 Dec 2;280(48):40301-9
Expression of NOD2 in Paneth cells: a possible link to Crohn's ileitis.
Ogura Y, Lala S, Xin W, Smith E, Dowds TA, Chen FF, Zimmermann E, Tretiakova M, Cho JH, Hart J, Greenson JK, Keshav S, Nuñez G
Gut 2003 Nov;52(11):1591-7
Gut 2003 Nov;52(11):1591-7
Crohn's disease and the NOD2 gene: a role for paneth cells.
Lala S, Ogura Y, Osborne C, Hor SY, Bromfield A, Davies S, Ogunbiyi O, Nuñez G, Keshav S
Gastroenterology 2003 Jul;125(1):47-57
Gastroenterology 2003 Jul;125(1):47-57
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Supportive validation
- Submitted by
- antibodies-online (provider)
- Main image
- Experimental details
- Detection of NOD2 in 20ug of NOD2 transfected 293T cell lysate using ABIN151959. ECL detection in 10 seconds.
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- antibodies-online (provider)
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- Experimental details
- WB
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- WB
- Submitted by
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- WB
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- WB
Supportive validation
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- IHC
Supportive validation
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- FACS
- Submitted by
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- Experimental details
- FACS