Tissue expression
Cell line expression
Protein structure
NOD2
Nucleotide binding oligomerization domain containing 2BLAU, CARD15, CD, CLR16.3, IBD1, NLRC2, PSORAS1
This gene is a member of the Nod1/Apaf-1 family and encodes a protein with two caspase recruitment (CARD) domains and six leucine-rich repeats (LRRs). The protein is primarily expressed in the peripheral blood leukocytes. It plays a role in the immune response to intracellular bacterial lipopolysaccharides (LPS) by recognizing the muramyl dipeptide (MDP) derived from them and activating the NFKB protein. Mutations in this gene have been associated with Crohn disease and Blau syndrome. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jun 2014]
Top validated antibodies |
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Novus Biologicals | NB100-524 | 22 references | Monoclonal |
WB
ICC
IP
IHC
FC
|
|
antibodies-online | ABIN251659 | 13 references | Monoclonal |
WB
ICC
IP
IHC
FC
|
|
GeneTex | GTX30615 | Monoclonal |
WB
ICC
IP
IHC
FC
|
||
OriGene | AP08944PU-N | Polyclonal |
WB
EL
ICC
IHC |
||
Proteintech Group | 20980-1-AP | 14 references | Polyclonal |
WB
EL |
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Enhanced validation
Supportive data in Antibodypedia
Data presented on provider website
Data in Antibodypedia (inconclusive)
Recommended by provider
Supportive data in Antibodypedia
Data presented on provider website
Data in Antibodypedia (inconclusive)
Recommended by provider