EIF4EBP2

This gene encodes a member of the eukaryotic translation initiation factor 4E binding protein family. The gene products of this family bind eIF4E and inhibit translation initiation. However, insulin and other growth factors can release this inhibition via a phosphorylation-dependent disruption of their binding to eIF4E. Regulation of protein production through these gene products have been implicated in cell proliferation, cell differentiation and viral infection. [provided by RefSeq, Oct 2008]

Description

Eukaryotic translation initiation factor 4E binding protein 2

Tissue specificity

Low tissue specificity

Subcell location

Nucleoplasm, Mitochondria

Predicted location

Intracellular

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

10 (70404145 - 70428618)

Ensembl ID

ENSG00000148730  (ver. 103.38)

Orthologs

Mouse Eif4ebp2: ENSMUSG00000020091

UniProt

Q13542

neXtProt

NX_Q13542

Human splice variants
Mouse splice variants

Protein structure