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- Product number
- ABIN2842224 - Provider product page
- Provider
- antibodies-online
- Product name
- anti-6-phosphofructo-2-Kinase/fructose-2,6-Biphosphatase 4 (PFKFB4) (AA 266-296), (Center) antibody
- Antibody type
- Polyclonal
- Description
- This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
- Reactivity
- Human, Mouse
- Host
- Rabbit
- Epitope
- AA 266-296, Center
- Antibody clone number
- RB04059
- Vial size
- 80 μL
- Storage
- Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Submitted references Sertoli-secreted FGF-2 induces PFKFB4 isozyme expression in mouse spermatogenic cells by activation of the MEK/ERK/CREB pathway.
Functional metabolic screen identifies 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 as an important regulator of prostate cancer cell survival.
Nuclear targeting of 6-phosphofructo-2-kinase (PFKFB3) increases proliferation via cyclin-dependent kinases.
Ras inhibition in glioblastoma down-regulates hypoxia-inducible factor-1alpha, causing glycolysis shutdown and cell death.
Gómez M, Manzano A, Figueras A, Viñals F, Ventura F, Rosa JL, Bartrons R, Navarro-Sabaté À
American journal of physiology. Endocrinology and metabolism 2012 Sep 15;303(6):E695-707
American journal of physiology. Endocrinology and metabolism 2012 Sep 15;303(6):E695-707
Functional metabolic screen identifies 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 as an important regulator of prostate cancer cell survival.
Ros S, Santos CR, Moco S, Baenke F, Kelly G, Howell M, Zamboni N, Schulze A
Cancer discovery 2012 Apr;2(4):328-43
Cancer discovery 2012 Apr;2(4):328-43
Nuclear targeting of 6-phosphofructo-2-kinase (PFKFB3) increases proliferation via cyclin-dependent kinases.
Yalcin A, Clem BF, Simmons A, Lane A, Nelson K, Clem AL, Brock E, Siow D, Wattenberg B, Telang S, Chesney J
The Journal of biological chemistry 2009 Sep 4;284(36):24223-32
The Journal of biological chemistry 2009 Sep 4;284(36):24223-32
Ras inhibition in glioblastoma down-regulates hypoxia-inducible factor-1alpha, causing glycolysis shutdown and cell death.
Blum R, Jacob-Hirsch J, Amariglio N, Rechavi G, Kloog Y
Cancer research 2005 Feb 1;65(3):999-1006
Cancer research 2005 Feb 1;65(3):999-1006
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Supportive validation
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- antibodies-online (provider)
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- Experimental details
- WB
- Submitted by
- antibodies-online (provider)
- Main image
- Experimental details
- WB
Supportive validation
- Submitted by
- antibodies-online (provider)
- Main image
- Experimental details
- IHC
