PFKFB4

The protein encoded by this gene is one of four bifunctional kinase/phosphatases that regulate the concentration of the glycolytic byproduct fructose-2,6-bisphosphate (F2,6BP). The encoded protein is highly expressed in cancer cells and is induced by hypoxia. This protein is essential to the survival of cancer cells under conditions of hypoxia, because it increases the amount of F2,6BP and ATP at a time when the cell cannot produce much of them. This finding suggests that this protein may be a good target for disruption in cancer cells, hopefully imperiling their survival. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2015]

Description

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4

Tissue specificity

Tissue enhanced (testis)

Subcell location

Nucleoli

Predicted location

Intracellular

Protein family

Enzymes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Metabolic proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

3 (48517684 - 48562015)

Ensembl ID

ENSG00000114268  (ver. 103.38)

Orthologs

Mouse Pfkfb4: ENSMUSG00000025648

UniProt

Q16877

neXtProt

NX_Q16877

Human splice variants
Mouse splice variants

Protein structure