LGI1

This gene encodes a member of the secreted leucine-rich repeat (LRR) superfamily and shares homology with members of the SLIT protein family. The encoded protein may regulate the activity of voltage-gated potassium channels and may be involved in neuronal growth regulation and cell survival. This gene is rearranged as a result of translocations in glioblastoma cell lines, and it is frequently down-regulated or rearranged in malignant gliomas. Mutations in this gene result in autosomal dominant lateral temporal epilepsy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]

Description

Leucine rich glioma inactivated 1

Tissue specificity

Group enriched (brain, choroid plexus)

Predicted location

Intracellular, Secreted in brain

Protein family

Cancer-related genes
Disease related genes
Human disease related genes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

10:q23.33 (93757840 - 93806272)

Ensembl ID

ENSG00000108231  (ver. 103.38)

Orthologs

Mouse Lgi1: ENSMUSG00000067242

UniProt

O95970

neXtProt

NX_O95970

Human splice variants
Mouse splice variants