GABRE

The product of this gene belongs to the ligand-gated ionic channel (TC 1.A.9) family. It encodes the gamma-aminobutyric acid (GABA) A receptor which is a multisubunit chloride channel that mediates the fastest inhibitory synaptic transmission in the central nervous system. This gene encodes an epsilon subunit. It is mapped to chromosome Xq28 in a cluster comprised of genes encoding alpha 3, beta 4 and theta subunits of the same receptor. Alternatively spliced transcript variants have been identified, but only one is thought to encode a protein. [provided by RefSeq, Oct 2008]

Description

Gamma-aminobutyric acid type A receptor subunit epsilon

Tissue specificity

Group enriched (adipose tissue, brain, heart muscle)

Predicted location

Membrane

Protein family

FDA approved drug targets
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted membrane proteins

Chromosome

X (151953124 - 151974680)

Ensembl ID

ENSG00000102287  (ver. 103.38)

Orthologs

Mouse Gabre: ENSMUSG00000031340

UniProt

P78334

neXtProt

NX_P78334

Human splice variants
Mouse splice variants

Protein structure