FHL3

The protein encoded by this gene is a member of a family of proteins containing a four-and-a-half LIM domain, which is a highly conserved double zinc finger motif. The encoded protein has been shown to interact with the cancer developmental regulators SMAD2, SMAD3, and SMAD4, the skeletal muscle myogenesis protein MyoD, and the high-affinity IgE beta chain regulator MZF-1. This protein may be involved in tumor suppression, repression of MyoD expression, and repression of IgE receptor expression. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]

Description

Four and a half LIM domains 3

Tissue specificity

Group enriched (skeletal muscle, tongue)

Subcell location

Nucleoplasm

Predicted location

Intracellular

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

1 (37996770 - 38005606)

Ensembl ID

ENSG00000183386  (ver. 103.38)

Orthologs

Mouse Fhl3: ENSMUSG00000032643

UniProt

Q13643

neXtProt

NX_Q13643

Human splice variants
Mouse splice variants

Protein structure