PROK2

This gene encodes a protein expressed in the suprachiasmatic nucleus (SCN) circadian clock that may function as the output component of the circadian clock. The secreted form of the encoded protein may also serve as a chemoattractant for neuronal precursor cells in the olfactory bulb. Proteins from other vertebrates which are similar to this gene product were isolated based on homology to snake venom and secretions from frog skin, and have been shown to have diverse functions. Mutations in this gene are associated with Kallmann syndrome 4. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Description

Prokineticin 2

Tissue specificity

Tissue enhanced (bone marrow, lymphoid tissue)

Predicted location

Secreted to blood

Protein family

Disease related genes
Human disease related genes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted secreted proteins
Protein evidence (Kim et al 2014)

Chromosome

3 (71771655 - 71785206)

Ensembl ID

ENSG00000163421  (ver. 103.38)

Orthologs

Mouse Prok2: ENSMUSG00000030069

UniProt

Q9HC23

neXtProt

NX_Q9HC23

Human splice variants
Mouse splice variants

Protein structure