DEDD

This gene encodes a protein that contains a death effector domain (DED). DED is a protein-protein interaction domain shared by adaptors, regulators and executors of the programmed cell death pathway. Overexpression of this gene was shown to induce weak apoptosis. Upon stimulation, this protein was found to translocate from cytoplasm to nucleus and colocalize with UBTF, a basal factor required for RNA polymerase I transcription, in the nucleolus. At least three transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

Description

Death effector domain containing

Tissue specificity

Low tissue specificity

Subcell location

Nucleoplasm, Nucleoli, Cytosol

Predicted location

Intracellular

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins

Chromosome

1 (161120974 - 161132688)

Ensembl ID

ENSG00000158796  (ver. 103.38)

Orthologs

Mouse Dedd: ENSMUSG00000013973

UniProt

O75618

neXtProt

NX_O75618

Human splice variants
Mouse splice variants

Protein structure